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1. Full Text Including ligand‐induced protein flexibility into protein tunnel prediction
by Kingsley, Laura J and Lill, Markus A
Journal of Computational Chemistry, ISSN 0192-8651, 09/2014, Volume 35, Issue 24, pp. 1748 - 1756
In proteins with buried active sites, understanding how ligands migrate through the tunnels that connect the exterior of the protein to the active site can... 
tunnel prediction | steered molecular dynamics | umbrella sampling | conformational ensemble | potential of mean force | induced fit | protein flexibility | cytochrome P450 2B6 | MOLECULAR-DYNAMICS | CRYSTAL-STRUCTURE | DRUG DISCOVERY | CHEMISTRY, MULTIDISCIPLINARY | MAMMALIAN CYTOCHROME P450S | BURIED ACTIVE-SITE | BIOMACROMOLECULAR CHANNELS | ACCESS CHANNELS | SUBSTRATES ENTER | PRODUCTS EXIT | EFFICIENT | Protein Structure, Tertiary | Catalytic Domain | Protein Structure, Secondary | Humans | Imidazoles - chemistry | Substrate Specificity | Molecular Dynamics Simulation | Thermodynamics | Algorithms | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Cytochrome P-450 CYP2B6 - chemistry | Tunnel prediction
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2. Full Text Oblique tunnel portal effects on train and tunnel aerodynamics based on moving model tests
by Zhang, Jian and Zhang, Lei and Yang, Ming-zhi and Liang, Xi-feng
Journal of Wind Engineering & Industrial Aerodynamics, ISSN 0167-6105, 08/2017, Volume 167, pp. 128 - 139
The objective of this study was to investigate the effects of oblique tunnel portals on train and tunnel aerodynamics using a 1:20 scale moving model device.... 
High-speed train | Micro-pressure wave | Oblique tunnel portal | Pressure gradient | Moving model device | NUMBER | RAPID CALCULATION | COMPRESSION WAVE | VENTED HOOD | MICRO-PRESSURE WAVES | ENGINEERING, CIVIL | MECHANICS | NOSE | EXIT | Aerodynamics | Sensors | Analysis | Tunnels
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3. Full Text Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates
by Lu, Jianli and Deutsch, Carol
Journal of Molecular Biology, ISSN 0022-2836, 12/2008, Volume 384, Issue 1, pp. 73 - 86
Electrostatic potentials along the ribosomal exit tunnel are nonuniform and negative. The significance of electrostatics in the tunnel remains relatively... 
translation | peptide elongation | electrostatics | nascent peptide | S4 transmembrane segment | ENDOPLASMIC-RETICULUM MEMBRANE | SHAKER K+ CHANNEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | TRANSLATION ELONGATION | TRYPTOPHAN INDUCTION | EXIT TUNNEL | IN-VITRO | MESSENGER-RNA | SIGNAL RECOGNITION PARTICLE | Amino Acid Sequence | Peptide Chain Elongation, Translational | Potassium Channels, Voltage-Gated - chemistry | Peptides - chemistry | Peptides - genetics | Ribosomes - chemistry | Molecular Sequence Data | Ribosomes - metabolism | Static Electricity | Thermodynamics | Peptides - metabolism | Potassium Channels, Voltage-Gated - metabolism | Time Factors | RNA, Messenger | Amino Acid Substitution | Potassium Channels, Voltage-Gated - genetics | Peptides | Lysine | Tunnels | Kv channels
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4. Full Text Protein Folding at the Exit Tunnel
by Fedyukina, Daria V and Cavagnero, Silvia
Annual Review of Biophysics, ISSN 1936-122X, 6/2011, Volume 40, Issue 1, pp. 337 - 359
Over five decades of research have yielded a large body of information on how purified proteins attain their native state when refolded in the test tube,... 
ribosome | molecular chaperones | ribosomal exit tunnel | ribosome-bound nascent chain | nascent protein | molecular crowding | POLYPEPTIDE-CHAINS | TRIGGER FACTOR | NMR-SPECTROSCOPY | NASCENT CHAIN COMPLEXES | ANGSTROM RESOLUTION | TRANSLATING RIBOSOMES | BIOPHYSICS | RIBOSOME-ASSOCIATED CHAPERONES | IN-VIVO | STAPHYLOCOCCAL NUCLEASE | STRUCTURE ACQUISITION | Models, Chemical | Computer Simulation | Models, Molecular | Protein Conformation | Proteins - chemistry | Protein Folding | Proteins - ultrastructure | Biomechanics | Physiological aspects | Polypeptides | Research | Protein folding | Ribosomes
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5. Full Text Small protein domains fold inside the ribosome exit tunnel
by Marino, Jacopo and Heijne, Gunnar and Beckmann, Roland and Institutionen för biokemi och biofysik and Naturvetenskapliga fakulteten and Stockholms universitet and Science for Life Laboratory (SciLifeLab)
FEBS Letters, ISSN 0014-5793, 03/2016, Volume 590, Issue 5, pp. 655 - 660
Cotranslational folding of small protein domains within the ribosome exit tunnel may be an important cellular strategy to avoid protein misfolding. However,... 
