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1. Full Text Method validation across the disciplines—Critical investigation of major validation criteria and associated experimental protocols
by Stöckl, Dietmar and D’Hondt, Heidi and Thienpont, Linda M
Journal of Chromatography B, ISSN 1570-0232, 2009, Volume 877, Issue 23, pp. 2180 - 2190
Analytical method development should aim at delivering reliable measurements within a given application. This implies that method validation is integrated in... 
Limit of detection | Accuracy | Analytical performance characteristics | Precision | Linearity | Statistical significance testing | Trueness | Limit of quantitation | Total error | Experimental protocols | Analytical acceptance criteria | CHEMISTRY, ANALYTICAL | 2 LABORATORIES | PERFORMANCE | BIOCHEMICAL RESEARCH METHODS | HARMONIZATION | SFSTP PROPOSAL | EQUIVALENCE | IUPAC TECHNICAL REPORT | ACCURACY PROFILES | ERROR | QUANTITATIVE ANALYTICAL PROCEDURES | BLAND-ALTMAN PLOT | Guidelines as Topic - standards | Validation Studies as Topic | Chemistry - methods | Chemistry - standards | Pharmacy | Analysis | Methods
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2. Full Text Conceptualization, development and validation of T‐QoL© (Teenagers’ Quality of Life): a patient‐focused measure to assess quality of life of adolescents with skin diseases
by Basra, M.K.A and Salek, M.S and Fenech, D and Finlay, A.Y
British Journal of Dermatology, ISSN 0007-0963, 01/2018, Volume 178, Issue 1, pp. 161 - 175
Summary Background Skin disease can affect the quality of life (QoL) of teenagers in a variety of different ways, some being unique to this age group.... 
UNITED-STATES | ORAL ISOTRETINOIN | DEPRESSION | ISOTRETINOIN THERAPY | METAANALYSIS | SEVERE NODULOCYSTIC ACNE | DESCRIPTIVE EPIDEMIOLOGY | CYSTIC ACNE | VULGARIS | CLINICAL-PRACTICE | DERMATOLOGY | Medical research | Analysis | Medicine, Experimental | Youth | Skin diseases | Teenagers | Skin | Children | Diseases | Qualitative research | Adolescence | Factor analysis | Disease | Dermatology | Childrens health | Clinical trials | Quality of life | Quantitative psychology | Age | Content analysis
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3. Full Text Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials
by Costa, Francesco, MD and van Klaveren, David, MSc and James, Stefan, Prof and Heg, Dik, PhD and Räber, Lorenz, MD and Feres, Fausto, MD and Pilgrim, Thomas, MD and Hong, Myeong-Ki, Prof and Kim, Hyo-Soo, MD and Colombo, Antonio, MD and Steg, Philippe Gabriel, Prof and Zanchin, Thomas, MD and Palmerini, Tullio, MD and Wallentin, Lars, Prof and Bhatt, Deepak L, Prof and Stone, Gregg W, Prof and Windecker, Stephan, Prof and Steyerberg, Ewout W, Prof and Valgimigli, Marco, Prof and PRECISE-DAPT Study Investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Kardiologi and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Uppsala universitet and Institutionen för medicinska vetenskaper and Uppsala kliniska forskningscentrum (UCR)
Lancet, The, ISSN 0140-6736, 2017, Volume 389, Issue 10073, pp. 1025 - 1034
Summary Background Dual antiplatelet therapy (DAPT) with aspirin plus a P2Y12 inhibitor prevents ischaemic events after coronary stenting, but increases... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | IMPACT | CLOPIDOGREL | EFFICACY | BARE-METAL STENTS | RISK STRATIFICATION | GUIDELINES | ACUTE MYOCARDIAL-INFARCTION | ACUTE CORONARY SYNDROMES | DURATION | DRUG-ELUTING STENTS | Medical policy | Complications and side effects | Medical research | Medical colleges | Aspirin | Clinical trials | Medicine, Experimental | Cardiology | Medicine, Preventive | Stent (Surgery) | Preventive health services | Anticoagulants | Heart attacks | Cardiovascular disease | Hemorrhage | Thrombosis | Patients | Risk assessment | Coronary vessels | Clinical medicine | Acute coronary syndromes | Stents | Age | Medical and Health Sciences | Medicin och hälsovetenskap
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4. Full Text Mechanistic Validation
by Hartung, T and Hoffmann, S and Stephens, M
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, ISSN 1868-596X, 2013, Volume 30, Issue 2, pp. 119 - 130
Validation of new approaches in regulatory toxicology is commonly defined as the independent assessment of the reproducibility and relevance (the scientific... 
