X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (20) 20
humans (15) 15
male (15) 15
endothelin receptor antagonists (12) 12
endothelin-1 (12) 12
et (12) 12
endothelin (9) 9
pharmacology & pharmacy (8) 8
cloning (7) 7
index medicus (7) 7
potent (7) 7
pyrrolidine-3-carboxylic acids (7) 7
receptor, endothelin b (7) 7
receptors (7) 7
biochemistry & molecular biology (6) 6
cardiac & cardiovascular systems (6) 6
chemistry, medicinal (6) 6
discovery (6) 6
eta (6) 6
female (6) 6
physiology (6) 6
rats (6) 6
receptors, endothelin - metabolism (6) 6
side-chain (6) 6
cells (5) 5
chemistry, organic (5) 5
endothelin-1 - metabolism (5) 5
endothelins - pharmacology (5) 5
expression (5) 5
mixed eta/etb (5) 5
nonpeptide (5) 5
receptor, endothelin a (5) 5
endothelins - metabolism (4) 4
et/et (4) 4
eta/etb (4) 4
etb receptor (4) 4
rabbits (4) 4
rat (4) 4
receptors, endothelin - drug effects (4) 4
series (4) 4
smooth-muscle cells (4) 4
antagonist (3) 3
binding, competitive (3) 3
biology (3) 3
blood pressure - drug effects (3) 3
calcium - metabolism (3) 3
cardiovascular system (3) 3
contraction (3) 3
endothelin-1 - pharmacology (3) 3
endothelins - physiology (3) 3
et receptors (3) 3
eta receptor (3) 3
etb (3) 3
etb receptors (3) 3
hypertension, pulmonary - physiopathology (3) 3
in vitro techniques (3) 3
mechanism (3) 3
microbiology (3) 3
muscle contraction - drug effects (3) 3
nitric-oxide (3) 3
oligopeptides - pharmacology (3) 3
peripheral vascular disease (3) 3
physiological aspects (3) 3
radioligand assay (3) 3
rats, sprague-dawley (3) 3
rats, wistar (3) 3
receptors, endothelin - genetics (3) 3
respiratory system (3) 3
sitaxentan (3) 3
smooth-muscle (3) 3
structure-activity relationship (3) 3
vasoconstriction (3) 3
vasoconstriction - drug effects (3) 3
vasoconstriction - physiology (3) 3
ambrisentan (2) 2
amino acid sequence (2) 2
antagonist bosentan (2) 2
antihypertensive agents - therapeutic use (2) 2
aristolochic acid a (2) 2
arterial-hypertension (2) 2
atherosclerosis (2) 2
autoradiography (2) 2
azepines - pharmacology (2) 2
big et (2) 2
binding sites (2) 2
binding-sites (2) 2
bioassay evaluation (2) 2
bosentan (2) 2
bq-123 (2) 2
cell biology (2) 2
cell line (2) 2
cho cells (2) 2
chronic heart-failure (2) 2
cricetinae (2) 2
cyclic nucleotide phosphodiesterases, type 5 - metabolism (2) 2
dose-response relationship, drug (2) 2
dual eta/etb receptor (2) 2
endothelin a receptor antagonists (2) 2
endothelin receptor subtypes (2) 2
endothelin-1 - antagonists & inhibitors (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Journal Article
American Journal of Physiology: Lung Cellular and Molecular Physiology, ISSN 1040-0605, 03/2014, Volume 306, Issue 5, pp. L442 - L452
textabstractBoth phosphodiesterase 5 (PDE5) inhibition and endothelin (ET) receptor blockade have been shown to induce pulmonary vasodilation. However, little... 
Big ET | Exercise | Pulmonary vascular tone | PDE5 inhibition | PHYSIOLOGY | RECEPTOR BLOCKADE | MYOCARDIAL-INFARCTION | ORAL SILDENAFIL | HEART-FAILURE | exercise | VASOMOTOR TONE | VASCULAR-TONE | OXYGEN-UPTAKE | TREADMILL EXERCISE | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | ETA/ETB receptor blockade | NITRIC-OXIDE | pulmonary vascular tone | Tetrazoles - pharmacology | Humans | Male | Endothelins - metabolism | Pulmonary Circulation - physiology | Vasoconstriction - physiology | Endothelin A Receptor Antagonists | Female | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Vasoconstrictor Agents - pharmacology | Endothelins - antagonists & inhibitors | Endothelin B Receptor Antagonists | Physical Conditioning, Animal - physiology | Vasoconstriction - drug effects | Drug Synergism | Animals | Cyclic GMP - metabolism | Signal Transduction - drug effects | Receptor, Endothelin A - metabolism | Signal Transduction - physiology | Pulmonary Circulation - drug effects | Pyridines - pharmacology | Receptor, Endothelin B - metabolism | Sus scrofa | Medical research | Dilatation | Vasodilators | Vasoconstriction | Physiological aspects | Blood vessels | Medicine, Experimental | Dosage and administration | Research | Phosphodiesterases | ETA | ETB receptor blockade
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 03/2011, Volume 43, Issue 3, pp. 299 - 302
Journal Article
Journal of Biological Research (Italy), ISSN 1826-8838, 2011, Volume 84, Issue 1, pp. 161 - 163
The present study evaluated the effects of a non-selective endothelin (ETA/B) receptors antagonist, on collagen type I (COLI) synthesis on in vitro culture of... 
