X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry, organic (19) 19
alkaloids (16) 16
eudistomin u (13) 13
derivatives (12) 12
β-carboline (11) 11
beta-carboline (10) 10
eudistomin-u (10) 10
carbolines - chemistry (8) 8
index medicus (8) 8
pictet-spengler reaction (8) 8
carbolines - chemical synthesis (7) 7
analogs (6) 6
carbolines - pharmacology (6) 6
chemistry, medicinal (6) 6
chemistry, multidisciplinary (6) 6
article (5) 5
biological evaluation (5) 5
carbolines (5) 5
selenium dioxide oxidations (5) 5
structure-activity relationship (5) 5
aromatization (4) 4
biochemistry & molecular biology (4) 4
dehydrogenation (4) 4
design (4) 4
efficient synthesis (4) 4
humans (4) 4
molecular structure (4) 4
olivaceum (4) 4
synthesis (4) 4
acid (3) 3
alkynes (3) 3
antibacterial (3) 3
antitumor agents (3) 3
beta-carbolines (3) 3
bischler-napieralski reaction (3) 3
cell line, tumor (3) 3
chemistry (3) 3
cyclization (3) 3
eudistomins (3) 3
gamma-carbolines (3) 3
harmane (3) 3
isoeudistomin u (3) 3
isoeudistomin-u (3) 3
one-pot synthesis (3) 3
pot decarboxylative aromatization (3) 3
sarcoplasmic-reticulum (3) 3
tetrahydro-beta-carbolines (3) 3
β-carbolines (3) 3
adenosine (2) 2
animals (2) 2
anti-hiv (2) 2
anti-hiv agents (2) 2
antimalarial (2) 2
antineoplastic agents - chemical synthesis (2) 2
antineoplastic agents - chemistry (2) 2
antineoplastic agents - pharmacology (2) 2
aporphines (2) 2
arylation (2) 2
beta-carboline alkaloids (2) 2
bischler–napieralski reaction (2) 2
caffeine (2) 2
calcium release (2) 2
catalysis (2) 2
cell line (2) 2
cycloaromatization (2) 2
decarboxylative aromatization (2) 2
dose-response relationship, drug (2) 2
drug discovery (2) 2
efficient (2) 2
eudistomin-t (2) 2
heterocycles (2) 2
homoaporphines (2) 2
hyrtiosulawesine (2) 2
inducer (2) 2
iodine (2) 2
mass spectrometry (2) 2
organic chemistry (2) 2
palladium catalysis (2) 2
pictet–spengler reaction (2) 2
room-temperature (2) 2
sar (2) 2
tetra-n-butylammonium bromide (2) 2
tetrahydro-beta-carboline (2) 2
tetrahydro-β-carboline (2) 2
tryptophan (2) 2
unified approach (2) 2
全合成 (2) 2
-harmicine (1) 1
1--9h-pyrido (1) 1
1--9h-pyrido[3,4-b]indole (1) 1
1-phenethyltetrahydroisoquinolines (1) 1
19-bromoisoeudistomin u (1) 1
2,3,7,8-tetrachlorodibenzo-p-dioxin (1) 1
2-b]carbazole (1) 1
3,4-dihydro-beta-carboline (1) 1
3,4-dihydro-β-carboline (1) 1
3-indole (1) 1
4-b]indole (1) 1
5-ht1a dual-agonist (1) 1
6-formylindolo (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2016, Volume 26, Issue 19, pp. 4705 - 4708
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 10/2015, Volume 56, Issue 44, pp. 6012 - 6015
Reductive Pictet Spengler cyclization was used for the synthesis of naturally occurring β-carbolines, eudistomin U, and canthine. Other biologically important... 
Eudistomin U | Reductive Pictet Spengler cyclization | (±)-Harmicine | Canthine | SYNTHASE | (+/-)-Harmicine | NITRILES | CHEMISTRY, ORGANIC | ALKALOIDS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2018, Volume 59, Issue 25, pp. 2387 - 2392
Temperature controlled chemoselective dehydrogenation and aromatization of tetrahydro- -carbolines, using molecular I and H O , in DMSO solvent affords a... 
Aromatization | Carbolines | Dehydrogenation | Iodine | Kumujian-C | Eudistomin-U | ROOM-TEMPERATURE | DESIGN | FORMAL SYNTHESIS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | CARBAZOLE ALKALOIDS | HETEROCYCLES | BIOLOGICAL EVALUATION | DERIVATIVES | UTILITY | CYCLIZATION
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2014, Volume 24, Issue 15, pp. 3549 - 3551
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2018, Volume 157, pp. 333 - 338
Thirty-two new 3,9-disubstituted eudistomin U derivatives were designed and synthesized based on computer-aided drug discovery (CADD). Sixteen... 
