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Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 08/2013, Volume 21, Issue 16, pp. 4768 - 4777
A chemoenzymatic glycosylation remodeling method for the synthesis of selectively fluorinated glycoproteins is described. The method consists of chemical... 
Fluorosugar | Transglycosylation | Endoglycosidase | Lectin | Fluorine | Glycoprotein
Journal Article
Journal Article
Journal Article
Journal of Innate Immunity, ISSN 1662-811X, 02/2012, Volume 4, Issue 2, pp. 121 - 131
Journal Article
ChemBioChem, ISSN 1439-4227, 04/2018, Volume 19, Issue 7, pp. 660 - 663
We developed a fluorescence‐quenching‐based assay system to determine the hydrolysis activity of endo‐β‐N‐acetylglucosaminidases (ENGases). The pentasaccharide... 
carbohydrates | hydrolases | endoglycosidases | fluorescent probes | glycoconjugates | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NGLY1 | GLYCANS | DOLICHOL-LINKED OLIGOSACCHARIDES | GLYCOPROTEINS | GLYCOSYLATION | MAMMALIAN-CELLS | ENDOGLYCOSIDASE | CHEMOENZYMATIC SYNTHESIS | NONLYSOSOMAL DEGRADATION | EXPRESSION | Hydrolysis | Fluorescence | Pharmacology | Inhibitors | Chemical compounds
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2018, Volume 115, Issue 4, pp. 720 - 725
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 42, pp. 8946 - 8951
N-Glycans are normally involved in crucial physiological and disease processes by interactions with glycan-binding proteins. So far structurally defined... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 13, pp. 1643 - 1646
We synthesized a fluorogenic probe with a high-mannose type heptasaccharide structure to detect the hydrolytic activity of endo-β- -acetylglucosaminidase from... 
Molecular probe | Glycosylation | Endo-glycosidase | Endo-β-N-acetylglucosaminidase | FRET quenching | CHEMISTRY, MEDICINAL | OLIGOSACCHARIDES | PROTEIN | CHEMISTRY, ORGANIC | IDENTIFICATION | ENDOGLYCOSIDASE | CLONING | PURIFICATION | Endo-beta-N-acetylglucosaminidase | GLYCOPEPTIDES | EXPRESSION | ACTS
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 10/2019, Volume 33, Issue 10, pp. 10808 - 10818
Colonization of the oropharynx is the initial step in Group A Streptococcus (GAS) pharyngeal infection. We have previously reported that the highly virulent... 
PROTEIN | ABO BLOOD-GROUPS | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRUCTURAL-ANALYSIS | PHENOTYPE | glycosylation | ENDOGLYCOSIDASE | CELL BIOLOGY | pathogenesis | blood group antigens | BIOLOGY | PYOGENES | INFECTION | INHIBITORS | BINDING | TISSUE TROPISMS | M protein
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 34, pp. 10611 - 10616
Antibodies have been developed as therapeutic agents for the treatment of cancer, infection, and inflammation. In addition to binding activity toward the... 
Fc glycosylation | Endoglycosidase | Glycoengineered antibodies | Sugar oxazoline | Homogeneous antibodies | RHEUMATOID-ARTHRITIS | N-ACETYLGLUCOSAMINE | ANTIINFLAMMATORY ACTIVITY | FC-GAMMA-RIII | MULTIDISCIPLINARY SCIENCES | GLYCOFORMS | ANTIBODY | FUCOSE | DEPENDENT CELLULAR CYTOTOXICITY | STAUDINGER LIGATION | glycoengineered antibodies | endoglycosidase | sugar oxazoline | CHEMICAL LIGATION | homogeneous antibodies | Orthomyxoviridae Infections - prevention & control | Acetylglucosamine - immunology | Humans | Structure-Activity Relationship | Sialic Acids - chemistry | Immunoglobulin Fc Fragments - immunology | Immunoglobulin G - immunology | HEK293 Cells | Protein Engineering | Polysaccharides - chemistry | Female | Rituximab - chemistry | Sialic Acids - immunology | Trastuzumab - chemistry | Antibodies, Viral - therapeutic use | Antibody-Dependent Cell Cytotoxicity | alpha-L-Fucosidase - metabolism | Immunoglobulin G - chemistry | Neuraminidase - metabolism | Immunoglobulin Fc Fragments - chemistry | Bacteroides fragilis - enzymology | Receptors, IgG - immunology | Acetylglucosamine - chemistry | Animals | Streptococcus pyogenes - enzymology | Antibodies, Viral - chemistry | Lymphoma, B-Cell - pathology | Cell Line, Tumor | Antibodies, Viral - immunology | Bacterial Proteins - metabolism | Mice | Mice, Inbred BALB C | Rituximab - immunology | Trastuzumab - immunology | Viral antibodies | Medical research | Tissue engineering | Immunoglobulin G | Antibodies | Medicine, Experimental | Genetic aspects | Research | Properties | Immune system | Biological Sciences | Physical Sciences
Journal Article
Angewandte Chemie (International Ed. in English), ISSN 1433-7851, 2/2016, Volume 55, Issue 7, pp. 2361 - 2367
Glycosylation patterns in antibodies critically determine biological and physical properties but their precise control is a significant challenge in biology... 
glycoengineering | endoglycosidases | Communications | glycosylation | native mass spectrometry | antibodies | Communication
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2017, Volume 214, Issue 9, pp. 2759 - 2776
CD79B and MYD88 mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk... 
Immunoglobulin M | Cell proliferation | NF-κB protein | Antigens | Autoantibodies | Cell survival | Anergy | Trafficking | Crosstalk | Endoglycosidase H | Autoantigens | Constraining | Clonal deletion | Lymphocytes B | Lymphocytes | Cooperation | Plasma cells | MyD88 protein | Deletion | Lymphomas | Mutation | Differentiation | 317 | 304
Journal Article