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Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6057, pp. 809 - 813
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here,... 
Datasets | Brain | Enzymes | Prostaglandins | Cytokines | Neurodegenerative diseases | REPORTS | Eicosanoids | Lipids | Endocannabinoids | Vehicles | SYSTEM | INHIBITION | CYCLOOXYGENASE-2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | INJURY | LIPOPOLYSACCHARIDE | PHOSPHOLIPASE A | MICE | PARKINSONS-DISEASE | Cannabinoid Receptor Modulators - metabolism | Inflammation - pathology | Metabolomics | Arachidonic Acid - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Monoacylglycerol Lipases - genetics | Brain - metabolism | Parkinsonian Disorders - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Inflammation Mediators - pharmacology | Lung - metabolism | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Phospholipases A2 - metabolism | Prostaglandins - biosynthesis | Glycerides - metabolism | Brain - drug effects | Hydrolysis | Animals | Parkinsonian Disorders - pathology | Eicosanoids - metabolism | Lipopolysaccharides - pharmacology | Brain - pathology | Mice | Cyclooxygenase 1 - metabolism | Benzodioxoles - pharmacology | Phospholipases A2 - genetics | Prostaglandins - metabolism | Physiological aspects | Inflammation | Research | Risk factors | Hydrology | Neurology | Inflammatory diseases | Animal models | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 22, pp. 8517 - 8522
Dietary fish oil containing ω3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), elicit cardioprotective and anti-inflammatory effects... 
Prostaglandins | Receptors | Cellular metabolism | Cyclooxygenase inhibitors | Eicosanoids | Lipids | Phospholipids | Cell membranes | Lipid metabolism | Fatty acids | P388D MACROPHAGES | CYTOSOLIC PHOSPHOLIPASE A | INHIBITION | RAW264.7 CELLS | PROSTAGLANDIN-E SYNTHASE-1 | MULTIDISCIPLINARY SCIENCES | PURIFICATION | N-3 FATTY-ACIDS | CELL-PROLIFERATION | EXPRESSION | ARACHIDONATE | Arachidonic Acid - metabolism | Gas Chromatography-Mass Spectrometry | Male | Macrophages, Peritoneal - cytology | Adenosine Triphosphate - pharmacology | Lipoxygenase - metabolism | Fatty Acids, Omega-3 - pharmacology | Toll-Like Receptor 4 - agonists | Cell Membrane - metabolism | Macrophages, Peritoneal - drug effects | Cell Membrane - drug effects | Cell Line | Fatty Acids, Omega-3 - metabolism | Cells, Cultured | Fatty Acids, Unsaturated - pharmacology | Phospholipases A2 - metabolism | Fatty Acids, Unsaturated - metabolism | Macrophages - cytology | Toll-Like Receptor 4 - metabolism | Blotting, Western | Docosahexaenoic Acids - pharmacology | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Prostaglandin-Endoperoxide Synthases - metabolism | Eicosanoids - metabolism | Arachidonic Acid - pharmacology | Lipopolysaccharides - pharmacology | Membrane Lipids - metabolism | Receptors, Purinergic P2X7 - metabolism | Macrophages - drug effects | Mice | Macrophages, Peritoneal - metabolism | Docosahexaenoic Acids - metabolism | Physiological aspects | Eicosanoic acid | Research | Health aspects | Omega-3 fatty acids | Proteomics | Enzymes | Signal transduction | Membranes | Fish oils | Cells | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 490, Issue 7418, pp. 107 - 111
Detection of microbial products by host inflammasomes is an important mechanism of innate immune surveillance. Inflammasomes activate the caspase-1 (CASP1)... 
