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Nature cell biology, ISSN 1476-4679, 2011, Volume 13, Issue 10, pp. 1202 - 1213
Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch... 
LYMPHATIC ENDOTHELIUM | KINASE-ACTIVITY | VASCULAR NETWORK FORMATION | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C | MOUSE EMBRYOS | EXTRACELLULAR-MATRIX | MONOCLONAL-ANTIBODY | TUMOR ANGIOGENESIS | FACTOR RECEPTOR-3 | CELL BIOLOGY | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Receptors, Notch - antagonists & inhibitors | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Vascular Endothelial Growth Factor D - genetics | Phosphatidylinositol 3-Kinase - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Transduction, Genetic | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Rhombencephalon - blood supply | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Forkhead Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Antibodies - pharmacology | Macrophages - metabolism | Vascular Endothelial Growth Factor D - metabolism | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Physiological aspects | Blood vessels | Cellular signal transduction | Growth factor receptors | Research | Vascular endothelial growth factor
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 6, pp. 2425 - 2430
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and... 
Proteins | Angiogenesis | Receptors | Vascular endothelial growth factors | Endothelial growth factors | Ligands | Dimers | Chimeras | Monomers | Crystal structure | Vascular endothelial growth factor receptor-2 | Lymphangiogenesis | Vascular endothelial growth factor C | ACTIVATION | COMPLEX | FACTOR-C | angiogenesis | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ORF-VIRUS | TYROSINE KINASES | vascular endothelial growth factor receptor-2 | VASCULAR-PERMEABILITY | FAMILY-MEMBER | lymphangiogenesis | KINASE DOMAIN RECEPTOR | vascular endothelial growth factor C | Humans | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Recombinant Fusion Proteins - metabolism | Spodoptera | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor Receptor-1 - genetics | Protein Structure, Tertiary | Cell Line | Cell Survival | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor Receptor-3 - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Hydrogen Bonding | Vascular Endothelial Growth Factor C - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Kinetics | Mutation | Vascular Endothelial Growth Factor Receptor-3 - genetics | Development and progression | Research | Growth factor receptors | Neovascularization | Properties | Vascular endothelial growth factor | Protein binding | Lymphangioma | Biological Sciences
Journal Article
Angiogenesis (London), ISSN 1573-7209, 2012, Volume 15, Issue 2, pp. 171 - 185
Pharmacological inhibition of VEGF-A has proven to be effective in inhibiting angiogenesis and vascular leak associated with cancers and various eye diseases.... 
Biomedicine | Age-related macular degeneration | Cancer Research | Oncology | Affinity | Ophthalmology | VEGF receptor | Cardiology | Aflibercept | Placental growth factor | Biomedicine general | Cell Biology | ANGIOGENESIS | EFFICACY | MACULAR DEGENERATION | PHASE-II | ANTIBODY | FACTOR THERAPY | EYE | IN-VITRO | PEGAPTANIB | RETINAL DISEASES | PERIPHERAL VASCULAR DISEASE | Angiogenesis Inhibitors - immunology | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor B - antagonists & inhibitors | Recombinant Fusion Proteins - pharmacology | Endothelial Cells - metabolism | Humans | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor B - immunology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - immunology | Enzyme Activation - drug effects | Bevacizumab | Endothelial Cells - immunology | Vascular Endothelial Growth Factor B - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | HEK293 Cells | Ranibizumab | Vascular Endothelial Growth Factor Receptor-1 - immunology | Antibodies, Monoclonal, Humanized - immunology | Original Paper
Journal Article
Circulation research, ISSN 1524-4571, 2017, Volume 120, Issue 9, pp. 1414 - 1425
RATIONALE:Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas... 
