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1. Full Text Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG
by Wang, Weiwei and MacKinnon, Roderick
Cell (Cambridge), ISSN 0092-8674, 04/2017, Volume 169, Issue 3, pp. 422 - 430.e10
K+ channel | drug-induced Long QT | hERG | voltage-dependent gating | inactivation | hERG block | cryo-EM | structure | channel | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cryoelectron Microscopy | Amino Acid Sequence | Sequence Alignment | ERG1 Potassium Channel - ultrastructure | ERG1 Potassium Channel - chemistry | Humans | Models, Molecular | Protein Conformation | ERG1 Potassium Channel - isolation & purification | ERG1 Potassium Channel - metabolism | Index Medicus
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2. Full Text hERG potassium channels and cardiac arrhythmia
by Sanguinetti, Michael C and Tristani-Firouzi, Martin
Nature, ISSN 0028-0836, 03/2006, Volume 440, Issue 7083, pp. 463 - 469
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Arrhythmias, Cardiac - metabolism | Ether-A-Go-Go Potassium Channels - chemistry | Heart - physiology | Humans | Electrophysiology | Arrhythmias, Cardiac - etiology | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Long QT Syndrome - metabolism | Potassium Channels | Animals | Protein Conformation | Ether-A-Go-Go Potassium Channels - physiology | Mutation | Ion Channel Gating | Arrhythmias, Cardiac - genetics | Drugs | Clinical trials | Cardiac arrhythmia | Potassium | Genes | Index Medicus
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3. Full Text A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
by Schewe, Marcus and Sun, Han and Mert, Umit and Mackenzie, Alexandra and Pike, Ashley C. W and Schulz, Friederike and Constantin, Cristina and Vowinkel, Kirsty S and Conrad, Linus J and Kiper, Aytug K and Gonzalez, Wendy and Musinszki, Marianne and Tegtmeier, Marie and Pryde, David C and Belabed, Hassane and Nazare, Marc and de Groot, Bert L and Decher, Niels and Fakler, Bernd and Carpenter, Elisabeth P and Tucker, Stephen J and Baukrowitz, Thomas
Science (American Association for the Advancement of Science), ISSN 0036-8075, 02/2019, Volume 363, Issue 6429, pp. 875 - 880
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Xenopus | Tetrazoles - pharmacology | ortho-Aminobenzoates - chemistry | ortho-Aminobenzoates - pharmacology | Cricetulus | Humans | Crystallography, X-Ray | Thiourea - pharmacology | Large-Conductance Calcium-Activated Potassium Channels - chemistry | Tetrazoles - chemistry | Chlorobenzenes - pharmacology | Drug Design | HEK293 Cells | Chlorobenzenes - chemistry | Protein Domains | CHO Cells | ERG1 Potassium Channel - chemistry | Large-Conductance Calcium-Activated Potassium Channels - agonists | ERG1 Potassium Channel - agonists | Thiourea - chemistry | Molecular Dynamics Simulation | Animals | Tetrahydronaphthalenes - chemistry | Tetrahydronaphthalenes - pharmacology | Thiourea - analogs & derivatives | Ion Channel Gating - drug effects | Molecular dynamics | Analysis | Pharmaceutical research | Potassium channels | Research | Pharmacokinetics | Calcium | Epilepsy | Activation | Potassium conductance | Selectivity | Drug development | Crystallography | Channels | X-ray crystallography | Pain | Occupancy | Potassium channels (voltage-gated) | Calcium channels | Channel gating | Calcium channels (voltage-gated) | Pharmacology | Functional analysis | Resistance | Dynamic tests | Calcium conductance | Conductance | Potassium | Calcium ions
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4. Full Text hERG K(+) channels: structure, function, and clinical significance
by Vandenberg, Jamie I and Perry, Matthew D and Perrin, Mark J and Mann, Stefan A and Ke, Ying and Hill, Adam P
Physiological reviews, ISSN 0031-9333, 2012, Volume 92, Issue 3, pp. 1393 - 1478
Life Sciences & Biomedicine | Physiology | Science & Technology | Potassium - metabolism | Ether-A-Go-Go Potassium Channels - chemistry | Genetic Predisposition to Disease | Heart Conduction System - metabolism | Long QT Syndrome - etiology | Ether-A-Go-Go Potassium Channels - drug effects | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Heart Conduction System - drug effects | Structure-Activity Relationship | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Long QT Syndrome - physiopathology | Protein Transport | Long QT Syndrome - metabolism | Phenotype | Animals | Heart Conduction System - physiopathology | Protein Conformation | Ion Channel Gating | Potassium Channel Blockers - pharmacology | Prescription drugs | Genetic disorders | Cardiovascular disease | Biosynthesis | Gene expression | Chromosomes | Index Medicus
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