CYTOSOLIC PHOSPHOLIPASE A | FLAGELLIN | III SECRETION APPARATUS | MECHANISM | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | INFECTION | PYROPTOSIS | CASPASE-1 ACTIVATION | IMMUNE RECOGNITION | Inflammation - pathology | Inflammasomes - metabolism | Hematocrit | Salmonella Infections - immunology | Eicosanoids - biosynthesis | Caspase 1 - metabolism | Male | Inflammation - metabolism | Time Factors | Flagellin - metabolism | Bacterial Toxins - genetics | Antigens, Bacterial - chemistry | Neuronal Apoptosis-Inhibitory Protein - deficiency | Macrophages, Peritoneal - immunology | Calcium-Binding Proteins - deficiency | Interleukin-1beta | Bacterial Toxins - chemistry | Apoptosis Regulatory Proteins - metabolism | Cyclooxygenase 1 - deficiency | Body Fluids - metabolism | Caspase 1 - deficiency | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | Death | Mice | Antigens, Bacterial - metabolism | Capillary Permeability | Peritoneal Cavity | Legionella pneumophila | Intestines - metabolism | Antigens, Bacterial - genetics | Recombinant Fusion Proteins - metabolism | Peritoneal Lavage | Apoptosis Regulatory Proteins - deficiency | Flagellin - genetics | Female | Interleukin-18 | Calcium Signaling | Calcium-Binding Proteins - metabolism | Flagellin - immunology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Inflammation - immunology | Body Temperature | Neuronal Apoptosis-Inhibitory Protein - metabolism | Immunity, Innate - immunology | Bacterial Toxins - metabolism | Animals | Eicosanoids - metabolism | Fluid Shifts | Cellular signal transduction | Research | Properties | Bacterial proteins | Flagella (Microbiology) | Immune system | Proteins | Bone marrow | Pathology | Infections | Biosynthesis | Rodents | Index Medicus
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2014, Volume 55, Issue 12, pp. 2471 - 2478
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2007, Volume 35, Issue 7, pp. 1126 - 1134
Cytochrome P450 ( P450) eicosanoids regulate vascular tone, renal tubular transport, cellular proliferation, and inflammation. Both the CYP4A... 
SOLUBLE EPOXIDE HYDROLASE | INHIBITION | METABOLISM | GENE-EXPRESSION | PPAR-GAMMA | PHARMACOLOGY & PHARMACY | FATTY-ACIDS | MOLECULAR-CLONING | ARACHIDONIC-ACID | CYP4A ISOFORMS | APOLIPOPROTEIN-A-I | Gene Expression Regulation, Enzymologic - drug effects | Humans | Transcriptional Activation | Apolipoprotein A-II - genetics | Cytochrome P-450 Enzyme System - metabolism | 8,11,14-Eicosatrienoic Acid - metabolism | Hepatocytes - metabolism | Steroid 16-alpha-Hydroxylase - metabolism | PPAR gamma - metabolism | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Cytochrome P450 Family 2 | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Apolipoprotein A-I - genetics | Transfection | Cytochrome P450 Family 4 | Apolipoprotein A-II - metabolism | Retinoid X Receptors - metabolism | Hepatocytes - drug effects | Eicosanoids - pharmacology | Response Elements | Cytochrome P-450 CYP4A - metabolism | Rats | PPAR alpha - genetics | Peroxisome Proliferators - pharmacology | Apolipoprotein A-I - metabolism | Pyrimidines - pharmacology | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Epoxide Hydrolases - genetics | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Eicosanoids - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | PPAR alpha - agonists | Epoxide Hydrolases - metabolism | PPAR alpha - metabolism | Hepatocytes - enzymology | Index Medicus
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 11/2013, Volume 54, Issue 11, pp. 3085 - 3097
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2013, Volume 33, Issue 9, pp. 2193 - 2201
OBJECTIVE—The activity of eicosanoid pathways is critical to the inflammatory and immune responses that are associated with the progression of atherosclerosis.... 
atherosclerosis | pattern recognition receptors | eicosanoids | peptidoglycan | immunity, innate | inflammation | ACTIVATED PROTEIN-KINASE | CROHNS-DISEASE | HUMAN SYNOVIAL-CELLS | HUMAN ENDOTHELIAL-CELLS | LEUKOTRIENE B-4 | MURAMYL DIPEPTIDE | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | E-DEFICIENT MICE | STIMULATES COLLAGENASE | PROSTAGLANDIN E-2 | Carotid Arteries - metabolism | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Arachidonate 12-Lipoxygenase - metabolism | Humans | Transcriptional Activation | Nod2 Signaling Adaptor Protein - genetics | Case-Control Studies | Time Factors | Carotid Artery Diseases - pathology | Interleukin-1beta - metabolism | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | Carotid Artery Diseases - metabolism | Fibroblasts - metabolism | Carotid Artery Diseases - immunology | Arachidonate 5-Lipoxygenase - metabolism | Signal Transduction | Endothelial Cells - metabolism | Tissue Culture Techniques | Cells, Cultured | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | Arachidonate 15-Lipoxygenase - metabolism | Immunity, Innate | Plaque, Atherosclerotic | Dinoprostone - metabolism | Endothelial Cells - immunology | Nod2 Signaling Adaptor Protein - metabolism | Eicosanoids - metabolism | Carotid Arteries - immunology | Carotid Artery Diseases - genetics | Cyclooxygenase 2 - metabolism | Fibroblasts - immunology | Ligands | Carotid Arteries - pathology | Index Medicus | Kardiologi | Klinisk medicin | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e80316 - e80316
Inflammation may be a major contributing factor to peripartum metabolic disorders in dairy cattle. We tested whether administering an inflammatory cytokine,... 
