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1. Full Text Is circulating endothelin evaluation useful for clinicians?
by Ferri, Claudio and Desideri, Giovambattista
Internal and emergency medicine, ISSN 1828-0447, 05/2019, pp. 1 - 3
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2. Full Text Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by ET.sub.AR-dependent JNK/AP-1 pathway
by Weng, Chih-Ming and Yu, Chung-Chi and Kuo, Min-Liang and Chen, Bing-Chang and Lin, Chien-Huang
Biochemical Pharmacology, ISSN 0006-2952, 04/2014, Volume 88, Issue 3, p. 402
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3. Full Text PKC-I[micro] mediates multiple endothelin-1 actions on systolic Ca.sup.2+ and contractility in ventricular myocytes
by Kang, Misuk and Chung, Ka Young
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2012, Volume 423, Issue 3
a* Dn-PKC-I[micro] and dn-PKC-[delta] showed distinct subcellular localization in adult myocytes. a* ET-1 induces positive inotropy, increase in [Ca.sup.2+]i... 
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4. Full Text Reverse-mode Na.sup.+/Ca.sup.2+ exchange is an important mediator of venous contraction
by Tykocki, Nathan R and Jackson, William F and Watts, Stephanie W
Pharmacological Research, ISSN 1043-6618, 12/2012, Volume 66, Issue 6, p. 544
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5. Full Text La natriurese induite par l'hypercalcemie implique l'endotheline-1
by Tokonami, N and Cheval, L and Doucet, A and Houillier, P
Nephrologie & Therapeutique, ISSN 1769-7255, 09/2015, Volume 11, Issue 5, p. 446
L'hypercalcemie provoque une perte renale de sodium, d'eau et d'acide. Ces effets ne sont pas reproduits par le traitement par calcimimetique et ne sont pas... 
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6. Endothelin and its inhibitors
by Battistini, B and Warner, Timothy D
2001, Handbook of experimental pharmacology, ISBN 3540679855, Volume 152., xxiv, 532
Endothelins | Antagonists
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7. Full Text Antibodies targeting human endothelin-1 receptors reveal different conformational states in cancer cells
by Herbet, A and Costa, N and Leventoux, N and Mabondzo, A and Couraud, J.-Y and Borrull, A and Hugnot, J.-P and Boquet, D
Physiological Research, ISSN 0862-8408, 2018, Volume 67, Issue Suppl 1, pp. S257 - S264
The endothelin axis (endothelins and their receptors) is strongly involved in physiological and pathological processes. ET-1 plays a crucial role in particular... 
Monoclonal antibodies | Endothelin B receptor | Endothelin A receptor | Endothelin-1 | POTENT | PHYSIOLOGY | MONOCLONAL-ANTIBODY | EXPRESSION | Amino Acid Sequence | Cricetinae | Cricetulus | Endothelin A Receptor Antagonists - administration & dosage | Endothelin-1 - genetics | Endothelin-1 - metabolism | Humans | Receptor, Endothelin A - genetics | Xenograft Model Antitumor Assays - methods | Endothelin A Receptor Antagonists - metabolism | Receptor, Endothelin B - genetics | Animals | Antibodies, Monoclonal - administration & dosage | Mice, Nude | Cell Line, Tumor | Female | Receptor, Endothelin A - metabolism | Mice | Receptor, Endothelin B - metabolism | Antibodies, Monoclonal - metabolism | CHO Cells | Protein Binding - physiology | Flow cytometry | Immunoglobulins | Immunization | Pulmonary arteries | Brain tumors | Brain cancer | Melanoma | Endothelin ETB receptors | Endothelin 1 | Experiments | Cancer therapies | Rodents | Glioma cells | Cell lines | Stem cells | Diabetes
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8. Full Text Synthesis and pharmacological activity of 1,3,6-trisubstituted-4-oxo-1,4-dihydroquinoline-2-carboxylic acids as selective ET.sub.A antagonists
by Patel, Hardik J and Olgun, Nicole and Lengyel, IstvaN and Reznik, Sandra and Stephani, Ralph A
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2010, Volume 20, Issue 22, p. 6840
The synthesis and structure-activity relationship studies of endothelin A antagonists 2a-m are reported. 
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9. Full Text The Role of Calcium‐Sensing Receptors in Endothelin‐1‐Dependent Effects on Adult Rat Ventricular Cardiomyocytes: Possible Contribution to Adaptive Myocardial Hypertrophy
by Dyukova, Elena and Schreckenberg, Rolf and Arens, Christoph and Sitdikova, Guzel and Schlüter, Klaus‐Dieter
Journal of Cellular Physiology, ISSN 0021-9541, 09/2017, Volume 232, Issue 9, pp. 2508 - 2518
Current manuscript is the first report indicating the ET‐1‐dependent upregulation of CaR receptor in cardiomyocytes and it shows that this upregulation allows... 
