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The Oncologist, ISSN 1083-7159, 04/2016, Volume 21, Issue 4, pp. 481 - 486
摘要 背景 . 非小细胞肺癌 (NSCLC) 包含的特异性遗传改变可能对靶向疗法高度敏感。 材料与方法 . 我们对 54 例不同疾病分期且从不吸烟、无驱动突变的 NSCLC 患者进行了靶基因重排检测。由于 MET 外显子 14 跳读是最常见的改变, 因此我们当前的分子谱板纳入了这一改变。本研究特别调查了麻省总院... 
Targeted therapy | MET | Lung cancer | exon 14 skipping | MET exon 14 skipping | GEFITINIB | RESPONSIVENESS | ACTIVATION | SENSITIVITY | TUMORS | INHIBITION | GENE | ONCOLOGY | CRIZOTINIB | MUTATIONS | Carcinoma, Non-Small-Cell Lung - pathology | Smoking - adverse effects | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Humans | Middle Aged | Exons - genetics | Male | Molecular Targeted Therapy | Proto-Oncogene Proteins c-met - genetics | Neoplasm Recurrence, Local - pathology | Carcinoma, Non-Small-Cell Lung - therapy | Aged, 80 and over | Female | Neoplasm Recurrence, Local - genetics | Aged | Gene Rearrangement - genetics | Neoplasm Staging | Index Medicus | 14 | Lung Cancer | 29
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 08/2015, Volume 5, Issue 8, pp. 850 - 860
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 29, pp. 28211 - 28222
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2019, Volume 14, Issue 4, pp. 737 - 741
Introduction: Genomic variants that lead to MET proto-oncogenem receptor tyrosine kinase (MET) exon 14 skipping represent a potential targetable molecular... 
Molecular testing | Non–small cell lung cancer | Next-generation sequencing | MET exon 14 skipping | AMPLIFICATION | ONCOLOGY | RESPIRATORY SYSTEM | Non-small cell lung cancer | MUTATIONS | INHIBITORS
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2001, Volume 7, Issue 9, pp. 2832 - 2839
Deficiency of dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in 5-fluorouracil (5-FU) catabolism, has been linked to toxic side effects of... 
CANCER-PATIENTS | RNA | PHARMACOKINETICS | ONCOLOGY | COLORECTAL-CANCER | POLYMERASE CHAIN-REACTION | PHARMACOGENETICS | FAMILIAL PYRIMIDINEMIA | FLUOROURACIL | DEFICIENCY | CHEMOTHERAPY | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Humans | Middle Aged | DNA, Complementary - genetics | Male | Diarrhea - chemically induced | Diarrhea - pathology | Fluorouracil - therapeutic use | Breast Neoplasms - enzymology | Rectal Neoplasms - genetics | Fluorouracil - adverse effects | Stomatitis - pathology | Leukopenia - chemically induced | Adult | Female | Rectal Neoplasms - drug therapy | Severity of Illness Index | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Introns - genetics | Oxidoreductases - metabolism | Oxidoreductases - genetics | Alternative Splicing - genetics | Gene Frequency | Exons - genetics | Genotype | Thrombocytopenia - chemically induced | Stomach Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Thrombocytopenia - pathology | Breast Neoplasms - drug therapy | Leukopenia - pathology | Rectal Neoplasms - enzymology | Homozygote | Point Mutation | Antimetabolites, Antineoplastic - therapeutic use | Breast Neoplasms - genetics | Stomatitis - chemically induced | Antimetabolites, Antineoplastic - adverse effects | Heterozygote | Aged | Colonic Neoplasms - enzymology | Dihydrouracil Dehydrogenase (NADP) | Index Medicus
Journal Article
Journal Article