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Journal Article
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7334, pp. 404 - 408
Activating AMPK or inactivating calcineurin slows ageing in Caenorhabditis elegans(1,2) and both have been implicated as therapeutic targets for age-related... 
COACTIVATOR CRTC2 | TORC2 | UNFOLDED PROTEIN RESPONSE | CAENORHABDITIS-ELEGANS | PATHWAY | INSULIN-RESISTANCE | ER STRESS | MULTIDISCIPLINARY SCIENCES | KINASE | GENE-REGULATION | C-ELEGANS | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Caenorhabditis elegans Proteins - chemistry | Humans | Caenorhabditis elegans Proteins - metabolism | Trans-Activators - chemistry | Gene Knockdown Techniques | Caenorhabditis elegans - physiology | Calcineurin Inhibitors | HEK293 Cells | Trans-Activators - genetics | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP Response Element-Binding Protein - biosynthesis | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Down-Regulation | Transcription Factors - biosynthesis | Longevity - genetics | Transcription Factors - metabolism | Animals | Trans-Activators - deficiency | Aging - physiology | Energy Metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Trans-Activators - metabolism | Enzyme Activation | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Caenorhabditis elegans - enzymology | Calcineurin - metabolism | Aging - metabolism | Caenorhabditis elegans Proteins - biosynthesis | Physiological aspects | Chemical properties | Protein kinases | Calcineurin | Proteins | Homeostasis | Mutation | Kinases | DNA repair | Metabolic disorders | Binding sites | Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2015, Volume 350, Issue 6266, pp. 1375 - 1377
Journal Article
Science, ISSN 0036-8075, 10/2012, Volume 338, Issue 6106, pp. 543 - 545
Vasopressin- and oxytocin-related neuropeptides are key regulators of animal physiology, including water balance and reproduction. Although these neuropeptides... 
Receptors | Calcium | Neurons | REPORTS | Plasticity | Associative learning | Neuropeptides | Gene expression regulation | CHO cells | Chemotaxis | Behavioral neuroscience | CAENORHABDITIS-ELEGANS | MULTIDISCIPLINARY SCIENCES | DOPAMINE | SEROTONIN | IDENTIFICATION | MOTIVATION | OXYTOCIN RECEPTORS | PLASTICITY | CUES | Oxytocin - pharmacology | Receptors, G-Protein-Coupled - metabolism | Learning - drug effects | Caenorhabditis elegans Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Male | Vasopressins - chemistry | Neuropeptides - physiology | Receptors, G-Protein-Coupled - agonists | Caenorhabditis elegans - physiology | Caenorhabditis elegans Proteins - agonists | Neuropeptides - pharmacology | Neuropeptides - genetics | Oxytocin - chemistry | Receptors, G-Protein-Coupled - physiology | Amino Acid Sequence | Signal Transduction | Caenorhabditis elegans - genetics | Oxytocin - physiology | Vasopressins - genetics | Vasopressins - pharmacology | Taste - physiology | Biological Evolution | Learning - physiology | Animals | Taste - drug effects | Oxytocin - genetics | Caenorhabditis elegans Proteins - physiology | Receptors, G-Protein-Coupled - genetics | Vasopressins - physiology | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans Proteins - pharmacology | Neuropeptides - chemistry | Physiological aspects | Caenorhabditis elegans | Oxytocin | Health aspects | Vasopressin | Nematodes | Signal transduction | Neurosciences | Peptides | Animal behavior | Animal cognition | Index Medicus | Learning | Associative | Evolutionary | Sheep | Mammals | Invertebrates | Bonding | Worms
Journal Article
Science, ISSN 0036-8075, 9/2003, Volume 301, Issue 5638, pp. 1387 - 1391
Both dauer formation (a stage of developmental arrest) and adult life-span in Caenorhabditis elegans are negatively regulated by insulin-like signaling, but... 
Morphogenesis | Yeasts | Receptors | Phenotypes | Endocytosis | HEK293 cells | Internalization | Nematodes | Nematode larvae | Reports | Riddles | YEAST | PATHWAYS | LONGEVITY | MUTANTS | CAENORHABDITIS-ELEGANS | PROTEIN-DEGRADATION | MULTIDISCIPLINARY SCIENCES | SENESCENCE | MACROAUTOPHAGY | SACCHAROMYCES-CEREVISIAE | NEMATODE | Saccharomyces cerevisiae - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Genes, Helminth | Caenorhabditis elegans Proteins - metabolism | Recombinant Fusion Proteins - metabolism | RNA Interference | Receptor, Insulin - genetics | Genes, Fungal | Phagosomes - ultrastructure | Autophagy - genetics | Vesicular Transport Proteins | Beclin-1 | Proteins - physiology | Saccharomyces cerevisiae - physiology | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | Signal Transduction | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Longevity | Membrane Proteins | Proteins - genetics | Caenorhabditis elegans - ultrastructure | Phenotype | Animals | Apoptosis Regulatory Proteins | Receptor, Insulin - metabolism | Caenorhabditis elegans Proteins - physiology | Mutation | Proteins - chemistry | Caenorhabditis elegans Proteins - genetics | Physiological aspects | Caenorhabditis elegans | Developmental genetics | Genetic aspects | Research | Microorganisms | Genes | Cells | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2012, Volume 15, Issue 4, pp. 451 - 465
Journal Article
Science, ISSN 0036-8075, 10/2012, Volume 338, Issue 6106, pp. 540 - 543
Many biological functions are conserved, but the extent to which conservation applies to integrative behaviors is unknown. Vasopressin and oxytocin... 