GFP | cotranslational protein folding | translational arrest | ribosome exit tunnel | SecM | fast‐folding domains | fast-folding domains | IN-VITRO | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Protein Structure, Tertiary | Transcription Factors - metabolism | Animals | Molecular Weight | Escherichia coli Proteins - biosynthesis | Escherichia coli - metabolism | Models, Molecular | Ribosomes - metabolism | Escherichia coli Proteins - metabolism | Escherichia coli - cytology | Escherichia coli Proteins - chemistry | Protein Folding | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
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6. Full Text Social influence in a virtual tunnel fire – Influence of conflicting information on evacuation behavior
by Kinateder, Max and Müller, Mathias and Jost, Michael and Mühlberger, Andreas and Pauli, Paul
Applied Ergonomics, ISSN 0003-6870, 11/2014, Volume 45, Issue 6, pp. 1649 - 1659
Evacuation from a smoke filled tunnel requires quick decision-making and swift action from the tunnel occupants. Technical installations such as emergency... 
Social influence | Tunnel evacuation | Virtual reality | RISK PERCEPTION | EXIT CHOICE | DESIGN | REALITY | ACCIDENTS | PSYCHOLOGY, APPLIED | ROAD-TUNNEL | TIME | ERGONOMICS | SPEED | RESPONSES | MOVEMENT | ENGINEERING, INDUSTRIAL | Decision Making | User-Computer Interface | Computer Simulation | Fires | Humans | Mass Behavior | Emergencies | Spatial Navigation | Task Performance and Analysis | Evacuation of civilians | Analysis | Tunnels
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7. Full Text The Geometry of the Ribosomal Polypeptide Exit Tunnel
by Voss, N.R and Gerstein, M and Steitz, T.A and Moore, P.B
Journal of Molecular Biology, ISSN 0022-2836, 2006, Volume 360, Issue 4, pp. 893 - 906
The geometry of the polypeptide exit tunnel has been determined using the crystal structure of the large ribosomal subunit from . The tunnel is a component of... 
ribosome | solvent content | geometry | exit tunnel | COMPLEX | PROTEIN | RNA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANGSTROM-RESOLUTION | TRANSLATING RIBOSOME | ALPHA-HELICES | MOLECULAR RECOGNITION | NASCENT PEPTIDE | SUBUNIT | Haloarcula marismortui - chemistry | Solvents | Peptides - chemistry | Surface Properties | Ribosomes - chemistry | Water - chemistry | Chaperonins - chemistry | Models, Molecular | Polypeptides | Structure | Biopolymers | Crystals | Tunnels
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8. Full Text Macrolide antibiotics in the ribosome exit tunnel: species‐specific binding and action
by Kannan, Krishna and Mankin, Alexander S
Annals of the New York Academy of Sciences, ISSN 0077-8923, 12/2011, Volume 1241, Issue 1, pp. 33 - 47
Macrolide antibiotics bind in the nascent peptide exit tunnel of the ribosome and inhibit protein synthesis. The majority of information on the principles of... 
posttranscriptional modifications | ribosome | protein synthesis | nascent peptide exit tunnel | macrolide | Nascent peptide exit tunnel | Posttranscriptional modifications | Ribosome | Protein synthesis | Macrolide | ESCHERICHIA-COLI RIBOSOME | MULTIDISCIPLINARY SCIENCES | MICROBIOLOGY | PROTEIN-SYNTHESIS | CONFERRING RESISTANCE | ERYTHROMYCIN-RESISTANT MUTANTS | STREPTOCOCCUS-PNEUMONIAE | STRUCTURAL BASIS | PEPTIDYL TRANSFERASE CENTER | NASCENT PEPTIDE | TRANSFER-RNA | HELICOBACTER-PYLORI | Bacteria - metabolism | Ribosome Subunits, Large, Bacterial - metabolism | Species Specificity | Humans | Bacteria - drug effects | Ribosomes - chemistry | Models, Molecular | Ribosomes - metabolism | Anti-Bacterial Agents - metabolism | Macrolides - metabolism | Deinococcus - metabolism | Ribosome Subunits, Large, Bacterial - drug effects | Macrolides - chemistry | Ribosome Subunits, Large, Bacterial - chemistry | Anti-Bacterial Agents - chemistry | Ribosomes - drug effects | Macrolides - pharmacology | Anti-Bacterial Agents - pharmacology | Deinococcus - drug effects | Drug Resistance, Bacterial - genetics | Binding Sites | Drug resistance in microorganisms | Peptides | Antibiotics | Analysis | Protein biosynthesis | Chemical properties | Tunnels | Proteins
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9. Full Text Case Series: Pediatric Shunt Tunnel Catheter Infection
by Pease, Matthew and Dewan, Sheri and Greene, Stephanie
Pediatric Neurosurgery, ISSN 1016-2291, 09/2018, Volume 53, Issue 5, pp. 342 - 345
Shunt infections are common pediatric neurosurgical cases with high morbidity that almost always requires surgical removal of the shunt, external ventricular... 
