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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2018, Volume 61, Issue 22, pp. 10141 - 10154
Omapatrilat was designed as a vasopeptidase inhibitor with dual activity against the zinc metallopeptidases angiotensin-1 converting enzyme (ACE) and... 
SELECTIVE-INHIBITION | NEPRILYSIN | POTENT | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | N-DOMAIN | ENKEPHALINASE | ELECTROSTATICS | ANGIOTENSIN-CONVERTING ENZYME | PEPTIDE | BRADYKININ
Journal Article
Endocrine Regulations, ISSN 1336-0329, 04/2019, Volume 53, Issue 2, pp. 59 - 64
Enkephalins are neuropeptides involved in functions such as pain modulation and/ or cognitive processes. It has been reported that dietary fat modifies... 
enkephalinases | frontal cortex | diet | fatty acids | enkephalins
Journal Article
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, ISSN 1742-7835, 08/2018, Volume 123, pp. 16 - 16
Conference Proceeding
Pain, ISSN 0304-3959, 02/2019, Volume 160, Issue 2, pp. 307 - 321
Ocular pain is a core symptom of inflammatory or traumatic disorders affecting the anterior segment. To date, the management of chronic ocular pain remains a... 
RAT | MORPHINE | PEPTIDERGIC INNERVATION | NEUROSCIENCES | OPIOID-INDUCED HYPERALGESIA | CLINICAL NEUROLOGY | DENKI | Enkephalins | Corneal pain | CROSS-TOLERANCE | ANESTHESIOLOGY | SUBSTANCE-P | EXPRESSION | ANTINOCICEPTIVE TOLERANCE | MODULATION | Ocular inflammation | ANALGESIA | Index Medicus
Journal Article
Biological Research For Nursing, ISSN 1099-8004, 7/2019, Volume 21, Issue 4, pp. 431 - 439
Objectives: Fibromyalgia (FM) is a chronic pain condition of unclear etiology. We have analyzed, for the first time, the activity of a broad spectrum of... 
oxytocinase | enkephalinase | fibromyalgia | aminopeptidase | PSYCHOMETRIC PROPERTIES | WOMEN | PAIN | ANXIETY | NURSING | DISEASE | OPIOID-PEPTIDES | SPANISH VERSION | Index Medicus | Nursing
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 04/2015, Volume 353, Issue 1, pp. 132 - 149
Journal Article
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 02/2000, Volume 296, Issue 2, pp. 341 - 349
Journal Article
Acta Crystallographica Section F, ISSN 2053-230X, 06/2019, Volume 75, Issue 6, pp. 405 - 411
Neutral endopeptidase (neprilysin; NEP) is a proteinase that cleaves a wide variety of peptides and has been implicated in Alzheimer's disease, cardiovascular... 
phosphoramidon | thiorphan | neprilysin | neutral endopeptidase | SYSTEM | TUBERCULOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | ENKEPHALINASE | CRYSTALLOGRAPHY | PEPTIDE | POTENT | INHIBITION | BIOPHYSICS | NEP | SECRETION | Peptides | Neurodegenerative diseases | Endopeptidase | Proteinase | Neprilysin | Arthritis | Alzheimers disease | Neutral endopeptidase | Alzheimer's disease | Inflammatory diseases
Journal Article
IJC Heart & Vasculature, ISSN 2352-9067, 03/2019, Volume 22, pp. 102 - 104
Aim of this study was to assess the impact of the introduction of new class of drugs (ARNI: angiotensin receptor-neprilysin inhibitor) on hospital related... 
ARNI | Chronic heart failure | Sacubitril | Cost analysis | Neprilysin inhibition | Angiotensin receptor blockers
Journal Article
Circulation, ISSN 0009-7322, 08/2014, Volume 130, Issue 6, pp. 496 - 507
BACKGROUND—Pulmonary hypertension (PH) is a life-threatening disorder characterized by increased pulmonary artery pressure, remodeling of the pulmonary... 
Phosphodiesterase inhibitor | Cyclic nucleotide | Natriuretic peptide | Nitric oxide | Pulmonary hypertension | SURVIVAL | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | ATRIAL-NATRIURETIC-PEPTIDE | pulmonary hypertension | NITRIC-OXIDE SYNTHASE | PROSTACYCLIN | natriuretic peptide | DIFFERENTIAL REGULATION | RESPONSES | THERAPY | RIGHT HEART-FAILURE | phosphodiesterase inhibitor | ARTERIAL-HYPERTENSION | PERIPHERAL VASCULAR DISEASE | cyclic nucleotide | EXPRESSION | Cyclic Nucleotide Phosphodiesterases, Type 2 - antagonists & inhibitors | Phosphodiesterase Inhibitors - therapeutic use | Triazines - pharmacology | Cyclic GMP - physiology | Triazines - therapeutic use | Humans | Mice, Inbred C57BL | Cells, Cultured | Phosphodiesterase Inhibitors - pharmacology | Rats | Male | Imidazoles - pharmacology | Rats, Sprague-Dawley | Mice, Knockout | Cyclic AMP - physiology | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Hypertension, Pulmonary - drug therapy | Mice | Imidazoles - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 2 - physiology | Hypertension, Pulmonary - enzymology | Care and treatment | Usage | Treprostinil | Diagnosis | Phosphodiesterases | Health aspects | Index Medicus | Abridged Index Medicus | vasodilatation | endothelium | hypoxia | prostacyclin | cGMP | phosphodiesterase | cAMP
Journal Article