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Seminars in Cancer Biology, ISSN 1044-579X, 06/2018, Volume 50, pp. 77 - 89
The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are... 
TO-MESENCHYMAL TRANSITION | IN-VITRO | ACTIVATED PROTEIN-KINASE | STEM-LIKE CELLS | ONCOLOGY | DNA-DAMAGE RESPONSE | ESTROGEN-RECEPTOR-ALPHA | JUN NH2-TERMINAL KINASE | FOXO TRANSCRIPTION FACTORS | FORKHEAD BOX M1 | NEGATIVE BREAST-CANCER | DNA Repair - drug effects | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Cell Self Renewal - genetics | Forkhead Box Protein O3 - genetics | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Forkhead Box Protein M1 - genetics | Cell Proliferation - drug effects | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | AURKA, aurora kinase A | Fox, forkhead box | Bim, B-cell lymphoma 2 interacting mediator | EGF, epidermal growth factor | JNK | BRIP1, BRCA1-interacting protein-terminal helicase 1 | GICs, glioma-initiating cells | MCL, mantle cell lymphoma | PKB, protein kinase B | SCs, stem cells | LEF, T-cell factor | Skp2, S-phase kinase-associated protein 2 | SSBs, single-strand breaks | mTOR, mammalian target of rapamycin | NBS1, Nijmegen breakage syndrome 1 | stress activated protein kinase | MEK, mitogen-activated protein kinase kinase | PIP3, phosphatidylinositol- 3,4,5-trisphosphate | BER, base excision repair | lymphoid enhancer factor | VEGF, vascular endothelial growth factor | AML, acute myeloid leukaemia | ER+ve, estreogen receptor positive | EXO1, exonuclease 1 | EGFR, epidermal growth factor receptor | MDR1, multidrug resistance protein 1 | ChIP-seq, chromatin immunoprecipitation with massively parallel DNA sequencing | ABCB1, ATP-binding cassette sub-family B member 1 | TCF | SOD-2, superoxide dismutase | TKIs, tyrosine kinase inhibitors | PDK, phosphoinositide-dependent kinase | IFNɣ, interferon-ɣ | BRCA2, breast cancer-associated gene 2 | DDR, DNA damage response | Cks1, cyclin-dependent kinases regulatory subunit 1 | ESR1, estrogen receptor alpha gene | NHEJ, non-homologous end joining | XRCC1, X-ray cross-complementing group 1 | OTUB1, OUT domain-containing ubiquitin aldehyde-binding protein 1 | IGF, insulin growth factor | TRAIL, tumour necrosis factor-related apoptosis inducing ligand | ER, estrogen receptor | MRN, MER11-RAD50-NBS1 | BRCA1, breast cancer susceptibility gene product 1 | FasL, fas ligand | RTKs, receptor tyrosine kinases | Sox1, sex determining region Y box 2 | GADD45, DNA damage-inducible protein 45 | MMR, mismatch repair | PI3K, phosphatidylinositol 3-kinase | ROS, reactive oxygen species | NAMPT, nicotinamide-phosphribosyltransferase | miRs, Micro-RNAs | FHRE, forkhead response element | ATM, Ataxia-telangiectasia mutated | NER, nucleotide excision repair | ERK, extracellular signal-regulated kinase | HR, homologous recombination | AMPK, adenosine monophosphate-activated protein kinase | DSBs, double strands breaks | PA, Psammaplysene A | CML, chronic myeloid leukaemia | HCC, hepatocellular carcinoma | Mst1, macrophage stimulating 1 | Rb2, retinoblastoma-related p130 | SAPK, c-Jun N-terminal kinase | CSCs, cancer stem cells
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1725 - 13
Breast cancer (BC) in the Asia Pacific regions is enriched in younger patients and rapidly rising in incidence yet its molecular bases remain poorly... 
