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Journal of Molecular Endocrinology, ISSN 0952-5041, 05/2016, Volume 56, Issue 4, pp. T49 - T62
Journal Article
11/2012
The conformational conversion of the cellular prion protein (PrPC) to PrP scrapie (PrPSc) is a hallmark of prion diseases [1]. The cellular role of PrP and the... 
ZIP | 0379 | ZIP10 | Prion | LIV1 | Endoproteolysis | ZIP5 | ZIP6 | PrP
Dissertation
Biological Chemistry, ISSN 1431-6730, 09/2012, Volume 393, Issue 9, pp. 899 - 905
γ-Secretase is a membrane-embedded protease complex with presenilin as the catalytic component. Cleavage within the transmembrane domain of the amyloid... 
protease | endoproteolysis | amyloid | presenilin | carboxypeptidase
Journal Article
FASEB Journal, ISSN 0892-6638, 06/2011, Volume 25, Issue 6, pp. 1934 - 1942
The hallmarks of Alzheimer's disease are the aggregates of amyloid-beta (A beta) peptide and tau protein. Autophagy is one major cellular pathway leading to... 
SMER28 | Beclin1 | Ulk1 | Alzheimer's disease | ENDOPROTEOLYSIS | LIFE-SPAN | CELLS | AMYLOID PROTEIN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | SIGNALING PATHWAY | TOR | IN-VIVO | BIOLOGY | MICE | PRESENILIN-1 | Research Communications
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2019, Volume 516, Issue 1, pp. 264 - 269
Clinical case study and functional characterization of the disease-associated ( ) mutations may help reveal the roles of in the pathogenesis of Alzheimer's... 
Familial Alzheimer's disease | PSEN1 | Aβ43 | Early-onset | ENDOPROTEOLYSIS | A beta 43 | DEMENTIA | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | HYPOTHESIS | IDENTIFICATION | FAMILY | Case studies | Medicine, Experimental | Medical research | Genetic aspects | Alzheimer's disease | Amyloid beta-protein
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 07/2019, Volume 58, Issue 27, pp. 2953 - 2966
gamma-Secretase is a membrane-embedded protease complex, with presenilin as the catalytic component containing two transmembrane aspartates in the active site.... 
C-TERMINAL FRAGMENT | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC PORE | FAMILIAL ALZHEIMERS-DISEASE | TRANSMEMBRANE DOMAIN | MEMBRANE-PROTEIN | NOTCH SIGNALING PATHWAY | PRESENILIN ENDOPROTEOLYSIS | AMYLOID PRECURSOR PROTEIN | BETA-PEPTIDE PRODUCTION
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2017, Volume 114, Issue 27, pp. 6885 - 6887
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 06/2011, Volume 117, Issue 5, pp. 856 - 867
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2/2016, Volume 73, Issue 3, pp. 667 - 683
The cellular prion protein (PrPC) is a ubiquitously expressed protein of currently unresolved but potentially diverse function. Of putative relevance to normal... 
Life Sciences | Biochemistry, general | Life Sciences, general | Protein processing | Protein cleavage | Prion protein | Endoproteolysis | Biomedicine general | Cell Biology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2003, Volume 100, Issue 11, pp. 6382 - 6387
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2006, Volume 281, Issue 43, pp. 32240 - 32253
Ubiquilin 1 (UBQLN1) is a ubiquitin-like protein, which has been shown to play a central role in regulating the proteasomal degradation of various proteins,... 
GAMMA | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FAMILIAL ALZHEIMERS-DISEASE | CELL-SURFACE | DEGRADATION | PRESENILIN ENDOPROTEOLYSIS | GENERATION | IDENTIFICATION | MISSENSE MUTATIONS | ONSET
Journal Article
NEUROCHEMICAL RESEARCH, ISSN 0364-3190, 01/2019, Volume 44, Issue 1, pp. 5 - 11
Genetics strongly implicate the amyloid -peptide (A) in the pathogenesis of Alzheimer's disease. Dominant missense mutation in the presenilins and the amyloid... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | Biochemistry | AMYLOID-BETA-PROTEIN | PRESENILIN ENDOPROTEOLYSIS | TERMINAL FRAGMENT | NEUROSCIENCES | PEPTIDE | Protease | A-BETA | Genetics | Amyloid | GENERATION | PRECURSOR PROTEIN | INHIBITORS | GAMMA-SECRETASE
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7479, pp. 301 - 305
CAAX proteins have essential roles in multiple signalling pathways, controlling processes such as proliferation, differentiation and carcinogenesis(1). The... 
A-FACTOR | ENDOPROTEOLYSIS | RAS-DERIVED PEPTIDES | LOCALIZATION | SPECIFICITY | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SECONDARY STRUCTURE | PROTEOLYSIS | CIRCULAR-DICHROISM SPECTROSCOPY | Prenylation | Humans | Archaeal Proteins - chemistry | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Metalloendopeptidases - metabolism | DNA-Binding Proteins - metabolism | Methanococcus - enzymology | Endopeptidases - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Conserved Sequence | Cysteine - metabolism | Membrane Proteins - metabolism | Peptide Hydrolases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Archaeal Proteins - metabolism | Endoplasmic Reticulum - enzymology | Protein Structure, Tertiary | Amino Acid Sequence | Endopeptidases - metabolism | Biocatalysis | Signal Transduction | Models, Molecular | Escherichia coli Proteins - metabolism | DNA-Binding Proteins - chemistry | Peptide Hydrolases - chemistry | Amino Acid Motifs | Animals | Membrane Proteins - chemistry | Peptide Hydrolases - classification | Metalloendopeptidases - chemistry | Glutamic Acid - metabolism | Mice | Escherichia coli Proteins - chemistry | Proteins | Cysteine | Proteases | Physiological aspects | Amino acids | Cell membranes | Research | Molecular biology | Health aspects | Index Medicus
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2003, Volume 278, Issue 20, pp. 18664 - 18670
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been known to reduce risk for Alzheimer's disease. In addition to the anti-inflammatory effects of NSAIDs to... 
ENDOPROTEOLYSIS | SITE | THYMOCYTE DEVELOPMENT | COMPLEX | OVERPRODUCTION | C-TERMINUS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | STATE | MUTANT PRESENILIN-2 | AMYLOID PRECURSOR PROTEIN
Journal Article