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Cancer Discovery, ISSN 2159-8274, 10/2012, Volume 2, Issue 10, pp. 922 - 933
EGFR-mutant lung cancers eventually become resistant to treatment with EGFR tyrosine kinase inhibitors (TKIs). The combination of EGFR-TKI afatinib and... 
lung cancer | EGFR tyrosine kinase inhibitors | afatinib | EGFR mutations | erlotinib | HER2 amplification | cetuximab | EGFR T790M | acquired resistance
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 99, pp. 37274 - 37275
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 01/2017, Volume 429, Issue 2, pp. 280 - 294
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (TK) that—once activated upon ligand binding—leads to receptor dimerization,... 
non-small cell lung cancer | protein–protein interaction | two-hybrid screening | oncogenic signaling | EGFR | Protein-protein interaction | PATHWAYS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | FAMILY | ACIDIC COILED-COIL | TACC3 | protein-protein interaction | FUSIONS | PROTEINS | EXPRESSION | AURORA | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Immunoprecipitation | Microtubule-Associated Proteins - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Cell Survival | Microtubule-Associated Proteins - metabolism | Humans | Computational Biology | Gene Expression Regulation, Neoplastic | Receptor, Epidermal Growth Factor - metabolism | Gene Deletion | HEK293 Cells | Mitogen-Activated Protein Kinases - genetics | Protein Interaction Domains and Motifs | HeLa Cells | Mitogen-Activated Protein Kinases - metabolism | RNA, Small Interfering - metabolism | Tyrosine | Epidermal growth factor | Drug discovery | Lung cancer, Non-small cell | Mitogens | Protein kinases | Protein-protein interactions | Index Medicus | FGFR, fibroblast growth factor receptor | SH, Src homology | EGF, epidermal growth factor | TF, transcription factor | EGFR-ex19del, EGFR-exon19 deletion | TACC, transforming acidic coiled-coil protein | PBS, phosphate-buffered saline | DMEM, Dulbecco's modified Eagle's medium | PEI, polyethylenimine | Nub, N-terminal half of ubiquitin | SRE, serum response element | GFP, green fluorescent protein | NSCLC, non-small cell lung cancer | GO, gene ontology | TKI, TK inhibitor | EGFR, epidermal growth factor receptor | TK, tyrosine kinase | ERK, extracellular signal-regulated kinase | EGFR-WT, EGFR-wildtype | MOI, multiplicity of infection | MaMTH, mammalian membrane two-hybrid | KM, Kaplan–Meier | Grb2, growth factor receptor-bound protein 2 | Cub, C-terminal half of ubiquitin | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 06/2019, Volume 111, pp. 12 - 18
Treatment failure through radioresistance of tumors is associated with activation of the epidermal growth factor receptor (EGFR). Tumor cell proliferation,... 
Hypoxia | Radiosensitivity | Autophagy | EGFR
Journal Article
American Journal of Kidney Diseases, ISSN 0272-6386, 11/2018, Volume 72, Issue 5, pp. 653 - 661
Reduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the... 
diabetic kidney disease | chronic kidney disease | nonproteinuric | kidney function | macroalbuminuria | proteinuria | normoalbuminuria | CKD progression | incident ESKD | Nonalbuminuric | eGFR slope | microalbuminuria | estimated glomerular filtration rate (eGFR) | end-stage kidney disease (ESKD) | eGFR decline | diabetes | reduced eGFR | kidney impairment
Journal Article
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, ISSN 1357-2725, 06/2014, Volume 51, pp. 23 - 28
Epidermal growth factor (EGF) receptor (EGFR) signalling regulates diverse cellular functions, promoting cell proliferation, differentiation, migration, cell... 
CLATHRIN-MEDIATED ENDOCYTOSIS | EGFR trafficking | MECHANISM | PHOSPHORYLATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EGFR signalling | EGFR ligands | ACQUIRED-RESISTANCE | FACTOR-ALPHA | CELL BIOLOGY | TYROSINE KINASE INHIBITORS | CELL LUNG-CANCER | Endocytosis | INTERNALIZATION | ACTIVATED EGFR | Cancer
Journal Article
by Gong, L and Qin, J and Xie, FJ and Han, N and Lu, HY
JOURNAL OF THORACIC ONCOLOGY, ISSN 1556-0864, 06/2019, Volume 14, Issue 6, pp. E120 - E123
Journal Article
Lung Cancer, ISSN 0169-5002, 06/2017, Volume 108, pp. 228 - 231
Acquired epidermal growth factor receptor (EGFR) resistance mutations to osimertinib are common, including the EGFR C797S that abolishes the covalent binding... 
ctDNA assay | Solvent front mutation | EGFR G796 | EGFR+ lung cancer | Osimertinib | EGFR L792 | EGFR C797 | Genetic aspects | Epidermal growth factor | Codon | Analysis
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 06/2018, Volume 13, Issue 6, pp. e103 - e105
Journal Article
Lung Cancer, ISSN 0169-5002, 09/2019, Volume 135, pp. 116 - 122
The utility of malignant pleural effusion (MPE) as a source for determining mutations to guide EGFR TKI therapy in advanced adenocarcinoma of the lung remains... 
Pleural effusions | EGFR mutation | Lung adenocarcinoma | EGFR-TKI
Journal Article
Annals of oncology : official journal of the European Society for Medical Oncology, ISSN 0923-7534, 05/2019, Volume 30, Issue 5, pp. 839 - 844
Concurrent programmed death-ligand-1 (PD-(L)1) plus osimertinib is associated with severe immune related adverse events (irAE) in epidermal growth factor... 
TKI | irAE | PD-1 | EGFR | osimertinib
Journal Article
Applied Immunohistochemistry and Molecular Morphology, ISSN 1541-2016, 06/2018, p. 1
Epidermal growth factor receptor (EGFR) amplification is one of the common alterations in IDH-wildtype glioblastoma. It is frequently associated with EGFRvIII... 
EGFRvIII | glioblastoma | immunohistochemistry | EGFR amplification | EGFR
Journal Article
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 08/2018, Volume 13, Issue 8, pp. 1138 - 1145
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 95, pp. 36730 - 36731
Journal Article
Journal Article
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