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Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1044 - 1065
Anti-self/tumor T cell function can be improved by increasing TCR-peptide MHC (pMHC) affinity within physiological limits, but paradoxically further increases... 
MEDICINE, RESEARCH & EXPERIMENTAL | TCR | BINDING-KINETICS | MM-GBSA | IN-VIVO | PEPTIDE-MHC | GENE-THERAPY | SODIUM STIBOGLUCONATE | PD-1 | FREE-ENERGY DECOMPOSITION | ANTIGEN | Phosphorylation | Humans | Transcriptome | MicroRNAs - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Programmed Cell Death 1 Receptor - physiology | Signal Transduction - immunology | ZAP-70 Protein-Tyrosine Kinase - metabolism | Cell Line | HLA-A2 Antigen - immunology | Immunotherapy, Adoptive | Antigens, Neoplasm - immunology | Lymphocyte Activation | Programmed Cell Death 1 Receptor - metabolism | Membrane Proteins - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Receptors, Antigen, T-Cell, alpha-beta - genetics | CD8-Positive T-Lymphocytes - physiology | CD8-Positive T-Lymphocytes - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Down-Regulation - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Antimony Sodium Gluconate - pharmacology | Protein Binding | MicroRNAs - genetics | Protein Processing, Post-Translational | Receptors, Antigen, T-Cell, alpha-beta - metabolism | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | Antigen receptors, T cell | Receptors | Phosphatases | Physiological aspects | Cellular immunity | Genetic aspects | Research | Gene expression | T cells
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, p. e0163530
Pyrophosphate is a potent mitogen, capable of stimulating proliferation in multiple cell types, and a critical participant in bone mineralization.... 
CELLS | IN-VITRO | CALCIUM-PHOSPHATE | INORGANIC PYROPHOSPHATE | MULTIDISCIPLINARY SCIENCES | VASCULAR CALCIFICATION | MINERALIZATION | DIHYDRATE CRYSTALS | BONE | ASCORBIC-ACID | FIBROBLASTS | Cell Line | Diphosphates - pharmacology | Diphosphates - metabolism | Extracellular Matrix Proteins - genetics | Humans | Alkaline Phosphatase - metabolism | Enzyme Activation - drug effects | Gene Expression Regulation - drug effects | Animals | Calcification, Physiologic | Cell Differentiation - drug effects | Biomarkers | Cell Proliferation - drug effects | Mice | Osteoblasts - cytology | Osteoblasts - metabolism | Osteogenesis | Physiological aspects | Calcium phosphate | Phosphatases | Gene expression | Collagen | Genes | Alkaline phosphatase | Physiological effects | Fourier transforms | Calcium | Low concentrations | Science | Biochemistry | Hydroxyapatite | Kinases | Phosphatase | Osteoblasts | Chronic exposure | Sodium pyrophosphate | Engineering | Biomedical materials | Osteosarcoma | Mineralization | Fibroblasts | Extracellular matrix | Biocompatibility | Physiology | Osteocalcin | Markers | Glycerol | Osteopontin | Exposure | Metabolism | Biological activity | Studies | Osteoblastogenesis | Sodium | Calcification | Cyclooxygenase-2 | Differentiation | Medical Biotechnology | Biomaterials Science | Engineering and Technology | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Teknik och teknologier | Biomaterialvetenskap
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e22608
The purpose of this study was to develop a paradigm for quantitative molecular imaging of bone cell activity. We hypothesized the feasibility of non-invasive... 
VITRO | HYPOPHOSPHATASIA | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MINERALIZATION | NONINVASIVE OPTICAL-DETECTION | MICE | DIFFERENTIATION | Cell Line | Magnetic Resonance Spectroscopy | Alkaline Phosphatase - metabolism | Rats | Molecular Imaging - methods | Bone and Bones - enzymology | Hymecromone - metabolism | Hydrolysis | Hymecromone - analogs & derivatives | Extracellular Space - metabolism | Animals | Cattle | Bone and Bones - metabolism | Mice | Bone and Bones - cytology | Phosphates | Enzymes | Nuclear magnetic resonance spectroscopy | Phosphatases | Fluorides | Disease | Fluorine | Metastasis | Health physics | Phosphatase | Osteoblasts | Magnetic resonance spectroscopy | Cell activation | Bone growth | Mineralization | Tibia | Surgery | Imaging | Biocompatibility | Physiology | Spectroscopy | Magnetic resonance | Levamisole | Hospitals | Morphology | Bone imaging | Metabolic disorders | Alkaline phosphatase | Nuclear magnetic resonance--NMR | Biomedical research | Molecular structure | Laboratories | Fluorescence | Biology | Activation | Biomedical materials | Spectrum analysis | Bones | Trends | Atomic structure | Medical imaging | Tissue engineering | Therapeutic applications | Feasibility studies | Pharmacology | Physics | Magnetic resonance imaging | Resonance | Fluorination | Osteogenesis | Cancer | Nuclear magnetic resonance | NMR
Journal Article
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 01/2018, Volume 57, Issue 1, pp. 57 - 69
Neoplastic cells exhibit higher oxidative stress compared to normal cells; however, antioxidants based clinical trials have mostly failed. Another attractive... 
