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1. Full Text Ion Conduction through the hERG Potassium Channel
by Ceccarini, Luisa and Masetti, Matteo and Cavalli, Andrea and Recanatini, Maurizio
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49017 - e49017
The inward rectifier voltage-gated potassium channel hERG is of primary importance for the regulation of the membrane potential of cardiomyocytes. Unlike most... 
INACTIVATION | RECTIFICATION | BIOMOLECULAR SIMULATIONS | HUMAN INWARD RECTIFIER | KCSA K+ CHANNEL | MOLECULAR-DYNAMICS | MECHANISM | MULTIDISCIPLINARY SCIENCES | SINGLE-FILE PORES | FORCE-FIELDS | SELECTIVITY FILTER | Motion | Humans | Molecular Conformation | Electrophysiology | Ether-A-Go-Go Potassium Channels - metabolism | Models, Molecular | Ions | Electric Conductivity | ERG1 Potassium Channel | Potassium - chemistry | Crystallography, X-Ray - methods | Ion Channel Gating - physiology | Membrane Potentials | Models, Biological | Computer Simulation | Lipid Bilayers - chemistry | Molecular dynamics | Potassium channels | Conduction | Electric potential | Biotechnology | Computer simulation | Cardiomyocytes | Homology | Selectivity | Resistance | Penetration | Simulation | Pharmacy | Potassium channels (voltage-gated) | Conductance | Membrane potential | Mutation | Potassium | Index Medicus
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2. Full Text Selective molecular potassium channel blockade prevents atrial fibrillation
by Amit, Guy and Kikuchi, Kan and Greener, Ian D and Yang, Lizhu and Novack, Victor and Donahue, J. Kevin
Circulation, ISSN 0009-7322, 06/2010, Volume 121, Issue 21, pp. 2263 - 2270
Background-Safety and efficacy limit currently available atrial fibrillation (AF) therapies. We hypothesized that atrial gene transfer would allow focal... 
Electrophysiology | Ion channels | Arrhythmia | Gene therapy | Atrial fibrillation | SURGERY | PERSISTENT | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | gene therapy | MECHANISMS | PREVALENCE | ion channels | atrial fibrillation | electrophysiology | arrhythmia | CATHETER ABLATION | PERIPHERAL VASCULAR DISEASE | LONG QT SYNDROME | GENE-TRANSFER | CONGESTIVE-HEART-FAILURE | HEMATOLOGY | Gene Transfer Techniques | Genetic Therapy | Action Potentials - genetics | Atrial Fibrillation - therapy | Humans | Risk Factors | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Mutation - genetics | Action Potentials - physiology | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Animals | Atrial Fibrillation - epidemiology | Heart Conduction System - physiopathology | Swine | Adenoviridae - genetics | Models, Animal | Ether-A-Go-Go Potassium Channels - physiology | Heart Atria - physiopathology | Atrial Fibrillation - prevention & control | Prevention | Usage | Potassium channel blockers | Health aspects | Index Medicus | Abridged Index Medicus
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3. Full Text Kinetics of drug interaction with the Kv11.1 potassium channel
by Hill, Adam P and Perrin, Mark J and Heide, Juliane and Campbell, Terence J and Mann, Stefan A and Vandenberg, Jamie I
Molecular Pharmacology, ISSN 0026-895X, 2014, Volume 85, Issue 5, pp. 769 - 776
The Kv11.1 potassium channel is the molecular target for the majority of drugs implicated in acquired long QT syndrome, the most common cause of drug-induced... 
Membrane Potentials - drug effects | Potassium Channel Blockers - pharmacokinetics | Clozapine - metabolism | Cricetinae | Cricetulus | Cells, Cultured | Ether-A-Go-Go Potassium Channels - metabolism | ERG1 Potassium Channel | Membrane Potentials - physiology | Potassium Channel Blockers - metabolism | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Animals | Ether-A-Go-Go Potassium Channels - agonists | Drug Interactions - physiology | Kinetics | CHO Cells | Clozapine - pharmacokinetics | Index Medicus
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4. Full Text HERG1a and hERG1b potassium channel subunits directly interact and preferentially form heteromeric channels
by McNally, Beth A and Pendon, Zeus D and Trudeau, Matthew C
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 52, pp. 21548 - 21557
Voltage-activated human ether-a-go-go-related gene (hERG) potassium channels are critical for the repolarization of cardiac action potentials and tune-spike... 
