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eucomm (6) 6
science & technology (5) 5
life sciences & biomedicine (4) 4
animals (3) 3
humans (3) 3
mice (3) 3
acetaldehyde (2) 2
alcohol (2) 2
alcohol, denatured (2) 2
aldh (2) 2
analysis (2) 2
developmental biology (2) 2
knockout (2) 2
liver (2) 2
methods (2) 2
mutation - genetics (2) 2
pathology (2) 2
1- o-β- d-glucopyranosyl eucommiol (1) 1
1-o-β-d-glucopyranosyl eucommiol (1) 1
1h and 13c nmr (1) 1
acetaldehyde - metabolism (1) 1
acetaldehyde - toxicity (1) 1
alcoholic liver disease (1) 1
aldehyde dehydrogenase - genetics (1) 1
aldehyde dehydrogenase - metabolism (1) 1
animal genetics (1) 1
aucuba japonica (1) 1
birch reduction (1) 1
c nmr (1) 1
c57bl (1) 1
c57bl/6 (1) 1
carcinogenesis - drug effects (1) 1
carcinogens (1) 1
cell biology (1) 1
cell proliferation - drug effects (1) 1
colorectal cancer (1) 1
colorectal neoplasms - enzymology (1) 1
colorectal neoplasms - etiology (1) 1
colorectal neoplasms - pathology (1) 1
conditional knockout (1) 1
conserved sequence - genetics (1) 1
cornaceae (1) 1
cre recombinase (1) 1
crispr-cas systems - genetics (1) 1
cytochrome p-450 (1) 1
development and progression (1) 1
disease (1) 1
disease susceptibility (1) 1
dna damage (1) 1
dna damage - drug effects (1) 1
embryo, mammalian - embryology (1) 1
embryo, mammalian - metabolism (1) 1
embryonic lethal (1) 1
embryos (1) 1
endocrinology (1) 1
endocrinology & metabolism (1) 1
epidemiology (1) 1
ethanol - metabolism (1) 1
ethanol - toxicity (1) 1
eucommiol (1) 1
eucommioside ii (1) 1
feasibility studies (1) 1
female (1) 1
flp recombinase (1) 1
fluorescence (1) 1
gen (1) 1
gene (1) 1
gene targeting - methods (1) 1
genes (1) 1
genes, essential - genetics (1) 1
genes, lethal - genetics (1) 1
genetic research (1) 1
genome-wide association study (1) 1
genomes (1) 1
genomics (1) 1
genotype (1) 1
genotype & phenotype (1) 1
h and (1) 1
hek293 cells (1) 1
hepatic steatosis (1) 1
high-throughput screening (1) 1
high-throughput screening assays (1) 1
homozygote (1) 1
imaging, three-dimensional (1) 1
immunohistochemistry (1) 1
impc (1) 1
inducible knockout (1) 1
international knockout mouse consortium (1) 1
international mouse phenotyping consortium (1) 1
intestine (1) 1
intestines - drug effects (1) 1
intestines - pathology (1) 1
knockout mouse project, komp (1) 1
komp (1) 1
liver cancer (1) 1
liver cirrhosis (1) 1
lymphomas (1) 1
male (1) 1
mamals (1) 1
medical research (1) 1
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1. Full Text High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Edie, Sarah M and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Johnson, Sara J and Lawson, Thomas N and Lek, Monkol and Mason, Jeremy and McElwee, Melissa L and Nutter, Lauryl M.J and Rowland, Douglas J and Samocha, Kaitlin E and Seavitt, John R and Szoke-Kovacs, Zsombor and Trainor, Amanda G and Wakana, Shigeharu and Warren, Jonathan and West, David B and Tocchini-Valentini, Glauco P and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Svenson, Karen L and Herault, Yann and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Urban, Barbara and Lund, Caroline and LaCasse, Taylor and Mehalow, Adrienne and Taft, Robert and Kutney, Peter and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and Weber, Bruno and Jacobs, Hughes and Ennah, Hamid and Ali-Hadji, Dalila and Wattenhofer-Donze, Marie and André, Philippe and Birling, Marie-Christine and Pavlovic, Guillaume and Sorg, Tania and Morse, Iva and Benso, Frank and Harrison, Jackie and Guo, Ruolin and Qu, Dawei and Spring, Shoshana and Ellegood, Jacob and Shang, Xueyuan and Feugas, Pat and Creighton, Amie and Penton, Patricia Castellanos and Danisment, Ozge and Griggs, Nicola and Tudor, Catherine L and Green, Angela L and Icoresi Mazzeo, Cecilia and Siragher, Emma and Lillistone, Charlotte and Gleeson, Diane and Sethi, Debarati and Bayzetinova, Tanya and Burvill, Jonathan and Habib, Bishoy and Maswood, Ryea and Woods, Michael and Grau, Evelyn and Sinclair, Caroline and Brown, Ellen and Ayabe, Shinya and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature (London), ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | Index Medicus | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
