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Oncotarget, ISSN 1949-2553, 05/2019, Volume 10, Issue 36, p. 3385
Metastatic and relapsed Ewing sarcoma typically afflicts the adolescent population and is largely fatal. These bone tumors are most commonly driven by the... 
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 9/2015, Volume 21, Issue 18, pp. 4184 - 4193
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 08/2019, Volume 25, Issue 16, pp. 5167 - 5176
Purpose: Transcription factors are commonly deregulated in cancer, and they have been widely considered as difficult to target due to their nonenzymatic... 
CELLS | ONCOLOGY | SMALL NUCLEOLAR RNAS | PROTEIN EWS-FLI1 | LENALIDOMIDE | ANTITUMOR-ACTIVITY | COMBINATION | TRANSCRIPTION FACTOR | EXPRESSION | SYNERGIZES | GENOME
Journal Article
Neoplasia, ISSN 1476-5586, 08/2019, Volume 21, Issue 8, pp. 740 - 751
Myxoid liposarcoma is a malignant lipogenic tumor that develops in deep soft tissues. While local control rates are good, current chemotherapy options remain... 
TRANSFORMATION | REARRANGEMENT | DOMAIN | ONCOLOGY | ONCOGENIC FUSION | EWS-FLI1 | BAF COMPLEXES | GENES | CHOP | CANCER | RNA-BINDING PROTEIN
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 18, pp. 14428 - 14443
Ewing's sarcoma (ES) is the second-most frequent pediatric bone tumor. Chromosomal translocation t(11;22)(q24:q12) results in the formation of EWS/FLI1 gene... 
Ewing's sarcoma (ES) | XBP1 | EWS/FLI1 | Proteomics | Unfolded protein response (UPR)
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 10/2019, Volume 47, Issue 18, pp. 9619 - 9636
Abstract Connections between epigenetic reprogramming and transcription or splicing create novel mechanistic networks that can be targeted with tailored... 
EWINGS-SARCOMA | CHROMATIN | RNA HELICASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN EWS-FLI1 | EWS/FLI-1 FUSION | GENE-REGULATION | BLOCKING | BINDING | CANCER | PREDICTION | Index Medicus
Journal Article
Japanese Journal of Gastroenterological Surgery, ISSN 0386-9768, 2017, Volume 50, Issue 11, pp. 872 - 879
Journal Article
Oncogene, ISSN 0950-9232, 5/2011, Volume 30, Issue 18, pp. 2173 - 2180
EWS-FLI1 is a chromosome translocation-derived chimeric transcription factor that plays a central and rate-limiting role in the pathogenesis of Ewing’s... 
mir-145 | EWS-FLI1 | Ewing’s Sarcoma | microRNA
Journal Article
Cell, ISSN 0092-8674, 09/2017, Volume 171, Issue 1, pp. 163 - 178.e19
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 148 - 160
The Hedgehog (Hh) pathway is activated in some human cancers, including medulloblastoma The glioma-associated oncogene homolog (GLI) transcription factors are... 
INTRAFLAGELLAR TRANSPORT PROTEINS | MEDICINE, RESEARCH & EXPERIMENTAL | KAPPA-B ACTIVATION | EWINGS-SARCOMA FAMILY | INDUCED APOPTOSIS | SONIC HEDGEHOG | EWS-FLI1 ONCOPROTEIN | REPRESSOR FUNCTIONS | HUMAN HOMOLOG | ACUTE PROMYELOCYTIC LEUKEMIA | PRIMARY CILIA | Neoplasm Transplantation | Oncogene Proteins - genetics | Gene Expression - drug effects | Humans | Sarcoma, Ewing - pathology | Transplantation, Heterologous | DNA Primers - genetics | Recombinant Fusion Proteins - metabolism | Base Sequence | Medulloblastoma - pathology | Smoothened Receptor | Trans-Activators - genetics | Antineoplastic Agents - pharmacology | Sarcoma, Ewing - metabolism | Arsenicals - pharmacology | Oncogene Proteins - metabolism | Mice, Transgenic | Medulloblastoma - metabolism | Hedgehog Proteins - antagonists & inhibitors | Mice, SCID | Hep G2 Cells | Oncogene Proteins - antagonists & inhibitors | Sarcoma, Ewing - drug therapy | Oxides - pharmacology | Animals | Signal Transduction - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Trans-Activators - antagonists & inhibitors | Medulloblastoma - drug therapy | Physiological aspects | Genetic aspects | Research | Growth | Oncogenes | Cancer cells
Journal Article
Pathology, ISSN 0031-3025, 10/2019, Volume 51, Issue 6, pp. 605 - 609
Ewing sarcoma (ES) is the second most common primary malignant bone tumour, mainly occurs in children and adolescents, and has an overwhelming mortality.... 
EGR1 | Ewing sarcoma | EWS-FLI1 | IGF1R | PATHWAYS | PATHOLOGY | P53 | FACTOR EGR-1 | MUTATION | MOLECULAR PATHOGENESIS | FACTOR-I RECEPTOR | TRANSCRIPTION FACTOR | EXPRESSION
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2015, Volume 5
Ewing sarcoma family of tumors are aggressive bone malignancies that affect children and young adults. Ewing sarcoma is the second most common primary bone... 
DAX-1 | Ewing sarcoma | EWS/FLI1 | LOX | CCK | FOXM1 | GLI1 | FOXO1 | EWS/Fli1 | FoxM1
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2010, Volume 28, Issue 12, pp. 1982 - 1988
Journal Article
Oncotarget, ISSN 1949-2553, 11/2017, Volume 8, Issue 55, pp. 94780 - 94792
Treatment failure in high risk neuroblastoma (NB) is largely due to the development of chemotherapy resistance. We analyzed the gene expression changes... 
YK-4-279 | Chemotherapy | Neuroblastoma | EWSR1 | Doxorubicin | REGRESSION | EWINGS-SARCOMA | CELLS | ACTIVATION | neuroblastoma | chemotherapy | TUMORS | STRATEGIES | FAMILY | CELL BIOLOGY | TRANSCRIPTS | THERAPY | PROTEIN EWS-FLI1 | doxorubicin
Journal Article
Genes and Development, ISSN 0890-9369, 08/2018, Volume 32, Issue 15-16, pp. 991 - 992
Journal Article