KCNH2 | CELLS | hERG | DOMAIN | fluorescence resonance energy transfer (FRET) | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | hERG1a | SENSITIVITY | hERG1b | CARDIAC-ARRHYTHMIA | EAG | LONG-QT SYNDROME | FAMILY | electrophysiology | RECTIFIER K+ CURRENT | Long QT syndrome | human eag-related gene | potassium channel | cysteine-mediated cross-linking | DEACTIVATION | Protein Subunits | Heart - physiology | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Ether-A-Go-Go Potassium Channels - genetics | Long QT Syndrome - metabolism | Myocardium - metabolism | Protein Isoforms | ERG1 Potassium Channel - genetics | Fluorescence Resonance Energy Transfer - methods | Ether-A-Go-Go Potassium Channels - physiology | Ion Channel Gating | Potassium Channels, Voltage-Gated - genetics | Index Medicus | Membrane Biology
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5. Full Text Drug block of the hERG potassium channel: Insight from modeling
by Stansfeld, Phillip J and Gedeck, Peter and Gosling, Martin and Cox, Brian and Mitcheson, John S and Sutcliffe, Michael J
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 08/2007, Volume 68, Issue 2, pp. 568 - 580
Many commonly used, structurally diverse, drugs block the human ether‐a‐go‐go‐related gene (hERG) K + channel to cause acquired long QT syndrome, which can... 
gating | potassium channel | hERG | helix motion | drug block | molecular modeling | Drug block | Gating | Helix motion | Potassium channel | Molecular modeling | DEPENDENT K+ CHANNELS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-ARRHYTHMIA | MOLECULAR DETERMINANTS | I-KR | BIOPHYSICS | AFFINITY | SLOW INACTIVATION | BINDING-SITE | LONG-QT-SYNDROME | HOMOLOGY MODEL | Amino Acid Sequence | Ether-A-Go-Go Potassium Channels - chemistry | Heart - physiology | Humans | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Sequence Homology, Amino Acid | Sequence Alignment | Neurons - physiology | Protein Conformation | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology | Amino Acid Substitution | Index Medicus
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6. Full Text Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
by Zhang, Yihong and Colenso, Charlotte K and El Harchi, Aziza and Cheng, Hongwei and Witchel, Harry J and Dempsey, Chris E and Hancox, Jules C
Biochemical Pharmacology, ISSN 0006-2952, 08/2016, Volume 113, pp. 24 - 35
The antiarrhythmic drug amiodarone delays cardiac repolarisation through inhibition of -encoded potassium channels responsible for the rapid delayed rectifier... 
Antiarrhythmic | IKr | QT interval | hERG | Amiodarone | Long QT | DOMAIN | DRUG-BINDING | BLOCK | I-Kr | MOLECULAR DETERMINANTS | STRUCTURAL BASIS | AFFINITY | INACTIVATED STATE | PHARMACOLOGY & PHARMACY | LONG QT SYNDROME | XENOPUS OOCYTES | K+ CHANNEL | Amino Acid Sequence | Action Potentials - genetics | Anti-Arrhythmia Agents - pharmacology | Humans | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Transfection | Alanine - genetics | Mutagenesis | HEK293 Cells | Protein Binding | ERG1 Potassium Channel - genetics | Molecular Docking Simulation | ERG1 Potassium Channel - antagonists & inhibitors | Mutation | Action Potentials - drug effects | Amiodarone - pharmacology | Potassium channels | Index Medicus | IC50, half-maximal inhibitory concentration | IKs, slow delayed rectifier potassium current | diLQTS, drug induced long QT syndrome | hERG, human-Ether-à-go-go-Related Gene | HEK, human embryonic kidney | IKr, rapid delayed rectifier potassium current | LQTS, long QT syndrome | DEA, desethylamiodarone | AF, atrial fibrillation | IhERG, ionic current carried by hERG potassium channels | I Kr
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7. Full Text Fluid flow modulates electrical activity in cardiac hERG potassium channels
by Roy, Samrat and Mathew, M.K
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 12, pp. 4289 - 4303
Fluid movement within the heart generates substantial shear forces, but the effect of this mechanical stress on the electrical activity of the human heart has... 
