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1. Full Text Multidrug efflux pumps: Substrate selection in ATP‐binding cassette multidrug efflux pumps – first come, first served?
by Ernst, Robert and Kueppers, Petra and Stindt, Jan and Kuchler, Karl and Schmitt, Lutz
The FEBS Journal, ISSN 1742-464X, 02/2010, Volume 277, Issue 3, pp. 540 - 549
Multidrug resistance is a major challenge in the therapy of cancer and pathogenic fungal infections. More than three decades ago, P‐glycoprotein was the first... 
multidrug resistance | Pdr5 | TAP | ABCB1 | ATP hydrolysis | kinetic substrate selection | multidrug efflux | transport mechanism | ABC transporter | ligand binding | Transport mechanism | Ligand binding | Multidrug resistance | Kinetic substrate selection | Multidrug efflux | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE PROTEINS | HYDROLYSIS | SACCHAROMYCES-CEREVISIAE | MUTATIONAL ANALYSIS | P-GLYCOPROTEIN | YEAST | CANDIDA-ALBICANS | DRUG TRANSPORT | PDR5P | ATP-Binding Cassette Transporters - chemistry | Drug Resistance, Multiple - genetics | Models, Biological | ATP-Binding Cassette Transporters - metabolism | Adenosine Triphosphatases - metabolism | Saccharomyces cerevisiae Proteins - physiology | Kinetics | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Drug Resistance, Multiple - physiology | Protein Structure, Tertiary - physiology | Saccharomyces cerevisiae Proteins - chemistry | Hydrolysis | Mycoses | Medical colleges | Drug resistance in microorganisms | Twins | Drug delivery systems | Pharmacology | Drug resistance | Binding sites | Adenosine triphosphatase
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2. Full Text Practical applications and feasibility of efflux pump inhibitors in the clinic—A vision for applied use
by Lomovskaya, Olga and Bostian, Keith A
Biochemical Pharmacology, ISSN 0006-2952, 2006, Volume 71, Issue 7, pp. 910 - 918
The world of antibiotic drug discovery and development is driven by the necessity to overcome antibiotic resistance in common Gram-positive and Gram-negative... 
Fluoroquinolones | Efflux | RND transporters | Pseudomonas | EPIs | Multidrug resistance | multidrug resistance | MUTANT SELECTION WINDOW | efflux | ANTIBACTERIAL DRUG DISCOVERY | GRAM-NEGATIVE BACTERIA | MEMBRANE-FUSION PROTEIN | RESISTANT ENTEROBACTER-AEROGENES | PSEUDOMONAS-AERUGINOSA | KLEBSIELLA-PNEUMONIAE STRAINS | BETA-LACTAM ANTIBIOTICS | PHARMACOLOGY & PHARMACY | MULTIDRUG EFFLUX | fluoroquinolones | IN-VITRO ACTIVITY | Gram-Negative Bacteria - drug effects | Cell Wall - drug effects | Drug Resistance, Multiple, Bacterial - physiology | Cell Membrane Permeability - physiology | Cell Membrane Permeability - drug effects | Humans | Membrane Transport Proteins - drug effects | Anti-Bacterial Agents - pharmacology | Gram-Negative Bacteria - metabolism | Cell Wall - physiology | Drug Resistance, Multiple, Bacterial - drug effects | Drug resistance in microorganisms | Technology application | Bacterial infections
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3. Full Text Fast, Na+/K+ pump driven, steady‐state transcytolemmal water exchange in neuronal tissue: A study of rat brain cortical cultures
by Bai, Ruiliang and Springer, Charles S and Plenz, Dietmar and Basser, Peter J
Magnetic Resonance in Medicine, ISSN 0740-3194, 06/2018, Volume 79, Issue 6, pp. 3207 - 3217
Purpose Water homeostasis and transport play important roles in brain function (e.g., ion homeostasis, neuronal excitability, cell volume regulation, etc.).... 
