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Cancer discovery, ISSN 2159-8290, 2012, Volume 2, Issue 10, pp. 922 - 933
EGFR-mutant lung cancers eventually become resistant to treatment with EGFR tyrosine kinase inhibitors (TKIs). The combination of EGFR-TKI afatinib and... 
lung cancer | EGFR tyrosine kinase inhibitors | afatinib | EGFR mutations | erlotinib | HER2 amplification | cetuximab | EGFR T790M | acquired resistance
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 01/2017, Volume 429, Issue 2, pp. 280 - 294
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (TK) that—once activated upon ligand binding—leads to receptor dimerization,... 
non-small cell lung cancer | protein–protein interaction | two-hybrid screening | oncogenic signaling | EGFR | Protein-protein interaction | PATHWAYS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | FAMILY | ACIDIC COILED-COIL | TACC3 | protein-protein interaction | FUSIONS | PROTEINS | EXPRESSION | AURORA | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Immunoprecipitation | Microtubule-Associated Proteins - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Cell Survival | Microtubule-Associated Proteins - metabolism | Humans | Computational Biology | Gene Expression Regulation, Neoplastic | Receptor, Epidermal Growth Factor - metabolism | Gene Deletion | HEK293 Cells | Mitogen-Activated Protein Kinases - genetics | Protein Interaction Domains and Motifs | HeLa Cells | Mitogen-Activated Protein Kinases - metabolism | RNA, Small Interfering - metabolism | Tyrosine | Epidermal growth factor | Drug discovery | Lung cancer, Non-small cell | Mitogens | Protein kinases | Protein-protein interactions | FGFR, fibroblast growth factor receptor | SH, Src homology | EGF, epidermal growth factor | TF, transcription factor | EGFR-ex19del, EGFR-exon19 deletion | TACC, transforming acidic coiled-coil protein | PBS, phosphate-buffered saline | DMEM, Dulbecco's modified Eagle's medium | PEI, polyethylenimine | Nub, N-terminal half of ubiquitin | SRE, serum response element | GFP, green fluorescent protein | NSCLC, non-small cell lung cancer | GO, gene ontology | TKI, TK inhibitor | EGFR, epidermal growth factor receptor | TK, tyrosine kinase | ERK, extracellular signal-regulated kinase | EGFR-WT, EGFR-wildtype | MOI, multiplicity of infection | MaMTH, mammalian membrane two-hybrid | KM, Kaplan–Meier | Grb2, growth factor receptor-bound protein 2 | Cub, C-terminal half of ubiquitin | MAPK, mitogen-activated protein kinase
Journal Article
Lung Cancer, ISSN 0169-5002, 2010, Volume 67, Issue 3, pp. 355 - 360
Journal Article
Journal Article
Journal Article
The Journal of infectious diseases, ISSN 0022-1899, 8/2014, Volume 210, Issue 3, pp. 363 - 373
Journal Article
Journal Article
Genes & development, ISSN 0890-9369, 2010, Volume 24, Issue 16, pp. 1731 - 1745
Journal Article