Eudistomin U | Design | Synthesis | Antibacterial | Molecular docking | Mechanism | DNA-BINDING | CHEMISTRY, MEDICINAL | SERIES | ANALOGS | GYRASE | IN-VITRO | BIOLOGICAL EVALUATION | RESISTANCE | Drugs | Antiviral agents | Drug discovery | Ciprofloxacin | Anti-HIV agents
Journal Article
Tetrahedron, ISSN 0040-4020, 08/2014, Volume 70, Issue 33, pp. 4910 - 4920
A series of 1-indolyl substituted β-carbolines including the natural products hyrtiosulawesine, pityriacitrin and pityriacitrin B were prepared via... 
Pityriacitrin | Eudistomin U | Hyrtiosulawesine | Antimalarial | β-Carboline | Pictet–Spengler reaction | Pictet-Spengler reaction | ACID | PACIFIC MARINE SPONGES | YEAST MALASSEZIA-FURFUR | CHEMISTRY, ORGANIC | ISOEUDISTOMIN U | beta-Carboline | INDOLE-DERIVATIVES | HYRTIOS | EUDISTOMIN-T | CYCLIZATION | ALKALOIDS | Panels | Biotechnology | Natural products | Tumours | Condensing | Colon | Biological | Aldehydes
Journal Article
Tetrahedron, ISSN 0040-4020, 06/2015, Volume 71, Issue 22, pp. 3637 - 3641
A novel route was developed for the C3-formation of indoles using iodine as the catalyst. This transformation involves the cleavage of the C–N bond of tertiary... 
Tertiary amine | Aerobic | Formylation | Iodine-catalyzed | TRANSFORMATION | ACYLATION | CHEMISTRY, ORGANIC | ISOEUDISTOMIN U | CYANATION | EUDISTOMIN-U | ANNULATED GAMMA-CARBOLINES | GREEN CHEMISTRY | ALKALOIDS | CHLORIDE | Amines
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 03/2019, Volume 60, Issue 11, pp. 800 - 804
Organic base DBN has been identified as an efficient reagent for promoting the dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines under... 
Aromatization | β-Carboline | Dehydrogenation | Decarboxylation | NORHARMANE | DESIGN | POT DECARBOXYLATIVE AROMATIZATION | HARMANE | CHEMISTRY, ORGANIC | beta-Carboline | DERIVATIVES | EUDISTOMIN U | N-HETEROCYCLES
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 04/2017, Volume 82, Issue 8, pp. 4328 - 4335
A cross-coupling/reductive cyclization protocol has been employed in a unified approach to all four carbolines. So, for example, the 2-nitropyridine 8, which... 
ONE-POT SYNTHESIS | ANALOGS | COUPLING STRATEGY | NATURAL-PRODUCTS | ARYLATION | CATALYZED AMINATION | CHEMISTRY, ORGANIC | ANTI-HIV | ARYL AZIDES | DERIVATIVES | EUDISTOMIN U | Palladium catalysts | Chemical reactions | Ring formation (Chemistry) | Research | Analysis
Journal Article
Chemical Communications, ISSN 1359-7345, 06/2011, Volume 47, Issue 23, pp. 6656 - 6658
A flexible approach towards substituted beta- and gamma-carbolines based on transition metal catalysed [2 + 2 + 2] cycloaddition reactions between... 
EUDISTOMIN-U | VERSATILE | N-FUNCTIONALIZED 1-ALKYNYLAMIDES | ALKYNES | DERIVATIVES | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY | FLEXIBLE SYNTHESIS | ALKALOIDS | Carbolines - chemical synthesis | Carbolines - chemistry | Cyclization | Formates - chemistry | Alkynes - chemistry | Catalysis | Ruthenium - chemistry | Rhodium - chemistry
Journal Article
Tetrahedron, ISSN 0040-4020, 12/2016, Volume 72, Issue 52, pp. 8537 - 8541
A synthetic strategy was developed for the preparation of β-carbolines by one-pot decarboxylation and aromatization of tetrahydro-β-carboline-3-carboxylic... 