systems biology | MEDICINE, RESEARCH & EXPERIMENTAL | 21ST-CENTURY | QUALITY-CONTROL | CHALLENGES | THOUGHT | Tox-21c | alternatives to animal testing | 3 RS | SYSTEMS | CELL-CULTURE | ALTERNATIVE METHODS | regulatory toxicology | EVIDENCE-BASED TOXICOLOGY | validation | FOOD | Predictive Value of Tests | Animal Testing Alternatives - methods | Reproducibility of Results | Humans | Risk Factors | Computational Biology | Gene Expression Regulation | Homeostasis | Animal Testing Alternatives - standards | Animal Experimentation - standards | Algorithms | Animals | Computer Simulation
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5. Full Text FACES—A database of facial expressions in young, middle-aged, and older women and men: Development and validation
by Ebner, Natalie C and Riediger, Michaela and Lindenberger, Ulman
Behavior Research Methods, ISSN 1554-351X, 2/2010, Volume 42, Issue 1, pp. 351 - 362
Faces are widely used as stimuli in various research fields. Interest in emotion-related differences and age-associated changes in the processing of faces is... 
Cognitive Psychology | Psychology | LIFE-SPAN | PERCEPTION | ATTENTION | RECOGNITION | MEMORY | PSYCHOLOGY, MATHEMATICAL | RATINGS | EMOTIONAL FACES | HUMAN EXTRASTRIATE CORTEX | IDENTIFICATION | PSYCHOLOGY, EXPERIMENTAL | ACCURACY | Young Adult | Reproducibility of Results | Humans | Middle Aged | Facial Expression | Adult | Female | Male | Aged | Face | Databases, Factual | Women | Research & development--R&D | Older people | Memory | Digital libraries | Data bases | Age
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6. Full Text A proposal for validation of antibodies
by Uhlen, Mathias and Bandrowski, Anita and Carr, Steven and Edwards, Aled and Ellenberg, Jan and Lundberg, Emma and Rimm, David L and Rodriguez, Henry and Hiltke, Tara and Snyder, Michael and Yamamoto, Tadashi and Science for Life Laboratory, SciLifeLab and Proteomik och nanobioteknologi and Centra and Skolan för bioteknologi (BIO) and KTH
Nature Methods, ISSN 1548-7091, 10/2016, Volume 13, Issue 10, pp. 823 - 827
We convened an ad hoc International Working Group for Antibody Validation in order to formulate the best approaches for validating antibodies used in common... 
LOCALIZATION | CELLS | ASSAYS | MICROARRAYS | PROTEINS | BIOCHEMICAL RESEARCH METHODS | Antibodies - immunology | Antigens - immunology | Reproducibility of Results | Validation Studies as Topic | Humans | Viral antibodies | Medical research | Growth | Innovations | Antibodies | Medicine, Experimental | Biological assay | Science | Immunoglobulins | Research | Guidelines | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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7. Full Text The next generation of molecular pathology is here validation of next-generation sequencing technology for clinical molecular testing across multiple different disciplines
by Weck, Karen E
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 06/2017, Volume 141, Issue 6, pp. 749 - 750
Next-generation sequencing technology allows for the parallel generation of multiple DNA sequence reactions using template libraries generated from either... 
MEDICINE, RESEARCH & EXPERIMENTAL | MEDICAL LABORATORY TECHNOLOGY | PATHOLOGY | RNA sequencing | Usage | Diagnostic equipment (Medical) | Analysis | Nucleic acids | Nucleotide sequencing | DNA sequencing | Polymerase chain reaction | Gene mutations | Research | Genomics | Genetic disorders | Disease | Laboratories | Diagnostic tests | Colleges & universities | Genomes | Medicine | Pathology | Genetics | Mutation | Bioinformatics | Deoxyribonucleic acid--DNA | Cancer
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8. Full Text Economic evaluation of the 21-gene signature (Oncotype DX®) in lymph node-negative/positive, hormone receptor-positive early-stage breast cancer based on Japanese validation study (JBCRG-TR03)
by Kondo, Masahide and Hoshi, Shu-Ling and Yamanaka, Takeharu and Ishiguro, Hiroshi and Toi, Masakazu
Breast Cancer Research and Treatment, ISSN 0167-6806, 6/2011, Volume 127, Issue 3, pp. 739 - 749
The 21-gene signature is validated as a good predictor of recurrence for lymph node-negative/positive, hormone receptor-positive, early-stage breast cancer in... 
21-Gene signature | Medicine & Public Health | Oncology | Breast cancer | Gene diagnosis | Cost-effectiveness | Adjuvant therapy | ADJUVANT CHEMOTHERAPY | SURVIVAL | TAMOXIFEN | RISK | RT-PCR ASSAY | WOMEN | THERAPY | ONCOLOGY | GENE-EXPRESSION | RECURRENCE | Quality-Adjusted Life Years | Receptors, Estrogen - genetics | Breast Neoplasms - economics | Reagent Kits, Diagnostic - economics | Humans | Japan | Lymphatic Metastasis | Receptors, Progesterone - genetics | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cost-Benefit Analysis | Sensitivity and Specificity | Female | Chemotherapy, Adjuvant | Neoplasm Staging | Oncology, Experimental | Genes | Adjuvant treatment | Economic aspects | Hormones | Research | Social aspects | Analysis | Genetic research | Markov processes | Diagnosis | Cancer
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9. Full Text Validation of Catquest‐9SF in Danish: developing a revised form of the Catquest‐9SF – the Danish Catquest‐7SF
by Nielsen, Esben and Lundström, Mats and Pesudovs, Konrad and Hjortdal, Jesper and Oftalmologi, Lund and Lund University and Ophthalmology, Lund and Lunds universitet
Acta Ophthalmologica, ISSN 1755-375X, 03/2019, Volume 97, Issue 2, pp. 173 - 177
Purpose The primary goal was to validate a Danish translated version of the Catquest‐9SF by Rasch analysis. The secondary goal was to investigate whether... 
