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animals (18) 18
em-12 (18) 18
thalidomide - analogs & derivatives (12) 12
enantiomers (10) 10
female (10) 10
thalidomide (10) 10
mice (8) 8
analog (7) 7
em 12 (7) 7
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toxicology (6) 6
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derivatives (5) 5
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2--phthalimidine (3) 3
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species specificity (3) 3
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supidimide (3) 3
teratogens - pharmacokinetics (3) 3
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2-arylpropionic acids (2) 2
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activation (2) 2
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blood (2) 2
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chiral inversion (2) 2
clausenamide (2) 2
dose-response relationship, drug (2) 2
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embryo, mammalian - drug effects (2) 2
esonarimod (2) 2
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integrins (2) 2
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mice, inbred c57bl (2) 2
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microsomes, liver - metabolism (2) 2
necrosis factor alpha (2) 2
oncology (2) 2
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phthalate (2) 2
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Tetrahedron, ISSN 0040-4020, 10/2016, Volume 72, Issue 40, pp. 6136 - 6141
Click analogues of thalidomide were prepared from 3-azidoglutarimide and a diverse array of arylacetylenes and -ethynyl/ -propargyl phthalimide derivatives.... 
Teratogenesis | Angiogenesis | TNF-α | EM-12 | Multiple myeloma | Thalidomide | Cancer | MULTIPLE-MYELOMA | ACTIVATION | TNF-alpha | ENANTIOMERS | CHEMISTRY, ORGANIC | PHTHALIMIDINE | CYCLOADDITION | ANTIANGIOGENIC ACTIVITY | METABOLISM | CHEMISTRY | DERIVATIVES | Triazoles
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2003, Volume 46, Issue 18, pp. 3793 - 3799
Versatile synthesis of the teratogenic, TNFalpha-modulatory, and antiangiogenic thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine (1) and its... 
IN-VITRO | CHEMISTRY, MEDICINAL | ACID | ANGIOGENESIS | MARMOSET MONKEY | ENANTIOMERS | EM-12 | INHIBITORS | DERIVATIVES
Journal Article
Journal Article
Life Sciences, ISSN 0024-3205, 1995, Volume 58, Issue 4, pp. 295 - 316
In spite of ongoing speculation, there has been no evidence that adhesion receptors are expressed on the cells of mammalian embryos. In this report, we provide... 
integrins | thalidomide | marmosets | adhesion receptors | EM 12 | EM12 | MEDICINE, RESEARCH & EXPERIMENTAL | CALLITHRIX-JACCHUS | IMMUNE-SYSTEM | EM-12 | BIOLOGY | PHARMACOLOGY & PHARMACY | DERIVATIVES | BLOOD
Journal Article
Combinatorial Chemistry and High Throughput Screening, ISSN 1386-2073, 06/2007, Volume 10, Issue 5, pp. 326 - 335
Journal Article
ARCHIVES OF TOXICOLOGY, ISSN 0340-5761, 09/1996, Volume 70, Issue 11, pp. 749 - 756
Journal Article
Life sciences, ISSN 0024-3205, 1995, Volume 56, Issue 6, p. 407
Thalidomide (Thd) is capable of down-regulating the CD26 receptor on CD4+ lymphocytes after treatment of healthy volunteers. Similar effects are observed when... 
Dipeptidyl Peptidase 4 - drug effects | Callithrix | Humans | Receptors, HIV - drug effects | Male | Reference Values | Antibodies, Monoclonal | Thalidomide - pharmacology | Down-Regulation - drug effects | Animals | Flow Cytometry | T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - drug effects | T-Lymphocytes - immunology
Journal Article
Archives of Toxicology, ISSN 0340-5761, 1988, Volume 62, Issue 2-3, pp. 200 - 204
Journal Article
Archives of Toxicology, ISSN 0340-5761, 1988, Volume 62, Issue 2-3, pp. 205 - 208
The teratogenic potencies of the enantiomers of 2-(2,6-dioxopiperidine-3-yl)-phthalimidine ( = EM 12), a teratogenic thalidomide analogue, were investigated in... 
Marmoset | Thalidomide derivative | Enantiomers | Callithrix jacchus | EM 12 | 2-(2,6-Dioxopiperidine-3-yl)-phthalimidine | Pregnancy | Thalidomide - analogs & derivatives | Animals | Callithrix | Stereoisomerism | Abnormalities, Drug-Induced - etiology | Female | Thalidomide - toxicity
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 1984, Volume 33, Issue 9, pp. 1471 - 1477
Thalidomide metabolites inhibited the attachment of tumor cells to concanavalin a coated polyethylene surfaces. Thalidomide, itself, was non-inhibitory.... 
Oxygen - pharmacology | Thalidomide - metabolism | Concanavalin A - pharmacology | Microsomes, Liver - metabolism | Epoxide Hydrolases - pharmacology | Structure-Activity Relationship | Cell Adhesion - drug effects | Animals | Biotransformation | Lymphocytes - drug effects | Dogs | Mice | Plastics | Teratogens - metabolism
Journal Article
TERATOLOGY, ISSN 0040-3709, 1972, Volume 5, Issue 2, pp. 233 - 233
Journal Article
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