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1. Full Text Investigating Ebola virus pathogenicity using molecular dynamics
by Pappalardo, Morena and Collu, Francesca and Macpherson, James and Michaelis, Martin and Fraternali, Franca and Wass, Mark N
BMC genomics, ISSN 1471-2164, 2017, Volume 18, Issue Suppl 5, pp. 566 - 566
Pathogenicity | Molecular dynamics | Ebola | Protein structure | Virology | alpha Karyopherins - metabolism | Ebolavirus - metabolism | Viral Proteins - chemistry | Humans | Ebolavirus - pathogenicity | Protein Conformation | Viral Proteins - metabolism | Hemorrhagic Fever, Ebola - metabolism | Molecular Dynamics Simulation | Ebola virus | Proteins | Research | Structure | Analysis | Binding | Dynamic structural analysis | VP24 protein | Pathogens | Epidemics | Water chemistry | Viral diseases | Amino acid sequence | Amino acids | Viruses | Mutants | Signaling | Simulation | Interferon | Mutation | Structural analysis | Index Medicus
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2. Full Text Replication, Pathogenicity, Shedding, and Transmission of Zaire ebolavirus in Pigs
by Gary P. Kobinger and Anders Leung and James Neufeld and Jason S. Richardson and Darryl Falzarano and Greg Smith and Kevin Tierney and Ami Patel and Hana M. Weingartl
The Journal of infectious diseases, ISSN 0022-1899, 7/2011, Volume 204, Issue 2, pp. 200 - 208
Ebola virus | Pulmonary alveoli | Disease transmission | Animals | Lungs | Swine | Humans | Primates | Viruses | Infections | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Infectious diseases | Medical sciences | Lung - pathology | Swine Diseases - virology | Swine Diseases - pathology | Ebolavirus - pathogenicity | Hemorrhagic Fever, Ebola - transmission | Ebolavirus - growth & development | Virus Shedding | Hemorrhagic Fever, Ebola - pathology | Hemorrhagic Fever, Ebola - veterinary | Respiratory System - virology | Swine Diseases - transmission | Virus Replication | Mouth Mucosa - virology | Hemorrhagic Fever, Ebola - virology | Nasal Mucosa - virology | Ebola virus infections | Development and progression | Research | Health aspects | Index Medicus | Abridged Index Medicus
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3. Full Text Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages
by Olejnik, Judith and Forero, Adriana and Deflubé, Laure R and Hume, Adam J and Manhart, Whitney A and Nishida, Andrew and Marzi, Andrea and Katze, Michael G and Ebihara, Hideki and Rasmussen, Angela L and Mühlberger, Elke
Journal of virology, ISSN 0022-538X, 06/2017, Volume 91, Issue 11
Ebola virus | Host response | Cytokines | Interferons | Toll-like receptor 4 | Toll-like receptors | Filovirus | Macrophages | Reston virus | Chemokines | Dendritic Cells - immunology | Humans | Virulence | Cercopithecus aethiops | Ebolavirus - pathogenicity | Gene Expression Profiling | NF-kappa B p50 Subunit - genetics | Interferons - immunology | Interferon Regulatory Factor-3 - genetics | Ebolavirus - immunology | Macrophages - virology | Dendritic Cells - virology | Vero Cells | Macrophages - immunology | Chemokines - immunology | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Cell Line | NF-kappa B p50 Subunit - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 4 - metabolism | Host-Pathogen Interactions | Macrophages - metabolism | Animals | Chemokines - metabolism | Ebolavirus - physiology | Index Medicus
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4. Full Text NK cells accumulate in infected tissues and contribute to pathogenicity of Ebola virus in mice
by Fausther-Bovendo, H and Qiu, X and He, S and Bello, A and Audet, J and Ippolito, G and Wong, G and Kobinger, G
Journal of virology, ISSN 0022-538X, 05/2019, Volume 93, Issue 10
Autologous killing | Ebola virus | NK cells | ULBP-1 | Lymphopenia | Life Sciences & Biomedicine | Science & Technology | Virology | Lymphocytes - metabolism | Ebolavirus - metabolism | T-Lymphocytes | Mice, Inbred C57BL | Virulence | Ebolavirus - pathogenicity | Virus Replication - immunology | Disease Progression | Histocompatibility Antigens Class I - metabolism | Animals | Lymphocytes - virology | Hemorrhagic Fever, Ebola - virology | Killer Cells, Natural - immunology | Female | Hemorrhagic Fever, Ebola - immunology | Membrane Proteins - metabolism | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Ebolavirus - physiology | Hemorrhagic Fever, Ebola - metabolism | Cytokines - immunology | Disease Models, Animal | Index Medicus
