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Molecular Cell, ISSN 1097-2765, 06/2017, Volume 66, Issue 6, pp. 772 - 779
The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring... 
hypoxia | noncoding RNA | lncRNA | EGLN | miRNA | metabolism | HIF2α | oxygen | PHD | HIF1α | HIF2 | HIF1 | Oxygen | HIF2 inhibitors | EGLN inhibitors | kidney cancer | Hypoxia
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2005, Volume 387, Issue 3, pp. 711 - 717
Journal Article
Journal Article
Hypoxia (Auckland, N.Z.), ISSN 2324-1128, 2018, Volume 6, pp. 57 - 71
In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes... 
Proteins | Transcription factors | Animals | Hypoxia | Physiology | Roles | RNA polymerase | Mammals | Kinases | hypoxia | hypoxic response | hypoxia-inducible factor (HIF) | dioxygenase | oxygen sensing | evolution | PHD/EGLN prolyl hydroxylases | 2-oxoglutarate oxygenase | enzyme structure | Trichoplax adhaerens
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 2005, Volume 74, Issue 1, pp. 115 - 128
Hypoxia-inducible factor (HIF) is a master transcriptional regulator of hypoxia-inducible genes and consists of a labile a subunit (such as HIF1 alpha) and a... 
Von Hippel-Lindau | EGLN | FIH | Hydroxylation | Hypoxia-inducible factor (HIF) | HYPOXIA-INDUCIBLE FACTOR | hydroxylation | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPEL-LINDAU PROTEIN | FACTOR 1-ALPHA | hypoxia-inducible factor (HIF) | MITOCHONDRIAL RESPIRATORY-CHAIN | von Hippel-Lindau | NITRIC-OXIDE | PROLYL-HYDROXYLASES | TUMOR-SUPPRESSOR PROTEIN | ENDOTHELIAL GROWTH-FACTOR | UBIQUITIN-PROTEASOME PATHWAY | PAS DOMAIN PROTEIN | Transcription Factors - chemistry | Humans | Multiprotein Complexes | Hypoxia-Inducible Factor 1, alpha Subunit | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Immediate-Early Proteins - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Immediate-Early Proteins - chemistry | Nuclear Proteins - genetics | Tumor Suppressor Proteins - metabolism | Hypoxia-Inducible Factor 1 | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Dioxygenases | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Proline - chemistry | Transcription Factors - metabolism | Animals | Immediate-Early Proteins - genetics | Procollagen-Proline Dioxygenase - genetics | Models, Biological | Von Hippel-Lindau Tumor Suppressor Protein | Procollagen-Proline Dioxygenase - chemistry | Ubiquitin-Protein Ligases - genetics | Proline | Research | Gene expression | Proteins | Oxygen | Biochemistry | Tumors
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2005, Volume 390, Issue 1, pp. 189 - 197
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2004, Volume 381, Issue 3, pp. 761 - 767
An important regulator involved in oxygen-dependent gene expression is the transcription factor HIF (hypoxia-inducible factor), which is composed of an... 
Post-translational modification | Hypoxia-inducible factor | Protein degradation | Oxygen sensing | Prolyl hydroxylation | Von-Hippel-Lindau protein | TRANSCRIPTIONAL ACTIVITY | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | hypoxia-inducible factor | oxygen sensing | post-translational modification | von-Hippel-Lindau protein | FAMILY | OXYGEN | FACTOR-1-ALPHA | GENE-EXPRESSION | HIF-1-ALPHA | VHL | protein degradation | prolyl hydroxylation | Humans | Half-Life | Kidney Neoplasms - metabolism | Ubiquitin-Protein Ligases - physiology | Bone Neoplasms - pathology | Hypoxia-Inducible Factor 1, alpha Subunit | RNA, Messenger - biosynthesis | Liver Neoplasms - pathology | Liver Neoplasms - enzymology | Kidney Tubules, Proximal - cytology | DNA-Binding Proteins - physiology | Hypoxia - enzymology | Hydroxylation | Hypoxia-Inducible Factor 1 | Immediate-Early Proteins - biosynthesis | Carcinoma, Hepatocellular - enzymology | Tumor Suppressor Proteins - physiology | Epithelial Cells - enzymology | Liver Neoplasms - metabolism | Cell Line, Tumor | Von Hippel-Lindau Tumor Suppressor Protein | Enzyme Induction - physiology | Osteosarcoma - pathology | Carcinoma, Hepatocellular - metabolism | Epithelial Cells - metabolism | Gene Expression Regulation, Enzymologic - physiology | Oxygen - metabolism | Procollagen-Proline Dioxygenase - biosynthesis | Bone Neoplasms - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Kidney Tubules, Proximal - enzymology | Gene Expression Regulation, Neoplastic - physiology | Osteosarcoma - metabolism | Cell Line | Transcription Factors - physiology | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Adenocarcinoma, Clear Cell - metabolism | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Dioxygenases | Transcription Factors - metabolism | Kidney Neoplasms - enzymology | Carcinoma, Hepatocellular - pathology | Kidney Tubules, Proximal - metabolism | Kidney Neoplasms - pathology | Adenocarcinoma, Clear Cell - pathology | Nuclear Proteins - physiology | Adenocarcinoma, Clear Cell - enzymology | DNA-Binding Proteins - biosynthesis | ODD, oxygen-dependent degradation domain | aRP, acidic ribosomal protein | RNAi, RNA interference | pVHL, von-Hippel-Lindau protein | EGLN, egg-laying deficient nine-like protein | HIF, hypoxia-inducible factor | siRNA, small interfering RNA | IVTT, in vitro transcription | PHD, prolyl hydroxylase domain containing protein | translation | RT, reverse transcriptase | RPTEC, human renal proximal tubular epithelial cells
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 2, pp. 231 - 240
HIFs [hypoxia-inducible (transcription) factors] are essential for the induction of an adaptive gene expression programme under low oxygen partial pressure.... 
Hypoxia | Von Hippel-Lindau protein (VHL protein) | Proline hydroxylase domain (PHD) | EGL nine homologue (EGLN) | Hypoxia-inducible factor (HIF) | Oxygen-degradation domain (ODD) | hypoxia | CELLS | ACTIVATION | MODIFY | BIOCHEMISTRY & MOLECULAR BIOLOGY | von Hippel-Lindau protein (VHL protein) | proline hydroxylase domain (PHD) | FAMILY | HIGH-EFFICIENCY TRANSFORMATION | DESTRUCTION | hypoxia-inducible factor (HIF) | HYDROXYLASES PHD1 | INHIBITION | FACTOR-1-ALPHA | oxygen-degradation domain (ODD) | HIF-ALPHA | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Substrate Specificity - physiology | Oxygen - metabolism | Procollagen-Proline Dioxygenase - metabolism | Sequence Homology, Amino Acid | Procollagen-Proline Dioxygenase - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | HeLa Cells | Procollagen-Proline Dioxygenase - chemistry | Protein Binding - physiology | Protein Structure, Tertiary - physiology | NODD, N-terminal ODD (oxygen-dependent degradation domain) | VHL, von Hippel–Lindau | HRE, hypoxia-response element | AD, Gal4 activation domain | HIF, hypoxia-inducible factor | SD, synthetic defined | DBD, Gal4 DNA-binding domain | CODD, C-terminal ODD | MYND, myeloid, Nervy, and DEAF-1 | EGLN, EGL nine homologue | von Hippel–Lindau protein (VHL protein)
Journal Article