Novel Insights from Clinical Practice | Tunnel infection | Shunt infection | Shunt tunnel | Shunt catheter-related infection | SURGERY | CEREBROSPINAL-FLUID SHUNT | MANAGEMENT | RISK | EXIT-SITE | CLINICAL NEUROLOGY | PERITONITIS | VENTRICULOPERITONEAL SHUNT | SILICONE ALLERGY | PEDIATRICS | Humans | Ventriculoperitoneal Shunt - adverse effects | Child, Preschool | Hydrocephalus - complications | Catheter-Related Infections - drug therapy | Anti-Bacterial Agents - therapeutic use | Hydrocephalus - surgery | Catheter-Related Infections - microbiology | Catheters, Indwelling - adverse effects | Female | Catheter-Related Infections - diagnosis | Neurosurgical Procedures - methods | Retrospective Studies
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10. Research on the Mode of Single-track Tunnel or Double-track Tunnel of Super-long Railway Tunnel
by Liu, Cheng
Journal of Railway Engineering Society, ISSN 1006-2106, 09/2018, Volume 35, Issue 9, pp. 49 - 66
Two single-track tunnels | Cross passage | Evacuation | One double-track tunnel | Railway tunnel | Emergent rescue station under the fire conditions | Emergency exit
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11. Full Text Exit site and tunnel infections in children on chronic peritoneal dialysis: findings from the Standardizing Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) Collaborative
by Swartz, Sarah J and Neu, Alicia and Skversky Mason, Amy and Richardson, Troy and Rodean, Jonathan and Lawlor, John and Warady, Bradley and Somers, Michael J.G
Pediatric Nephrology, ISSN 0931-041X, 6/2018, Volume 33, Issue 6, pp. 1029 - 1035
The Standardizing Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) Collaborative is a quality improvement initiative to reduce... 
Pediatrics | Nephrology | Medicine & Public Health | Exit site infection | Tunnel infection | Children | Urology | Peritoneal dialysis | UROLOGY & NEPHROLOGY | RISK | PEDIATRICS | ACCESS | Catheter-Related Infections - etiology | Guideline Adherence - statistics & numerical data | Follow-Up Studies | Standard of Care | United States | Humans | Risk Factors | Child, Preschool | Infant | Male | Catheter-Related Infections - therapy | Incidence | Kidney Failure, Chronic - therapy | Young Adult | Peritoneal Dialysis - adverse effects | Quality Improvement | Adolescent | Catheters, Indwelling - adverse effects | Female | Catheter-Related Infections - epidemiology | Child | Care and treatment | Usage | Chronic kidney failure | Patient outcomes | Hospital care | Management | Continuous ambulatory peritoneal dialysis | Pediatric research | Risk factors | Etiology | Collaboration | Quality control | Infections | Kidney diseases | Epidemiology | Peritonitis | Peritoneum
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12. Full Text The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling
by Wilson, Daniel N and Beckmann, Roland
Current Opinion in Structural Biology, ISSN 0959-440X, 2011, Volume 21, Issue 2, pp. 274 - 282
As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit and emerges at the solvent side where... 
EXIT TUNNEL | ANGSTROM RESOLUTION | OPEN READING FRAME | BACTERIAL RIBOSOME | EUKARYOTIC RIBOSOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARGININE ATTENUATOR PEPTIDE | HUMAN CYTOMEGALOVIRUS | SIGNAL RECOGNITION PARTICLE | CRYO-EM | TRANSFER-RNA | CELL BIOLOGY | Protein Biosynthesis | Peptides - metabolism | Nucleocapsid - metabolism | Computer Simulation | Gene Expression Regulation | Ribosomes - chemistry | Models, Molecular | Protein Binding | Ribosomes - metabolism | Protein Conformation | Protein Folding
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