PAS DOMAIN | ADHESION | PORE REGION | MECHANISM | INTEGRINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MISSENSE MUTATION | MECHANOSENSITIVITY | LONG-QT SYNDROME | RAT VENTRICULAR MYOCYTES | K+ CHANNELS | Action Potentials - physiology | Mechanotransduction, Cellular | Ion Channel Gating - physiology | Heart - physiology | Humans | HEK293 Cells | Stress, Mechanical | ERG1 Potassium Channel - genetics | Hydrodynamics | ERG1 Potassium Channel - metabolism | Index Medicus | hERG | patch clamp | focal adhesions | cytoskeleton | Membrane Biology | mechanotransduction | mechanical stress | LSS | cardiac fluid movement | heart | Per-Arnt-Sim (PAS) | laminar shear stress | membrane biophysics | shear stress | electrophysiology | focal adhesion kinase (FAK) | potassium channel | integrin | action potential duration (APD)
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8. Full Text Molecular diversity and functional evolution of scorpion potassium channel toxins
by Zhu, Shunyi and Peigneur, Steve and Gao, Bin and Luo, Lan and Jin, Di and Zhao, Yong and Tytgat, Jan
Molecular and Cellular Proteomics, ISSN 1535-9476, 02/2011, Volume 10, Issue 2, pp. M110.002832 - M110.002832
Scorpion toxins affecting K+ channels (KTxs) represent important pharmacological tools and potential drug candidates. Here, we report molecular... 
PEPTIDES | CONSERVATION | BEE VENOM | KV1.3 CHANNELS | GENES | BIOCHEMICAL RESEARCH METHODS | ODONTHOBUTHUS-DORIAE | K+-CHANNELS | INHIBITOR | SELECTIVITY | BETA-KTX | Xenopus | Amino Acid Sequence | Gene Library | Oocytes - metabolism | Drosophila | Humans | Mice, Inbred C57BL | DNA, Complementary - genetics | Ether-A-Go-Go Potassium Channels - metabolism | Molecular Sequence Data | Male | ERG1 Potassium Channel | Sequence Homology, Amino Acid | Animals | Scorpion Venoms - chemistry | Scorpions | Potassium Channels - chemistry | Mice | Index Medicus | Regular Issue | Research
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9. Full Text hERG potassium channel gating is mediated by N-and C-terminal region interactions
by Gustina, Ahleah S and Trudeau, Matthew C
Journal of General Physiology, ISSN 0022-1295, 03/2011, Volume 137, Issue 3, pp. 315 - 325
Human ether-a-go-go-related gene (hERG) potassium channels have voltage-dependent closing (deactivation) kinetics that are unusually slow. A Per-Arnt-Sim (PAS)... 
