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Current Protocols in Immunology, ISSN 1934-3671, 2015, Volume 2015, pp. 9.10.1 - 9.10.9
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Tetrahedron, ISSN 0040-4020, 05/2017, Volume 73, Issue 21, pp. 3074 - 3078
A new one pot oxidative coupling of methyl arenes with cinnamic acids has been developed for the synthesis of α,β-epoxy ketones using MnO /TBHP combination.... 
Epoxidation | Carboxylic acids | C[sbnd]H activation | Oxidative coupling | Decarboxylation | ORGANIC-SYNTHESIS | ALPHA,BETA-UNSATURATED KETONES | CHEMISTRY, ORGANIC | VERSATILE BUILDING-BLOCKS | ALDEHYDES | FUNCTIONALIZATION | ALKENES | C-H activation | ASYMMETRIC EPOXIDATION | N BOND FORMATION | EPOXYKETONE PROTEASOME INHIBITORS | CARBOXYLIC-ACIDS
Journal Article
2009, ISBN 9780123786425, Volume 57
The ubiquitin–proteasome complex is an important molecular target for the design of novel chemotherapeutics. This complex plays a critical role in signal... 
multiple myeloma | clinical trials | epoxyketones | Proteasome inhibitors | lactacystin | solid tumors | boronic acids
Book Chapter
Journal Article
Journal of Chemical Research, ISSN 1747-5198, 02/2016, Volume 40, Issue 2, pp. 82 - 86
A novel and efficient preparation of epoxyketone intermediates for the synthesis of carfilzomib and its derivatives has been developed. Compared to reported... 
Carfilzomib | Epoxyketone derivatives | Vanadium(III) acetylacetonate | epoxyketone derivatives | PR-171 | PROTEASOME INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | carfilzomib | vanadium(III) acetylacetonate | Synthesis | Scaling up | Derivatives
Journal Article
Biologics: Targets and Therapy, ISSN 1177-5475, 01/2013, Volume 7, Issue 1, pp. 13 - 32
Spotlights the second generation proteasome inhibitors with special focus on the safety and efficacy of carfilzomib, an epoxyketone with lesser peripheral... 
Second generation | Carfilzomib | Epoxyketone | Myeloma | Proteasome inhibitor | Lymphomas | Treatment | Protease inhibitors | Antineoplastic agents | Multiple myeloma | FDA approval | Peripheral neuropathy | Tumors | epoxyketone | myeloma | proteasome inhibitor | Review | second generation | carfilzomib
Journal Article