PHYSIOLOGY | STIMULATION | ENDOTHELIAL DYSFUNCTION | POLYAMINES | HEART-FAILURE | CARDIAC-HYPERTROPHY | NITRIC-OXIDE | MECHANISMS | HYPERTENSION | STRESS | EXPRESSION | CELL BIOLOGY | Adaptation, Physiological | Up-Regulation | Rats, Wistar | Endothelin-1 - pharmacology | Cardiomegaly - pathology | Receptors, Calcium-Sensing - metabolism | Receptor, Endothelin B - agonists | Transfection | RNA Interference | Heart Ventricles - pathology | Disease Models, Animal | Paracrine Communication | Receptor, Endothelin A - agonists | Isolated Heart Preparation | Ventricular Function, Left - drug effects | Cells, Cultured | Cardiomegaly - physiopathology | Receptor Activity-Modifying Protein 1 - metabolism | Receptor, Endothelin A - genetics | Myocytes, Cardiac - pathology | Receptor, Endothelin B - genetics | Animals | Myocytes, Cardiac - drug effects | Heart Ventricles - physiopathology | Signal Transduction - drug effects | Myocytes, Cardiac - metabolism | Receptors, Calcium-Sensing - drug effects | Receptor, Endothelin A - metabolism | Receptors, Calcium-Sensing - genetics | Heart Ventricles - metabolism | Nitric Oxide Synthase - metabolism | Receptor, Endothelin B - metabolism | Cardiomegaly - genetics | Nitric Oxide - metabolism | Ventricular Remodeling - drug effects | Cardiomegaly - metabolism | Heart Ventricles - drug effects | Heart | Endothelin | Heart cells | Hypertrophy | Endothelium | Calcium | Endothelin ETB receptors | Paracrine signalling | Tissues | Receptor activity modifying proteins | Receptors | Arginine | Rodents | Down-regulation | Inhibition | Heart diseases | Cars | Rats | Cardiomyocytes | siRNA | Endothelin 1 | Nitric-oxide synthase | NG-Nitroarginine methyl ester | Polymerase chain reaction | Endothelin receptors | Nitric oxide | Receptor mechanisms | Cell size | Ventricle | Calcium-sensing receptors | Index Medicus
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10. Endothelin in renal physiology and disease
by Barton, Matthias and Kohan, Donald Elliott
2011, 1, Contributions to nephrology, ISBN 9783805597944, Volume 172., viii, 266
A comprehensive reference book on basic and clinical aspects Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the... 
Kidney Diseases | Endothelins | physiopathology | Kidneys | drug therapy | physiology | Receptor, Endothelin A | metabolism | Kidney | Diseases
Book
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11. Full Text Functional properties of cell-free expressed human endothelin A and endothelin B receptors in artificial membrane environments
by Proverbio, Davide and Roos, Christian and Beyermann, Michael and Orbán, Erika and Dötsch, Volker and Bernhard, Frank
BBA - Biomembranes, ISSN 0005-2736, 09/2013, Volume 1828, Issue 9, pp. 2182 - 2192
The human endothelin receptors are members of the rhodopsin class A of G-protein coupled receptors and key modulators of blood pressure regulation. Their... 
Nanodisc | Vasoactive peptide | G-protein coupled receptor | Cell-free expression | Human endothelin system | Lipid screening | ANTAGONIST | FREE SYSTEMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED RECEPTORS | DETERGENT | MONOMERIC RHODOPSIN | NANODISCS | POTENT | LIPID-BILAYERS | BIOPHYSICS | SURFACE-PLASMON RESONANCE | BINDING | Gene Expression | Receptor, Endothelin B - biosynthesis | Detergents - chemistry | Endothelin-1 - metabolism | Humans | Receptor, Endothelin A - genetics | Protein Folding | Receptor, Endothelin A - biosynthesis | Liposomes - chemistry | Receptor, Endothelin B - genetics | Cell-Free System - metabolism | Nanostructures - chemistry | Protein Binding | Receptor, Endothelin B - chemistry | Kinetics | Receptor, Endothelin A - chemistry | Endothelin-1 - chemistry | Proteins | Fluorescence | Rhodopsin | Endothelin | Analysis | Index Medicus
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12. Full Text Contribution of peripheral endothelin ET.sub.A and ET.sub.B receptors in neuropathic pain induced by spinal nerve ligation in rats
by Werner, Maria Fernanda P and Trevisani, Marcello and Campi, Barbara and Andre, Eunice and Geppetti, Pierangelo and Rae, Giles A
European Journal of Pain, ISSN 1090-3801, 10/2010, Volume 14, Issue 9, p. 911
Endothelins (ETs) contribute to the sensory changes seen in animals models of inflammatory, cancer and diabetic neuropathic pain, but little is known about... 
