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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 31, pp. 12949 - 12954
In the kidney, the actions of vasopressin on its type-2 receptor (V2R) induce increased water reabsorption alongside polyphosphorylation and membrane targeting... 
Urine | Receptors | Phosphorylation | Prostaglandins | Kidneys | Nondestructive testing | Nephrogenic diabetes insipidus | Agonists | Cell membranes | Kidney cells | Drug development/discovery | Water balance | Autocoid | Lipid mediators | Cell signaling | RENAL EPITHELIAL-CELLS | LOCALIZATION | drug development/discovery | PHOSPHORYLATION | SUBTYPES | MULTIDISCIPLINARY SCIENCES | MEMBRANE INSERTION | RATS | water balance | PLASMA-MEMBRANE | lipid mediators | COLLECTING DUCT | EP4 RECEPTOR | cell signaling | autocoid | WATER | Rats, Wistar | Receptors, Prostaglandin E, EP2 Subtype - metabolism | Receptors, Vasopressin - metabolism | Immunoblotting | Male | Vasopressins - metabolism | Protein Transport - drug effects | Alprostadil - analogs & derivatives | Dose-Response Relationship, Drug | Kidney - metabolism | Diabetes Insipidus, Nephrogenic - genetics | Pyrrolidinones - pharmacology | Cell Membrane - metabolism | Diabetes Insipidus, Nephrogenic - prevention & control | Phosphorylation - drug effects | Cyclic AMP - metabolism | Cell Membrane - drug effects | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Receptors, Prostaglandin E, EP4 Subtype - genetics | Cell Line | Dinoprostone - pharmacology | Kidney - drug effects | Receptors, Prostaglandin E, EP2 Subtype - genetics | Alprostadil - pharmacology | Rats | Vasopressins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Aquaporin 2 - metabolism | Microscopy, Confocal | Animals | Dogs | Receptors, Vasopressin - genetics | Dinoprostone - analogs & derivatives | Antidiuretic Hormone Receptor Antagonists | Aquaporin 2 - genetics | Receptors, Prostaglandin E, EP2 Subtype - agonists | Diabetes Insipidus, Nephrogenic - metabolism | Aquaporins | Diabetes insipidus | Physiological aspects | Development and progression | Health aspects | Vasopressin | Agonists (Biochemistry) | Biological Sciences | discovery | drug development
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 6, pp. 1123 - 1136
Many chemical mediators regulate neutrophil recruitment to inflammatory sites. Although the actions of each chemical mediator have been demonstrated with... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | PROSTANOID RECEPTORS | ACTIVATED PROTEIN-KINASE | INHIBITION | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PATHWAY | MAP KINASE | INFLAMMATION | EP4 | IMMUNOLOGY | PROSTAGLANDIN E-2 | Diphenylamine - pharmacology | Intestine, Small - pathology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Green Fluorescent Proteins - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Neutrophil Infiltration | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Diphenylamine - analogs & derivatives | Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors | Fluorescence Resonance Energy Transfer | Phenylbutyrates - pharmacology | Female | Time-Lapse Imaging - methods | Benzamides - pharmacology | Microscopy, Fluorescence, Multiphoton | Enteritis - metabolism | Neutrophils - metabolism | Neutrophils - pathology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Green Fluorescent Proteins - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Neutrophils - drug effects | Mice, Transgenic | Methyl Ethers - pharmacology | Cell Adhesion - drug effects | Naphthalenes - pharmacology | Cell Movement - drug effects | Animals | Mice | Intestine, Small - metabolism
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 3, pp. 604 - 618
Background and Purpose Prostaglandin E2 (PGE2) has been implicated in the regulation of adhesion molecules, leukocyte adhesion and infiltration into inflamed... 
