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European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 371 - 390
Purines can be considered as the most ubiquitous and functional N-heterocyclic compounds in nature. Structural modifications of natural purines, particularly... 
Isostere | Enzyme inhibitor | Antiviral | Triazine | Purine | Anticancer
Journal Article
Original Article - Blockade of Rennin-Angiotensin system blunts the fibrotic response in experimental acute pyelonephritis, 12/2005
Aim : To study the impact of Renin-Angiotensin system blockade in experimental acute pyelonephritis, induced by a novel surgical approach via dorsal lumbotomy... 
angiotensin converting enzyme inhibitor | angiotensin receptor blocker | lumbotomy incision | renal scar | renin-angiotensin system | Experimental pyelonephritis
Journal
Chemosphere, ISSN 0045-6535, 01/2020, Volume 238, p. 124619
Perfluorooctane sulfonamide (FOSA) is known as a key intermediate of perfluorooctane sulfonic acid (PFOS) precursors, which can be frequently detected in the... 
Earthworm | Enzyme inhibitor | FOSA | Biotransformation | Gut microbes
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111600
Carbonic anhydrase inhibitors (CAIs) of the sulfonamide, sulfamate and coumarin classes bearing the phenylureido tail found in the clinically used drug... 
Enzyme inhibitor | Sulfamate | Sulfonamide | Carbonic anhydrase | Coumarin | Sorafenib
Journal Article
02/2007
Clinicians should be cognizant of potential drug drug interactions and become familiar with the substrates, inhibitors and inducers of the common enzymatic... 
enzyme inhibitor | drug interaction | Cytochrome P450
Web Resource
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 6/2017, Volume 56, Issue 26, pp. 7387 - 7392
Antivitamins B 12 have a growing biomedical impact as robust B 12 -dummies. Here, the potential antivitamin B 12 2,4-difluorophenyl-ethynyl-cobalamin... 
antivitamin | protein crystallography | vitamin B12 | enzyme inhibitor | glutathione
Journal Article
Organic Process Research and Development, ISSN 1083-6160, 02/2016, Volume 20, Issue 2, pp. 140 - 177
This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and... 
PILOT-PLANT-SCALE | LEUKOCYTE ELASTASE INHIBITOR | CONVERTING-ENZYME-INHIBITOR | PRACTICAL ASYMMETRIC-SYNTHESIS | RESEARCH-AND-DEVELOPMENT | NONACTIVATED CARBOXYLIC-ACIDS | CHEMISTRY, ORGANIC | CATHEPSIN-K INHIBITOR | HYDROGENATION-BASED SYNTHESIS | HCV PROTEASE INHIBITOR | CHEMISTRY, APPLIED | COST-EFFECTIVE SYNTHESIS
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 07/2019, Volume 25, Issue 14, pp. 4231 - 4237
Purpose: The prognosis of patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) remains poor, and novel therapies are needed. The proteasome... 
LYSOSOMAL THIOL REDUCTASE | ONCOLOGY | MLN4924 | MIDOSTAURIN | NEDD8-ACTIVATING ENZYME-INHIBITOR | INTERMEDIATE-DOSE CYTARABINE | BORTEZOMIB | CANCER
Journal Article
by Cao, Y Y and Xiang, X and Song, J and Tian, Y H and Wang, M Y and Wang, X W and Li, M and Huang, Z and Wu, Y and Wu, T and Wu, Y Q and Hu, Y H
Journal of affective disorders, ISSN 0165-0327, 08/2019, Volume 259, pp. 386 - 391
Evidence is increasing that pathways of antihypertensives may have a role in the pathogenesis of depression. However, how the class of antihypertensives... 
Journal Article
The American Journal of Pathology, ISSN 0002-9440, 02/2019, Volume 189, Issue 2, pp. 248 - 257
Mitotic catastrophe (MC) is a major cause of podocyte loss and . We evaluated urine samples (  = 184 urine samples from diabetic patients;  = 41 patients) from... 
CONVERTING ENZYME-INHIBITOR | GLOMERULOSCLEROSIS | APOPTOSIS | CELLS | PODOCALYXIN | PATHOLOGY | EXCRETION | IDENTIFICATION | NEPHROPATHY | DISEASE-ACTIVITY | CHILDREN
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 18, pp. 11376 - 11383
Autophagy is a cell-protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of... 
CROSS-TALK | HYDROXYCHLOROQUINE | COMPLEX | ADVANCED SOLID TUMORS | PHASE-I TRIAL | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMPK | VPS34 | MTOR
Journal Article
Atherosclerosis, ISSN 0021-9150, 10/2019, Volume 289, pp. 109 - 117
Studies of the comparative clinical outcomes between statin with angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) in... 
Myocardial infarction | Statin | Angiotensin receptor blocker | Angiotensin converting enzyme inhibitor
Journal Article
CHEMICAL REVIEWS, ISSN 0009-2665, 12/2016, Volume 116, Issue 23, pp. 14379 - 14455
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 08/2018, Volume 24, Issue 15, pp. 3477 - 3479
The ability of uveal melanoma cells to enter and exit dormancy plays a fundamental role in the development of metastatic disease. Neddylation blockade is a... 
CELLS | NEDD8-ACTIVATING ENZYME-INHIBITOR | PEVONEDISTAT TAK-924/MLN4924 | ONCOLOGY | PHASE-I | Dormancy | Angiogenesis | Melanoma | Metastases | Cancer
Journal Article