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Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2019, Volume 294, Issue 15, pp. 5784 - 5789
In mammals, leptin production in adipocytes is up-regulated by feeding and insulin. Although this regulatory connection is central to all physiological effects... 
MAMMALIAN TARGET | RAPAMYCIN | insulin | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSLATION | leptin | MTORC1 | MESSENGER-RNA | INTEGRATION | PATHWAY | OBESE GENE | adipocyte | GENE-EXPRESSION | INHIBITS LIPOLYSIS | early growth response protein 1 (Egr1) | mTOR complex (mTORC)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 28, pp. 17331 - 17338
Early growth response transcription factor Egr1 controls multiple aspects of cell physiology and metabolism. In particular, Egr1 suppresses lipolysis and... 
MAMMALIAN TARGET | TRANSCRIPTION FACTORS | ADIPOSE TRIGLYCERIDE LIPASE | SIGNALING PATHWAYS | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TRANSLATION INITIATION | DIET-INDUCED OBESITY | LIPID HOMEOSTASIS | RESPONSE GENES | TOR Serine-Threonine Kinases - metabolism | Humans | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Eukaryotic Initiation Factors - antagonists & inhibitors | Early Growth Response Protein 1 - genetics | HEK293 Cells | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Signal Transduction | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Lipid Metabolism | Lipase - metabolism | Phosphoproteins - genetics | 3T3-L1 Cells | Gene Knockout Techniques | Lipolysis | Carrier Proteins - genetics | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Adipocytes - metabolism | Early Growth Response Protein 1 - antagonists & inhibitors | Mice | Early Growth Response Protein 1 - metabolism | Gene Regulation | mammalian target of rapamycin (mTOR) | adipose triglyceride lipase (ATGL) | insulin | lipolysis | early growth response protein 1 (EGR1)
Journal Article
Journal Article
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2019, Volume 294, Issue 17, pp. 6871 - 6887
EPHB6 is a member of the erythropoietin-producing hepatocellular kinase (EPH) family and a receptor tyrosine kinase with a dead kinase domain. It is involved... 
ACTIVATION | PROTEIN | CONTRACTILITY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING | c-JUN transcription factor | early growth response protein 1 (EGR1) | BLOOD-PRESSURE | tyrosine hydroxylase | EPHRINB1 | SIGNAL-TRANSDUCTION | EFNB1 | catecholamine | adrenal | chromaffin cells | ELK-1 | receptor tyrosine kinase
Journal Article
Journal Article
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2012, Volume 329, Issue 2, pp. 217 - 227
Abstract 2′-Benzoyloxycinnamaldehyde (BCA) induces apoptosis in human cancer cells through ROS generation. BCA upregulates proapoptotic genes such as... 
Hematology, Oncology and Palliative Medicine | Prostate cancer cells | Growth arrest and DNA-damage-inducible protein alpha (GADD45A) | Early growth response protein 1 (EGR1) | Activating transcription factor 3 (ATF3) | 2′-Benzoyloxycinnamaldehyde (BCA) | Importin-7 (IPO7) | NSAID-activated gene 1 protein (NAG-1) | 2'-Benzoyloxycinnamaldehyde (BCA) | CARCINOMA-CELLS | APOPTOSIS | OXIDATIVE STRESS | SUPPRESSOR GENE | DNA-DAMAGE | ACTIVATING TRANSCRIPTION FACTOR-3 | CYCLOOXYGENASE INHIBITORS | BETA SUPERFAMILY MEMBER | ONCOLOGY | GENE-EXPRESSION | 2 '-Benzoyloxycinnamaldehyde (BCA) | EGR-1 EXPRESSION | Acrolein - analogs & derivatives | RNA, Small Interfering - genetics | Gene Expression - drug effects | Apoptosis - drug effects | Humans | Male | Growth Differentiation Factor 15 - genetics | Gene Knockdown Techniques | Prostatic Neoplasms | Glutathione - pharmacology | Cell Nucleus - metabolism | Early Growth Response Protein 1 - genetics | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Active Transport, Cell Nucleus | Nuclear Proteins - genetics | Activating Transcription Factor 3 - genetics | Acrolein - pharmacology | Cell Survival - drug effects | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Antioxidants - pharmacology | Activating Transcription Factor 3 - metabolism | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Karyopherins - metabolism | Benzoates - pharmacology | Cell Line, Tumor | Karyopherins - genetics | Cell Nucleus - drug effects | Growth Differentiation Factor 15 - metabolism | Early Growth Response Protein 1 - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Antioxidants | Anopheles | Growth | Cell death | Genes | Biochemistry | Genetic transcription | Cell growth | Prostate cancer | Rodents | Apoptosis
Journal Article
BMC Molecular Biology, ISSN 1471-2199, 05/2017, Volume 18, Issue 1, pp. 14 - 14
Journal Article
Molecular Metabolism, ISSN 2212-8778, 2012, Volume 2, Issue 1, pp. 31 - 37
Abstract FGF21 is a multifunctional metabolic regulator. The co-factor βKlotho (KLB) allows FGF21 to signal via FGF receptors. Given the widespread nature of... 
Endocrinology & Metabolism | Adipose tissue | FGF19 | FGF21 | FGFR1 | ENDOCRINOLOGY & METABOLISM
Journal Article