Catquest | Rasch analysis | subjective outcome | cataract surgery | OPHTHALMOLOGY | OUTCOMES | QUESTIONNAIRE | CATARACT-SURGERY | Medicine, Experimental | Medical research | Cataract | Comorbidity | Analysis | Surgery | Cornea | Regression models | Statistical analysis | Correlation analysis | Eigenvalues | Visual acuity | Regression analysis | Patients | Astigmatism | Acuity | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Oftalmologi | Ophthalmology | Klinisk medicin
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10. Full Text Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
by Jurisica, Igor and Eschrich, Steven and Tsao, Ming-Sound and Meyerson, Matthew and Zakowski, Maureen and Seymour, Lesley and Verhaak, Roel and Gerald, William L and Kris, Mark and Kuick, Rork and Gruidl, Michael and Sharma, Anupama and Naoki, Katsuhiko and Shedden, Kerby and Dobbin, Kevin K and Motoi, Noriko and Strumpf, Daniel and Weir, Barbara and Ladd-Acosta, Christine and Jacobson, James W and Golub, Todd and Travis, William and Enkemann, Steven A and Hanash, Samir and Szoke, Janos and Giordano, Thomas J and Chang, Andrew C and Lively, Tracy and Misek, David E and Conley, Barbara and Ding, Keyue and Pennell, Nathan and Yeatman, Timothy J and Taylor, Jeremy M G and Beer, David G and Rusch, Valerie and Zhu, Chang Qi and Viale, Agnes and Seshan, Venkatraman E and Shepherd, Frances A and Director's Challenge Consortium Mo and Director's Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma
Nature Medicine, ISSN 1078-8956, 08/2008, Volume 14, Issue 8, pp. 822 - 827
Although prognostic gene expression signatures for survival in early-stage lung cancer have been proposed, for clinical application, it is critical to... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Oligonucleotide Array Sequence Analysis | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Risk | Treatment Outcome | Gene Expression Profiling | Models, Statistical | Adenocarcinoma - metabolism | Algorithms | Female | ROC Curve | Aged | Adenocarcinoma - mortality | Usage | DNA microarrays | Lung cancer | Adjuvant treatment | Reports | Genetic aspects | Research | Metastasis | Gene expression | Health aspects | Cancer | Clinical trials | Medical research | Survival analysis | Validation studies
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11. Full Text The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: a derivation and validation study
by Hijazi, Ziad, Dr and Oldgren, Jonas, PhD and Lindbäck, Johan, MSc and Alexander, John H, Prof and Connolly, Stuart J, Prof and Eikelboom, John W, MD and Ezekowitz, Michael D, Prof and Held, Claes, PhD and Hylek, Elaine M, Prof and Lopes, Renato D, PhD and Siegbahn, Agneta, Prof and Yusuf, Salim, Prof and Granger, Christopher B, Prof and Wallentin, Lars, Prof and ARISTOTLE RE-LY Investigators and ARISTOTLE and RE-LY Investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Kardiologi and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Uppsala universitet and Institutionen för medicinska vetenskaper and Uppsala kliniska forskningscentrum (UCR)
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10035, pp. 2302 - 2311
Summary Background The benefit of oral anticoagulation in atrial fibrillation is based on a balance between reduction in ischaemic stroke and increase in major... 
Internal Medicine | STROKE | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | CARDIOVASCULAR EVENTS | WARFARIN | LY RANDOMIZED EVALUATION | RENAL-FUNCTION | THROMBOEMBOLIC EVENTS | PREDICTION MODELS | APIXABAN | INSIGHTS | Biomarkers - metabolism | Pyrazoles - therapeutic use | Stroke | Prognosis | Humans | Middle Aged | Risk Factors | Atrial Fibrillation - complications | Anticoagulants - therapeutic use | Male | Hemorrhage - prevention & control | Warfarin - therapeutic use | Young Adult | Aged, 80 and over | Adult | Female | Aged | Pyridones - therapeutic use | Medical research | Care and treatment | Atrial fibrillation | Medicine, Experimental | Anticoagulants (Medicine) | Cardiology | Risk factors | Biological markers | Cardiac arrhythmia | Anticoagulants | Medical prognosis | Biomarkers | Health risk assessment | Thromboembolism | Epidemiology | Patients | Hemorrhage | Age | Medical and Health Sciences | Medicin och hälsovetenskap
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