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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 7, pp. E1273 - E1281
Creatine, a nitrogenous organic acid, replenishes cytoplasmic ATP at the expense of mitochondrial ATP via the phosphocreatine shuttle. Creatine levels are... 
Inflammatory bowel disease | Glycine amidinotransferase | N-ethyl-N-nitrosourea | MTOR | LRBA | MULTIDISCIPLINARY SCIENCES | KINASE | IBD | inflammatory bowel disease | COLON-CANCER | glycine amidinotransferase | INFLAMMATORY-BOWEL-DISEASE | METABOLISM | PATHWAY | mTOR | AMPK | MICE | MUTATIONS | Biological Sciences | PNAS Plus
Journal Article
NATURE REVIEWS GENETICS, ISSN 1471-0056, 10/2008, Volume 9, Issue 10, pp. 803 - 803
The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human... 
ENU MUTAGENESIS | CHROMOSOME | ETHYLNITROSOUREA | MULTIPLE INTESTINAL NEOPLASIA | SEQUENCE | GENETICS & HEREDITY | PHENOTYPE | MUTAGENIZED MICE | ETHYL-N-NITROSOUREA | MUTATIONS | IDENTIFICATION
Journal Article
Oncotarget, ISSN 1949-2553, 07/2018, Volume 9, Issue 59, p. 31330
Notch-1 and osteopontin (OPN) mediate angiogenesis and glioma stem-like cell (GSLC) maintenance. However, the relationship between these molecules and GSLCs... 
Journal Article
CARCINOGENESIS, ISSN 0143-3334, 09/2014, Volume 35, Issue 9, pp. 2002 - 2006
Exposure to environmental agents and endogenous metabolism can both give rise to DNA alkylation. Thymine is known to be alkylated at O-2, N3 and O-4 positions;... 
Y-FAMILY | ONCOLOGY | IN-VIVO | HUMAN LUNG-TISSUE | ETHYL-N-NITROSOUREA | POL-V | TANDEM MASS-SPECTROMETRY | INDUCED ESCHERICHIA-COLI | MAMMALIAN-CELLS | LIVER DNA | DNA-POLYMERASES | Original Manuscript
Journal Article
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 01/2018, Volume 31, Issue 1, pp. 48 - 57
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a powerful lung carcinogen in animal models and is considered a... 
DEOXYRIBONUCLEIC-ACID | CHEMISTRY, MEDICINAL | TANDEM MASS-SPECTROMETRY | MAMMALIAN-CELLS | CHEMISTRY, MULTIDISCIPLINARY | TEMPLATE PROPERTIES | ESCHERICHIA-COLI-ADA | TOBACCO-SPECIFIC NITROSAMINES | ALKYLATING-AGENTS | ETHYL-N-NITROSOUREA | F344 RATS | PHOSPHOTRIESTERS | TOXICOLOGY | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 5, pp. E440 - E449
With the wide availability of massively parallel sequencing technologies, genetic mapping has become the rate limiting step in mammalian forward genetics. Here... 
genetic mapping | N-ethyl-N-nitrosourea | mutagenesis | MULTIDISCIPLINARY SCIENCES | forward genetics | massively parallel sequencing | Genes, Lethal | Point Mutation | Phenotype | Animals | Pedigree | Alleles | Female | Male | Mice | Quantitative Trait Loci | Genetic Linkage | Nucleotide sequencing | Gene mutations | Observations | Genetic variation | Methods | DNA sequencing | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Disease models & mechanisms, ISSN 1754-8403, 05/2018, Volume 11, Issue 5, p. dmm034678
In this study, we performed a genome-wide N-ethyl-N-mtrosourea (ENU) mutagenesis screen in mice to identify novel genes or alleles that regulate... 
Erythropoiesis | Transplantation | Anaemia | N-ethyl-N-nitrosourea | TPI deficiency | TRIOSEPHOSPHATE ISOMERASE DEFICIENCY | PROTEIN | PATHOLOGY | DROSOPHILA | CELL BIOLOGY | GLYCOLYSIS | MUTANTS | GENE | MUTATIONS | CELL
Journal Article
DISEASE MODELS & MECHANISMS, ISSN 1754-8403, 09/2018, Volume 11, Issue 9
Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from... 
LOCALIZATION | Dextran sodium sulfate | SODIUM-SULFATE COLITIS | SENSITIVITY | PATHOLOGY | INTESTINAL HOMEOSTASIS | MEMBRANE TRAFFICKING | CELL BIOLOGY | Inflammatory bowel disease | DISEASES | N-ethyl-N-nitrosourea | INFLAMMATION | CALMODULIN | UNCONVENTIONAL MYOSIN | MICE
Journal Article
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 08/2013, Volume 755, Issue 2, pp. 126 - 134
Journal Article
Journal Article
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 03/2018, Volume 827, pp. 27 - 41
Journal Article
Evolution, ISSN 0014-3820, 10/2017, Volume 71, Issue 10, pp. 2445 - 2456
Journal Article