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Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 11/2004, Volume 432, Issue 7016, pp. 512 - 516
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 01/2018, Volume 314, Issue 1, pp. H52 - H64
Hyperglycemia-induced production of endothelin (ET)-1 is a hallmark of endothelial dysfunction in diabetes. Although the detrimental vascular effects of... 
Endothelial dysfunction | Hyperglycemia | Endothelin-1 | TRAF3 interacting protein 2 | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Inflammation - chemically induced | Coculture Techniques | Humans | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Male | Monocytes - metabolism | Inflammation - metabolism | I-kappa B Kinase - metabolism | Inflammation Mediators - metabolism | Female | Glucose - toxicity | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Diabetic Angiopathies - chemically induced | Diabetic Angiopathies - metabolism | Cytokines - metabolism | Endothelial Cells - metabolism | Endothelin-1 - genetics | Endothelin-1 - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Cells, Cultured | Diabetes Mellitus, Type 1 - genetics | Cell Adhesion | Cell Adhesion Molecules - metabolism | Endothelin-1 - toxicity | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Animals | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Mice, Inbred NOD | Adaptor Proteins, Signal Transducing - metabolism | Endothelial Cells - drug effects | Reactive oxygen species | Vascular cell adhesion molecule 1 | Transcription | Activation | Glucose | NAD(P)H oxidase | Proteins | Aorta | Inhibition | Chemical synthesis | Intercellular adhesion molecule 1 | Complications | Adapters | Diabetes mellitus | JNK protein | Pharmacology | Inflammation | Endothelin 1 | Tumor necrosis factor-α | IL-1β | Adhesion | Endothelial cells | Endothelium | E-selectin | Molecular modelling | Monocyte chemoattractant protein | Diabetes | Monocyte chemoattractant protein 1 | Index Medicus | hyperglycemia | endothelin-1 | endothelial dysfunction
Journal Article
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 01/2012, Volume 59, Issue 1, pp. 136 - 144
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2012, Volume 87, Issue 6, pp. 134 - 134
ABSTRACT Preeclampsia affects 5%–8% of pregnancies and is the leading worldwide cause of maternal and fetal morbidity and mortality. Preeclampsia is associated... 
angiogenesis | hypoxia-inducible factor-1 (HIF1A | soluble Fms-like tyrosine kinase-1 (sFLT-1) | endothelin-,1 hypoxia | HIF-1α | preeclampsia | angiotensin II receptor type I autoimmune antibody | soluble endoglin | Angiotensin II receptor type I autoimmune antibody | Solublefms-like tyrosine kinase-1 (sFLT-1) | Angiogenesis | Soluble endoglin | Endothelin-,1 hypoxia, hypoxia-inducible factor-1 (HIF1A; HIF-1a) | Preeclampsia | Life Sciences & Biomedicine | Reproductive Biology | Science & Technology | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Receptor, Angiotensin, Type 1 - chemistry | Antigens, CD - metabolism | Cell Hypoxia | Endoglin | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Autoantibodies - analysis | Female | Receptors, Cell Surface - chemistry | Antigens, CD - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Pre-Eclampsia - metabolism | Endothelin-1 - chemistry | Placenta - immunology | Endothelin-1 - metabolism | Solubility | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - blood | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Pre-Eclampsia - etiology | Endothelin-1 - blood | Placenta - metabolism | Pregnancy | Antigens, CD - blood | Animals | Pre-Eclampsia - blood | Vascular Endothelial Growth Factor Receptor-1 - blood | Pre-Eclampsia - immunology | Index Medicus
Journal Article
Cellular signalling, ISSN 0898-6568, 08/2017, Volume 36, pp. 240 - 254
G-protein coupled receptor (GPCR) mediated activation of the MAPK signalling cascade is a key pathway in the induction of hypertrophic remodelling of the heart... 
Cardiac hypertrophy | Signalling | MAPK | GPCRs | Endothelin-1 | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Animals, Newborn | Transcription, Genetic - drug effects | Rats, Wistar | Endothelin-1 - pharmacology | Humans | RNA, Messenger - genetics | Cardiomegaly - pathology | Male | RNA, Messenger - metabolism | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Animals | Myocytes, Cardiac - drug effects | Phenylephrine - pharmacology | Signal Transduction - drug effects | HEK293 Cells | Myocytes, Cardiac - metabolism | Receptor, Endothelin A - metabolism | Protein Kinase Inhibitors - pharmacology | Cardiomegaly - genetics | Heart | Endothelin | Genetic transcription | Physiological aspects | Protein kinases | Natriuretic peptides | Index Medicus | DPM, disintegrations per minute | CVD, cardiovascular disease | β-MHC, myosin heavy chain, β isoform | IEG, immediate early gene | ECC, excitation contraction coupling | NFAT, nuclear factor of activated T cells | ara-C, cytosine b-d-arabinofuranoside | BNP, brain natriuretic factor | ETB receptor, endothelin type B receptor | ECE, endothelin converting enzyme | ERK1 | 2, extracellular signal-regulated kinase 1 | Act D, actinomycin D | TCA, trichloroacetic acid | DN β-Arr1, dominant negative β-arrestin-1 | PD, PD184352 | GPCR, G-protein coupled receptor | α-MHC, myosin heavy chain, α isoform | MEF2, myocyte enhancer factor-2 | TAC, transverse aortic constriction | ET-1, endothelin-1 | Ang II, angiotensin II | PE, phenylepherine | ANF, atrial natriuretic factor | CN, calcineurin | DUSP6, dual specificity phosphatase-6 | ETA receptor, endothelin type A receptor | NRVMs, neonatal rat ventricular myocytes | MAPK, mitogen activated protein kinase | SRF, serum response factor
Journal Article