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Journal of Virology, ISSN 0022-538X, 2016, Volume 90, Issue 21, pp. 9683 - 9692
RNA viruses present an extraordinary threat to human health, given their sudden and unpredictable appearance, the potential for rapid spread among the human... 
DRUG | EFLORNITHINE | REPLICATION | VIROLOGY | ALPHA-DIFLUOROMETHYLORNITHINE | DEPLETION | INFECTION | TRANSLATION | MAMMALIAN-CELLS | RESPIRATORY SYNDROME CORONAVIRUS | SPERMIDINE | Zika Virus Infection - drug therapy | Acetyltransferases - metabolism | Ebolavirus - metabolism | Chikungunya virus - metabolism | Humans | Eflornithine - pharmacology | Ebolavirus - drug effects | Zika Virus Infection - virology | Disease Outbreaks | RNA Viruses - drug effects | Hemorrhagic Fever, Ebola - virology | Hemorrhagic Fever, Ebola - drug therapy | Spermine - analogs & derivatives | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Mice, Inbred C57BL | Chikungunya Fever - drug therapy | Zika Virus - drug effects | Chikungunya Fever - virology | Polyamines - metabolism | Chikungunya virus - drug effects | Animals | Spermine - pharmacology | Mice | Spermine/analogs & derivatives | Virus Replication/drug effects | Hemorrhagic Fever, Ebola/virology | Life Sciences | Zika Virus/drug effects | Immunology | Chikungunya virus/metabolism | Chikungunya Fever/drug therapy | Zika Virus Infection/drug therapy | Ebolavirus/drug effects | Acetyltransferases/metabolism | Chikungunya virus/drug effects | Eflornithine/pharmacology | Spermine/pharmacology | Polyamines/metabolism | Chikungunya Fever/virology | Hemorrhagic Fever, Ebola/drug therapy | Virology | Microbiology and Parasitology | Zika Virus Infection/virology | Ebolavirus/metabolism | Antiviral Agents/pharmacology | RNA Viruses/drug effects
Journal Article
Nature, ISSN 0028-0836, 09/2011, Volume 477, Issue 7364, pp. 340 - 343
Infections by the Ebola and Marburg filoviruses cause a rapidly fatal haemorrhagic fever in humans for which no approved antivirals are available(1). Filovirus... 
GENE | MECHANISM | HEMORRHAGIC-FEVER | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | ZAIRE-EBOLAVIRUS | RECEPTOR | ANTIBODY | GLYCOPROTEIN | VESICULAR STOMATITIS-VIRUS | IDENTIFICATION | Viral Fusion Proteins - metabolism | Membrane Glycoproteins - metabolism | Receptors, Virus - metabolism | Humans | Glycoproteins - metabolism | Membrane Fusion - genetics | Multiprotein Complexes - genetics | Endosomes - metabolism | Virus Internalization | Haploidy | Multiprotein Complexes - metabolism | Lysosomes - metabolism | Biological Transport | Marburg Virus Disease - drug therapy | Multiprotein Complexes - deficiency | Hemorrhagic Fever, Ebola - drug therapy | Fibroblasts - metabolism | Fibroblasts - virology | Cell Line | Marburgvirus - physiology | Cholesterol - metabolism | Fibroblasts - pathology | Mutation - genetics | Niemann-Pick Diseases - pathology | Genome, Human - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Multiprotein Complexes - chemistry | Niemann-Pick Diseases - virology | Animals | Carrier Proteins - metabolism | Host-Pathogen Interactions - genetics | Marburg Virus Disease - metabolism | Ebolavirus - physiology | Membrane Fusion - physiology | Hemorrhagic Fever, Ebola - metabolism | Membrane Glycoproteins - deficiency | Ebola virus | Proteins | Murders & murder attempts | Cloning | Viruses | Infections | Mutation | Viral infections
Journal Article
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 20, pp. 10399 - 10406
Ebola virus (EBOV) initially targets monocytes and macrophages, which can lead to the release of proinflammatory cytokines and chemokines. These inflammatory... 