SURVIVAL | MUTATIONAL PROCESSES | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | SOMATIC MUTATION | MATRIX FACTORIZATION | DNA-SEQUENCING DATA | TUMORS | RNA-SEQ DATA | GENOME | AGE | Carcinoma, Lobular - pathology | Receptor, ErbB-2 - genetics | Breast Neoplasms - immunology | Carcinoma, Ductal - genetics | Carcinoma, Ductal - pathology | Humans | Middle Aged | Carcinoma, Ductal - immunology | Transcriptome | Carcinoma, Lobular - ethnology | Estrogen Receptor alpha - immunology | Tumor Suppressor Protein p53 - genetics | Tumor Microenvironment - genetics | Carcinoma, Lobular - genetics | Postmenopause | Adult | Female | Receptor, ErbB-2 - immunology | BRCA2 Protein - immunology | Breast Neoplasms - ethnology | Carcinoma, Ductal - ethnology | Carcinoma, Lobular - immunology | Transforming Growth Factor beta - immunology | BRCA1 Protein - immunology | Premenopause | European Continental Ancestry Group | Tumor Suppressor Protein p53 - immunology | Whole Exome Sequencing | BRCA1 Protein - genetics | Asian Continental Ancestry Group | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Transforming Growth Factor beta - genetics | Breast Neoplasms - pathology | Biomarkers, Tumor - genetics | Neoplasm Staging | Biomarkers, Tumor - immunology | BRCA2 Protein - genetics | Cohort Studies | Enrichment | BRCA2 protein | BRCA1 protein | p53 Protein | Homologous recombination | Homology | Breast cancer | Patients | ErbB-2 protein | Molecular chains | Homologous recombination repair | ESR1 protein | Mutation | Signatures | Cancer | Tumors
Journal Article
World Journal of Surgical Oncology, ISSN 1477-7819, 03/2017, Volume 15, Issue 1, p. 63
Journal Article
Journal Article
Breast Cancer Research, ISSN 1465-5411, 04/2019, Volume 21, Issue 1, pp. 47 - 17
Background: Our previous genome-wide association study using the MA.27 aromatase inhibitors adjuvant trial identified SNPs in the long noncoding RNA MIR2052HG... 
EGR1 | Aromatase inhibitor | ERα | LMTK3 | MIR2052HG | PKC | Lon noncoding RNA | PATHWAYS | ACTIVATION | PHOSPHORYLATION | TRANSCRIPTION | BREAST-CANCER-CELLS | TERM | ONCOLOGY | ESTROGEN-RECEPTOR-ALPHA | GROWTH | EXPRESSION | BINDING | ER alpha
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0126978
Glutathione S-transferases (GSTs) play important roles in the protection of cells against toxins and oxidative damage where one Arabidopsis member, GSTF8, has... 
DIFFERENTIAL GENE | RESPONSIVE GENE-REGULATION | THALIANA | MULTIDISCIPLINARY SCIENCES | FUSARIUM-OXYSPORUM | PLANT-DISEASE RESISTANCE | ANALYSIS TOOLKIT | DEPENDENT DEFENSE | GENOME ANALYSIS | EXPRESSION | PRE-MESSENGER-RNA | RNA-Binding Proteins - genetics | Up-Regulation | Transcription Factors - chemistry | Arabidopsis - growth & development | Adaptation, Physiological - drug effects | Plant Diseases - microbiology | Recombinant Fusion Proteins - metabolism | Arabidopsis Proteins - metabolism | Salicylic Acid - pharmacology | Fusarium - physiology | Cloning, Molecular | Plant Diseases - genetics | Stress, Physiological - drug effects | Disease Resistance - genetics | Gene Ontology | Protein Structure, Tertiary | Arabidopsis Proteins - genetics | Stress, Physiological - genetics | RNA-Binding Proteins - chemistry | Disease Resistance - drug effects | Glutathione Transferase - metabolism | Signal Transduction - genetics | Transcriptome - genetics | Transcription Factors - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Arabidopsis - genetics | Transcription Factors - metabolism | Arabidopsis - microbiology | Oxylipins - metabolism | Gene Expression Regulation, Plant - drug effects | Sequence Analysis, RNA | Arabidopsis Proteins - chemistry | Signal Transduction - drug effects | Alleles | Cyclopentanes - metabolism | Mutation | RNA-Binding Proteins - metabolism | Botanical research | Plant defenses | Gene mutations | Development | Genetic research | Genetic aspects | Plants | Research | Binding proteins | Properties | Identification and classification | Genes | Crosstalk | Genetic screening | Gene sequencing | Proteins | ESR1 protein | Signal transduction | Reporter gene | Fusarium | Physiology | Life sciences | Plant sciences | Jasmonic acid | Glutathione | Stresses | Pathogens | Salicylic acid | Fusarium oxysporum | Abiotic stress | Cloning | Gene expression | Ribonucleic acid--RNA | Mutants | Plant diseases | Gene silencing | Signaling | RNA-binding protein | Acids | Toxins | RNA | Ribonucleic acid
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 6669 - 9
Identifying effective drug targets, with little or no side effects, remains an ever challenging task. A potential pitfall of failing to uncover the correct... 