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5. Full Text Pathogenicity Comparison between the Kikwit and Makona Ebola Virus Variants in Rhesus Macaques
by Wong, Gary and Qiu, Xiangguo and De La Vega, Marc-Antoine and Fernando, Lisa and Wei, Haiyan and Bello, Alexander and Fausther-Bovendo, Hugues and Audet, Jonathan and Kroeker, Andrea and Kozak, Robert and Tran, Kaylie and He, Shihua and Tierney, Kevin and Soule, Geoff and Moffat, Estella and Günther, Stephan and Gao, George F and Strong, Jim and Embury-Hyatt, Carissa and Kobinger, Gary
The Journal of infectious diseases, ISSN 0022-1899, 10/2016, Volume 214, Issue suppl 3, pp. S281 - S289
Ebola virus | Kikwit | Pathogenicity | Makona | Nonhuman primates | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Animals | Species Specificity | Viremia | Hemorrhagic Fever, Ebola - virology | Humans | Virulence | Ebolavirus - pathogenicity | Macaca mulatta | Virus Shedding | Hemorrhagic Fever, Ebola - pathology | Ebolavirus - physiology | Index Medicus | Abridged Index Medicus | pathogenicity | nonhuman primates | Ebola Outbreak in West Africa
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6. Full Text RNA Editing of the GP Gene of Ebola Virus is an Important Pathogenicity Factor
by Valentina A. Volchkova and Olga Dolnik and Mikel J. Martinez and Olivier Reynard and Viktor E. Volchkov
The Journal of infectious diseases, ISSN 0022-1899, 10/2015, Volume 212, Issue suppl 2, pp. S226 - S233
PATHOGENESIS | Ebola virus | glycoprotein GP | pathogenicity | RNA editing | editing site | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Cell Line | Viral Envelope Proteins - genetics | Guinea Pigs | Virulence Factors - genetics | RNA Editing - genetics | Viral Proteins - genetics | Ebolavirus - pathogenicity | Gene Expression Regulation, Viral - genetics | Ebolavirus - genetics | Mutation - genetics | Down-Regulation - genetics | Membrane Glycoproteins - genetics | Animals | Genes, Viral - genetics | Hemorrhagic Fever, Ebola - virology | Index Medicus | Abridged Index Medicus | Life Sciences | Microbiology and Parasitology | Bacteriology | Virology
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7. Full Text Recently Identified Mutations in the Ebola Virus-Makona Genome Do Not Alter Pathogenicity in Animal Models
by Marzi, Andrea and Chadinah, Spencer and Haddock, Elaine and Feldmann, Friederike and Arndt, Nicolette and Martellaro, Cynthia and Scott, Dana P and Hanley, Patrick W and Nyenswah, Tolbert G and Sow, Samba and Massaquoi, Moses and Feldmann, Heinz
Cell reports (Cambridge), ISSN 2211-1247, 05/2018, Volume 23, Issue 6, pp. 1806 - 1816
Ebola virus | glycoprotein GP | polymerase L | pathogenicity | L mutation D759G | West African epidemic | Ebola Makona | GP mutation A82V | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Genome, Viral | Receptor, Interferon alpha-beta - deficiency | Viremia | Ebolavirus - pathogenicity | Male | Macaca mulatta | Phylogeny | Ebolavirus - genetics | Mutation - genetics | Viral Load | Mice, Knockout | Hemorrhagic Fever, Ebola - blood | Animals | Base Sequence | Hemorrhagic Fever, Ebola - virology | Blood Coagulation | Survival Analysis | Female | Mice | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Index Medicus
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8. Full Text Transmissibility and pathogenicity of Ebola virus: A systematic review and meta-analysis of household secondary attack rate and asymptomatic infection
by Dean, Natalie E and Halloran, M. Elizabeth and Yang, Yang and Longini, Ira M
Clinical infectious diseases, ISSN 1058-4838, 05/2016, Volume 62, Issue 10, pp. 1277 - 1286
asymptomatic infection | household | Ebola | secondary attack rate | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Asymptomatic Infections | Family Characteristics | Hemorrhagic Fever, Ebola - virology | Humans | Ebolavirus - pathogenicity | Hemorrhagic Fever, Ebola - transmission | Disease Outbreaks - statistics & numerical data | Hemorrhagic Fever, Ebola - epidemiology | Ebola virus infections | Care and treatment | Usage | Nursing care | Management | Meta-analysis | Ebola virus | Disease transmission | Disease control | Asymptotic methods | Risk factors | Index Medicus | Review
