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Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 06/2014, Volume 53, Issue 23, pp. 3758 - 3766
We isolated a novel, atypical long-chain three-finger toxin (TFT), alpha-elapitoxin-Dpp2d (alpha-EPTX-Dpp2d), from black mamba (Dendroaspis polylepis... 
KAPPA-BUNGAROTOXIN | ALPHA-NEUROTOXINS | SNAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | NICOTINIC RECEPTOR PROBE | CRYSTAL-STRUCTURES | 3-FINGERED TOXINS | PROTEINS | BINDING | ACETYLCHOLINE-RECEPTOR | Reptilian Proteins - chemistry | Humans | alpha7 Nicotinic Acetylcholine Receptor - antagonists & inhibitors | Nicotinic Antagonists - pharmacology | Nicotinic Agonists - chemistry | Reptilian Proteins - pharmacology | Receptors, Nicotinic - chemistry | Neurons - metabolism | Amino Acid Sequence | Nicotinic Antagonists - isolation & purification | Receptors, Nicotinic - metabolism | Nerve Tissue Proteins - agonists | Carrier Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | alpha7 Nicotinic Acetylcholine Receptor - genetics | Reptilian Proteins - isolation & purification | Elapid Venoms - pharmacology | Nicotinic Antagonists - chemistry | Calcium Signaling - drug effects | Neurotoxins - metabolism | Protein Conformation | Protein Processing, Post-Translational | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Reptilian Proteins - metabolism | Elapid Venoms - chemistry | Nicotinic Antagonists - metabolism | Molecular Sequence Data | Neurotoxins - isolation & purification | Carrier Proteins - chemistry | Protein Stability | Elapid Venoms - isolation & purification | Neurons - drug effects | Nicotinic Agonists - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Neurotoxins - chemistry | alpha7 Nicotinic Acetylcholine Receptor - agonists | Recombinant Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Neurotoxins - pharmacology | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Elapidae - metabolism | Elapid Venoms - metabolism | Receptors, Nicotinic - genetics | Venom | Chemical properties | Research | Index Medicus
Journal Article
Toxicology Letters, ISSN 0378-4274, 08/2016, Volume 257, pp. 60 - 71
The venom of , a coral snake of wide geographical distribution in South America, was fractionated by reverse-phase HPLC and the fractions screened for... 
Amino acid sequence | Cytotoxicity | Inflammation | Micrurus lemniscatus | Myotoxicity | Group I phospholipase A2 | Group I phospholipase A | Rats, Wistar | Muscular Diseases - enzymology | Humans | Elapid Venoms - enzymology | Inflammation Mediators - isolation & purification | Male | Chromatography, High Pressure Liquid | Muscle Fibers, Skeletal - drug effects | Dose-Response Relationship, Drug | Chromatography, Reverse-Phase | Sequence Analysis, Protein | Time Factors | Inflammation Mediators - metabolism | Muscular Diseases - chemically induced | Elapid Venoms - isolation & purification | Elapid Venoms - toxicity | Cell Line | Human Umbilical Vein Endothelial Cells - drug effects | Creatine Kinase - blood | Inflammation Mediators - toxicity | Edema - enzymology | Phospholipases A2 - metabolism | Muscular Diseases - pathology | Phospholipases A2 - toxicity | Mast Cells - enzymology | Mast Cells - drug effects | Animals | Human Umbilical Vein Endothelial Cells - enzymology | Blood Coagulation - drug effects | Elapidae - metabolism | Muscle Fibers, Skeletal - pathology | Mice | Edema - chemically induced | Elapid Venoms - metabolism | Phospholipases A2 - isolation & purification | Cell Degranulation - drug effects | Muscle Fibers, Skeletal - enzymology | Index Medicus | Anticoagulants | Residues | Phospholipase | Venom toxins | Corals | Amino acids | Endothelial cells
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 11/2015, Volume 14, Issue 11, pp. 4896 - 4906
This study demonstrates a direct role of venom protein expression alteration in the evolution of snake venom toxicity. Avian skeletal muscle contractile... 