NETWORK ANALYSIS | PROTEINS | PATHWAY | MULTIDISCIPLINARY SCIENCES | SYSTEMS BIOLOGY | Histone deacetylase | Retinoid X receptor α | Drug development | Grb2 protein | Proteins | ESR1 protein | Side effects | Janus kinase 2 | Lck protein | Janus kinase | Syk protein | Lyn protein | HDAC2 protein | Cancer | Fyn protein
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 2036 - 2052
Earlier studies reported allelic deletion of the essential autophagy regulator BECN1 in breast cancers implicating BECN1 loss, and likely defective autophagy,... 
TNBCs, triple-negative breast cancers | EGF, epidermal growth factor | DAPI, 4′, 6-diamidino-2-phenylindole | MEGM, mammary epithelial growth medium | ATG, autophagy-related | 8-O-dG, 8-oxo-7, 8-dihydroguanine | ITGB1/CD29, Integrin, beta 1 (fibronectin receptor beta polypeptide, antigen CD29 includes MDF2, MSK12) | LY76 | E, 17b-estradiol | EM, electron microscopy | | DMEM, Dulbecco's modified Eagle's medium | CD24, cluster of differentiation 24 | KRT, keratin | TNFSF11 | TNBC | TNFRSF11A/TNR11/RANK, tumor necrosis factor receptor superfamily, member 11a, NFKB activator | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta | LY76/TER119, lymphocyte antigen 76 | EGFP, enhanced green fluorescent protein | MaPC, mammary progenitor cell | PI, propidium iodide | TNF, tumor necrosis factor | ) | TP53 (TRP53 in mice), tumor protein p53 (transformation related protein 53 in mice) | NFKB | BECN1, Beclin 1, autophagy-related | PECAM1/CD31, platelet/endothelial cell adhesion molecule 1 | RELA/P65, v-rel avian reticuloendotheliosis viral oncogene homolog a | IL, interleukin | lineage negative (CD31 | IF, immunofluorescence | CD45 | SQSTM1/p62, sequestosome1 | GSEA, gene set enrichment analysis | H&E, hematoxylin &, eosin | DFS, disease-free survival | basal-like breast cancer | parity | iMMECs, immortalized mouse mammary epithelial cells | TNFRSF11A | HR, hormone receptor | PGR, progesterone receptor | FACS, fluorescence activated cell sorting | PBS, phosphate-buffered saline | TEBs, terminal end buds | IHC, immunohistochemistry | SD, standard deviation | MGs, mammary glands | ROS, reactive oxygen species | WNT1 | MEC, mammary epithelial cell | ITGB3/CD61, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | MKI67, marker of proliferation Ki-67 | CASP3, caspase 3 | BSA, bovine serum albumin | MaSC, mammary stem cell | EMT, epithelial-to-mesenchymal transition | Keratin 6 | WNT1, wingless-Type MMTV integration site family, member 1 | TNF11 | NFKB/NFkB, nuclear factor of kappa light polypeptide gene enhancer in B-cells | MMTV, mouse mammary tumor virus | FGF2/bFGF, fibroblast growth factor 2 (basic) | LIN | p-KRT8/p-K8, phosphorylated Keratin 8 | SNPs, single nucleotide polymorphisms | PTPRC/CD45, protein tyrosine phosphatase, receptor type, C | EGFR/ERBB1, epidermal growth factor receptor | Beclin 1 | TNFSF11/TNF11/RANKL, tumor necrosis factor (ligand) superfamily, member 11 | ESR1, estrogen receptor 1 | TNR11 | ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Parity | Basal-like breast cancer | PROGENITOR CELLS | STEM-CELLS | MOUSE | DEFICIENT MICE | CELL BIOLOGY | BREAST-CANCER | EPITHELIAL-CELLS | BECLIN-1 | TUMOR-SUPPRESSOR | LUNG-TUMORS | TRANSGENIC MICE | Beclin-1 | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Stem Cells - cytology | Wnt1 Protein - metabolism | Mammary Neoplasms, Experimental - metabolism | Autophagy | Apoptosis Regulatory Proteins - metabolism | Breast Neoplasms - metabolism | Animals | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Mammary Neoplasms, Animal - metabolism | Alleles | Female | Heterozygote | Membrane Proteins - metabolism | Mice | Epithelial Cells - cytology | Apoptosis
Journal Article