receptor antagonist | Systemic sclerosis | Endothelin-1 | Fibrosis | ET | endothelin-1, ETa/ETb receptor antagonist, fibrosis, systemic sclerosis
Journal Article
NEUROREPORT, ISSN 0959-4965, 02/2000, Volume 11, Issue 3, pp. 649 - 652
Endothelin-1 (ET-1) is recognized as being involved in the pathophysiology of cerebrovascular diseases. Using organ culture as a model for possible... 
ETA/ETB receptor | endothelin | potency | PLASMA | ENDOTHELIN-B RECEPTORS | organ culture | SUBARACHNOID HEMORRHAGE | SAH | stroke | NEUROSCIENCES | ISCHEMIC STROKE | PLASTICITY
Journal Article
Cellular and Molecular Neurobiology, ISSN 0272-4340, 4/2002, Volume 22, Issue 2, pp. 207 - 226
1. Interaction in the recognition of endothelin-1 (ET-1), a typical bivalent ET receptor-ligand, between ETA and ETB receptors was investigated in the rat... 
Life Sciences | Neurosciences | bivalent ligand | ET B receptor | ET A receptor | ET receptor-related compounds | anterior pituitary gland (rat) | endothelin-1 | Animal Anatomy / Morphology / Histology | 125 I-endothelin-1 | ET A –ET B receptor heterodimer | quantitative receptor autoradiography | Bivalent ligand | receptor | I-endothelin-1 | Endothelin-1 | receptor heterodimer | Quantitative receptor autoradiography | ET | ETA receptor | RADIOLIGAND | ET(A) RECEPTOR | SUBTYPES | I-125-endothelin-1 | NEUROSCIENCES | CONTRACTIONS | CELL BIOLOGY | ETB receptor | POTENT | LIGANDS | CLONING | ANTAGONISTS | ETA-ETB receptor heterodimer | EXPRESSION | ET(B) RECEPTOR | Viper Venoms | Endothelins | Peptide Fragments | Epithelial Cells - metabolism | Iodine Radioisotopes | Receptors, Endothelin - genetics | Oligopeptides | Rats, Wistar | Endothelin-1 - pharmacology | Epithelial Cells - drug effects | Male | Receptor, Endothelin A | Receptor, Endothelin B | RNA, Messenger - metabolism | Pituitary Gland, Anterior - metabolism | Azepines | Protein Binding - drug effects | Cell Membrane - metabolism | Radioligand Assay | Epithelial Cells - cytology | Dimerization | Binding Sites - drug effects | Cell Membrane - drug effects | Endothelin-1 - metabolism | Receptors, Endothelin - metabolism | Rats | Receptors, Endothelin - drug effects | Binding Sites - genetics | Peptides, Cyclic | Animals | Pituitary Gland, Anterior - cytology | Ligands | Pituitary Gland, Anterior - drug effects | Kinetics | Protein Binding - physiology
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 05/2004, Volume 12, Issue 9, pp. 2139 - 2150
The synthesis and structure-activity relationships of a series of 5,7-diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acids are described. Our efforts have been... 
CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ENDOTHELIN RECEPTOR ANTAGONISTS | MIXED ETA/ETB | NONPEPTIDE | PYRROLIDINE-3-CARBOXYLIC ACIDS | DISCOVERY
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 08/2000, Volume 10, Issue 16, pp. 1875 - 1878
The synthesis and structure activity relationships of a series of sulfonamide endothelin antagonists are described. In the course of our modification studies,... 
CHEMISTRY, MEDICINAL | SERIES | CLONING | SIDE-CHAIN | CHEMISTRY, ORGANIC | ETA/ETB | ENDOTHELIN RECEPTOR ANTAGONISTS | NONPEPTIDE | PYRROLIDINE-3-CARBOXYLIC ACIDS
Journal Article