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engase (21) 21
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biochemistry & molecular biology (9) 9
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mannosyl-glycoprotein endo-beta-n-acetylglucosaminidase - metabolism (5) 5
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Trends in Glycoscience and Glycotechnology, ISSN 0915-7352, 11/2018, Volume 30, Issue 177, pp. J169 - E219
Journal Article
Trends in Glycoscience and Glycotechnology, ISSN 0915-7352, 2019, Volume 31, Issue 179, pp. J35 - J41
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2017, Volume 27, Issue 13, pp. 2962 - 2966
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 02/2018, Volume 14, Issue 1, pp. 416 - 429
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 7/2017, Volume 27, Issue 13, pp. 2962 - 2966
N -glycanase deficiency, or NGLY1 deficiency, is an extremely rare human genetic disease. N -glycanase, encoded by the gene NGLY1 , is an important enzyme... 
proton pump inhibitors | drug repurposing | endo-β-N-acetylglucosaminidase (ENGase) inhibitors | structure-based virtual screening | NGLY1
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2016, Volume 55, Issue 16, pp. 5058 - 5061
Journal Article
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, ISSN 0915-7352, 03/2019, Volume 31, Issue 179, pp. E33 - E39
Cytosolic peptide: N-glycanase (PNGase, Ngly1) is a de-N-glycosylating enzyme that cleaves N-glycans from glycoproteins. Ngly1 is known to be involved in... 
Ngly1 | ACETYLGLUCOSAMINE | DROSOPHILA MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISORDER | BMP signaling | NGLY1-deficiency | DEGRADATION | Nrf1 | MECHANISMS | INSIGHT | ENGase
Journal Article
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, ISSN 0915-7352, 07/2019, Volume 31, Issue 181, pp. SE55 - SE56
Peptide:N-glycanase (PNGase) is a deglycosylating enzyme that acts on asparagine-linked (N-linked) glycans. I was involved in the discovery of this enzyme... 
NGLY1 DEFICIENCY | TRANSCRIPTION FACTOR NRF1 | INHIBITION | PATHWAY | DROSOPHILA MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISORDER | NGLY1-deficiency | non-lysosomal glycan degradation | N-glycans | ENGase | peptide:N-glycanase
Journal Article
Angewandte Chemie, ISSN 0044-8249, 04/2016, Volume 128, Issue 16, pp. 5142 - 5145
The majority of lysosomal enzymes are targeted to the lysosome by post‐translational tagging with N‐glycans terminating in mannose‐6‐phosphate (M6P) residues.... 
Mannose-6-phosphat | Kohlenhydrate | N-Glykane | ENGase | Glykoproteine | Carbohydrate Sequence | Phosphorylation | Glycoproteins - chemistry | Acetylglucosaminidase - chemistry | Glycoproteins - chemical synthesis | Phosphates | Polysaccharides | Ribonuclease | Catalysis | Sugars | Monosaccharides | Backbone | Residues | Enzymes | Synthesis (chemistry) | Glycoprotein | Glycan | Bearing | Recombinant
Journal Article
Bioinformation, ISSN 0973-2063, 2014, Volume 10, Issue 8, pp. 507 - 511
Endo- β-N-acetylgucosaminidases (ENGases) are the enzymes that catalyze both hydrolysis and transglycosylation reactions. It is of interest to study ENGases... 
Journal Article
Trends in Glycoscience and Glycotechnology, ISSN 0915-7352, 11/2018, Volume 30, Issue 177, pp. E209 - E219
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 09/2014, Volume 5, p. 429
Free N-glycans (FNGs) are present at micromolar concentrations in plant cells during their differentiation, growth, and maturation stages. It has been... 
PNGase | Free N-glycans | Knockout plant | ENGase | Glycochaperone | ACETYLGLUCOSAMINIDASE | TOMATO FRUIT | ALPHA-MANNOSIDASE | GOLGI-APPARATUS | SEED DEVELOPMENT | free N-glycans | PEPTIDE | knockout plant | PLANT SCIENCES | glycochaperone | AMIDASE | GENE | OLIGOMANNOSIDE TYPE | HIGH-MANNOSE TYPE
Journal Article
Journal Article
Trends in Glycoscience and Glycotechnology, ISSN 0915-7352, 2017, Volume 29, Issue 165, pp. E1 - J11
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2006, Volume 400, Issue 1, pp. 33 - 41
The endoplasmic-reticulum-associated degradation of misfolded (glyco)proteins ensures that only functional, correctly folded proteins exit from the endoplasmic... 
Peptide:N-glycanase (PNGase) | N-glycan | Non-lysosomal degradation | α-mannosidase | Cytosol | Free oligosaccharide | RAT-LIVER | non-lysosomal degradation | cytosol | BIOCHEMISTRY & MOLECULAR BIOLOGY | FULL-LENGTH CDNA | alpha-mannosidase | SUBSTRATE-SPECIFICITY | free oligosaccharide | peptide : N-glycanase (PNGase) | PEPTIDE-N-GLYCANASE | HEPG2 CELLS | POLYMANNOSE-TYPE OLIGOSACCHARIDES | ENDOPLASMIC-RETICULUM | HEN OVIDUCT | EXPRESSION | JAPANESE-QUAIL OVIDUCT | Immunohistochemistry | Membrane Glycoproteins - metabolism | Oligopeptides | Humans | alpha-Mannosidase - metabolism | Cytosol - drug effects | Peptides - genetics | alpha-Mannosidase - antagonists & inhibitors | Green Fluorescent Proteins - genetics | Mannosidases - metabolism | Chromatography, High Pressure Liquid | Recombinant Fusion Proteins - metabolism | Cytosol - enzymology | Peptides - metabolism | Transfection | Cobalt - pharmacology | RNA Interference | Oligosaccharides - chemistry | Mannosidases - genetics | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Swainsonine - pharmacology | Cell Line | Green Fluorescent Proteins - metabolism | Alkaloids - pharmacology | Mannosidases - antagonists & inhibitors | Oligosaccharides - metabolism | Blotting, Western | Gene Expression Regulation, Enzymologic | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | alpha-Mannosidase - genetics | EGFP, enhanced green fluorescent protein | KIF, kifunensine | RNAi, RNA interference | 2-AA, 2-aminobenzoic acid | PNGase, peptide:N-glycanase | DMM, deoxymannojirimycin | siRNA, small interfering RNA | pNP-α-Man, p-nitrophenyl-α-D-mannoside | peptide:N-glycanase (PNGase) | PA, pyridylamino | MALDI–TOF MS, matrix-assisted laser desorption ionization–time-of-flight MS | ERAD, ER-associated degradation | RNase B, ribonuclease B | ENGase, endo-β-N-acetylglucosaminidase | SW, swainsonine | ER, endoplasmic reticulum | PDI, protein disulfide-isomerase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | TFA, trifluoroacetic acid
Journal Article
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