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Acta Ophthalmologica, ISSN 1755-375X, 12/2018, Volume 96, Issue S261, pp. 143 - 143
Journal Article
Aging Cell, ISSN 1474-9718, 04/2017, Volume 16, Issue 2, pp. 349 - 359
The dry (nonneovascular) form of age‐related macular degeneration ( AMD ), a leading cause of blindness in the elderly, has few, if any, treatment options at... 
lysosomes; mechanistic target of rapamycin | visual cycle proteins | transcription factors EB (TFEB) and E3 (TFE3) | amino acid transporter (PAT4/SLC36A4) | age‐related macular degeneration | coordinated lysosomal expression and regulation (CLEAR) network | mouse model | signal transduction | retinal pigmented epithelium (RPE) | complex 1 (mTORC1) | photoreceptor degeneration | age-related macular degeneration | CLEARANCE | RAG GTPASES | ATPASE | TFEB | mechanistic target of rapamycin | AUTOPHAGY | RPE65 | LYSOSOMAL BIOGENESIS | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | MTORC1 ACTIVATION | SENSES | DEGRADATION | lysosomes | Crystallins - metabolism | Retinal Pigment Epithelium - metabolism | Phosphorylation | Epithelial Cells - metabolism | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Retinal Photoreceptor Cell Outer Segment - metabolism | Visual Pathways - metabolism | Epithelial Cells - ultrastructure | Gene Regulatory Networks | Amino Acid Transport Systems - metabolism | Mechanistic Target of Rapamycin Complex 1 | Mice, Knockout | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Animals | Lysosomes - metabolism | Retinal Pigment Epithelium - ultrastructure | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cytosol - metabolism | Retinal Pigment Epithelium - cytology | Aging - metabolism | Macular degeneration | Analysis | Blindness | Development and progression | Amino acids | Cellular signal transduction | DNA binding proteins | Adenosine triphosphatase | TOR protein | H+-transporting ATPase | Transcription factors | Lecithin | Epithelial cells | Lysosomes | Retina | Rapamycin | Electron microscopy | Acyltransferase | Epithelium | Retinal pigment epithelium | Vitamin A | Crystallin | Retinal degeneration | Photoreceptors | Cytoplasm | Geriatrics | Index Medicus | amino acid transporter (PAT4 | Original | SLC36A4
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2010, Volume 285, Issue 6, pp. 4060 - 4073
Aberrant epithelial-mesenchymal transition (EMT) is involved in development of fibrotic disorders and cancer invasion. Alterations of cell-extracellular matrix... 
PROTEIN-KINASE-C | PROLIFERATIVE DIABETIC-RETINOPATHY | FIBROBLAST MIGRATION | HYALURONAN-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | ENDOTHELIAL-CELLS | ANCHORAGE-INDEPENDENT GROWTH | ADHESION MOLECULES | UP-REGULATION | MICROARRAY DATA | Retinal Pigment Epithelium - metabolism | Receptors, Transforming Growth Factor beta - genetics | Oligonucleotide Array Sequence Analysis | Transforming Growth Factor beta2 - metabolism | Humans | Mesoderm - drug effects | Immunoblotting | Gene Expression Profiling | Retinal Pigment Epithelium - pathology | Protein Binding - drug effects | Hyaluronan Receptors - metabolism | Microfilament Proteins - metabolism | Phosphorylation - drug effects | Microfilament Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Retinal Pigment Epithelium - drug effects | Cell Line | Epithelium - drug effects | Epithelium - pathology | Tissue Culture Techniques | Protein-Serine-Threonine Kinases - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hyaluronan Receptors - genetics | Mice, Knockout | Tumor Necrosis Factor-alpha - pharmacology | Animals | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Models, Biological | Hyaluronic Acid - metabolism | Fibrosis | Mice | Transforming Growth Factor beta2 - genetics | Mesoderm - pathology | Cluster Analysis | Index Medicus | Molecular Basis of Cell and Developmental Biology | Hyaluronan | Cytokines | Extracellular Matrix | Actin | TGF-β | Cytoskeleton | Glycoproteins | Cell | Tumor Necrosis Factor | Epithelial | Surface
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2012, Volume 258, Issue 2, pp. 226 - 236
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1855 - 8
LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that... 
CELLS | SPECIFICITIES | ENDONUCLEASE | EFFICACY | INJECTION | MULTIDISCIPLINARY SCIENCES | CPF1 | CRISPR-CAS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | NUCLEASES | Dependovirus - genetics | Endonucleases - genetics | Genetic Vectors - administration & dosage | Intravitreal Injections | RNA, Guide - genetics | Humans | Choroidal Neovascularization - therapy | Choroidal Neovascularization - etiology | Male | Vascular Endothelial Growth Factor A - genetics | Retinal Pigment Epithelium - pathology | Choroidal Neovascularization - pathology | Endonucleases - administration & dosage | Retinal Pigment Epithelium - blood supply | Clostridiales - genetics | Retinal Pigment Epithelium - radiation effects | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Disease Models, Animal | Lasers - adverse effects | Macular Degeneration - etiology | Cell Line | Specific Pathogen-Free Organisms | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Bacterial Proteins - genetics | Treatment Outcome | Bacterial Proteins - administration & dosage | Genetic Vectors - genetics | Animals | Macular Degeneration - genetics | Macular Degeneration - therapy | Gene Editing - methods | Mice | Choroidal Neovascularization - genetics | Genetic Therapy - methods | Macular Degeneration - pathology | CRISPR | Therapeutic applications | Medical treatment | Viruses | Retina | Genomes | Ribonucleic acid--RNA | Epithelium | Retinal pigment epithelium | Vascularization | Macular degeneration | Angiogenesis | Gene disruption | Hypoxia | Degeneration | Endonuclease | Vascular endothelial growth factor | Genetic modification | Age | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2015, Volume 5, Issue 1, pp. 16386 - 16386
Journal Article
Journal Article
Theriogenology, ISSN 0093-691X, 05/2019, Volume 130, pp. 49 - 61
The study describes the sequence of ultrastructural changes of the endometrial lining epithelium, first in the primordial paramesonephric ducts, then in the... 
Paramesonephric ducts | Domestic cat | TEM | Fetuses | Uterine mucosal epithelium | CELLS | ENDOMETRIUM | UTERUS | TIGHT JUNCTIONS | REPRODUCTIVE BIOLOGY | EARLY-PREGNANCY | VETERINARY SCIENCES | LUMINAL EPITHELIUM | DIFFERENTIATION | GLANDULAR EPITHELIUM | LIPID DROPLETS | ESTROUS-CYCLE | Fetus | Cats | Epithelium | Growth | Pregnant women
Journal Article
Journal Article