TRANSITION | TUMOR-NECROSIS-FACTOR | ORGANIC NUTRIENT METABOLISM | PLASMA | PHOSPHORYLATION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | CATTLE | FATTY LIVER | PREVENTION | EXPRESSION | Tumor Necrosis Factor-alpha - blood | Lactation - drug effects | Haptoglobins - metabolism | Insulin - blood | Inflammation - blood | Inflammation - metabolism | Liver - drug effects | Cattle | Fatty Acids, Nonesterified - blood | Female | Eating | 3-Hydroxybutyric Acid - blood | Liver - metabolism | Recombinant Proteins - pharmacology | Methylhistidines - blood | Triglycerides - metabolism | Blood Glucose - drug effects | Recombinant Proteins - blood | Tumor Necrosis Factor-alpha - pharmacology | Animals | Milk - metabolism | Lactation - metabolism | Lipid Metabolism - drug effects | Triglycerides - blood | Glucose - metabolism | Blood Glucose - metabolism | Energy Metabolism - drug effects | Parturition | Phosphorylation | Lactation | Liver | Body weight | Disorders | Eicosanoids | Dry matter | Lipids | Glucose | Kinases | Dosage | Turnover rate | Animal lactation | Proteins | Glucose metabolism | E coli | Haptoglobin | Rodents | Tumor necrosis factor-TNF | Oxidation | Water intakes | Lipid metabolism | Milk | Recombinant | Cytokines | Health | Animal sciences | Glycerol | Inflammation | Tumor necrosis factor-α | Gene expression | Metabolism | Insulin | Fatty acids | Esterification | Milk production | Water intake | Feeds | Metabolic disorders | Index Medicus
Journal Article
Mediators of Inflammation, ISSN 0962-9351, 2016, Volume 2016, pp. 9160540 - 10
Journal Article
Endocrinology, ISSN 0013-7227, 01/2018, Volume 159, Issue 1, pp. 238 - 247
Hyperaldosteronism is associated with hypertension, cardiac hypertrophy, and congestive heart failure. Steroidogenic factors facilitate aldosterone secretion... 
STEROIDOGENESIS | ALDOSTERONE RELEASE | STEROID-SECRETION | ENDOCRINOLOGY & METABOLISM | RAT ADRENALS | AMINOPEPTIDASE | MEDIUM FLOW-RATE | BLOOD-FLOW | RECEPTORS | GLAND | ENDOTHELIAL NITRIC-OXIDE | Endothelium, Vascular - cytology | Gene Expression Regulation, Enzymologic - drug effects | Abattoirs | Muscle, Smooth, Vascular - metabolism | Zona Glomerulosa - drug effects | Adrenal Cortex - metabolism | Endothelium, Vascular - drug effects | Peptide Fragments - pharmacology | Protease Inhibitors - pharmacology | Aldosterone - metabolism | Cattle | Adrenal Cortex - drug effects | Aminopeptidases - metabolism | Arterioles - cytology | Muscle, Smooth, Vascular - drug effects | Aminopeptidases - genetics | Angiotensin II - pharmacology | Peptide Fragments - metabolism | Angiotensin II - metabolism | Cells, Cultured | Zona Glomerulosa - metabolism | Adrenal Cortex - blood supply | Aminopeptidases - antagonists & inhibitors | Angiotensin II - analogs & derivatives | Angiotensin I - metabolism | Muscle, Smooth, Vascular - cytology | Arterioles - drug effects | Zona Glomerulosa - cytology | Angiotensin III - metabolism | Angiotensin II - chemistry | Animals | Arterioles - metabolism | Endothelium, Vascular - metabolism | Peptide Fragments - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Angiotensin I - antagonists & inhibitors | Heart | Enzyme activity | Angiotensin III | Adrenal glands | Eicosanoids | Congestive heart failure | Aldosterone | Arteries | Receptors | Metabolites | Enzymatic activity | Adrenal gland | Inhibition | Angiotensin II | Hypertension | Peptidase | Secretion | Cortex | Mass spectroscopy | Liquid chromatography | Metabolism | Blood flow | Angiotensin | Aminopeptidase | Mass spectrometry | Adrenal metabolism | Hypertrophy | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article