ouabain | active | Na+/K+ pump | steady‐state | transcytolemmal water exchange | neurons | steady-state | pump | NERVOUS-SYSTEM | CELLS | K+ pump | CONTRAST REAGENTS | RESOLUTION | RELAXATION | INHIBITION | IN-VIVO | Na+ | DIFFUSION | CHANNELS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Fluorescence | Brain | Neurons | Contrast media | Ouabain | Exchanging | Neuroimaging | Membranes | Nuclear magnetic resonance--NMR | Calcium | Homeostasis | Pathways | Water transport | Efflux | Calcium (intracellular) | Cortex | Excitability | Cultures | Cell membranes | Na+/K+-exchanging ATPase | Magnetic resonance imaging | Perfusion | Water exchange | Resonance | Kinetics | Cell size | Intracellular | Transport
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4. Full Text Bacterial efflux pump inhibitors from natural sources
by Stavri, Michael and Piddock, Laura J. V and Gibbons, Simon
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 06/2007, Volume 59, Issue 6, pp. 1247 - 1260
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since... 
Efflux | Escherichia | Mycobacterium | NorA | MRSA | MDR | Pseudomonas | Modulators | Staphylococcus aureus | INFECTIOUS DISEASES | MEDIATED MULTIDRUG-RESISTANCE | TEA CAMELLIA-SINENSIS | TETRACYCLINE RESISTANCE | FLUOROQUINOLONE RESISTANCE | MICROBIOLOGY | efflux | RESISTANT STAPHYLOCOCCUS-AUREUS | CIPROFLOXACIN RESISTANCE | IN-VITRO | STREPTOCOCCUS-PNEUMONIAE | MOUSE LYMPHOMA-CELLS | PSEUDOMONAS-AERUGINOSA | PHARMACOLOGY & PHARMACY | modulators | Drug Synergism | Bacteria - metabolism | Animals | Fungi - drug effects | Humans | Anti-Bacterial Agents - pharmacology | Biological Products - pharmacology | Plants - chemistry | Drug Evaluation, Preclinical | Fungi - metabolism | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Bacteria - genetics | Bacteria | Pharmacology | Inhibitor drugs | Antibiotics | Drug resistance
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5. Full Text Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria
by Nikaido, Hiroshi and Pagès, Jean-Marie
FEMS Microbiology Reviews, ISSN 0168-6445, 03/2012, Volume 36, Issue 2, pp. 340 - 363
Abstract Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a worldwide health problem. The continuous dissemination of... 
structure–function relationship | RND family drug transporters | antibiotic resistance | outer membrane permeability | MDR bacteria | bacterial efflux pump | Outer membrane permeability | Bacterial efflux pump | Structure-function relationship | Antibiotic resistance | URINARY-TRACT-INFECTIONS | structure-function relationship | LARGE PERIPLASMIC LOOPS | OUTER-MEMBRANE PERMEABILITY | MICROBIOLOGY | SITE-DIRECTED MUTAGENESIS | ESCHERICHIA-COLI STRAINS | ANTIMICROBIAL DRUG SUSCEPTIBILITY | PSEUDOMONAS-AERUGINOSA PORIN | CYSTIC-FIBROSIS PATIENTS | KLEBSIELLA-PNEUMONIAE STRAINS | BETA-LACTAM ANTIBIOTICS | Humans | Bacterial Proteins - genetics | Anti-Bacterial Agents - metabolism | Gram-Negative Bacterial Infections - drug therapy | Gram-Negative Bacteria - metabolism | Gram-Negative Bacterial Infections - microbiology | Gram-Negative Bacteria - drug effects | Animals | Membrane Transport Proteins - genetics | Drug Resistance, Multiple, Bacterial | Bacterial Proteins - metabolism | Membrane Transport Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Gram-Negative Bacteria - genetics | Translocation | Antibiotics | Multidrug resistance | Data processing | Gram-negative bacteria | Kinetics | Drug development | Drug resistance | Antibacterial agents | selectivity
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6. Full Text Activity of the efflux pump inhibitor phenylalanine-arginine β-naphthylamide against the AdeFGH pump of Acinetobacter baumannii
by Cortez-Cordova, Jenny and Kumar, Ayush
International Journal of Antimicrobial Agents, ISSN 0924-8579, 2011, Volume 37, Issue 5, pp. 420 - 424
Abstract AdeFGH is a multidrug resistance efflux pump of Acinetobacter baumannii belonging to the resistance–nodulation–cell division (RND) family. Analysis of... 