INACTIVATION | PAS DOMAIN | HUMAN INWARD RECTIFIER | PHYSIOLOGY | FUNCTIONAL-ANALYSIS | CARDIAC-ARRHYTHMIA | LONG QT SYNDROME | ERG | NUCLEOTIDE-GATED CHANNELS | K+ CHANNELS | DEACTIVATION | Nucleotides, Cyclic - metabolism | Potassium - metabolism | Protein Structure, Tertiary | Ether-A-Go-Go Potassium Channels - chemistry | Humans | Xenopus laevis | Ether-A-Go-Go Potassium Channels - metabolism | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Recombinant Fusion Proteins - metabolism | Protein Interaction Mapping | Animals | Membrane Potentials | Protein Interaction Domains and Motifs | Kinetics | Mutation | Binding Sites | Ion Channel Gating | Potassium channels | Research | Genes | Protein binding | Proteins | Reaction kinetics | Biochemistry | Physiology | Potassium | Binding sites | Index Medicus
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10. Full Text hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine
by Melgari, Dario and Brack, Kieran E and Zhang, Chuan and Zhang, Yihong and Harchi, Aziza El and Mitcheson, John S and Dempsey, Christopher E and André Ng, G and Hancox, Jules C
Journal of the American Heart Association, ISSN 2047-9980, 2015, Volume 4, Issue 4
Background-Ivabradine is a specific bradycardic agent used in coronary artery disease and heart failure, lowering heart rate through inhibition of sinoatrial... 
Bradycardic agent | HCN4 | QT interval | Repolarization | HCN | hERG | Ivabradine | TORSADES-DE-POINTES | CARDIAC & CARDIOVASCULAR SYSTEMS | 37 DEGREES-C | ELECTRICAL RESTITUTION | repolarization | MOLECULAR DETERMINANTS | SHORT QT SYNDROME | HETEROMERIC CURRENTS | ivabradine | bradycardic agent | HEART-RATE | K+ CHANNEL | CARDIAC PREPARATIONS | CORONARY-ARTERY-DISEASE | Guinea Pigs | Ether-A-Go-Go Potassium Channels - drug effects | Humans | Male | Benzazepines - pharmacology | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Patch-Clamp Techniques | Animals | HEK293 Cells | Heart - drug effects | Potassium Channel Blockers - pharmacology | Bradycardia - drug therapy | Index Medicus
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11. Full Text Effects of donepezil on hERG potassium channels
by Chae, Yun Ju and Lee, Hong Joon and Jeon, Ji Hyun and Kim, In-Beom and Choi, Jin-Sung and Sung, Ki-Wug and Hahn, Sang June
Brain Research, ISSN 0006-8993, 2014, Volume 1597, pp. 77 - 85
Abstract Donepezil is a potent, selective inhibitor of acetylcholinesterase, which is used for the treatment of Alzheimer’s disease. Whole-cell patch-clamp... 
Neurology | hERG | Alzheimer׳s disease | Channel trafficking | Donepezil | Alzheimers disease | ALZHEIMERS-DISEASE | BLOCK | CARDIAC-ARRHYTHMIA | CURRENTS | DELAYED RECTIFIER | FLUOXETINE | NEUROSCIENCES | DISSOCIATED HIPPOCAMPAL-NEURONS | ION CHANNELS | HYDROCHLORIDE E2020 | INHIBITOR | Alzheimer's disease | Membrane Potentials - drug effects | Fluoxetine - pharmacology | Humans | Cell Membrane - physiology | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Membrane Potentials - physiology | Blotting, Western | Dose-Response Relationship, Drug | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Patch-Clamp Techniques | Cholinesterase Inhibitors - pharmacology | Piperidines - pharmacology | HEK293 Cells | Kinetics | Serotonin Uptake Inhibitors - pharmacology | Cell Membrane - drug effects | Indans - pharmacology | Potassium channels | Metabolites | Analysis | Index Medicus
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12. Full Text The Human Ether-a-go-go-related Gene (hERG) potassium channel represents an unusual target for protease-mediated damage
by Lamothe, Shawn M and Guo, Jun and Li, Wentao and Yang, Tonghua and Zhang, Shetuan
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 39, pp. 20387 - 20401
The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (I-Kr), which is... 
