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Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 07/2010, Volume 400, Issue 4, pp. 743 - 754
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2012, Volume 84, Issue 9, pp. 1215 - 1222
Journal Article
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2011, Volume 2, Issue 2, pp. 91 - 96
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the... 
endocannabinoid | FAAH | irreversible inhibitor | clinical candidate | ALPHA-KETOHETEROCYCLE INHIBITORS | TARGET | URB597 | CHEMISTRY, MEDICINAL | MECHANISM | ANANDAMIDE | INACTIVATION | ENZYME | ACID AMIDE HYDROLASE | ESTERS | CHEMISTRY
Journal Article
Psychopharmacology, ISSN 0033-3158, 4/2014, Volume 231, Issue 7, pp. 1417 - 1425
Drug addicts constantly relapse to drug seeking after recall of memories linked to the drug experience. It is believed that a successful application of... 
URB597 | Reconsolidation | Neurosciences | Biomedicine | Conditioned place preference | Endocannabinoid | CB1 receptors | Morphine | Pharmacology/Toxicology | Psychiatry | ANANDAMIDE HYDROLYSIS | PSYCHIATRY | RECEPTOR ANTAGONIST RIMONABANT | NEUROSCIENCES | OPIOID SYSTEM | ESTER URB597 | ACID AMIDE HYDROLASE | CANNABINOID CB1 RECEPTORS | CONTEXTUAL FEAR MEMORY | DRUG-ADDICTION | PHARMACOLOGY & PHARMACY | SPATIAL MEMORY | Memory - drug effects | Recurrence | Rats, Wistar | Receptor, Cannabinoid, CB2 - agonists | Male | Benzoxazines | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Secondary Prevention - methods | Endocannabinoids - physiology | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Cues | Morphine - pharmacology | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Rats | Amidohydrolases - antagonists & inhibitors | Morpholines | Naphthalenes | Animals | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Memory - physiology | Complications and side effects | Drug addicts | Physiological aspects | Dosage and administration | Genetic aspects | Research | Endocannabinoids | Drug addiction | Narcotics | Psychopharmacology | Rodents | Animal memory | Addicts
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 820 - 833
Background and Purpose Binge eating disorder (BED) is characterized by excessive food intake during short periods of time. Recent evidence suggests that... 
URB597 | rimonabant | weight loss | high‐fat diet | THC | binge eating | food intake | high-fat diet | AMIDE-HYDROLASE FAAH | CB1 CANNABINOID RECEPTOR | BODY-COMPOSITION | ANOREXIA-NERVOSA | PALATABLE FOOD | ESTER URB597 | STIMULATES FOOD-INTAKE | MISSENSE POLYMORPHISM | PHARMACOLOGY & PHARMACY | NUCLEUS-ACCUMBENS SHELL | LIMITED ACCESS | Endocannabinoids - metabolism | Pyrazoles - therapeutic use | Endocannabinoids - agonists | Weight Loss - drug effects | Dose-Response Relationship, Drug | Receptor, Cannabinoid, CB1 - agonists | Behavior, Animal - drug effects | Female | Cannabinoid Receptor Agonists - toxicity | Disease Models, Animal | Piperidines - administration & dosage | Drug Tolerance | Rats | Energy Intake - drug effects | Random Allocation | Cannabinoid Receptor Agonists - administration & dosage | Rats, Sprague-Dawley | Cannabinoid Receptor Antagonists - therapeutic use | Feeding Behavior - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Margarine - adverse effects | Pyrazoles - administration & dosage | Animals | Binge-Eating Disorder - chemically induced | Signal Transduction - drug effects | Piperidines - therapeutic use | Drug Inverse Agonism | Binge-Eating Disorder - drug therapy | Cannabinoid Receptor Antagonists - administration & dosage | Dronabinol - administration & dosage | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dronabinol - toxicity | Endocannabinoids - antagonists & inhibitors | Binge-Eating Disorder - metabolism | Dietary fat | Enzymes | Hydrolases | Cannabinoids | Fatty acids | Compulsive eating | Bulimia | Rodents | Eating disorders | Cannabinoids 2012, Part Two | Themed Section
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 12/2018, Volume 367, Issue 3, pp. 551 - 563
Opioid-based therapies remain a mainstay for chronic pain management, but unwanted side effects limit therapeutic use. We compared efficacies of brain-permeant... 
CANNABINOID RECEPTORS | URB597 | FAAH | CB1 | MONOACYLGLYCEROL LIPASE | PAIN MODELS | BEHAVIOR | PERIPHERAL NEUROPATHY | DELTA-TETRAHYDROCANNABINOL | PHARMACOLOGY & PHARMACY | RAT MODEL
Journal Article