Tetrahydro-β-carboline | Decarboxylative aromatization | β-Carboline | Hydrogen peroxide | Iodine | MARINE BRYOZOAN | BENZODIAZEPINE RECEPTOR | ROOM-TEMPERATURE | CHEMISTRY, ORGANIC | beta-Carboline | Tetrahydro-beta-carboline | HUMAN MONOAMINE-OXIDASE | SELENIUM DIOXIDE OXIDATIONS | A-C | DERIVATIVES | METAL-FREE | EUDISTOMIN U | ALKALOIDS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 03/2016, Volume 57, Issue 9, pp. 1040 - 1043
Herein, we report a facile synthesis of 3,4-dihydro-β-carbolines and aromatic β-carbolines from tetrahydro-β-carbolines, mediated by -bromosuccinimide in... 
Tetrahydro-β-carboline | 3,4-Dihydro-β-carboline | β-Carboline | Harmine | N-Bromosuccinimide | FLAZINAMIDE | ANALOGS | CHEMISTRY, ORGANIC | beta-Carboline | Tetrahydro-beta-carboline | PERUVIAN-UNA | AROMATIZATION | ANTIMALARIAL | HARMALOL | EUDISTOMIN-U | 3,4-Dihydro-beta-carboline | SELENIUM DIOXIDE OXIDATIONS | DERIVATIVES | ALKALOIDS | Tetrahedrons | Toluene | Synthesis
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2013, Volume 54, Issue 48, pp. 6599 - 6601
The synthesis of β-carbolines is a mature field, yet new methods are desirable to introduce new functionality onto the core scaffold. We describe the... 
Sonogashira coupling | β-Carboline | Heteroannulation | Cyclotrimerization | Palladium catalysis | ROUTE | GAMMA-CARBOLINES | CHEMISTRY, ORGANIC | beta-Carboline | ALKYNES | IMINOANNULATION | EUDISTOMIN-U | EFFICIENT | DERIVATIVES | ALKALOIDS | palladium catalysis | cyclotrimerization | β-carboline | heteroannulation
Journal Article
ChemistrySelect, ISSN 2365-6549, 09/2017, Volume 2, Issue 28, pp. 9162 - 9167
An operationally simple and efficient protocol has been devised for the synthesis of various β‐carbolines using TCCA as a mild oxidant at ambient temperature.... 
β-carbolines | Eudistomins | Trichloroisocyanuric acid | Dehydrogenation | Oxidative Decarboxylation | OLIVACEUM | ANALOGS | EFFICIENT SYNTHESIS | ANTIBACTERIAL | BENZODIAZEPINE-RECEPTORS | CHEMISTRY, MULTIDISCIPLINARY | beta-carbolines | ANTITUMOR AGENTS | SELENIUM DIOXIDE OXIDATIONS | DERIVATIVES | BINDING | ALKALOIDS
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 03/2017, Volume 2017, Issue 9, pp. 1277 - 1280
Journal Article
Chinese Chemical Letters, ISSN 1001-8417, 08/2019, Volume 30, Issue 8, pp. 1541 - 1544
A mild and efficient Bu NBr-mediated oxidative cycloaromatization to prepare -carbolines from readily available tryptophans and aldehydes is described. The... 
Tryptophan | TBAB | Carbolines | Tetra-n-butylammonium bromide | Cycloaromatization | PICTET-SPENGLER REACTION | POT DECARBOXYLATIVE AROMATIZATION | GAMMA-CARBOLINES | H BOND FUNCTIONALIZATION | CHEMISTRY, MULTIDISCIPLINARY | UNIFIED APPROACH | HARMANE | BIOLOGICAL EVALUATION | C-H | EUDISTOMIN U | ALKALOIDS
Journal Article
CHINESE JOURNAL OF ORGANIC CHEMISTRY, ISSN 0253-2786, 08/2019, Volume 39, Issue 8, pp. 2323 - 2327
A mild and efficient (Bu4NBr)-Bu-n-mediated oxidative cycloaromatization to prepare beta-carbolines from readily available tryptophans and N-methylaniline is... 
DESIGN | N-methylaniline | PICTET-SPENGLER REACTION | POT DECARBOXYLATIVE AROMATIZATION | tetra-n-butylammonium bromide | GAMMA-CARBOLINES | CHEMISTRY, ORGANIC | ALPHA | UNIFIED APPROACH | HARMANE | BIOLOGICAL EVALUATION | beta-carboline | cycloaromatization | EUDISTOMIN U | ALKALOIDS
Journal Article