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JAMA, ISSN 0098-7484, 03/2013, Volume 309, Issue 11, pp. 1154 - 1162
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7450, pp. 498 - 502
There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection. Previous... 
UNITED-STATES | 1918 SPANISH INFLUENZA | ACTIVATION | VIRUS | ENDOTOXIN ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | INHIBITORS | TETRASODIUM E5564 | SEVERE SEPSIS | Disaccharides - metabolism | Lymphocyte Antigen 96 - metabolism | Lipopolysaccharide Receptors - metabolism | Disaccharides - pharmacology | Sugar Phosphates - pharmacology | Time Factors | Acute Lung Injury - prevention & control | Female | Acute Lung Injury - drug therapy | Disaccharides - therapeutic use | Toll-Like Receptor 4 - antagonists & inhibitors | Cytokines - genetics | Orthomyxoviridae Infections - drug therapy | Cytokines - immunology | Antiviral Agents - pharmacology | Sugar Phosphates - therapeutic use | Antiviral Agents - therapeutic use | Mice, Inbred C57BL | Orthomyxoviridae Infections - pathology | Influenza A Virus, H1N1 Subtype - pathogenicity | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Influenza A Virus, H1N1 Subtype - drug effects | Acute Lung Injury - pathology | Animals | Sugar Phosphates - metabolism | Survival Analysis | Toll-Like Receptor 2 - immunology | Ligands | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Acute Lung Injury - complications | Prevention | Toll-like receptors | Health aspects | Influenza | Pathology | Cell culture | Respiratory distress syndrome | Cytokines | Mortality | Rodents | Sepsis | Infections | Gene expression | Drug dosages | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 130, Issue 5, pp. 906 - 917
TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its... 
PROTEINS | MOLIMMUNO | BACTERIAL LIPOPOLYSACCHARIDE | MD-2 BINDS | CELL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTORS | PROTEIN COMPLEXES | LEUCINE-RICH REPEAT | LIPID IVA | CONFERS LIPOPOLYSACCHARIDE RESPONSIVENESS | TLR4 | MONOMERIC ENDOTOXIN | CELL BIOLOGY | Disaccharides - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Immunoglobulin Variable Region - chemistry | Lipopolysaccharides - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Hagfishes | Lipopolysaccharides - antagonists & inhibitors | Disaccharides - chemistry | Lymphocyte Antigen 96 - genetics | Disaccharides - pharmacology | Sugar Phosphates - pharmacology | Lymphocyte Antigen 96 - chemistry | Cloning, Molecular | Protein Engineering | Molecular Structure | Toll-Like Receptor 4 - antagonists & inhibitors | Binding Sites | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Fish Proteins - chemistry | Sugar Phosphates - chemistry | Models, Molecular | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - chemistry | Recombinant Fusion Proteins - chemistry | Toll-Like Receptor 4 - metabolism | Animals | Sugar Phosphates - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Lipopolysaccharides - chemistry | Mice | Structural Homology, Protein | Mutation | Structure | Crystals | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2005, Volume 280, Issue 48, pp. 39914 - 39924
The CATERPILLER (CLR, also NOD and NLR) proteins share structural similarities with the nucleotide binding domain ( NBD)leucine- rich repeat (LRR) superfamily... 
ENDOTOXIN-TOLERANT CELLS | CROHNS-DISEASE | AUTOINFLAMMATORY DISORDERS | HOST RECOGNITION | NEGATIVE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BACTERIAL PEPTIDOGLYCAN | NF-KAPPA-B | CIAS1 MUTATIONS | CUTTING EDGE | FAMILY | Protein Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Immunoprecipitation | Luciferases - metabolism | Humans | Transcriptional Activation | Interleukin-1 Receptor-Associated Kinases | Monocytes - metabolism | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Transfection | Retroviridae - genetics | Antigens, Differentiation - metabolism | Toll-Like Receptors - metabolism | Caspases - chemistry | Mycobacterium tuberculosis - metabolism | Genes, Reporter | RNA - metabolism | Protein Structure, Tertiary | Cell Line | Promoter Regions, Genetic | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Nuclear Pore Complex Proteins - metabolism | TNF Receptor-Associated Factor 2 - metabolism | Inflammation | Cytoskeletal Proteins - chemistry | Myeloid Differentiation Factor 88 | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Pyrin | Amino Acid Motifs | Transcription Factor RelA - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Intracellular Signaling Peptides and Proteins - physiology | RNA-Binding Proteins - metabolism | Receptors, Immunologic - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 51, pp. 18303 - 18308
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 2, pp. 379 - 385
Background Asthma with neutrophil predominance is challenging to treat with corticosteroids. Novel treatment options for asthma include those that target... 
