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Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 8, pp. 2505 - 2509
This paper describes the preparation and in vitro evaluation of 18 newly prepared bis-quinolinium inhibitors on human recombinant acetylcholinesterase (AChE)... 
Inhibitor | Myasthenia gravis | Molecular modelling | Quaternary | In vitro | Cholinesterase | COMPLEX | CHEMISTRY, MEDICINAL | MUSCLE | CHEMISTRY, ORGANIC | QUATERNARY AMMONIUM ANALOGS | ANTICHOLINESTERASES | ACETYLCHOLINESTERASE | SUBSTRATE | PYRIDOSTIGMINE | PATIENT | Butyrylcholinesterase - genetics | Humans | Cholinesterase Inhibitors - chemistry | Structure-Activity Relationship | Acetylcholinesterase - genetics | Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide - pharmacology | Edrophonium - pharmacology | Quinolinium Compounds - pharmacology | Butyrylcholinesterase - chemistry | Butyrylcholinesterase - metabolism | Edrophonium - chemistry | Quinolinium Compounds - therapeutic use | Binding Sites | Recombinant Proteins - metabolism | Recombinant Proteins - chemistry | Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide - chemistry | Ambenonium Chloride - chemistry | Recombinant Proteins - genetics | Acetylcholinesterase - chemistry | Molecular Dynamics Simulation | Cholinesterase Inhibitors - pharmacology | Protein Binding | Kinetics | Cholinesterase Inhibitors - therapeutic use | Myasthenia Gravis - drug therapy | Acetylcholinesterase - metabolism | Ambenonium Chloride - pharmacology | Quinolinium Compounds - chemistry | Index Medicus | Chloride | Neuromuscular junctions | Acetylcholinesterase
Journal Article
Journal Article
BMJ Case Reports, ISSN 1757-790X, 2013, Volume 2013, Issue jan31 1, pp. bcr2012007616 - bcr2012007616
Journal Article