Blood vessels | vascular leakage | VE-Cadherin | vascular biology | VEGF receptor regulation | REGRESSION | LYMPHATIC ENDOTHELIUM | CARDIAC & CARDIOVASCULAR SYSTEMS | RECEPTOR VEGFR-3 | ANGIOGENESIS | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C | MOUSE EMBRYOS | blood vessels | IN-VIVO | PERIPHERAL VASCULAR DISEASE | ADHERENS JUNCTIONS | HEMATOLOGY | Cadherins - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Neovascularization, Pathologic | Capillary Permeability - drug effects | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Carcinoma, Lewis Lung - blood supply | Adherens Junctions - metabolism | Antigens, CD - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Transfection | Female | Vascular Endothelial Growth Factor A - pharmacology | Tight Junctions - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Vascular Endothelial Growth Factor Receptor-2 - deficiency | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Genotype | Retinal Vessels - drug effects | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Carcinoma, Lewis Lung - metabolism | Mice, Knockout | Phenotype | Animals | Signal Transduction - drug effects | Lung - blood supply | Neovascularization, Physiologic | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Leakage | Phosphorylation | Kidneys | Cell junctions | Permeability | Gene deletion | Cadherin | Endothelial cells | Vascular endothelial growth factor receptors | Gene silencing | Angiogenesis | Clonal deletion | Rodents | Fibrinogen | Localization | Vascular endothelial growth factor | Tumors
Journal Article
Journal of biochemistry (Tokyo), ISSN 0021-924X, 2012, Volume 153, Issue 1, pp. 13 - 19
Vascular endothelial growth factors (VEGFs) belong to the platelet-derived growth factor supergene family, and they play central roles in the regulation of... 
VEGFR | hypoxia | preeclampsia | VEGF | tumor angiogenesis | SUPPRESSES TUMOR-GROWTH | CELLS | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | VEGF RECEPTOR-1 | BEVACIZUMAB PLUS IRINOTECAN | NUTRIENT STARVATION | DNA-SYNTHESIS | FLT-1 | IN-VIVO | Neoplasms - metabolism | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Angiogenesis Inhibitors - therapeutic use | Female | Pre-Eclampsia - metabolism | Lymphangiogenesis | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Neoplasm Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Neoplasms - drug therapy | Pregnancy | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Pre-Eclampsia - drug therapy | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Neovascularization, Pathologic - metabolism | Neovascularization, Physiologic | JB Reviews
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 09/2012, Volume 122, Issue 9, pp. 3101 - 3113
Osteoporotic bones have reduced spongy bone mass, altered bone architecture, and increased marrow fat. Bone marrow stem cells from osteoporotic patients are... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | COLONY-STIMULATING FACTOR | OSTEOGENIC CELLS | BONE-MARROW | TISSUE | PROLIFERATION | ADIPOGENESIS | MESENCHYMAL STEM-CELLS | OSTEOPOROSIS | ENDOTHELIAL GROWTH-FACTOR | Mesenchymal Stromal Cells - enzymology | Vascular Endothelial Growth Factor A - deficiency | Femur - pathology | Bone Marrow Cells - physiology | Male | Alkaline Phosphatase | Femur - diagnostic imaging | Adipocytes - physiology | PPAR gamma - metabolism | Vascular Endothelial Growth Factor A - genetics | Core Binding Factor Alpha 1 Subunit - metabolism | Tibia - pathology | Vascular Endothelial Growth Factor Receptor-2 - genetics | Adiposity | Osteoporosis - metabolism | Cell Differentiation | Colony-Forming Units Assay | Mesenchymal Stromal Cells - physiology | PPAR gamma - genetics | Vascular Endothelial Growth Factor Receptor-1 - genetics | Gene Expression | Bone Density | Osteoblasts - physiology | Cells, Cultured | Gene Expression Regulation | Tibia - diagnostic imaging | Mesenchymal Stromal Cells - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Lamin Type A - metabolism | Mice, Knockout | Radiography | Animals | Osteoporosis - pathology | Bone Marrow - pathology | Mice | Osteoblasts - metabolism | Vascular Endothelial Growth Factor A - physiology | Bone Marrow Cells - metabolism | Osteogenesis | Fat cells | Growth | Genetic aspects | Cell differentiation | Properties | Vascular endothelial growth factor | Osteoblasts
Journal Article
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 17713 - 11
Alzheimer's disease (AD) is a common disorder of progressive cognitive decline among elderly subjects. Angiogenesis-related factors including vascular... 