Infectious Disease | RND pumps | Acinetobacter baumannii | Efflux pump inhibitors | AdeFGH | SYSTEM | INFECTIOUS DISEASES | BACTERIA | INFECTIONS | AMINOGLYCOSIDE RESISTANCE | SUSCEPTIBILITY | MICROBIOLOGY | CALCOACETICUS COMPLEX | INTENSIVE-CARE-UNIT | PSEUDOMONAS-AERUGINOSA | GENES | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | Trimethoprim - pharmacology | Dipeptides - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Pseudomonas aeruginosa - drug effects | Clindamycin - pharmacology | Microbial Sensitivity Tests | Pseudomonas aeruginosa - genetics | Membrane Transport Proteins - genetics | Chloramphenicol - pharmacology | Cloning, Molecular | Membrane Transport Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Acinetobacter baumannii - drug effects | Acinetobacter baumannii - genetics
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7. Full Text Multidrug efflux pumps: structure, function and regulation
by Du, Dijun and Wang-Kan, Xuan and Neuberger, Arthur and van Veen, Hendrik W and Pos, Klaas M and Piddock, Laura J. V and Luisi, Ben F
Nature Reviews Microbiology, ISSN 1740-1526, 09/2018, Volume 16, Issue 9, pp. 523 - 539
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of... 
2-COMPONENT SIGNAL-TRANSDUCTION | BACTERIAL PERSISTENCE | MACB ABC TRANSPORTER | CRYSTAL-STRUCTURE | PSEUDOMONAS-AERUGINOSA | X-RAY-STRUCTURE | ESCHERICHIA-COLI | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | ALTERNATING-ACCESS | ANTIMICROBIAL RESISTANCE | Drug resistance in microorganisms | Usage | Bacterial infections | Antibiotics | Escherichia coli | Genetic aspects | Research | Drug therapy | Health aspects | Risk factors | Efflux | Molecular modelling | Pumps | Virulence | Bacteria | Extrusion | Infections | Antimicrobial resistance | Drug resistance | Structure-function relationships
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8. Full Text Recent advances toward a molecular mechanism of efflux pump inhibition
by Opperman, Timothy J and Nguyen, Son T
Frontiers in Microbiology, ISSN 1664-302X, 2015, Volume 6, Issue MAY
Multidrug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae and Pseudomonas aeruginosa, poses a significant threat to our ability to... 
Efflux pump inhibitor | Escherichia coli | MexB | RND family pumps | Pseudomonas aeruginosa | AcrD | Mechanism of action | AcrB | CRYSTAL-STRUCTURE | LARGE PERIPLASMIC LOOPS | ESCHERICHIA-COLI | mechanism of action | MICROBIOLOGY | MULTIDRUG TRANSPORTER ACRB | SITE-DIRECTED MUTAGENESIS | DYNAMICS SIMULATIONS | efflux pump inhibitor | GRAM-NEGATIVE BACTERIA | ANTIMICROBIAL DRUG SUSCEPTIBILITY | PSEUDOMONAS-AERUGINOSA | BINDING POCKET | Adjunctive therapy | EPI
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9. Full Text Efflux pump-mediated drug resistance in burkholderia
by Podnecky, Nicole L and Rhodes, Katherine A and Schweizer, Herbert P
Frontiers in Microbiology, ISSN 1664-302X, 2015, Volume 6, pp. 1 - 25
Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic... 
Resistance | Burkholderia | Antibiotics | Efflux pump | Adaptation | AMINOGLYCOSIDE RESISTANCE | ESCHERICHIA-COLI | efflux pump | adaptation | MICROBIOLOGY | resistance | BPEAB-OPRB | CEPACIA COMPLEX BACTERIA | GRAM-NEGATIVE BACTERIA | CYSTIC-FIBROSIS PATIENTS | PSEUDOMONAS-AERUGINOSA | MULTIDRUG-RESISTANCE | antibiotics | IN-VITRO ACTIVITY | MULTIPLE ANTIBIOTIC-RESISTANCE | VDP | Basale biofag: 470 | Generell mikrobiologi: 472 | General microbiology: 472 | Matematikk og Naturvitenskap: 400 | Mathematics and natural science: 400 | Basic biosciences: 470 | efflux pump | adapdation
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10. Full Text Bacterial multidrug efflux pumps: Mech