exchange protein activated by | receptor | PI3K | prostaglandin | cerebrovascular endothelial cell | EP4 | intercellular adhesion molecule 1 | cAMP | nuclear factor‐κ | nuclear factor-κB | EP4 receptor | exchange protein activated by cAMP | prostaglandin E | PI3K/Akt | KAPPA-B ACTIVATION | ICAM-1 EXPRESSION | RAT | nuclear factor-B | MURINE MACROPHAGES | Akt | E-2 | INHIBITION | prostaglandin E2 | PATHWAY | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | RECEPTORS | UP-REGULATION | Endothelium, Vascular - cytology | Monocytes - cytology | Humans | Endothelium, Vascular - drug effects | Monocytes - metabolism | Monocytes - immunology | Brain - metabolism | Cyclic AMP - physiology | Brain - blood supply | Cyclic AMP - analogs & derivatives | Guanine Nucleotide Exchange Factors - metabolism | Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors | Endothelium, Vascular - immunology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Receptors, Prostaglandin E, EP4 Subtype - genetics | Cell Line | Brain - cytology | Second Messenger Systems - drug effects | Vasodilator Agents - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Gene Silencing | Cell Adhesion - drug effects | Brain - drug effects | Cyclic AMP - pharmacology | Dinoprostone - metabolism | Monocytes - drug effects | Up-Regulation - drug effects | Intercellular Adhesion Molecule-1 - metabolism | Animals | Endothelium, Vascular - metabolism | Mice | Prostaglandins E | Analysis | Endothelium | Kinases | Phosphorylation | Rodents | Research Papers
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 01/2017, Volume 14, Issue 1, p. 3
Background: Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE(2)) is one of the products of COX activity. PGE(2) has... 
COX-2 | EP2 | EP4 | Neuroinflammation | Mice | Glia | PGE | EP2 RECEPTOR | CELLS | PROSTAGLANDIN E-2 PRODUCTION | IMMUNOLOGY | NEUROSCIENCES | GLUCOSE-6-PHOSPHATE-DEHYDROGENASE | INTERFERON-GAMMA | IMMUNE-RESPONSES | INFLAMMATION | NITRIC-OXIDE | BRAIN | INNATE IMMUNITY | Receptors, Prostaglandin E, EP2 Subtype - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Receptors, Prostaglandin E, EP2 Subtype - antagonists & inhibitors | Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors | Cytokines - genetics | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Animals, Newborn | Receptors, Prostaglandin E, EP4 Subtype - agonists | Receptors, Prostaglandin E, EP4 Subtype - genetics | Cytokines - metabolism | Microglia - drug effects | Mice, Inbred C57BL | Receptors, Prostaglandin E, EP2 Subtype - genetics | Enzyme Inhibitors - pharmacology | Gene Expression Regulation - physiology | Dinoprostone - metabolism | Gene Expression Regulation - drug effects | Animals | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Nitric Oxide - metabolism | Receptors, Prostaglandin E, EP2 Subtype - agonists | Nitric Oxide Synthase Type II - metabolism | Physiological aspects | Research | Tumor necrosis factor | Health aspects | Prostanoids | Lipopolysaccharides
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2011, Volume 31, Issue 2, pp. 261 - 269
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 06/2013, Volume 138, Issue 3, pp. 485 - 502
The large variety of biological functions governed by prostaglandin (PG) E is mediated by signaling through four distinct E-type prostanoid (EP) receptors. The... 