hERG | patch clamp | INTERVAL PROLONGATION | cell surface protein | MYOCARDIAL-INFARCTION | SERINE PROTEASES | HUMAN VENTRICULAR MYOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-ARRHYTHMIA | I-KR | MATRIX METALLOPROTEINASE-2 | protease | ISCHEMIA-REPERFUSION INJURY | electrophysiology | ion channel | potassium channel | LONG QT SYNDROME | CORONARY-ARTERY-DISEASE | Myocardial Ischemia - genetics | Endopeptidase K - chemistry | Myocardial Ischemia - metabolism | Rabbits | ERG1 Potassium Channel - chemistry | Humans | Male | ERG1 Potassium Channel - metabolism | Calpain - genetics | Calpain - chemistry | Scorpion Venoms - pharmacology | Animals | Proteolysis | Calpain - biosynthesis | HEK293 Cells | ERG1 Potassium Channel - genetics | Index Medicus | Cell Biology
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13. Full Text Role of the Cytosolic Chaperones Hsp70 and Hsp90 in Maturation of the Cardiac Potassium Channel hERG
by Ficker, Eckhard and Dennis, Adrienne T and Wang, Lu and Brown, Arthur M
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 06/2003, Volume 92, Issue 12, pp. e87 - e100
ABSTRACT—The human ether-a-gogo–related gene (hERG) encodes the α subunit of the cardiac potassium current IKr. Several mutations in hERG produce... 
CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | MOLECULAR CHAPERONES | human ether-a-gogo-related gene | VENTRICULAR MYOCYTES | HSP90-BINDING AGENT | SIGNAL-TRANSDUCTION | CHEMOTHERAPEUTIC-AGENTS | geldanamycin | IN-VIVO | DEGRADATION | PERIPHERAL VASCULAR DISEASE | LONG QT SYNDROME | HEMATOLOGY | heat shock proteins | chaperones | Transcriptional Regulator ERG | Potassium Channels, Voltage-Gated | HSP90 Heat-Shock Proteins - physiology | Humans | Ubiquitin - metabolism | L Cells (Cell Line) | ERG1 Potassium Channel | Lactams, Macrocyclic | Potassium Channels - metabolism | Transfection | Time Factors | Protein Binding - drug effects | Quinones - pharmacology | DNA-Binding Proteins | Membrane Potentials - drug effects | Cell Line | Guinea Pigs | Myocytes, Cardiac - cytology | Trans-Activators | Cells, Cultured | Ether-A-Go-Go Potassium Channels | Benzoquinones | Precipitin Tests | HSP70 Heat-Shock Proteins - metabolism | Potassium Channels - genetics | Animals | Myocytes, Cardiac - drug effects | Analysis of Variance | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Myocytes, Cardiac - physiology | HSP90 Heat-Shock Proteins - metabolism | Cytosol - metabolism | HSP70 Heat-Shock Proteins - physiology | Cation Transport Proteins | Mice | Mutation | COS Cells | Index Medicus
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14. Full Text Escitalopram block of hERG potassium channels
by Chae, Yun Ju and Jeon, Ji Hyun and Lee, Hong Joon and Kim, In-Beom and Choi, Jin-Sung and Sung, Ki-Wug and Hahn, Sang June
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 1/2014, Volume 387, Issue 1, pp. 23 - 32
Escitalopram, a selective serotonin reuptake inhibitor, is the pharmacologically active S-enantiomer of the racemic mixture of RS-citalopram and is widely used... 
Neurosciences | hERG | Biomedicine | Escitalopram | Channel trafficking | Pharmacology/Toxicology | Citalopram | DEPRESSION | INTERVAL PROLONGATION | MANAGEMENT | CURRENTS | FLUOXETINE | THERAPY | PHARMACOLOGY & PHARMACY | LONG QT SYNDROME | INHIBITOR | K+ CHANNELS | CITALOPRAM OVERDOSE | Dose-Response Relationship, Drug | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Membrane Potentials - drug effects | Citalopram - pharmacology | Humans | HEK293 Cells | Ether-A-Go-Go Potassium Channels - physiology | ERG1 Potassium Channel | Membrane Potentials - physiology | Potassium Channel Blockers - pharmacology | Potassium channels | Enantiomers | Antidepressants | Analysis | Depression, Mental | Index Medicus
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