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Molecular Biology of the Cell, ISSN 1059-1524, 03/2009, Volume 20, Issue 6, pp. 1785 - 1794
Protein ectodomain shedding is a critical regulator of many membrane proteins, including epidermal growth factor receptor-ligands and tumor necrosis factor... 
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2007, Volume 179, Issue 5, pp. 2686 - 2689
TNF-alpha, a potent proinflammatory cytokine, is synthesized as a membrane-anchored precursor and proteolytically released from cells. Soluble TNF is the... 
DISINTEGRIN | METALLOPROTEINASE | INFLAMMATION | MACROPHAGES | ECTODOMAIN | DISTINCT | NEUTROPHILS | NECROSIS-FACTOR-ALPHA | MICE | IMMUNOLOGY | INHIBITOR
Journal Article
Immunology, ISSN 0019-2805, 10/2014, Volume 143, Issue 2, pp. 300 - 309
Summary The ectodomain of matrix protein 2 (M2e) of influenza virus is considered a rational target for a universal influenza A vaccine. To better understand... 
influenza virus | matrix protein 2 ectodomain antibodies | matrix protein 2 ectodomain virus‐like particles | Fc receptor | T cells | Matrix protein 2 ectodomain antibodies | Matrix protein 2 ectodomain virus-like particles | Influenza virus | IMPROVED CROSS-PROTECTION | matrix protein 2 ectodomain virus-like particles | EXTRACELLULAR DOMAIN | MONOCLONAL-ANTIBODY | IMMUNOLOGY | A VIRUS | T-CELL RESPONSES | MATRIX PROTEIN-2 | IMMUNE-RESPONSES | VIRUS-LIKE PARTICLES | MICE | VACCINES | Orthomyxoviridae Infections - prevention & control | Influenza Vaccines - administration & dosage | Vaccination | Receptors, IgG - deficiency | Interferon-gamma - metabolism | Antibodies, Viral - blood | Receptors, IgG - metabolism | Viral Load | Orthomyxoviridae Infections - genetics | CD4-Positive T-Lymphocytes - immunology | Lung - virology | Receptors, IgG - genetics | Time Factors | Interleukin-6 - blood | Female | CD4-Positive T-Lymphocytes - virology | Disease Models, Animal | Orthomyxoviridae Infections - blood | Cells, Cultured | Inflammation Mediators - blood | Viral Matrix Proteins - administration & dosage | Remission Induction | Mice, Knockout | Hemagglutination | Animals | Influenza Vaccines - immunology | CD8-Positive T-Lymphocytes - virology | Weight Loss | Mice | Mice, Inbred BALB C | Viral Matrix Proteins - immunology | CD8-Positive T-Lymphocytes - immunology | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology | Influenza vaccines | Fc receptors | Influenza | Biological response modifiers | Health aspects | Medical research | Rodents | Original
Journal Article
Cellular Signalling, ISSN 0898-6568, 2011, Volume 23, Issue 6, pp. 980 - 990
Ahsg (fetuin-A) is a 55–59 kDa phosphorylated glycoprotein synthesized in the adult predominantly by hepatocytes, from which it enters the circulation. When... 
Insulin resistance | Harmonic oscillator model | Receptor mechanics | Diabetes | Ectodomain
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 05/2018, Volume 217, Issue 5, pp. 1643 - 1649
Insulin receptor (IR) signaling plays a critical role in the regulation of metabolism and growth in multicellular organisms. IRs are unique among receptor... 
DOMAIN | ACTIVATION | IMAGES | ECTODOMAIN | ELECTRON-MICROSCOPY | CONFORMATION | DIMERS | BINDING | EGF RECEPTOR | CELL BIOLOGY
Journal Article
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 12/2007, Volume 104, Issue 50, pp. 19796 - 19801
Cleavage and release (shedding) of membrane proteins is a critical regulatory step in many normal and pathological processes. Evidence suggests that the... 
PRECURSOR | metalloproteinase | MULTIDISCIPLINARY SCIENCES | ALPHA-CONVERTING-ENZYME | IDENTIFICATION | FAMILY | antiaging protein | ADHESION | insulin signaling | GENE | amyloid precursor protein | ECTODOMAIN | MICE | sheddase | TNF-ALPHA | MEMBRANE-PROTEINS
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2004, Volume 164, Issue 5, pp. 769 - 779
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases.... 
EGF receptor | Growth factor signaling | EGF receptor ligands | ADAMs | Ectodomain shedding | CELLS | ectodomain shedding | HB-EGF | TACE | PROTEIN-COUPLED RECEPTORS | ALPHA-CONVERTING-ENZYME | growth factor signaling | MICE LACKING | FAMILY | CELL BIOLOGY | EPIDERMAL-GROWTH-FACTOR | TGF-ALPHA | METALLOPROTEASE-DISINTEGRIN | ADAM17 Protein | Metalloendopeptidases - genetics | Phenylalanine - analogs & derivatives | Glycoproteins - metabolism | Metalloendopeptidases - metabolism | Thiophenes - metabolism | Epiregulin | Amphiregulin | Disintegrins - genetics | ADAM12 Protein | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Embryo, Mammalian - anatomy & histology | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Muscle Proteins - metabolism | Membrane Proteins - metabolism | Transforming Growth Factor alpha - metabolism | Fibroblasts - metabolism | Tetradecanoylphorbol Acetate - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Phenylalanine - metabolism | Disintegrins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Epidermal Growth Factor - metabolism | Genotype | Protease Inhibitors - metabolism | ADAM Proteins | Mice, Knockout | Muscle Proteins - genetics | Heparin-binding EGF-like Growth Factor | Animals | Endopeptidases - genetics | Betacellulin | Ligands | Fibroblasts - cytology | Mice | Cytology | Research | EGF receptor; EGF receptor ligands; ADAMs; ectodomain shedding; growth factor signaling
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2016, Volume 113, Issue 11, pp. 2940 - 2945
High-resolution crystal structures of the headpiece of lymphocyte function-associated antigen-1 (integrin alpha(L)beta(2)) reveal how the alpha I domain... 
COMPLEX | ACTIVATION | RECOGNITION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ECTODOMAIN | RECEPTOR | MODEL | PROTEINS | BETA-SUBUNIT | BINDING
Journal Article
PLOS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12
The adhesion molecule and co-receptor of receptor tyrosine kinases, CD44, is expressed in all cells of the immune system, but also in numerous non-immune... 
INDUCED EXPRESSION | ECTODOMAIN CLEAVAGE | ACTIVATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | HYALURONAN | RECEPTOR | PROLIFERATION | PROTEINS | IDENTIFICATION | INTRACELLULAR DOMAIN
Journal Article