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2004, Methods in molecular biology, ISBN 9781592596713, Volume 250., xi, 332
Mitogen-activated protein kinase (MAPK) signaling cascades initiate highly significant cellular processes and are involved in a large number of diseases,... 
Transduction du signal cellulaire | Protéine kinase | Methodology | Cellular signal transduction | Research | Recherche | Protein kinases | Méthodologie | Biochemistry, general | Biochemistry | Life Sciences
Book
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 50, pp. 20194 - 20199
The host immune system provides diverse defense mechanisms to fight harmful bacteria and viruses. One of these mechanisms is the production of antibodies... 
Erk pathways | SHIP-1 | Biological Sciences | ERK pathways
Journal Article
Cancer, ISSN 0008-543X, 2014, Volume 120, Issue 22, pp. 3446 - 3456
The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple... 
mitogen‐activated protein kinase (MAPK) | mitogen‐activated protein kinase‐kinase (MEK) | signaling | colorectal cancer | ovarian cancer | v‐raf murine sarcoma viral oncogene homolog (BRAF) | melanoma | extracellular signal‐regulated kinase (ERK) | Extracellular signal-regulated kinase (ERK) | Signaling | V-raf murine sarcoma viral oncogene homolog (BRAF) | Colorectal cancer | Melanoma | Mitogen-activated protein kinase (MAPK) | Mitogen-activated protein kinase-kinase (MEK) | Ovarian cancer | mitogen-activated protein kinase-kinase (MEK) | mitogen-activated protein kinase (MAPK) | v-raf murine sarcoma viral oncogene homolog (BRAF) | extracellular signal-regulated kinase (ERK) | RNA INTERFERENCE SCREEN | ACTIVATED PROTEIN-KINASE | BRAF(V600E) INHIBITION | ACQUIRED-RESISTANCE | POTENTIAL MECHANISM | TUMOR HETEROGENEITY | CELL LUNG-CANCER | MET AMPLIFICATION | ONCOLOGY | SIGNALING PATHWAY | BRAF MUTATIONS | Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | MAP Kinase Signaling System - physiology | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - physiology | Calcium Signaling | Neoplasms - drug therapy | Care and treatment | Usage | Rapamycin | Protein kinases | Health aspects | Tumors | MEK | BRAF | MAPK | ERK
Journal Article
Biochemical journal, ISSN 1470-8728, 2009, Volume 420, Issue 3, pp. 345 - 361
RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and differentiation. In addition, RTKs reveal oncogenic potential when their... 
Extracellular-signal-regulated kinase (ERK) | Pleiotrophin | Anaplastic large cell lymphoma (ALCL) | Neuroblastoma | Non-small cell lung cancer (NSLCL) | Midkine | Anaplastic lymphoma kinase (ALK) | Inflammatory myofibroblastic tumour (IMT) | ALK PROTEIN EXPRESSION | inflammatory myofibroblastic tumour (IMT) | NPM-ALK | HEPARIN-BINDING | GROWTH-FACTOR PLEIOTROPHIN | non-small cell lung cancer (NSLCL) | BIOCHEMISTRY & MOLECULAR BIOLOGY | anaplastic lymphoma kinase (ALK) | EML4-ALK FUSION GENE | neuroblastoma | LARGE-CELL LYMPHOMA | extracellular-signal-regulated kinase (ERK) | pleiotrophin | NEUROTROPHIC FACTOR HBNF | INFLAMMATORY MYOFIBROBLASTIC TUMOR | NON-HODGKINS-LYMPHOMA | midkine | anaplastic large cell lymphoma (ALCL) | RECEPTOR TYROSINE KINASE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Oncogene Proteins, Fusion - metabolism | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Neuroblastoma - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - pathology | Nuclear Proteins - metabolism | Receptor Protein-Tyrosine Kinases | Protein-Tyrosine Kinases - genetics | Models, Biological | Oncogene Proteins, Fusion - genetics | Lymphoma, Large-Cell, Anaplastic - pathology | Neuroblastoma - metabolism | Nuclear Proteins - genetics | Lymphoma, Large-Cell, Anaplastic - metabolism | Neuroblastoma - pathology | Lymphoma, Large-Cell, Anaplastic - genetics | ALK, anaplastic lymphoma kinase | LTK, leucocyte tyrosine kinase | MUC-1, mucin-1 | IRS-1, IR substrate-1 | PTN, pleiotrophin | TGFβ, transforming growth factor β | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | Shc, Src homology and collagen homology | TPM, tropomyosin | IMP cyclohydrolase | MK, midkine | MYH9, non-muscle myosin heavy chain | MAM, meprin, A5 protein and receptor protein tyrosine phosphatase mu | NPM, nucleophosmin | mTOR, mammalian target of rapamycin | NIPA, nuclear interacting partner of ALK | RPTP, receptor protein tyrosine phosphatase | DLBCL, diffuse large B-cell lymphoma | FOXO3a, forkhead box O 3a | NF-κB, nuclear factor κB | Shp1, SH2 domain-containing phosphatase 1 | RANBP2, Ran-binding protein 2 | ALCL, anaplastic large cell lymphoma | Dpp, decapentaplegic | FRS2, fibroblast growth factor receptor substrate 2 | LDLa, low-density lipoprotein class A | EGFR, epidermal growth factor receptor | SEC31L1, SEC31 homologue A | GIST, gastrointestinal stromal tumour | RTK, receptor tyrosine kinase | SH2, Src homology 2 | TFG, TRK-fused gene | ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase | CLTC, clathrin heavy chain | MAPK, mitogen-activated protein kinase | Hen-1, hesitation-1 | MEK, MAPK | PI3K, phosphoinositide 3-kinase | HEK, human embryonic kidney | SCD-2, suppressor of constitutive dauer 2 | Review | EBPβ, CCAAT | CARS, cysteinyl-tRNA synthetase | JNK, c-Jun N-terminal kinase | ERK kinase | Grb2, growthfactor-receptor-bound protein 2 | SCC, squamous cell carcinoma | EML4, echinoderm microtubule-associated protein like 4 | SHH, sonic hedghog | BCR-Abl, breakpoint cluster region-Abl | IR, insulin receptor | ALO17, ALK lymphoma oligomerization partner on chromosome 17 | enhancer-binding protein β | PLCγ, phospholipase Cγ | NSCLC, non-small cell lung cancer | UCN-01, unco-ordinated 1 | Cdc42, cell division cycle 42 | STAT, signal transducer and activator of transcription | DRG, dorsal root ganglia | MSN, moesin | dALK, Drosophila ALK | IL-3, interleukin-3 | CNS, central nervous system | JAK, Janus kinase | CML, chronic myeloid leukaemia | Jeb, jelly belly | IMT, inflammatory myofibroblastic tumour
Journal Article
Journal Article
Journal Article
Genes & cancer, ISSN 1947-6027, 2011, Volume 2, Issue 3, pp. 195 - 209
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling pathway that regulates a wide variety of stimulated cellular processes,... 
Nucleus | MEK | Mitochondria | Golgi | MAPK | ERK | mitochondria | Monographs | nucleus
Journal Article
Acta neuropathologica, ISSN 1432-0533, 2018, Volume 135, Issue 5, pp. 757 - 777
Adamantinomatous craniopharyngiomas (ACPs) are clinically challenging tumours, the majority of which have activating mutations in CTNNB1. They are... 
Odontogenesis | Paracrine signalling | Inflammasome | Craniopharyngioma | IL1-β | MAPK/ERK pathway | Trametinib | CELLS | INTERLEUKIN-1 | MOUSE | PATHOLOGY | DRIVEN | BETA-CATENIN | NEUROSCIENCES | CLINICAL NEUROLOGY | PATHOGENESIS | SUPPORT | IL1-beta | MUTATIONS | EXPRESSION | Craniopharyngioma - therapy | Craniopharyngioma - pathology | Cytokines - metabolism | Pituitary Gland - pathology | Tissue Culture Techniques | Humans | Computational Biology | Transcriptome | Laser Capture Microdissection | Pituitary Neoplasms - pathology | Tumor Microenvironment - physiology | Pituitary Neoplasms - metabolism | Pituitary Gland - embryology | MAP Kinase Signaling System | Craniopharyngioma - metabolism | Inflammation - therapy | Inflammation - metabolism | Animals | Pituitary Neoplasms - therapy | Sequence Analysis, RNA | Neuroglia - metabolism | Mice | Odontogenesis - physiology | Disease Models, Animal | Proteins | RNA sequencing | RNA | Analysis | Genes | Genetic research | Gene expression | Health aspects | Tumors | Cell culture | Fibroblast growth factor | Animal models | Transforming growth factor-b | Morphogenesis | β-catenin | Signal transduction | Bone morphogenetic proteins | Tumorigenesis | Enzyme-linked immunosorbent assay | Therapeutic applications | MEK inhibitors | Teeth | Extracellular signal-regulated kinase | MAP kinase | Inflammation | Epithelium | Ribonucleic acid--RNA | Dental enamel | Molecular modelling | Pituitary | Computer applications | Solid tumors | Mutation | Proteomes | Neoplasia | Apoptosis | Original Paper | ERK pathway | MAPK
Journal Article
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 10/2018, Volume 17, Issue 10, pp. 2144 - 2155
Effective treatment for pancreatic ductal adenocarcinoma (PDAC) is an urgent, unmet medical need. Targeting KRAS , the oncogene that is present in >95% of... 
Ulixertinib | Pancreatic cancer | KRAS | ERK
Journal Article
Redox biology, ISSN 2213-2317, 2014, Volume 2, Issue 1, pp. 411 - 429
Journal Article