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Cancer Research, ISSN 0008-5472, 01/2003, Volume 63, Issue 1, pp. 107 - 110
We have synthesized and explored the feasibility of using a novel nuclear factor (NF) kappaB inhibitor, a dehydroxymethylepoxyquinomicin designated as DHMEQ,... 
INDUCED CELL-DEATH | ONCOLOGY | INDUCED APOPTOSIS | CONSTITUTIVE ACTIVATION | ALPHA | EPOXYQUINOMICIN-C | JCA-1
Journal Article
Ocular Immunology and Inflammation, ISSN 0927-3948, 02/2020, Volume 28, Issue 2, pp. 240 - 248
Purpose: To determine the anti-inflammatory effects of dehydroxymethylepoxyquinomicin (DHMEQ), a nuclear factor-κB (NF-κB) inhibitor, on endotoxin-induced... 
peritoneal exudate cells (PEC) | Dexamethasone | endotoxin-induced uveitis (EIU) | NF-κB inhibitor | DHMEQ | APOPTOSIS | ACTIVATION | SMALL-MOLECULE INHIBITOR | NF-kappa B inhibitor | TUMOR-NECROSIS-FACTOR | PIGMENT EPITHELIAL-CELLS | INFLAMMATION | GENE-EXPRESSION | OPHTHALMOLOGY | BACTERIAL-ENDOTOXIN | EPOXYQUINOMICIN
Journal Article
Carcinogenesis, ISSN 0143-3334, 08/2005, Volume 26, Issue 8, pp. 1382 - 1388
Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type I (HTLV-I). The nuclear transcription factor, NF-kappa B, is... 
ANTIBODIES | APOPTOSIS | NATURAL-KILLER-CELLS | ACTIVATION | VIRUS | PARTICLES | ONCOLOGY | COMBINED IMMUNODEFICIENT MICE | SUPPRESSION | EPOXYQUINOMICIN-C | LINES
Journal Article
Clinical & Experimental Metastasis, ISSN 0262-0898, 4/2013, Volume 30, Issue 4, pp. 381 - 392
Activation of nuclear factor-κB (NF-κB) has been implicated in metastasis of pancreatic cancer. We investigated the effects of the novel NF-κB inhibitor... 
Anticancer effect | Biomedicine | Hematology | DHMEQ | Pancreatic cancer | Cancer Research | Oncology | NF-kappaB | Surgical Oncology | Biomedicine general | Liver metastasis | TRANSCRIPTION FACTORS | NUDE-MICE | T-CELL LEUKEMIA | NECROSIS-FACTOR-ALPHA | VIVO ANTITUMOR-ACTIVITY | MULTIPLE-MYELOMA CELLS | EPOXYQUINOMICIN-C | ONCOLOGY | SIGNALING PATHWAY | IN-VIVO | NF-KAPPA-B | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Deoxycytidine - pharmacology | NF-kappa B - metabolism | Interleukin-8 | Immunoenzyme Techniques | Pancreatic Neoplasms - drug therapy | Matrix Metalloproteinase 9 - metabolism | Adenocarcinoma - metabolism | Matrix Metalloproteinase 9 - genetics | Antimetabolites, Antineoplastic - pharmacology | Liver Neoplasms - pathology | Benzamides - pharmacology | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Disease Models, Animal | NF-kappa B - antagonists & inhibitors | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Liver Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols | Cyclohexanones - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Blotting, Western | Cell Movement - drug effects | Animals | NF-kappa B - genetics | Mice, Nude | Fluorescent Antibody Technique | Liver Neoplasms - metabolism | Cell Proliferation - drug effects | Mice | Deoxycytidine - analogs & derivatives | Antimitotic agents | Medical colleges | Liver cancer | Care and treatment | RNA | Endothelial growth factors | Analysis | Metastasis | Antineoplastic agents | Cancer
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2002, Volume 124, Issue 10, pp. 2221 - 2232
Journal Article
Experimental and Therapeutic Medicine, ISSN 1792-0981, 2014, Volume 8, Issue 1, pp. 100 - 104
Journal Article
Cancer Letters, ISSN 0304-3835, 2007, Volume 257, Issue 2, pp. 206 - 215
Journal Article
Journal of Antibiotics, ISSN 0021-8820, 06/2000, Volume 53, Issue 6, pp. 637 - 639
Epoxyquinomicins A, B, C and D were first isolated from Amycolatopsis sp. MK299-95F4 as weak antibiotics. Subsequent studies on their biological activities... 
epoxyquinomicins
Journal Article
Tetrahedron, ISSN 0040-4020, 2004, Volume 60, Issue 33, pp. 7061 - 7066
NF-κB is a transcription factor that induces inflammatory cytokines and anti-apoptotic proteins. We have designed a new NF-κB inhibitor based on the structure... 