AMP‐activated kinase | prostate cancer | extracellular‐signal‐regulated kinase | dual‐specificity phosphoprotein phosphatase | oxidative stress | procyanidin B2 3,3″‐di‐O‐gallate | extracellular-signal-regulated kinase | AMP-activated kinase | procyanidin B2 3,3″-di-O-gallate | dual-specificity phosphoprotein phosphatase | CARCINOMA-CELLS | VITAMIN-E | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RANDOMIZED CONTROLLED-TRIAL | procyanidin B2 3,3 ''-di-O-gallate | COMPLEX III | BETA-CAROTENE | MITOCHONDRIAL RESPIRATORY-CHAIN | REACTIVE OXYGEN | ONCOLOGY | DOUBLE-EDGED-SWORD | GRAPE SEED EXTRACT | Cell Survival - drug effects | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | AMP-Activated Protein Kinases - metabolism | Anthocyanins - pharmacology | Reactive Oxygen Species - metabolism | Humans | Immunoblotting | Male | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Dual Specificity Phosphatase 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Line, Tumor | Cell Death - drug effects | Oxidative Stress - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Oxidative stress | Biochemistry | Phosphatases | Cell death | Prostate cancer | Cancer cells | Seeds | Clinical trials | Cytotoxicity | Activation | Malignancy | Kinases | AMP-activated protein kinase | Phosphatase | MAP kinase phosphatase | Antioxidants | Electron transport chain | Biological effects | Mitochondria | Inhibition | Pretreatment | Medical research | AMP | Mortality | Extracellular signal-regulated kinase | MAP kinase | Superoxide | Plant extracts | Overexpression | Electron transport | Prostate | Cancer | Apoptosis | Dual-specificity phosphoprotein phosphatase | 3″-di-O-gallate | Procyanidin B2 3 | Extracellular-signal-regulated kinase
Journal Article
Pathologie Biologie, ISSN 0369-8114, 2009, Volume 57, Issue 4, pp. 318 - 323
In trabecular bone fracture repair in vivo, osteogenesis occurs through endochondral ossification under hypoxic conditions, or through woven bone deposition in... 
Alkaline phosphatase | Cartilage repair | Dexamethasone | Cellules de la moelle osseuse stromales | MC3T3-E1 | Phosphatase alcaline | Bone fracture repair | Ostéogénèse in vitro | Minéralisation | Réparation d’os | Glycérol phosphate | Bone cell culture | Mineralization | In vitro osteogenesis | Bone marrow stromal cells | Chitosan | Glycerol phosphate | Cultures ostéoblastes | Réparation du cartilage articulaire | DEFECTS | OSTEOBLAST DEVELOPMENT | PATHOLOGY | CARTILAGE | EXTRACELLULAR-MATRIX | SUBCHONDRAL BONE | DIFFERENTIATION | CULTURES | MARROW STROMAL CELLS | BETA-GLYCEROPHOSPHATE | Bone Marrow Cells - enzymology | Humans | Alkaline Phosphatase - metabolism | Bone Marrow Cells - physiology | Extracellular Matrix - metabolism | Cell Line - enzymology | Cell Line - drug effects | Stromal Cells - enzymology | Cell Line - physiology | Stromal Cells - drug effects | Bone Marrow Cells - drug effects | Minerals - metabolism | Mesenchymal Stromal Cells - physiology | Mesenchymal Stromal Cells - drug effects | Rabbits | Cells, Cultured - drug effects | Collagen Type I - metabolism | Osteoblasts - enzymology | Osteoblasts - drug effects | Osteoblasts - physiology | Cells, Cultured - physiology | Rats | Organ Specificity | Cells, Cultured - enzymology | Animals | Skull - cytology | Culture Media - pharmacology | Mice | In Vitro Techniques | Stromal Cells - physiology | Osteogenesis | Phosphates | Glycerin | Biological products | Phosphatases | Collagen | Analysis | Central nervous system depressants | Stem cells | Glycerol
Journal Article
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 10/2010, Volume 299, Issue 4, pp. C854 - C865
Journal Article
Acta Societatis Botanicorum Poloniae, ISSN 0001-6977, 2018, Volume 87, Issue 1, p. 1
We studied the effect of differential phosphorus (P) supply on the development of oat seedlings (Avena sativa L. 'Arab') as well as localization and activity... 
Split root | Pi deficit | Root exudates | APase localization | Extracellular acid phosphatase | Phytate | CLUSTER ROOTS | ACQUISITION | PHASEOLUS-VULGARIS L | phytate | split root | DEFICIENCY | PLANT SCIENCES | extracellular acid phosphatase | RESPONSES | METABOLISM | root exudates | PLANTS | SOIL | ARABIDOPSIS | EXPRESSION | Oats | Phosphorus in the body | Health aspects
Journal Article