Allergy and Immunology | anakinra | innate immunity | IL-1 receptor antagonist | induced sputum | asthma | IL-1β | Endotoxin | neutrophil | LPS | Innate immunity | Neutrophil | Anakinra | Asthma | Induced sputum | EOSINOPHILIC INFLAMMATION | IL-1 beta | IMMUNOLOGY | CHALLENGE | TUMOR-NECROSIS-FACTOR | EPITHELIAL-CELLS | ALLERGY | IN-VIVO | ATOPIC ASTHMATIC SUBJECTS | NF-KAPPA-B | INHALED ENDOTOXIN | EXPRESSION | Inflammation - chemically induced | Interleukin 1 Receptor Antagonist Protein - administration & dosage | Sputum - cytology | Respiratory Tract Diseases - metabolism | Humans | Lipopolysaccharides - administration & dosage | Male | Respiratory Tract Diseases - drug therapy | Healthy Volunteers | Lipopolysaccharides - adverse effects | Respiratory Tract Diseases - immunology | Young Adult | Inflammation - metabolism | Sputum - immunology | Inflammation - drug therapy | Inflammation Mediators - metabolism | Anti-Inflammatory Agents - therapeutic use | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Leukocyte Count | Neutrophil Infiltration - drug effects | Neutrophil Infiltration - immunology | Cytokines - metabolism | Administration, Inhalation | Respiratory Tract Diseases - chemically induced | Treatment Outcome | Inflammation - immunology | Sputum - metabolism | Receptors, Interleukin-1 - metabolism | Cross-Over Studies | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Endotoxins - administration & dosage | Receptors, Interleukin-1 - antagonists & inhibitors | Endotoxins - adverse effects | Premedication | Cytokines | Infections | Gene expression | Blood | Recruitment | Studies | Human subjects | Tuberculosis | Rodents | Risk assessment | Drug therapy | Drug dosages | Viral infections | Index Medicus | Abridged Index Medicus
Journal Article
Critical Care Medicine, ISSN 0090-3493, 01/2010, Volume 38, Issue 1, pp. 72 - 83
Journal Article
Journal Article
Toxicological Sciences, ISSN 1096-6080, 01/2013, Volume 131, Issue 1, pp. 247 - 258
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 10/2013, Volume 49, Issue 4, pp. 552 - 562
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by pulmonary edema attributable to alveolar... 
Alveolar injury | Inflammation | Cell therapy | IL-33 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | SEPSIS | MODEL | TRANSPLANTATION | CELL BIOLOGY | RESPONSES | alveolar injury | ENGRAFTMENT | INHIBITION | inflammation | RESPIRATORY SYSTEM | cell therapy | HOST-DEFENSE | LIPOPOLYSACCHARIDE | GENE-THERAPY | Bronchoalveolar Lavage Fluid | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Endotoxins | Acute Lung Injury - genetics | Male | Interferon-gamma - metabolism | Interleukin-1beta - genetics | Interleukins - metabolism | Receptors, Somatostatin - genetics | Interleukins - genetics | Inflammation - metabolism | Mesenchymal Stromal Cells - cytology | Interleukin-1beta - metabolism | HEK293 Cells | Interleukin-10 - metabolism | Female | Acute Lung Injury - metabolism | Interferon-gamma - genetics | Acute Lung Injury - surgery | Mesenchymal Stromal Cells - physiology | Interleukin-33 | Mesenchymal Stromal Cells - metabolism | Toll-Like Receptor 4 - chemistry | Toll-Like Receptor 4 - metabolism | Interleukins - antagonists & inhibitors | Mesenchymal Stem Cell Transplantation - methods | Receptors, Somatostatin - biosynthesis | Animals | Interleukin-10 - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Mice | Mice, Inbred BALB C | Index Medicus
Journal Article
Respiratory Research, ISSN 1465-9921, 12/2013, Volume 14, Issue 1, pp. 137 - 137
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 61, Issue 7, pp. 2895 - 2909
The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists formed by a glucosamine core linked to two phosphate esters and... 
CHEMISTRY, MEDICINAL | N-LINKED GLYCOSYLATIONS | LIPID-A ANALOGS | CELL ACTIVATION | ENDOTOXIN | MD-2 | CD14 | BINDING | ERITORAN | SEVERE SEPSIS | Index Medicus
Journal Article