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13. Endothelin
: molecular biology, physiology, and pathology
by Highsmith, Robert F
1998, Contemporary biomedicine, ISBN 0896034364, ix, 274
physiology | Endothelins | Receptors, Endothelin | Receptors | Pathophysiology | Physiological effect
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14. Full Text Repeated administration of ET.sub.B receptor agonist, IRL-1620, produces tachyphylaxis only to its hypotensive effect
by Leonard, Mary G and Gulati, Anil
Pharmacological Research, ISSN 1043-6618, 11/2009, Volume 60, Issue 5, p. 402
IRL-1620, a highly selective ET.sub.B receptor agonist, is presently in a phase I clinical trial (NCT00613691) in the United States for patients with recurrent... 
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15. Full Text Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats.sup.1
by Gulmen, Senol and Kiris, Ilker and Narin, Cuneyt and Ceylan, Berit Gokce and Mermi, Betul and Sutcu, Recep and Meteoglu, Ibrahim
Journal of Surgical Research, ISSN 0022-4804, 11/2009, Volume 157, Issue 1, p. e7-e13
Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute renal failure following abdominal... 
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16. Full Text TNFα-induced airway smooth muscle cell proliferation depends on endothelin receptor signaling, GM-CSF and IL-6
by Knobloch, Jürgen and Yanik, Sarah Derya and Körber, Sandra and Stoelben, Erich and Jungck, David and Koch, Andrea
Biochemical Pharmacology, ISSN 0006-2952, 09/2016, Volume 116, pp. 188 - 199
Pathological proliferation of human airway smooth muscle cells (HASMCs) causes hyperplasia in chronic lung diseases. Signaling pathways that link airway... 
Cell proliferation | Smooth muscle | Inflammation | Hyperplasia | Lung | Cytokine | CONTROLLED-TRIAL | COLONY-STIMULATING FACTOR | MAP KINASES | MECHANISMS | FIBROBLASTS | OBSTRUCTIVE PULMONARY-DISEASE | ASTHMA | PHARMACOLOGY & PHARMACY | EXPRESSION | BOSENTAN | Hyperplasia - immunology | Interleukin-6 - antagonists & inhibitors | DNA Replication - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Antibodies, Blocking - pharmacology | Bronchi - immunology | Bronchi - drug effects | Bronchial Neoplasms - immunology | Muscle, Smooth - drug effects | Bronchial Neoplasms - surgery | Bronchi - pathology | Interleukin-6 - metabolism | Biomarkers - metabolism | Interleukin-6 - genetics | Receptor, Endothelin A - agonists | Endothelin-1 - genetics | Recombinant Proteins - chemistry | Receptor, Endothelin A - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Endothelin Receptor Antagonists - pharmacology | Receptor, Endothelin B - genetics | Signal Transduction - drug effects | Bronchial Neoplasms - pathology | Receptor, Endothelin A - metabolism | Receptor, Endothelin B - metabolism | Tumor Necrosis Factor-alpha - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Muscle, Smooth - immunology | Receptor, Endothelin B - agonists | Bronchi - metabolism | Carcinoma - pathology | Hyperplasia - metabolism | Hyperplasia - prevention & control | Recombinant Proteins - metabolism | Carcinoma - immunology | Endothelin-1 - metabolism | Carcinoma - surgery | Cells, Cultured | Muscle, Smooth - metabolism | Endothelin-1 - agonists | Interleukin-6 - agonists | Gene Expression Regulation - drug effects | Hyperplasia - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - agonists | Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Receptor, Endothelin B - chemistry | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Carcinoma - metabolism | Bronchial Neoplasms - metabolism | Muscle, Smooth - pathology | Receptor, Endothelin A - chemistry | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus
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17. Full Text Protective effects of PPAR‐γ against pregnancy‐induced hypertension by differential ETR expression in rat models
by Wu, Ying and Ruan, Yan and Shen, Lin and Gong, Qing
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2018, Volume 119, Issue 4, pp. 3118 - 3128
Based on our findings, we conclude that PPAR‐γ activation inhibits ETR expression and reduces the effect of ET‐1 on vascular contraction thereby delaying PIH... 