NF-κB | Inflammation | DHMEQ | Optical resolution | Nuclear transport | Apoptosis | ACTIVATION | NF-kappa B | nuclear transport | inflammation | CHEMISTRY, ORGANIC | optical resolution | apoptosis | EPOXYQUINOMICIN-C
Journal Article
Leukemia Research, ISSN 0145-2126, 2006, Volume 30, Issue 1, pp. 90 - 97
Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type I (HTLV-I). The NF-κB pathway is activated in ATL cells and in... 
Animal model | NF-κB | HTLV-I | DHMEQ | ATL | Mice | NF-κB inhibitor | APOPTOSIS | ACTIVATION | SUPPRESSION | PS-341 | mice | EPOXYQUINOMICIN-C | NF-kappa B inhibitor | NF-kappa B | ONCOLOGY | GROWTH | HTLV-1 | AGENTS | animal model | PROTEASOME INHIBITOR | HEMATOLOGY
Journal Article
Molecules and Cells, ISSN 1016-8478, 10/2002, Volume 14, Issue 2, pp. 163 - 167
NF-kappaB is a transcription factor that induces inflammatory cytokines and anti-apoptotic proteins. We designed a new NF-kappaB inhibitor that is based on the... 
NF-κB | TNF-α | DHMEQ | Jurkat Cells | COS-1 Cells | Nuclear Transport | Apoptosis | ACTIVATION | COS-1 cells | TNF-alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | ENHANCER | apoptosis | TNF | EPOXYQUINOMICIN-C | CELL-DEATH | CELL BIOLOGY | SIGNAL-TRANSDUCTION | NF-kappa B | nuclear transport | NECROSIS | Jurkat cells | RECEPTORS
Journal Article
JOURNAL OF ANTIBIOTICS, ISSN 0021-8820, 07/2002, Volume 55, Issue 7, pp. 635 - 642
Cetoniacytone A (1) and some related minor. components (2, 6, 7) were produced by Actinomyces sp. (strain Lu 9419), which was isolated from the intestines of a... 
ANTIBIOTICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMYCOLATOPSIS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | IMMUNOLOGY | EPOXYQUINOMICIN-B
Journal Article
Drug News and Perspectives, ISSN 0214-0934, 05/2006, Volume 19, Issue 4, pp. 201 - 209
Adult T-cell leukemia/lymphoma (ATL), a fatal T-cell leukemia/lymphoma resistant to chemotherapy, is caused by human T-cell leukemia/lymphoma virus type I... 
TRANSCRIPTION FACTORS | ACTIVATION | VIRUS TYPE-I | LEUKEMIA-CELLS | PHARMACOLOGY & PHARMACY | INFECTED-CELLS | TAX TRANSFORMING PROTEIN | INHIBITOR | VIVO ANTITUMOR-ACTIVITY | EPOXYQUINOMICIN-C | STERNBERG CELLS
Journal Article
ANTI-CANCER DRUG DESIGN, ISSN 0266-9536, 08/2000, Volume 15, Issue 4, pp. 239 - 244
Nuclear factor (NF)-kappaB is a transcription factor that induces the immunoglobulin kappa chain, cytokines such as interleukin (IL)-1, IL-2, IL-6, IL-8, tumor... 
ACTIVATION | ANTIBIOTICS | CHEMISTRY, MEDICINAL | INDUCED APOPTOSIS | AMYCOLATOPSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TNF | CELL-DEATH | SIGNAL-TRANSDUCTION | EPOXYQUINOMICIN-A | NECROSIS | ONCOLOGY | PHARMACOLOGY & PHARMACY
Journal Article
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