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Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2015, Volume 172, Issue 22, pp. 5360 - 5376
BACKGROUND AND PURPOSE Sphingosine 1-phosphate (S1P), an important inflammatory mediator, has been shown to regulate COX-2 production and promote various... 
TRANSCRIPTION FACTORS | COX-2 EXPRESSION | MURINE MODEL | ACTIVATION | CONCISE GUIDE | PHARMACOLOGY | SPHINGOSINE-1-PHOSPHATE | AIRWAY INFLAMMATION | PHARMACOLOGY & PHARMACY | UP-REGULATION | STATINS | RNA, Small Interfering - genetics | Lovastatin - pharmacology | Membrane Glycoproteins - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | NADPH Oxidases - metabolism | Male | Lovastatin - analogs & derivatives | PPAR gamma - metabolism | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - genetics | Cyclooxygenase 2 - genetics | Forkhead Transcription Factors - metabolism | Lysophospholipids - pharmacology | Bronchoalveolar Lavage Fluid - cytology | Leukocyte Count | Phosphorylation - drug effects | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Myocytes, Smooth Muscle - metabolism | Trachea - cytology | Anti-Inflammatory Agents - pharmacology | Myocytes, Smooth Muscle - physiology | Elafin - metabolism | NADPH Oxidase 2 | Mice, Inbred ICR | Hydrogen Peroxide - metabolism | Dinoprostone - metabolism | Sphingosine - pharmacology | Cell Movement - drug effects | Sphingosine - analogs & derivatives | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cyclic AMP Response Element-Binding Protein - metabolism | Cyclooxygenase 2 - metabolism | Forkhead Box Protein O1 | Phosphates | Prostaglandins E | Sphingosine | Phosphorylation | Cell adhesion & migration | Research Papers | Research Paper
Journal Article
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2015, Volume 23, Issue 1, pp. 24 - 31
Elafin is a serine protease inhibitor produced by epithelial and immune cells with anti-inflammatory properties. Research has shown that dysregulated protease... 
MEDICINE, RESEARCH & EXPERIMENTAL | TRAPPIN-2 PRE-ELAFIN | ACUTE LUNG INJURY | NEUTROPHIL ELASTASE | HUMAN KERATINOCYTES | PROTEASE INHIBITOR | ELASTASE-SPECIFIC INHIBITOR | PROTEINASE-INHIBITOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | ALVEOLAR MACROPHAGES | CYSTIC-FIBROSIS | BACTERIAL-INFECTION | Humans | Cystic Fibrosis - pathology | Pneumonia - pathology | Molecular Sequence Data | Male | Lipopolysaccharides | Protease Inhibitors - pharmacology | Proteolysis - drug effects | Pneumonia - chemically induced | Protein Isoforms - chemistry | Protein Engineering | Lung - metabolism | Transglutaminases - antagonists & inhibitors | Elafin - genetics | Amino Acid Sequence | Gene Expression | Lung - pathology | Anti-Inflammatory Agents - pharmacology | Cystic Fibrosis - metabolism | Protease Inhibitors - chemistry | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Fibronectins - antagonists & inhibitors | Elafin - chemistry | Fibronectins - metabolism | Protein Isoforms - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Pneumonia - drug therapy | Lung - drug effects | Transglutaminases - metabolism | Mice | Bronchoalveolar Lavage Fluid - chemistry | Kinetics | Pneumonia - metabolism | Elafin - pharmacology | Protein Isoforms - genetics | Original
Journal Article
Microbiology, ISSN 1350-0872, 09/2009, Volume 155, Issue 9, pp. 2818 - 2825
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 9, p. e73867
Background: Although antimicrobial peptides protect mucus and mucosa from bacteria, Helicobacter pylori is able to colonize the gastric mucus. To clarify in... 
CROHNS-DISEASE | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | GASTROINTESTINAL-TRACT | HOST-DEFENSE | BETA-DEFENSINS | EXPRESSION | STOMACH | CAG PATHOGENICITY ISLAND | MUCOSAL TISSUES | INNATE IMMUNITY | Gastric Mucosa - microbiology | Gastritis - metabolism | Humans | Middle Aged | Gastritis - genetics | Gastric Mucosa - pathology | Helicobacter pylori - drug effects | Male | Antimicrobial Cationic Peptides - metabolism | Gastric Mucosa - metabolism | Cathelicidins - genetics | Young Adult | Gastritis - pathology | Aged, 80 and over | Gastritis - microbiology | Adult | Female | Helicobacter Infections - metabolism | beta-Defensins - metabolism | Antimicrobial Cationic Peptides - genetics | Cathelicidins - pharmacology | Elafin - genetics | beta-Defensins - genetics | Disease Resistance | Antimicrobial Cationic Peptides - pharmacology | Gene Expression Regulation | Elafin - metabolism | Helicobacter Infections - genetics | Cathelicidins - metabolism | Disk Diffusion Antimicrobial Tests | beta-Defensins - pharmacology | Aged | Elafin - pharmacology | Helicobacter Infections - microbiology | Helicobacter infections | Peptides | Helicobacter pylori | Health aspects | Antibacterial agents | Flow cytometry | Mucosa | Gastric mucosa | Infections | Mucus | Molecular weight | Gastroenterology | Antimicrobial peptides | Antibacterial activity | Bacteria | Strains (organisms) | Killing | Internal medicine | Agar | Antimicrobial agents | Pharmacology | Electron microscopy | Gene expression | Patients | Medicine | Pathology | Cytometry | Hospitals | Defensins | Biopsy | Plasmids | Colonization
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36463 - 36473
Shp2 has been known to mediate growth factor-stimulated cell proliferation, but its role in cell survival is less clear. Gain-of-function Shp2 mutants such as... 
Elafin - antagonists & inhibitors | Humans | Leukemia, Myeloid - genetics | Cell Survival - genetics | Apoptosis - genetics | Myeloid Progenitor Cells - enzymology | Mutation, Missense | Oncogene Protein p21(ras) - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Chromones - pharmacology | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Elafin - genetics | Cell Survival - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Down-Regulation - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Enzyme Activation - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Oncogene Protein p21(ras) - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Nitriles - pharmacology | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | bcl-X Protein - genetics | Interleukin-3 - pharmacology | Proto-Oncogene Proteins c-akt - genetics | Oncogene Protein p21(ras) - antagonists & inhibitors | MAP Kinase Signaling System - genetics | Mitochondria - genetics | bcl-X Protein - biosynthesis | Benzopyrans - pharmacology | Cell Line | Interleukin-3 - metabolism | Leukemia, Myeloid - enzymology | Neoplasm Proteins - biosynthesis | Purines - pharmacology | Elafin - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Morpholines - pharmacology | Up-Regulation - genetics | Mitochondria - metabolism | Down-Regulation - drug effects | Enzyme Activation - drug effects | Up-Regulation - drug effects | MAP Kinase Signaling System - drug effects | Myeloid Cell Leukemia Sequence 1 Protein | Chlorpropamide - analogs & derivatives | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Amino Acid Substitution | Chlorpropamide - pharmacology
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2012, Volume 83, Issue 12, pp. 1663 - 1673
Journal Article