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Nature Medicine, ISSN 1078-8956, 03/2013, Volume 19, Issue 3, pp. 295 - 304
The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-RENEWAL | FACTOR RECEPTOR | CELL BIOLOGY | STEM-CELL NUMBER | REPOPULATING CAPACITY | LETHALLY IRRADIATED MICE | EX-VIVO CULTURE | ENDOTHELIAL-CELLS | APOPTOTIC PATHWAYS | EGF RECEPTOR | Erlotinib Hydrochloride | Whole-Body Irradiation | Apoptosis - radiation effects | bcl-2 Homologous Antagonist-Killer Protein - genetics | Bone Marrow - radiation effects | Receptor, Epidermal Growth Factor - metabolism | Hematopoiesis | Radiation Injuries, Experimental - drug therapy | Hematopoietic Stem Cells - physiology | Female | Signal Transduction - radiation effects | Hematopoietic Stem Cells - radiation effects | bcl-2-Associated X Protein - genetics | Apoptosis Regulatory Proteins - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Epidermal Growth Factor - metabolism | Bone Marrow Cells - radiation effects | Mice, Knockout | Regeneration | Animals | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Quinazolines - pharmacology | Tumor Suppressor Proteins - biosynthesis | Care and treatment | Epidermal growth factor | Radiation injuries | Transplantation | Research | Health aspects | Hematopoietic stem cells | Cytokines | Gene expression | Stem cells | Radiation | Index Medicus
Journal Article
Science Translational Medicine, ISSN 1946-6234, 12/2015, Volume 7, Issue 316, pp. 316ra193 - 316ra193
Journal Article
Immunity, ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 275 - 284
Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here... 
CETUXIMAB | RESPONSES | TOLERANCE | MAST-CELLS | DISEASE | MODEL | IMMUNOLOGY | CARCINOMA | EXPRESSION | METASTATIC COLORECTAL-CANCER | EGF RECEPTOR | Forkhead Transcription Factors - immunology | Cell Communication - immunology | Receptor, Epidermal Growth Factor - genetics | T-Lymphocytes, Regulatory - metabolism | Humans | Colitis - pathology | Homeodomain Proteins - immunology | Amphiregulin | Glycoproteins - pharmacology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma, Experimental - immunology | EGF Family of Proteins | Colitis - chemically induced | Peptide Fragments - immunology | Mast Cells - metabolism | Colitis - immunology | Glycoproteins - genetics | Mast Cells - immunology | Receptor, Epidermal Growth Factor - immunology | Peptide Fragments - administration & dosage | Glycoproteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Melanoma, Experimental - pathology | Antibodies, Neutralizing - pharmacology | Membrane Proteins - immunology | Mice, Transgenic | Forkhead Transcription Factors - genetics | Mast Cells - drug effects | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Membrane Proteins - administration & dosage | Glycoproteins - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Melanoma, Experimental - genetics | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Lymphocyte Activation - drug effects | Colitis - metabolism | Mice | Intercellular Signaling Peptides and Proteins - immunology | Epidermal growth factor | Universities and colleges | T cells | Analysis | Vaccination | Cells | Flow cytometry | Cytokines | Cloning | Melanoma | Kinases | Experiments | Cancer therapies | Rodents | Bone marrow | Software | Tumors | Cancer | Index Medicus
Journal Article
CELLULAR SIGNALLING, ISSN 0898-6568, 10/2007, Volume 19, Issue 10, pp. 2013 - 2023
The Epidermal growth factor receptor (EGFR) is a membrane spanning glycoprotein, which frequently has been implicated in various cancer types. The mechanisms... 
