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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2013, Volume 4, Issue 2, pp. 201 - 205
The epidermal growth factor receptor (EGFR) family plays a critical role in vital cellular processes and in various cancers. Known EGFR inhibitors exhibit... 
crystal structure | EGFR T790/L858 mutant inhibitors | pyrrolo[3,2- d ]pyrimidine derivatives | NSCLC | TAK-285 | drug sensitivity and resistance | ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | PROTEIN | MECHANISM | pyrrolo[3,2-d]pyrimidine derivatives | KINASE DOMAIN | LUNG-CANCER | RECEPTOR-ACTIVITY
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2018, Volume 26, Issue 23-24, pp. 6087 - 6095
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2017, Volume 25, Issue 24, pp. 6563 - 6580
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 70, pp. 39797 - 39810
Epidermal growth factor receptor (EGFR) is one of the most promising targets for the treatment of cancers. Double mutations T790M/L858R lead to different... 
CELL LUNG-CANCER | LIGAND-BINDING | PROTEIN EXPRESSION | EFFICIENT GENERATION | PARTICLE MESH EWALD | EGFR MUTATIONS | HIV-1 PROTEASE | CHEMISTRY, MULTIDISCIPLINARY | FREE-ENERGY PERTURBATION | SOMATIC MUTATIONS | KINASE DOMAIN
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2014, Volume 22, Issue 7, pp. 2366 - 2378
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2017, Volume 142, pp. 131 - 151
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2013, Volume 21, Issue 24, pp. 7988 - 7998
Journal Article
Journal Article
Journal Article