endothelin receptor‐streptavidin‐biotin complex | rosiglitazone | pregnancy‐induced hypertension | endothelin receptor | bosentan | peroxisome proliferator activated receptor‐gamma | peroxisome proliferator activated receptor-gamma | pregnancy-induced hypertension | endothelin receptor-streptavidin-biotin complex | Endothelin Receptor Antagonists - administration & dosage | Rats, Wistar | Rats | Hypertension, Pregnancy-Induced - metabolism | Male | Random Allocation | PPAR gamma - metabolism | Receptor, Endothelin A - genetics | Sulfonamides - pharmacology | Hypertension, Pregnancy-Induced - genetics | Gene Expression Regulation - drug effects | Pregnancy | Hypertension, Pregnancy-Induced - chemically induced | Endothelin Receptor Antagonists - pharmacology | Animals | Hypertension, Pregnancy-Induced - prevention & control | Female | Receptor, Endothelin A - metabolism | Sulfonamides - administration & dosage | Endotoxins - adverse effects | PPAR gamma - genetics | Hypertension | Immunohistochemistry | Animal models | Endothelin | Reverse transcription | Gene expression | Contraction | Western blotting | Polymerase chain reaction | Rodents | Peroxisome proliferator-activated receptors | Index Medicus
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18. Full Text 350 DISTRIBUTION OF HLA-DR-EXPRESSING CELLS IN THE INTIMA OF HUMAN AORTA: POSSIBLE ROLE IN SURVEILLANCE AND MAINTENANCE OF VASCULAR HOMEOSTASIS
by Bobryshev, Y.V and Moisenovich, M.M and Pustovalova, O.L and Agapov, I.I and Orekhov, A.N
Atherosclerosis (Supplements) (Component), ISSN 1567-5688, 06/2011, Volume 12, Issue 1, pp. 75 - 75
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19. Full Text Ligand-dependent Differences in the Internalization of Endothelin A and Endothelin B Receptor Heterodimers
by Bernd Gregan and Jana Jürgensen and Gisela Papsdorf and Jens Furkert and Michael Schaefer and Michael Beyermann and Walter Rosenthal and Alexander Oksche
Journal of Biological Chemistry, ISSN 0021-9258, 06/2004, Volume 279, Issue 26, pp. 27679 - 27687
Endothelin-1 (ET-1) is a potent vasoactive peptide that acts on endothelin A (ET A ) and endothelin B (ET B ) receptors. Although both receptor subtypes are... 
ETB-RECEPTOR | CELLS | SMOOTH-MUSCLE | DISTINCT PHARMACOLOGICAL-PROPERTIES | ASTROGLIAL GAP-JUNCTIONS | ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAFFICKING | IDENTIFICATION | PROTEIN-KINASE ACTIVATION | ET(B) RECEPTORS | Binding, Competitive | Cell Line | Endothelins - pharmacology | Receptor, Endothelin A - agonists | Humans | Immunoblotting | Recombinant Fusion Proteins - chemistry | Receptor, Endothelin A - genetics | Recombinant Fusion Proteins - metabolism | Subcellular Fractions - metabolism | Precipitin Tests | Receptor, Endothelin B - agonists | Receptor, Endothelin B - genetics | Transfection | Fluorescence Resonance Energy Transfer | Recombinant Fusion Proteins - agonists | Recombinant Fusion Proteins - genetics | Receptor, Endothelin A - metabolism | Receptor, Endothelin B - chemistry | Receptor, Endothelin B - metabolism | Kinetics | Radioligand Assay | Dimerization | Receptor, Endothelin A - chemistry | Index Medicus
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20. Full Text Historical review: Endothelin
by Masaki, Tomoh
Trends in Pharmacological Sciences, ISSN 0165-6147, 2004, Volume 25, Issue 4, pp. 219 - 224
Endothelin (ET) is a potent vasoconstrictive peptide that was isolated initially from the conditioned medium of cultured endothelial cells. In 1988, details of... 
MOLECULAR CHARACTERIZATION | ANTAGONIST BOSENTAN | POTENT | PULMONARY ARTERIAL-HYPERTENSION | CONVERTING ENZYME-2 | CLONING | B RECEPTOR GENE | HEART-FAILURE | PHARMACOLOGY & PHARMACY | BLOOD-PRESSURE | KNOCKOUT MOUSE | Endothelins - physiology | Molecular Biology - history | Cardiovascular Diseases - drug therapy | History, 20th Century | Humans | Receptors, Endothelin - physiology | Endothelins - therapeutic use | Molecular Biology - trends | Receptors, Endothelin - therapeutic use | Endothelins - history | Receptors, Endothelin - history | Cardiovascular Diseases - history | Endothelin Receptor Antagonists | Endothelin | Research | Vasoconstrictors | Index Medicus
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