FACTOR-RECEPTOR GENE | signaling | EGF-RECEPTOR | downregulation | MEDIATED DOWN-REGULATION | PROTEIN-COUPLED RECEPTORS | IN-SITU-HYBRIDIZATION | GASTRIN-RELEASING-PEPTIDE | EGFR | transactivation | FACTOR-ALPHA | CELL BIOLOGY | CELL LUNG-CANCER | BREAST-CANCER | mutation | HUMAN PROSTATE-CANCER | oncogenesis | cancer | mechanism
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2011, Volume 17, Issue 10, pp. 1242 - 1250
Rapidly progressive glomerulonephritis (RPGN) is a life-threatening clinical syndrome and a morphological manifestation of severe glomerular injury that is... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | BOWMANS CAPSULE | PARIETAL EPITHELIAL-CELLS | NEPHROTOXIC SERUM | CELL BIOLOGY | MEDIATED-IMMUNITY | ENDOTHELIAL-CELLS | GENE-EXPRESSION | MESANGIAL CELLS | T-LYMPHOCYTES | CELLULAR CRESCENTS | TRANSGENIC MICE | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Humans | Kidney Glomerulus - injuries | Kidney Glomerulus - physiopathology | Quinazolines | Glomerulonephritis - metabolism | Renal Insufficiency - etiology | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | In Situ Hybridization | Bone Marrow Transplantation | Statistics, Nonparametric | Real-Time Polymerase Chain Reaction | Kidney Glomerulus - cytology | Microscopy, Electron, Transmission | Podocytes - metabolism | Enzyme-Linked Immunosorbent Assay | Intercellular Signaling Peptides and Proteins - genetics | Glomerulonephritis - complications | Blotting, Western | Mice, Knockout | Heparin-binding EGF-like Growth Factor | Animals | Analysis of Variance | Glomerulonephritis - pathology | Tyrphostins | Mice | Microscopy, Fluorescence | Glomerulonephritis | Care and treatment | Diagnosis | Research | Risk factors | T cell receptors | Biomedical research | Kidney diseases | Morphology | Index Medicus | Life Sciences | Human health and pathology | Cardiology and cardiovascular system
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 5/2010, Volume 189, Issue 5, pp. 871 - 883
Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR signaling. However, EGFR endocytosis mechanisms are poorly... 
Endocytosis | Receptors | Phosphorylation | Internalization | Cell lines | Small interfering RNA | Antibodies | Growth factor receptors | Acetylation | Endosomes | RNA INTERFERENCE | DOMAIN | PROTEIN | COATED PIT ADAPTINS | TYROSINE PHOSPHORYLATION | LIGAND-INDUCED INTERNALIZATION | TRAFFICKING | COMPLEX AP-2 | EPSIN 1 | EGF RECEPTORS | CELL BIOLOGY | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Interaction Domains and Motifs - physiology | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphorylation - genetics | Receptor, Epidermal Growth Factor - metabolism | Adaptor Protein Complex 2 - metabolism | Transfection | Swine | GRB2 Adaptor Protein - genetics | Lysine - metabolism | Ubiquitination - physiology | Proto-Oncogene Proteins c-akt - metabolism | Coated Pits, Cell-Membrane - metabolism | Endothelial Cells - metabolism | Cells, Cultured | Epidermal Growth Factor - metabolism | Clathrin - genetics | Adaptor Protein Complex 2 - genetics | Mutation - genetics | Clathrin - metabolism | Protein Processing, Post-Translational - physiology | Endocytosis - physiology | Animals | Models, Biological | Cell Line, Tumor | Amino Acid Substitution - genetics | GRB2 Adaptor Protein - metabolism | Post-translational modification | Analysis | Epidermal growth factor | Cell growth | Skin | Biochemistry | Ribonucleic acid--RNA | Cells | Index Medicus
Journal Article
Journal Article
Journal Article
Placenta, ISSN 0143-4004, 2014, Volume 36, Issue 3, pp. 270 - 278
Abstract Introduction The epidermal growth factor (EGF) signaling system regulates trophoblast differentiation, and its disruption could contribute to... 
Internal Medicine | Obstetrics and Gynecology | Epidermal growth factors | Preeclampsia | Placenta | CELLS | OXIDATIVE STRESS | CYTOTROPHOBLASTS | EGF | HUMAN-PLACENTA | TROPHOBLAST APOPTOSIS | DEVELOPMENTAL BIOLOGY | FACTOR RECEPTOR | OBSTETRICS & GYNECOLOGY | RETARDATION | REPRODUCTIVE BIOLOGY | EARLY-PREGNANCY | ENDOMETRIAL | Receptor, Epidermal Growth Factor - genetics | Humans | Trophoblasts - pathology | Young Adult | Receptor, Epidermal Growth Factor - metabolism | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Transforming Growth Factor alpha - blood | Epidermal Growth Factor - chemistry | Heparin-binding EGF-like Growth Factor - blood | Peptide Fragments - blood | Adult | Female | Pre-Eclampsia - metabolism | Transforming Growth Factor alpha - metabolism | Peptide Fragments - metabolism | Trophoblasts - metabolism | Placentation | Down-Regulation | Epidermal Growth Factor - metabolism | Chorionic Villi - metabolism | Pre-Eclampsia - pathology | Epidermal Growth Factor - blood | Receptor, Epidermal Growth Factor - chemistry | Heparin-binding EGF-like Growth Factor - metabolism | Placenta - metabolism | Pregnancy | Chorionic Villi - pathology | Pre-Eclampsia - blood | Placenta - pathology | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Line, Transformed | Apoptosis | Cohort Studies | Protein Isoforms - genetics | Physiological aspects | Medical colleges | Epidermal growth factor | Cells | Index Medicus | placenta | epidermal growth factors | preeclampsia
Journal Article