Mating behavior | Receptors | Spermatozoa | HEK293 cells | Neurons | REPORTS | Male animals | Reporter genes | Neuropeptides | Vulva | Behavioral neuroscience | MALE MATING-BEHAVIOR | OXYTOCIN | C-ELEGANS | CAENORHABDITIS-ELEGANS | MULTIDISCIPLINARY SCIENCES | Oxytocin - pharmacology | Caenorhabditis elegans Proteins - chemistry | Humans | Male | Vasopressins - chemistry | Neuropeptides - physiology | Receptors, G-Protein-Coupled - agonists | Sexual Behavior, Animal - physiology | Caenorhabditis elegans - physiology | Reproduction | Caenorhabditis elegans Proteins - agonists | Neuropeptides - pharmacology | Neuropeptides - genetics | Oxytocin - chemistry | CHO Cells | Receptors, G-Protein-Coupled - physiology | Amino Acid Sequence | Cricetinae | Caenorhabditis elegans - genetics | Oxytocin - physiology | Vasopressins - genetics | Vasopressins - pharmacology | Biological Evolution | Animals | Oxytocin - genetics | Caenorhabditis elegans Proteins - physiology | Receptors, G-Protein-Coupled - genetics | Vasopressins - physiology | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans Proteins - pharmacology | Neuropeptides - chemistry | Physiological aspects | Oxytocin | Health aspects | Vasopressin | Animal reproduction | Neurosciences | Hormones | Peptides | Index Medicus | Learning | Associative | Evolutionary | Sheep | Mammals | Invertebrates | Bonding | Worms
Journal Article
Genes and Development, ISSN 0890-9369, 02/2009, Volume 23, Issue 4, pp. 496 - 511
Rictor is a component of the target of rapamycin complex 2 (TORC2). While TORC2 has been implicated in insulin and other growth factor signaling pathways, the... 
AKT | Fat metabolism | C. Elegans | Life span | Insulin/IGF | NERVOUS-SYSTEM | C. elegans | AKT/PKB | life span | DEVELOPMENTAL BIOLOGY | AGE-1 PI3 KINASE | CELL BIOLOGY | INSULIN | RAPTOR | MTOR COMPLEX-2 | LONGEVITY | SIGNALING PATHWAY | insulin/IGF | GENETICS & HEREDITY | C-ELEGANS | fat metabolism | TRANSCRIPTION FACTOR | Caenorhabditis elegans Proteins - metabolism | Reproduction - physiology | Fixatives - metabolism | Intestines - metabolism | Adipose Tissue - metabolism | Caenorhabditis elegans - physiology | Immediate-Early Proteins - metabolism | Oxazines - metabolism | Oncogene Protein v-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Somatomedins - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Boron Compounds - metabolism | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | Signal Transduction | Caenorhabditis elegans - genetics | Mutation - genetics | Feeding Behavior - physiology | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Diet | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Lipid Metabolism - physiology | Life spans (Biology) | Caenorhabditis elegans | Immune response | Physiological aspects | Genetic aspects | Rapamycin | Research | Index Medicus | insulin | IGF | Research Paper
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 6, pp. e1004200 - e1004200
Microsporidia comprise a phylum of over 1400 species of obligate intracellular pathogens that can infect almost all animals, but little is known about the host... 
TRIGGERED IMMUNITY | IMMUNE-RESPONSE | LIFE-SPAN | MICROBIOLOGY | CELL-PROLIFERATION | LARGE GENE LISTS | TRANSLATIONAL INHIBITION | CAENORHABDITIS-ELEGANS | VIROLOGY | INTRACELLULAR BACTERIA | TRANSCRIPTION FACTOR | PARASITOLOGY | INNATE IMMUNITY | Caenorhabditis elegans Proteins - immunology | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin - metabolism | Caenorhabditis elegans Proteins - metabolism | Microsporidia - immunology | Autophagy - immunology | RNA Interference | Base Sequence | Caenorhabditis elegans - parasitology | Autophagy - genetics | Caenorhabditis elegans - virology | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Caenorhabditis elegans - immunology | Microsporidia - pathogenicity | Host-Pathogen Interactions | Animals | Sequence Analysis, RNA | Caenorhabditis elegans Proteins - antagonists & inhibitors | RNA, Small Interfering | Cullin Proteins - immunology | Transcription, Genetic - genetics | Caenorhabditis elegans Proteins - genetics | Ubiquitination - genetics | Caenorhabditis elegans Proteins - biosynthesis | Cullin Proteins - biosynthesis | Ubiquitin | Distribution | Genetic aspects | Research | Gene expression | Health aspects | Microsporidia | Index Medicus | Medical research | Nematodes | Infections | Experiments | Autophagy | Viral infections | Worms
Journal Article