NERVOUS-SYSTEM | MULTIDISCIPLINARY SCIENCES | FACTOR RECEPTOR-2 | CELL-PROLIFERATION | MILD COGNITIVE IMPAIRMENT | TUMOR-GROWTH | EXPRESSION | VASCULAR ENDOTHELIAL GROWTH | ANGIOGENIC FACTORS | BRAIN | BETA | Human Umbilical Vein Endothelial Cells | Angiogenesis Inducing Agents | Humans | Vascular Endothelial Growth Factor Receptor-1 - physiology | Male | Vascular Endothelial Growth Factor A - metabolism | Brain - metabolism | Cognitive Dysfunction - genetics | Female | Vascular Endothelial Growth Factor Receptor-2 - physiology | Disease Models, Animal | Vascular Endothelial Growth Factor Receptor-2 - analysis | Cognitive Dysfunction - metabolism | Vascular Endothelial Growth Factor A - blood | Vascular Endothelial Growth Factor Receptor-2 - blood | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor A - analysis | Animals | Vascular Endothelial Growth Factor Receptor-1 - analysis | Alzheimer Disease - metabolism | Vascular Endothelial Growth Factors - metabolism | Aged | Mice | Alzheimer Disease - genetics | Vascular Endothelial Growth Factor Receptor-1 - blood | Neurodegenerative diseases | Cognitive ability | mRNA | Endothelial cells | Angiogenesis | Transfection | Rodents | Plasma levels | Vascular endothelial growth factor | Umbilical vein | Alzheimer's disease | Enzyme-linked immunosorbent assay | Geriatrics
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 5, p. e63574
Genes involved in invasion of trophoblast cells and angiogenesis are crucial in determining pregnancy outcome. We therefore studied expression profiles of... 
IN-VITRO | HYPERTENSIVE DISORDERS | HUMAN PLACENTA | PROTEIN-COUPLED RECEPTOR | KISSPEPTIN-10 | MULTIDISCIPLINARY SCIENCES | VEGF EXPRESSION | METASTASIS-SUPPRESSOR GENE | HYPOXIA | ENDOTHELIAL GROWTH-FACTOR | SOLUBLE RECEPTOR | Immunohistochemistry | Receptors, G-Protein-Coupled - metabolism | Humans | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - metabolism | Vascular Endothelial Growth Factor A - metabolism | Kisspeptins - metabolism | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Placenta - metabolism | Pregnancy | Kisspeptins - genetics | Matrix Metalloproteinase 9 - metabolism | Trophoblasts | Matrix Metalloproteinase 9 - genetics | Gastrointestinal Hormones - genetics | Gastrointestinal Hormones - metabolism | Female | Receptors, G-Protein-Coupled - genetics | Receptors, Kisspeptin-1 | Vascular Endothelial Growth Factor Receptor-1 - genetics | Pregnant women | Genes | Genetic research | Research | Gene expression | Vascular endothelial growth factor | Regulators | Transcription | Biochemistry | Biology | Metastasis | Kinases | Tissues | Angiogenesis | Receptors | Consent | Extracellular matrix | Medical research | Fetuses | Gynecology | Decidua | Obstetrics | Gelatinase B | Endothelium | Polymerase chain reaction | Infectious diseases | Placenta | Preeclampsia | Endocrinology | Cancer | Veins & arteries
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2016, Volume 291, Issue 53, pp. 27265 - 27278
VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit... 
LYMPHATIC VESSELS | ACTIVATION | METASTASIS | SPECIFICITY | VEGF-D PROMOTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR LYMPHANGIOGENESIS | GENE-THERAPY | LIGAND | SPREAD | CANCER | Humans | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - genetics | Lymphatic Vessels - metabolism | Female | Lymphangiogenesis | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor D - genetics | Vascular Endothelial Growth Factor D - chemistry | Antibodies, Neutralizing | Dermis - metabolism | Mutagenesis, Site-Directed | Signal Transduction | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Mice, SCID | Mutation - genetics | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor D - metabolism | Animals | Endothelium, Vascular - metabolism | Vascular Endothelial Growth Factor C - metabolism | Lymphatic Vessels - pathology | Dermis - pathology | Endothelium, Vascular - pathology | Mice, Inbred NOD | Neovascularization, Pathologic - metabolism | Vascular Endothelial Growth Factor Receptor-3 - genetics | Index Medicus | receptor | angiogenesis | endothelial cell | lymphangiogenesis | mutagenesis in vitro | vascular endothelial growth factor (VEGF) | Cell Biology
Journal Article
Journal Article