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Cancer, ISSN 0008-543X, 01/2011, Volume 117, Issue 2, pp. 238 - 249
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 08/2019, Volume 104, Issue 9, pp. 1812 - 1821
Asparagine levels in cerebrospinal fluid and serum asparaginase activity were monitored in children with acute lymphoblastic leukemia treated with... 
ERWINIA | PEGASPARAGINASE | THERAPY | PHARMACOKINETICS | AMINO-ACIDS | DEPLETION | SERUM | PEG-ASPARAGINASE | HEMATOLOGY | ESCHERICHIA-COLI ASPARAGINASE
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 08/2019, Volume 37, Issue 23, pp. 2051 - 2051
PURPOSEPegaspargase (PEG-ASP) has largely replaced native Escherichiacoli asparaginase (L-ASP) in the treatment of acute lymphoblastic leukemia because of its... 
OLDER ADOLESCENTS | THERAPY | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | GLYCOL CONJUGATED-ASPARAGINASE | HYPERSENSITIVITY REACTIONS | POLYETHYLENE-GLYCOL | CANCER-INSTITUTE | ESCHERICHIA-COLI ASPARAGINASE | PREEXISTING IGG | CHILDREN | Index Medicus | ORIGINAL REPORTS
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 02/2019, Volume 104, Issue 2, pp. 319 - 329
Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase drug... 
ANTIBODIES | BASOPHILS | ACUTE LYMPHOBLASTIC-LEUKEMIA | IN-VIVO | MOUSE | REACTIVITY | ANAPHYLACTIC SHOCK | HEMATOLOGY | EXPRESSION | ESCHERICHIA-COLI ASPARAGINASE | CHILDREN
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 10/2019, Volume 33, Issue 10, pp. 10996 - 11005
Asparaginase (ASNase) is an important drug for the treatment of leukemias. However, hypersensitivity to ASNase can increase the risk of leukemia relapse. Two... 
ANTIBODIES | leukemia | HIGHER-RISK | BIOCHEMISTRY & MOLECULAR BIOLOGY | anaphylaxis | antidrug antibodies | immunogenicity | CHILDREN | CELL BIOLOGY | IMPACT | BASOPHILS | ACUTE LYMPHOBLASTIC-LEUKEMIA | BIOLOGY | basophil activation test | EXPRESSION | ESCHERICHIA-COLI ASPARAGINASE
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 10/2018, Volume 59, Issue 10, pp. 2360 - 2368
Asparaginase, an important treatment component for acute lymphoblastic leukemia (ALL), causes severe hepatotoxicity in some patients. Levocarnitine is a... 
levocarnitine | ALL | leukemia | hepatic injury | Asparaginase | hyperbilirubinemia | ESCHERICHIA-COLI-ASPARAGINASE | ADULTS | TOXICITY | SUPPLEMENTATION | L-CARNITINE | ONCOLOGY | ADOLESCENTS | ACUTE LYMPHOBLASTIC-LEUKEMIA | FATTY LIVER | CHILDRENS CANCER GROUP | HEPATOTOXICITY | HEMATOLOGY
Journal Article
PHARMACOLOGICAL REPORTS, ISSN 1734-1140, 04/2019, Volume 71, Issue 2, pp. 311 - 318
Background: L-asparaginase (L-asp) remains one of the key components of acute lymphoblastic leukemia therapy. Immune reactions to the drug are associated with... 
Allergy | DEXAMETHASONE | ERWINIA-ASPARAGINASE | CLINICAL UTILITY | Antineoplastic therapy | Hypersensitivity | ESCHERICHIA-COLI-ASPARAGINASE | RISK | PHARMACOLOGY & PHARMACY | Drug resistance | CANCER | CHILDREN
Journal Article
Journal Article
Haematologica, ISSN 0390-6078, 01/2016, Volume 101, Issue 3, pp. 279 - 285
Journal Article
Journal Article
Molecular BioSystems, ISSN 1742-206X, 06/2015, Volume 11, Issue 7, pp. 1887 - 1896
l-Asparaginases belong to a family of amidohydrolases that catalyze the conversion of l-asparagine into l-aspartic acid and ammonia. Although bacterial... 
Journal Article