Vascular disease | Osteoporosis | Prostaglandins | Inflammation | Renal function | Cancerogenesis | HUMAN DENDRITIC CELLS | DIETARY SALT INTAKE | DUODENAL BICARBONATE SECRETION | MICROVASCULAR ENDOTHELIAL-CELLS | PROSTAGLANDIN-E-RECEPTOR | AGONIST-INDUCED INTERNALIZATION | BREAST-CANCER CELLS | INFLAMMATORY-BOWEL-DISEASE | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Neoplasms - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Lung Diseases - metabolism | Cardiovascular Diseases - metabolism | Humans | Bone Diseases - metabolism | Dinoprostone - metabolism | Animals | Gastrointestinal Diseases - metabolism | Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors | Immunologic Factors - metabolism | Kidney Diseases - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | CREB, cAMP-response element-binding protein | Associate editor | TX, thromboxane receptor | EPRAP, EP4 receptor-associated protein | PK, protein kinase | COX, cyclooxygenase | AMPK, AMP-activated protein kinase | ICAM-1, intercellular adhesion molecule-1 | PI3K, phosphatidyl insositol 3-kinase | CFTR, cystic fibrosis transmembrane conductance regulator | IP, I-type prostanoid receptor | Epac, exchange protein activated by cAMP | NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells | NSAID, non-steroidal anti-inflammatory drug | IFN, interferon | MEK, MAP kinase kinase | PG, prostaglandin | DSS, dextran sodium sulfate | eNOS, endothelial nitric oxide synthase | Ig, immunoglobulin | P. Holzer | ICER, inducible cAMP early repressor | EGFR, epidermal growth factor receptor | FEM1a, feminization 1 homolog a | ERK, extracellular signal-regulated kinase | MCP, monocyte chemoattractant protein | 5-HETE, 5-hydroxyeicosatetraenoic acid | IL, interleukin | GRK, G protein-coupled receptor kinase | MAP, mitogen-activated protein kinase | LPS, lipopolysaccharide | ClC, chloride channel | DP, D-type prostanoid receptor | FP, F-type prostanoid receptor | TP, T-type prostanoid receptor | cAMP, cyclic adenylyl monophosphate | EP, E-type prostanoid receptor
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 05/2017, Volume 27, Issue 10, pp. 2094 - 2098
The potent and selective prostanoid EP4 receptor antagonist CJ-042794 was radiolabeled with F-18, and evaluated for imaging EP4 receptor expression in cancer... 
Molecular imaging | MIGRATION | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Prostanoid EP4 receptor | CELL-PROLIFERATION | PAIN | SUBTYPE EP4 | Antagonist | Fluorine-18 | PROSTAGLANDIN EP4 | Positron emission tomography | PET | CJ-042794
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 11/2011, Volume 60, Issue 11, pp. 1577 - 1586
Journal Article
Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6279, pp. 1333 - 1338
Journal Article
Kidney International, ISSN 0085-2538, 07/2012, Volume 82, Issue 2, pp. 158 - 171
Inflammatory responses in the kidney lead to tubulointerstitial fibrosis, a common feature of chronic kidney diseases. Here we examined the role of... 
renal fibrosis | prostaglandins | chronic kidney disease | Ureteral Obstruction - complications | Cell Proliferation | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Transforming Growth Factor beta1 - metabolism | Mice, 129 Strain | RNA, Messenger - metabolism | Kidney Diseases - genetics | Myofibroblasts - metabolism | Time Factors | Cyclooxygenase 2 - genetics | Receptors, Prostaglandin E, EP4 Subtype - deficiency | Chemokine CCL2 - metabolism | Chemokine CCL5 - metabolism | Kidney Tubules - pathology | Kidney Tubules - metabolism | Disease Models, Animal | Kidney Diseases - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Folic Acid | Heptanoates - pharmacology | Receptors, Prostaglandin E, EP4 Subtype - agonists | Receptors, Prostaglandin E, EP4 Subtype - genetics | Myofibroblasts - pathology | Kidney Tubules - drug effects | Macrophages - pathology | Signal Transduction | Kidney Diseases - pathology | Kidney Diseases - prevention & control | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Chemokine CCL2 - genetics | Epithelial Cells - pathology | Transforming Growth Factor beta1 - genetics | Mice, Knockout | Dinoprostone - metabolism | Macrophages - metabolism | Animals | Chemokine CCL5 - genetics | Cyclooxygenase 2 - metabolism | Fibrosis | Connective Tissue Growth Factor - genetics | Mice | Kidney Diseases - etiology | Connective Tissue Growth Factor - metabolism
Journal Article