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2. Full Text Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes
by Mashiko, Daisuke and Young, Samantha A. M and Muto, Masanaga and Kato, Hirotaka and Nozawa, Kaori and Ogawa, Masaki and Noda, Taichi and Kim, Yeon‐Joo and Satouh, Yuhkoh and Fujihara, Yoshitaka and Ikawa, Masahito
Development, growth & differentiation, ISSN 0012-1592, 01/2014, Volume 56, Issue 1, pp. 122 - 129
knockout | Eucomm | International Knockout Mouse Consortium | International Mouse Phenotyping Consortium | Knockout mouse project, KOMP | Knockout | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Gene Targeting - methods | Animals | Mice, Mutant Strains | Humans | HEK293 Cells | Plasmids - genetics | Zygote - metabolism | Mutagenesis, Site-Directed - methods | Mice | Mutation - genetics | CRISPR-Cas Systems - genetics | Feasibility Studies | Animal genetics | Fluorescence | Genomics | Index Medicus
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3. Full Text Effects of long‐term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice
by Müller, Mike F and Zhou, Ying and Adams, David J and Arends, Mark J
The Journal of pathology, ISSN 0022-3417, 04/2017, Volume 241, Issue 5, pp. 649 - 660
alcohol | Aldh | colorectal cancer | intestine | proliferation | DNA damage | EUCOMM | acetaldehyde | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | DNA Damage - drug effects | Intestines - drug effects | Colorectal Neoplasms - enzymology | Acetaldehyde - metabolism | Ethanol - metabolism | Intestines - pathology | Acetaldehyde - toxicity | Ethanol - toxicity | Humans | Aldehyde Dehydrogenase - genetics | Genotype | Male | Carcinogenesis - drug effects | Homozygote | Carcinogens | Colorectal Neoplasms - etiology | Animals | Female | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Colorectal Neoplasms - pathology | Aldehyde Dehydrogenase - metabolism | Alcohol, Denatured | Analysis | Liver | Cytochrome P-450 | Colorectal cancer | Alcohol | Lymphomas | Tumor proteins | Epidemiology | Acetaldehyde | Index Medicus
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4. Full Text The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss
by Müller, Mike Freya and Kendall, Timothy James and Adams, David James and Zhou, Ying and Arends, Mark Johan
Experimental and molecular pathology, ISSN 0014-4800, 08/2018, Volume 105, Issue 1, pp. 63 - 70
Aldh | Hepatic steatosis | Non-alcoholic fatty lover disease | EUCOMM | Alcoholic liver disease | Acetaldehyde | Life Sciences & Biomedicine | Pathology | Science & Technology | Immunohistochemistry | Medical research | Liver | Alcohol | Development and progression | Disease susceptibility | Liver cancer | Alcohol, Denatured | Analysis | Medicine, Experimental | Oxidoreductases | Liver cirrhosis | Index Medicus
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5. Full Text Rapid knockout and reporter mouse line generation and breeding colony establishment using EUCOMM conditional-ready embryonic stem cells: A case study
by Coleman, James L. J and Brennan, Karen and Ngo, Tony and Balaji, Poornima and Graham, Robert M and Smith, Nicola J
Frontiers in endocrinology (Lausanne), ISSN 1664-2392, 2015, Volume 6, pp. 105 - 105
Inducible knockout | EUCOMM | Conditional knockout | Mouse model | Flp recombinase | C57BL/6 | Cre recombinase | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | mouse model | C57BL | conditional knockout | inducible knockout | Endocrinology | FLP recombinase
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6. Full Text 1- O-β- d-glucopyranosyleucommiol, an iridoid glucoside from Aucuba japonica
by Bernini, Romolo and Iavarone, Carlo and Trogolo, Corrado
Phytochemistry (Oxford), ISSN 0031-9422, 1984, Volume 23, Issue 7, pp. 1431 - 1433
Cornaceae | 1H and 13C NMR | eucomm | eucommiol | eucommioside II | Birch reduction | 1- O-β- d-glucopyranosyl eucommiol | Aucuba japonica | 1-O-β-d-glucopyranosyl eucommiol | H and | C NMR
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