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Journal Article
Chest, ISSN 0012-3692, 2013, Volume 144, Issue 3, pp. 952 - 958
Journal Article
Journal Article
Chest, ISSN 0012-3692, 2012, Volume 142, Issue 6, pp. 1383 - 1390
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 12/2014, Volume 130, Issue 23, pp. 2021 - 2030
Journal Article
Life Sciences, ISSN 0024-3205, 08/2014, Volume 111, Issue 1-2, pp. 6 - 11
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2005, Volume 171, Issue 11, pp. 1292 - 1297
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 11/2000, Volume 102, Issue 19, pp. 2434 - 2440
The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin peptide family, which includes ET-2, ET-3, and ET-4. It exerts... 
Heart failure | Hypertension | Restenosis | Transplantation | Nitric oxide | Atherosclerosis | atherosclerosis | heart failure | restenosis | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | transplantation | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | hypertension | Index Medicus
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 10/2012, Volume 64, Issue 1, pp. 95 - 103
► Sitaxentan preclinical safety was assessed in mice, rats, and dogs. ► Coagulopathy, increased serum alkaline phosphatase, hepatic hypertrophy and decreased... 
Carcinogenicity tests | Testis | Toxicology | Drug evaluation | Toxicity | Risk assessment | Drug-induced liver injury | Preclinical | Bile salt export pump | Endothelin receptor | MEDICINE, LEGAL | SALT EXPORT PUMP | INJURY | LIVER TOXICITY | THERAPY | SITAXSENTAN | PHARMACOLOGY & PHARMACY | BOSENTAN | Hypertrophy - chemically induced | Liver - pathology | Species Specificity | Chemical and Drug Induced Liver Injury, Chronic - metabolism | Thiophenes - toxicity | Male | Antihypertensive Agents - classification | Chemical and Drug Induced Liver Injury, Chronic - etiology | Hypertrophy - pathology | Liver - physiopathology | Carcinogens - toxicity | Dose-Response Relationship, Drug | Carcinogens - classification | Antihypertensive Agents - toxicity | Thiophenes - classification | Liver - drug effects | Female | Carcinogens - pharmacokinetics | Hypertension, Pulmonary - drug therapy | Drug Evaluation, Preclinical | Alkaline Phosphatase - blood | Endothelin Receptor Antagonists | Isoxazoles - pharmacokinetics | Liver Function Tests | Isoxazoles - classification | Risk Assessment | Erythrocyte Indices - drug effects | Rats | Antihypertensive Agents - pharmacokinetics | Mice, Inbred Strains | Chemical and Drug Induced Liver Injury, Chronic - pathology | Rats, Sprague-Dawley | Carcinogenicity Tests | Thiophenes - pharmacokinetics | Organ Size - drug effects | Animals | Blood Coagulation - drug effects | Dogs | Mice | Isoxazoles - toxicity | Medical examination | Endothelin | Phosphatases | Hemoglobin | Aspartate | Thrombin | Blood | Pulmonary hypertension | Index Medicus
Journal Article
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2011, Volume 204, Issue 4, pp. 330.e1 - 330.e4
Journal Article