X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (369) 369
humans (349) 349
elafin (226) 226
female (144) 144
elafin - metabolism (120) 120
animals (116) 116
elafin - genetics (88) 88
elastase-specific inhibitor (88) 88
male (85) 85
adult (82) 82
biochemistry & molecular biology (82) 82
proteinase inhibitory proteins, secretory (80) 80
middle aged (74) 74
expression (66) 66
mice (62) 62
oncology (54) 54
inflammation (52) 52
cell biology (50) 50
immunohistochemistry (48) 48
neutrophil elastase (48) 48
aged (47) 47
leukocyte protease inhibitor (47) 47
elastase (46) 46
immunology (46) 46
proteinase-inhibitor (45) 45
cell line, tumor (42) 42
proteins (42) 42
epithelial-cells (40) 40
gene expression (40) 40
proteins - genetics (40) 40
dermatology (39) 39
slpi (38) 38
sequence (37) 37
article (36) 36
cells, cultured (36) 36
inhibitor (36) 36
proteins - metabolism (36) 36
skalp/elafin (36) 36
protease inhibitors (35) 35
proteases (35) 35
molecular sequence data (34) 34
purification (34) 34
blotting, western (33) 33
amino acid sequence (32) 32
respiratory system (32) 32
gene (31) 31
proto-oncogene proteins c-akt - metabolism (30) 30
research (30) 30
rna, messenger - metabolism (30) 30
skin (30) 30
analysis (29) 29
enzyme-linked immunosorbent assay (28) 28
gene expression regulation (28) 28
innate immunity (28) 28
apoptosis (27) 27
cancer (27) 27
health aspects (27) 27
leukocyte elastase - metabolism (27) 27
protease inhibitor (27) 27
signal transduction (27) 27
cells (26) 26
reverse transcriptase polymerase chain reaction (26) 26
abridged index medicus (25) 25
cell line (25) 25
human keratinocytes (25) 25
research article (25) 25
apoptosis - drug effects (24) 24
case-control studies (23) 23
elafin - pharmacology (23) 23
peptides (23) 23
activation (22) 22
amino-acid-sequence (22) 22
antimicrobial activity (21) 21
leukocyte elastase - antagonists & inhibitors (21) 21
lung (21) 21
rna, messenger - genetics (21) 21
serine proteinase inhibitors - metabolism (21) 21
signal transduction - drug effects (21) 21
young adult (21) 21
cytokines (20) 20
elafin - biosynthesis (20) 20
gene-expression (20) 20
pharmacology & pharmacy (20) 20
proto-oncogene proteins c-akt - genetics (20) 20
secretory leukocyte peptidase inhibitor - metabolism (20) 20
transfection (20) 20
antileukoprotease (19) 19
gene expression regulation, neoplastic (19) 19
human skin (19) 19
immunity, innate (19) 19
medicine (19) 19
medicine, research & experimental (19) 19
pancreatic elastase - antagonists & inhibitors (19) 19
pathology (19) 19
pregnancy (19) 19
prognosis (19) 19
protease inhibitors - metabolism (19) 19
secretory leukocyte peptidase inhibitor (19) 19
adolescent (18) 18
cystic-fibrosis (18) 18
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Immunology, ISSN 0019-2805, 02/2010, Volume 129, Issue 2, pp. 207 - 219
Journal Article
Journal Article
Inflammatory bowel diseases, ISSN 1078-0998, 12/2017, Volume 23, Issue 12, pp. 2134 - 2141
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2015, Volume 23, Issue 1, pp. 24 - 31
Elafin is a serine protease inhibitor produced by epithelial and immune cells with anti-inflammatory properties. Research has shown that dysregulated protease... 
