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2008, Cancer drug discovery and development, ISBN 9781597453561, xi, 393
The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor... 
drug therapy | Signal Transduction | drug effects | metabolism | Neoplasms | antagonists & inhibitors | Receptor, Epidermal Growth Factor | Clinical & internal medicine | Cancer | Chemotherapy | Treatment | Medicine & Public Health | Cancer Research | Oncology
Book
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 2010, Volume 21, Issue 9, pp. 922 - 928
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 11/2007, Volume 3, Issue 1, pp. 144 - n/a
Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we... 
mathematical modeling | breast cancer | receptor tyrosine kinases | kinetic analysis | Breast cancer | Kinetic analysis | Mathematical modeling | Receptor tyrosine kinases | ACTIVATION | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIMERIZATION | EGF RECEPTORS | IDENTIFICATION | PHOSPHORYLATION SITES | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | INTERNALIZATION | HER2 | Protein Structure, Tertiary | Butadienes - pharmacology | Reproducibility of Results | Nitriles - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Neuregulin-1 - pharmacology | Enzyme Activation - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - metabolism | Cell Membrane - enzymology | Androstadienes - pharmacology | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Feedback, Physiological - drug effects | Ligands | Epidermal Growth Factor - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Dimerization | Cell Membrane - drug effects | Biotechnology | Deregulation | Phosphorylation | Parameter estimation | AKT protein | Heregulin | Kinases | Proteins | Signal transduction | Receptors | Epidermal growth factor | Parameter robustness | Tumorigenesis | Growth factors | Immunoglobulins | Sensitivity analysis | ErbB protein | Extracellular signal-regulated kinase | Perturbation | ErbB-2 protein | Signaling | Computer applications | Breast | Ordinary differential equations | Kinetics
Journal Article
Nature Biotechnology, ISSN 1087-0156, 02/2017, Volume 35, Issue 2, pp. 164 - 172
Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer,... 
BREAST-CANCER | OVEREXPRESSION | ACTIVATION | PATHWAY | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TYROSINE KINASE | ERBB FAMILY | KRAS GENE AMPLIFICATION | PROLIFERATION | ERK | Cell interaction | Protein research | Cellular signal transduction | Research | Signal processing | Signal transduction | Epidermal growth factor | Cellular biology | Biological assays | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0178250
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2012, Volume 45, Issue 6, pp. 764 - 776
Aberrant ErbB2 receptor tyrosine kinase activation in breast cancer is strongly linked to an invasive disease. The molecular basis of ErbB2-driven invasion is... 
PATHWAYS | ONCOGENE | METASTASIS | EPITHELIAL-CELLS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | CYSTEINE CATHEPSINS | FIBROBLASTS | MULTISTAGE TUMORIGENESIS | ERBB RECEPTORS | CELL BIOLOGY | Cathepsin L - genetics | Protein Kinase C-alpha - metabolism | Proto-Oncogene Protein c-ets-1 - metabolism | Receptor, ErbB-2 - genetics | Protein-Tyrosine Kinases - metabolism | Cathepsin B - genetics | Humans | Protein Kinase C-alpha - genetics | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Cathepsin L - metabolism | Breast Neoplasms - metabolism | Protein-Tyrosine Kinases - genetics | Kruppel-Like Transcription Factors - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Female | Promoter Regions, Genetic | p21-Activated Kinases - genetics | Myotonin-Protein Kinase | Response Elements | Signal Transduction | Neoplasm Invasiveness | Cathepsin B - metabolism | p21-Activated Kinases - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Proto-Oncogene Protein c-ets-1 - genetics | Kruppel-Like Transcription Factors - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Tyrosine | Cysteine | Oncology, Experimental | Genes | Cathepsins | Breast cancer | DNA binding proteins | Genetic transcription | Research | Cystine | Analysis | Universities and colleges | Protein kinases | Phosphotransferases | Protein binding | Cancer | Protein kinase C | Transcription factors | Introns | Invasiveness | cathepsins | AKT protein | ErbB-2 protein | Zinc | Enhancers | Cathepsin B | Protein-tyrosine kinase receptors | Protein-serine/threonine kinase
Journal Article
Science Signaling, ISSN 1945-0877, 12/2013, Volume 6, Issue 306, pp. ra109 - ra109
The mechanisms of context-specific differences in signal transduction, such as those that occur among different cell types, are not fully understood. One... 
GROWTH-FACTOR RECEPTOR | BINDING DOMAINS | ACTIVATION | MECHANISM | RAS | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TRANSDUCTION | CANCER | CELL-LINE | CELL BIOLOGY | Models, Molecular | Protein Conformation | Oncogene Proteins v-erbB - metabolism | Signal Transduction
Journal Article
Journal Article