VP40 PROTEIN | SOCS-BOX | VIROLOGY | DENDRITIC CELLS | INNATE ANTIVIRAL RESPONSE | INTERACTS | MATRIX PROTEIN | GLYCOPROTEIN | VESICULAR STOMATITIS-VIRUS | RECEPTOR 4 | MOTIF | Ebolavirus - metabolism | Humans | Nucleoproteins - genetics | Glycoproteins - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Virion - genetics | Ebolavirus - genetics | DNA-Binding Proteins - metabolism | Ubiquitination | Macrophages - virology | Virus Release - genetics | HEK293 Cells | Viral Core Proteins - metabolism | Nedd4 Ubiquitin Protein Ligases | Fibroblasts - metabolism | Fibroblasts - virology | Glycoproteins - genetics | Cell Line | Signal Transduction | Mice, Inbred C57BL | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 4 - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Virion - metabolism | Toll-Like Receptor 4 - metabolism | Host-Pathogen Interactions | Transcription Factors - metabolism | Suppressor of Cytokine Signaling 3 Protein | Feedback, Physiological | Macrophages - metabolism | Animals | Gene Expression Regulation, Viral | Nucleoproteins - metabolism | Viral Core Proteins - genetics | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Ubiquitin-Protein Ligases - genetics
Journal Article
Cell, ISSN 0092-8674, 06/2016, Volume 165, Issue 6, pp. 1467 - 1478
Journal Article
Biochemistry, ISSN 0006-2960, 11/2013, Volume 52, Issue 47, pp. 8406 - 8419
Viral protein 35 (VP35), encoded by filoviruses, is a multifunctional dsRNA binding protein that plays important roles in viral replication, innate immune... 
DOUBLE-STRANDED-RNA | IN-VITRO | PROTEIN | RESTON | INTERFERON ANTAGONISM | STRUCTURAL BASIS | MARBURG-VIRUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | POSTEXPOSURE PROTECTION | INFECTION | IRF-3 ACTIVATION | Viral Regulatory and Accessory Proteins - antagonists & inhibitors | Ebolavirus - metabolism | Species Specificity | Antiviral Agents - metabolism | Molecular Targeted Therapy | Ebolavirus - drug effects | Antiviral Agents - chemistry | Conserved Sequence | Protein Interaction Domains and Motifs | RNA, Double-Stranded - metabolism | Nucleic Acid Conformation | Hemorrhagic Fever, Ebola - drug therapy | Mutant Proteins - antagonists & inhibitors | RNA - metabolism | Binding, Competitive | Recombinant Proteins - metabolism | Amino Acid Sequence | Aptamers, Nucleotide - pharmacology | Antiviral Agents - pharmacology | Viral Regulatory and Accessory Proteins - genetics | Aptamers, Nucleotide - chemistry | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Aptamers, Nucleotide - metabolism | RNA - chemistry | Viral Regulatory and Accessory Proteins - metabolism | Nucleoproteins - metabolism | RNA - pharmacology | SELEX Aptamer Technique | Mutant Proteins - chemistry | Protein Conformation | Kinetics | Hemorrhagic Fever, Ebola - metabolism | Viral Regulatory and Accessory Proteins - chemistry | Ebola virus | Genetic aspects | Chemical properties | Research | Nucleic acid aptamers | RNA aptamers | inhibitors | antivirals | viral protein VP35 | filovirus
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2015, Volume 112, Issue 15, pp. 4719 - 4724
Four Ebola patients received care at Emory University Hospital, presenting a unique opportunity to examine the cellular immune responses during acute Ebola... 
SEE COMMENTARY | Ebola infection | Human immune response | Immune activation | T cells | Plasmablasts | NONHUMAN-PRIMATES | plasmablasts | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | immune activation | MARBURG VIRUSES | CHALLENGE | LYMPHOCYTE APOPTOSIS | IN-VITRO | T-CELL RESPONSES | HEMORRHAGIC-FEVER | KIKWIT | human immune response | VACCINES | Tumor Necrosis Factor-alpha - metabolism | Ebolavirus - metabolism | Immunoglobulin G - blood | Immunity, Humoral - immunology | Humans | Precursor Cells, B-Lymphoid - metabolism | Viral Proteins - immunology | Precursor Cells, B-Lymphoid - immunology | Interferon-gamma - metabolism | Viral Proteins - metabolism | Ebolavirus - immunology | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Immunoglobulin G - immunology | Hemorrhagic Fever, Ebola - virology | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Hemorrhagic Fever, Ebola - immunology | Enzyme-Linked Immunosorbent Assay | CD4-Positive T-Lymphocytes - metabolism | Immunophenotyping | Hemorrhagic Fever, Ebola - blood | Immunity, Cellular - immunology | Interferon-gamma - immunology | CD8-Positive T-Lymphocytes - immunology | Complications and side effects | Ebola virus infections | Care and treatment | Immune response | Research | Biological Sciences
Journal Article