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MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 05/2019, Volume 17, Issue 5, pp. 1024 - 1035
Aberrant activation of the Hedgehog signaling pathway has been linked to the formation of numerous cancer types, including the myogenic soft tissue sarcoma,... 
EWINGS-SARCOMA | ALVEOLAR RHABDOMYOSARCOMAS | ORIGIN | GENE | ONCOLOGY | MICE | TRANSCRIPTIONAL TARGET | CELL | PRECURSORS | CD99 | EWS/FLI | CELL BIOLOGY
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2019, Volume 294, Issue 29, pp. 11286 - 11296
FUS and EWSR1 are RNA-binding proteins with prion-like domains (PrLDs) that aggregate in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).... 
TLS-CHOP | translocation | sarcoma | TERMINAL DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-SYNUCLEIN TOXICITY | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | GRANULES | heat shock protein (HSP) | chromosomal translocation | FUS-CHOP | RNA-BINDING PROTEINS | FET PROTEINS | chaperone | Hsp104 | protein aggregation | cancer | EWS-FLI | AGGREGATION
Journal Article
Genes and Cancer, ISSN 1947-6019, 11/2013, Volume 4, Issue 11-12, pp. 486 - 500
The vast majority of cancer-related deaths are attributable to metastasis. Effective treatment of metastatic disease will be improved by a better understanding... 
Ewing sarcoma | ZEB2 | metastasis | EMT | EWS/FLI | EWS | FLI | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2017, Volume 114, Issue 37, pp. 9870 - 9875
Ewing sarcoma usually expresses the EWS/FLI fusion transcription factor oncoprotein. EWS/FLI regulates myriad genes required for Ewing sarcoma development.... 
TRANSFORMATION | TRANSLOCATION | Ewing sarcoma | PROTEIN | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | FUSION GENE | transcriptional activation | FAMILY | microsatellites | ELEMENTS | EWS/FLI fusion | EXPRESSION | Physiological aspects | Binding proteins | Health aspects | Ewing's sarcoma | EWS | Biological Sciences | FLI fusion
Journal Article
Genes and Cancer, ISSN 1947-6019, 02/2012, Volume 3, Issue 2, pp. 102 - 116
Ewing sarcoma is a tumor of the bone and soft tissue caused by the expression of a translocation-derived oncogenic transcription factor, EWS/FLI. Overt... 
Ewing sarcoma | cytoskeleton | metastasis | cell adhesion | EWS/FLI | EWS | FLI | Review
Journal Article
Journal Article
Genes and Cancer, ISSN 1947-6019, 2015, Volume 6, Issue 3-4, pp. 129 - 143
In Ewing sarcoma, NKX2-2 is a critical activated target of the oncogenic transcription factor EWS/FLI that is required for transformation. However, its... 
Ewing sarcoma | Adhesion | EWS/FLI | Mesenchymal | NKX2-2 | EWS | FLI | mesenchymal | Research Paper | adhesion
Journal Article
Oncogene, ISSN 0950-9232, 2013, Volume 32, Issue 42, pp. 5089 - 5100
Ewing sarcoma provides an important model for transcription-factor-mediated oncogenic transformation because of its reliance on the ETS-type fusion oncoprotein... 
Ewing sarcoma | Repression | Transcription | NuRD | EWS/FLI | PROTEIN-PROTEIN | TARGET | TRANSFORMATION | CELLS | DNA-BINDING | transcription | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEDIATRIC SOLID TUMORS | FUSION GENE | CELL BIOLOGY | ONCOLOGY | RESPONSE ELEMENTS | GENETICS & HEREDITY | repression | EXPRESSION | REVEALS | Oncogene Proteins, Fusion - metabolism | Humans | Gene Expression Regulation, Neoplastic | Sarcoma, Ewing - pathology | Co-Repressor Proteins - metabolism | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism | Bone Neoplasms - pathology | Histone Demethylases - genetics | Cell Transformation, Neoplastic - genetics | Proto-Oncogene Protein c-fli-1 - metabolism | Transcription, Genetic | Bone Neoplasms - genetics | Genes, Tumor Suppressor | Protein Structure, Tertiary | Proto-Oncogene Protein c-fli-1 - genetics | RNA-Binding Protein EWS - genetics | Histone Deacetylases - metabolism | RNA-Binding Protein EWS - metabolism | Co-Repressor Proteins - genetics | Xenograft Model Antitumor Assays | Histone Demethylases - metabolism | Animals | Mice, Nude | Oncogene Proteins, Fusion - genetics | Protein-Lysine 6-Oxidase - metabolism | Cell Line, Tumor | Protein-Lysine 6-Oxidase - genetics | Sarcoma, Ewing - genetics | Genetic aspects | Genetic transcription | Research | Carcinogenesis | Ewing's sarcoma | Testing | Cancer | Proteins | Cellular biology | Gene expression | EWS | FLI
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 951 - 12
Ewing sarcoma is the second most common pediatric bone and soft tissue tumor presenting with an aggressive behavior and prevalence to metastasize. The... 
SKELETAL-MUSCLE | GENOMIC LANDSCAPE | INHIBITION | PROTEASOMAL DEGRADATION | MULTIDISCIPLINARY SCIENCES | FUSION PROTEIN | GENE-EXPRESSION | TARGET GENE | CANCER | EWS/FLI | ONCOGENIC TRANSCRIPTION FACTOR | Ubiquitin | Proteins | Cell survival | Sarcoma | Tumor cells | siRNA | FLI1 protein | Fusion protein | FLI-1 protein | Ewing's sarcoma | Protein turnover
Journal Article
Oncogene, ISSN 0950-9232, 02/2001, Volume 20, Issue 5, pp. 626 - 633
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2016, Volume 22, Issue 16, pp. 4105 - 4118
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2014, Volume 124, Issue 12, pp. 5275 - 5290
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2018, Volume 33, Issue 2, pp. 202 - 216.e6
Journal Article
PROTEOMICS – Clinical Applications, ISSN 1862-8346, 05/2019, Volume 13, Issue 3, pp. e1700130 - n/a
Ewing's sarcoma is an extremely rare mesenchymal malignancy of the bone, which predominantly occurs in children and young adolescents. Ewing's sarcoma is... 
biomarker | EWS‐FLI‐1 | Ewing's sarcoma | EWS-FLI-1 | Sarcoma | Proteomics | EWS protein | Adolescence | Transcription factors | Mesenchyme | Tumor cells | Secretion | Therapeutic applications | Malignancy | Drug resistance | Drug development | Chromosome translocations | Biomarkers |