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9. Full Text Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses
by Pappalardo, Morena and Julia, Miguel and Howard, Mark J and Rossman, Jeremy S and Michaelis, Martin and Wass, Mark N
Scientific reports, ISSN 2045-2322, 03/2016, Volume 6, Issue 1, pp. 23743 - 23743
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | alpha Karyopherins - metabolism | Ebolavirus - metabolism | Viral Matrix Proteins - genetics | Virulence Factors - genetics | Swine Diseases - virology | Humans | Ebolavirus - pathogenicity | Phylogeny | Ebolavirus - genetics | Viral Proteins - metabolism | Genetic Variation | Swine | Conserved Sequence | Viral Matrix Proteins - metabolism | Amino Acid Sequence | Viral Proteins - chemistry | Models, Molecular | Viral Proteins - genetics | Hemorrhagic Fever, Ebola - transmission | Host Specificity | Hemorrhagic Fever, Ebola - veterinary | Swine Diseases - transmission | Animals | Viral Matrix Proteins - chemistry | Protein Conformation | Virulence Factors - metabolism | Pathogenicity | Proteins | VP24 protein | Conserved sequence | VP40 protein | Amino acid sequence | Viruses | Interferon | Genomes | Hydrophobicity | Index Medicus
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10. Full Text Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin
by Sheli R. Radoshitzky and Lian Dong and Xiaoli Chi and Jeremiah C. Clester and Cary Retterer and Kevin Spurgers and Jens H. Kuhn and Sarah Sandwick and Gordon Ruthel and Krishna Kota and Dutch Boltz and Travis Warren and Philip J. Kranzusch and Sean P. J. Whelan and Sina Bavari
Journal of Virology, ISSN 0022-538X, 10/2010, Volume 84, Issue 20, pp. 10569 - 10580
Life Sciences & Biomedicine | Science & Technology | Virology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Miscellaneous | Microbiology | RNA, Small Interfering - genetics | Nipah Virus - pathogenicity | Humans | Arenaviruses, New World - genetics | Ebolavirus - pathogenicity | Marburgvirus - pathogenicity | Ebolavirus - genetics | Antigens, CD - genetics | Gene Knockdown Techniques | Membrane Glycoproteins - physiology | Filoviridae - genetics | Transfection | Base Sequence | Arenaviruses, New World - pathogenicity | Filoviridae - physiology | GPI-Linked Proteins - antagonists & inhibitors | Filoviridae - pathogenicity | Cell Line | Marburgvirus - physiology | Lassa virus - genetics | Marburgvirus - genetics | Membrane Glycoproteins - genetics | Lassa virus - pathogenicity | Lassa virus - physiology | Nipah Virus - physiology | Animals | Nipah Virus - genetics | Virus Release - physiology | GPI-Linked Proteins - physiology | Antigens, CD - physiology | Arenaviruses, New World - physiology | Mice | HeLa Cells | DNA, Viral - genetics | Ebolavirus - physiology | GPI-Linked Proteins - genetics | Host-Pathogen Interactions - physiology | Index Medicus | Virus-Cell Interactions
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11. Full Text Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo
by Ning, Yun-Jia and Ning, Yun-Jia and Kang, Zhenyu and Kang, Zhenyu and Xing, Jingjun and Xing, Jingjun and Min, Yuan-Qin and Min, Yuan-Qin and Liu, Dan and Liu, Dan and Feng, Kuan and Feng, Kuan and Wang, Manli and Wang, Manli and Deng, Fei and Deng, Fei and Zhou, Yiwu and Zhou, Yiwu and Hu, Zhihong and Hu, Zhihong and Wang, Hualin and Wang, Hualin
Protein & cell, ISSN 1674-800X, 4/2018, Volume 9, Issue 4, pp. 389 - 393
Life Sciences | Biochemistry, general | Protein Science | Stem Cells | Human Genetics | Developmental Biology | Cell Biology | Life Sciences & Biomedicine | Science & Technology | Glycoproteins - genetics | Gene Transfer Techniques | Inflammation - pathology | Viral Envelope Proteins - genetics | Humans | Inflammation - virology | Ebolavirus - pathogenicity | Genetic Vectors - therapeutic use | Hemorrhagic Fever, Ebola - pathology | Ebolavirus - genetics | Transfection | Hemorrhagic Fever, Ebola - virology | HEK293 Cells | Adenoviridae - genetics | Inflammation - genetics | Hemorrhagic Fever, Ebola - genetics | Mucins - genetics | Ebola virus | Medical colleges | Yuan (China) | Pathogenicity | Mucin | Index Medicus | Letter
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