MEDICINE, RESEARCH & EXPERIMENTAL | TRAPPIN-2 PRE-ELAFIN | ACUTE LUNG INJURY | NEUTROPHIL ELASTASE | HUMAN KERATINOCYTES | PROTEASE INHIBITOR | ELASTASE-SPECIFIC INHIBITOR | PROTEINASE-INHIBITOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | ALVEOLAR MACROPHAGES | CYSTIC-FIBROSIS | BACTERIAL-INFECTION | Humans | Cystic Fibrosis - pathology | Pneumonia - pathology | Molecular Sequence Data | Male | Lipopolysaccharides | Protease Inhibitors - pharmacology | Proteolysis - drug effects | Pneumonia - chemically induced | Protein Isoforms - chemistry | Protein Engineering | Lung - metabolism | Transglutaminases - antagonists & inhibitors | Elafin - genetics | Amino Acid Sequence | Gene Expression | Lung - pathology | Anti-Inflammatory Agents - pharmacology | Cystic Fibrosis - metabolism | Protease Inhibitors - chemistry | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Fibronectins - antagonists & inhibitors | Elafin - chemistry | Fibronectins - metabolism | Protein Isoforms - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Pneumonia - drug therapy | Lung - drug effects | Transglutaminases - metabolism | Mice | Bronchoalveolar Lavage Fluid - chemistry | Kinetics | Pneumonia - metabolism | Elafin - pharmacology | Protein Isoforms - genetics | Index Medicus | Original
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 09/2018, Volume 59, Issue 9, pp. 2261 - 2263
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 2014, Volume 51, Issue 2, pp. 262 - 272
Elafin (peptidase inhibitor 3 [PI3]) and its biologically active precursor, pre-elafin, are neutrophil serine proteinase inhibitors with an important role in... 
Acute respiratory distress syndrome | Replication | Singlenucleotide polymorphism | Elafin | Genetic association | replication | BACTERIAL LIPOPOLYSACCHARIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | elafin | genetic association | ACUTE LUNG INJURY | NEUTROPHIL ELASTASE | LEUKOCYTE PROTEASE INHIBITOR | HUMAN KERATINOCYTES | PRE-ELAFIN | CELL BIOLOGY | ELASTASE-SPECIFIC INHIBITOR | PROTEINASE-INHIBITOR | EPITHELIAL-CELLS | RESPIRATORY SYSTEM | PSEUDOMONAS-AERUGINOSA | acute respiratory distress syndrome | single-nucleotide polymorphism | Haplotypes | Leukocyte Elastase - metabolism | Multivariate Analysis | Humans | Middle Aged | Male | Respiratory Distress Syndrome, Adult - metabolism | Systemic Inflammatory Response Syndrome - genetics | Case-Control Studies | Respiratory Distress Syndrome, Adult - genetics | Transfection | Adult | Female | Transcription, Genetic | Odds Ratio | Binding Sites | Genes, Reporter | Elafin - genetics | Promoter Regions, Genetic | Systemic Inflammatory Response Syndrome - metabolism | Genetic Predisposition to Disease | Cytokines - metabolism | Genetic Association Studies | Gene Frequency | Risk Factors | Gene Expression Regulation | Elafin - metabolism | Logistic Models | Fibronectins - metabolism | Phenotype | Transglutaminases - metabolism | Cell Line, Tumor | Protein Binding | Aged | Polymorphism, Single Nucleotide | Proteins | Intensive care | Respiratory distress syndrome | Plasmids | Rodents | Quality control | Genetic testing | Gene expression | Patients | Deoxyribonucleic acid--DNA | Index Medicus | Original Research
Journal Article
Protein Science, ISSN 0961-8368, 03/2009, Volume 18, Issue 3, pp. 579 - 594
The secretory leukocyte protease inhibitor (SLPI), elafin, and its biologically active precursor trappin-2 are endogeneous low-molecular weight inhibitors of... 
Protein engineering | Inhibitory specificity | SLPI | Neutrophils | Serine protease | Elafin | Protease inhibitor | ELECTROSTATIC INTERACTIONS | protease inhibitor | TRAPPIN-2 PRE-ELAFIN | ALPHA-1-PROTEASE INHIBITOR | SECRETORY LEUKOPROTEASE INHIBITOR | LEUKOCYTE PROTEINASE-INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE | serine protease | protein engineering | EXPERIMENTAL EMPHYSEMA | SUBSTRATE-SPECIFICITY | inhibitory specificity | ACTIVATED NEUTROPHILS | neutrophils | TISSUE TRANSGLUTAMINASE | Secretory Leukocyte Peptidase Inhibitor - chemistry | Humans | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | Protein Engineering | Membrane Proteins - metabolism | Neutrophils - metabolism | Myeloblastin - metabolism | Secretory Leukocyte Peptidase Inhibitor - metabolism | Elafin - genetics | Amino Acid Sequence | Cathepsin G | Elafin - metabolism | Models, Molecular | Protease Inhibitors - chemistry | Protease Inhibitors - metabolism | Pancreatic Elastase - metabolism | Recombinant Fusion Proteins - chemistry | Static Electricity | Drug Discovery | Elafin - chemistry | Sequence Alignment | Cathepsins - metabolism | Transglutaminases - metabolism | Recombinant Fusion Proteins - genetics | Serine Endopeptidases - metabolism | Lung Diseases | Secretory Leukocyte Peptidase Inhibitor - genetics | Index Medicus
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2011, Volume 184, Issue 5, pp. 537 - 546
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 04/2016, Volume 31, Issue 2, pp. 146 - 155
Elafin is a potent reversible inhibitor of the pro-inflammatory proteases leukocyte elastase and protease 3. It is currently in clinical development for the... 
Tc-99m | Radiolabeling | Elafin | Pharmacokinetic | SPECT
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 12/2012, Volume 186, Issue 11, pp. 1117 - 1124
Rationale: Chronic obstructive pulmonary disease (COPD) exacerbations are associated with virus (mostly rhinovirus) and bacterial infections, but it is not... 
Bacteria | Chronic obstructive pulmonary disease | Disease exacerbation | Rhinovirus | disease exacerbation | RESPIRATORY VIRUSES | bacteria | AIRWAY INFLAMMATION | NEUTROPHIL ELASTASE | rhinovirus | BIOMARKERS | EPITHELIAL-CELLS | COMMUNITY | ACUTE EXACERBATIONS | RESPIRATORY SYSTEM | CYSTIC-FIBROSIS | INHIBITOR | chronic obstructive pulmonary disease | COPD | CRITICAL CARE MEDICINE | Sputum - cytology | Prognosis | Prospective Studies | Pulmonary Disease, Chronic Obstructive - microbiology | Bacterial Infections - etiology | Humans | Middle Aged | Pulmonary Disease, Chronic Obstructive - virology | Male | Secretory Leukocyte Peptidase Inhibitor - analysis | Antimicrobial Cationic Peptides - metabolism | Coinfection - physiopathology | Polymerase Chain Reaction - methods | C-Reactive Protein - metabolism | Inflammation Mediators - analysis | Statistics, Nonparametric | Adult | Female | C-Reactive Protein - analysis | Secretory Leukocyte Peptidase Inhibitor - metabolism | Severity of Illness Index | Risk Assessment | Coinfection - etiology | Elafin - metabolism | Pulmonary Disease, Chronic Obstructive - complications | Disease Progression | Serum Amyloid P-Component - analysis | Bacterial Infections - physiopathology | Analysis of Variance | Picornaviridae Infections - physiopathology | Aged | Elafin - analysis | Serum Amyloid P-Component - metabolism | Picornaviridae Infections - complications | Cohort Studies | Smoking | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 01/2015, Volume 34, Issue 3, pp. 299 - 309
High-grade serous ovarian carcinoma (HGSOC) and basal-like breast cancer (BLBC) share many features including TP53 mutations, genomic instability and poor... 
MAP kinase | Mitogen | Elafin | Basal-like breast cancer | Ovarian cancer | basal-like breast cancer | SURVIVAL | PROTEIN | ovarian cancer | HE-4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | elafin | VALIDATION | VERSUS-HOST-DISEASE | CELL BIOLOGY | GENOMIC INSTABILITY | mitogen | ONCOLOGY | GENES | GENETICS & HEREDITY | EXPRESSION | MICROARRAY DATA | MAMMARY EPITHELIAL-CELLS | Immunohistochemistry | Cell Proliferation | Prognosis | Humans | Cystadenocarcinoma, Serous - metabolism | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | bcl-X Protein - genetics | Gene Expression Profiling | Cystadenocarcinoma, Serous - genetics | Cystadenocarcinoma, Serous - pathology | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | MAP Kinase Signaling System - genetics | MCF-7 Cells | RNA Interference | Female | Ovarian Neoplasms - metabolism | Elafin - genetics | Kaplan-Meier Estimate | Proportional Hazards Models | Elafin - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Breast Neoplasms - genetics | Outcome Assessment (Health Care) - statistics & numerical data | Breast Neoplasms - pathology | Proteomics | Cell Line, Tumor | bcl-X Protein - metabolism | Care and treatment | Development and progression | Genetic aspects | Breast cancer | Tumor proteins | Gene expression | Health aspects | Biomarkers | Protein expression | Medical prognosis | Index Medicus
Journal Article