toxicity | label-free quantification | procoagulants | snake venom | neurotoxins | Oxyuranus scutellatus | evolution | quantitative proteomics | proteome | Pseudonaja textilis | MOLECULAR EVOLUTION | BIOCHEMICAL RESEARCH METHODS | IDENTIFICATION | PAPUA-NEW-GUINEA | BROWN SNAKE | HYDROPHIINAE | PRESYNAPTIC NEUROTOXIN | PSEUDONAJA-TEXTILIS | MASS | NEUTRALIZATION | PROTHROMBIN ACTIVATOR | Elapid Venoms - chemistry | Diaphragm - drug effects | Species Specificity | Neuromuscular Junction - drug effects | Molecular Sequence Data | Neurotoxins - genetics | Coagulants - isolation & purification | Coagulants - chemistry | Excitatory Postsynaptic Potentials - drug effects | Neurotoxins - isolation & purification | Excitatory Postsynaptic Potentials - physiology | Phrenic Nerve - drug effects | Muscle, Skeletal - drug effects | Coagulants - metabolism | Coagulants - toxicity | Elapid Venoms - isolation & purification | Elapid Venoms - genetics | Elapid Venoms - toxicity | Amino Acid Sequence | Elapidae - genetics | Neurotoxins - chemistry | Computational Biology - methods | Gene Expression | Serine Endopeptidases - toxicity | Peptide Fragments - isolation & purification | Elapidae - classification | Rats | Birds | Neurotoxins - toxicity | Serine Endopeptidases - chemistry | Muscle, Skeletal - physiology | Diaphragm - physiology | Peptide Fragments - chemistry | Sequence Alignment | Animals | Muscle Contraction - drug effects | Muscle Contraction - physiology | Serine Endopeptidases - metabolism | Elapid Venoms - metabolism | Australia | Serine Endopeptidases - isolation & purification | Trypsin - chemistry | Phrenic Nerve - physiology | Evolution, Molecular | Neuromuscular Junction - physiology | Index Medicus
Journal Article
Toxicon, ISSN 0041-0101, 03/2016, Volume 112, pp. 45 - 50
Paradoxin and taipoxin are neurotoxic phospholipases from the inland and coastal species of Australian taipan. Despite their relatively high sequence homology... 
Toxin | Structure | Mass spectrometry | Elapids | Venom | OXYURANUS-S-SCUTELLATUS | SNAKE-VENOM | NEUROMUSCULAR ACTIVITY | MASS-SPECTROMETRY | PRE-SYNAPTIC NEUROTOXIN | AMINO-ACID-SEQUENCE | PRESYNAPTIC NEUROTOXIN | MICROLEPIDOTUS | ASSEMBLIES | PHARMACOLOGY & PHARMACY | QUATERNARY STRUCTURE | TOXICOLOGY | Elapid Venoms - chemistry | Reptilian Proteins - chemistry | Molecular Weight | Protein Multimerization | Elapid Venoms - enzymology | Isoenzymes - chemistry | Chromatography, High Pressure Liquid | Neurotoxins - isolation & purification | Protein Subunits - metabolism | Isoenzymes - isolation & purification | Chromatography, Reverse-Phase | Tandem Mass Spectrometry | Spectrometry, Mass, Electrospray Ionization | Protein Subunits - isolation & purification | Isoenzymes - metabolism | Phospholipases A2, Secretory - chemistry | Protein Structure, Quaternary | Elapid Venoms - isolation & purification | Neurotoxins - chemistry | Phospholipases A2, Secretory - isolation & purification | Reptilian Proteins - isolation & purification | Animals | Elapidae - metabolism | Neurotoxins - metabolism | Phospholipases A2, Secretory - metabolism | Protein Subunits - chemistry | Elapid Venoms - metabolism | Australia | Chromatography, Gel | Reptilian Proteins - metabolism | Index Medicus | Positioning | Phospholipase | Homology | Coastal | Trimers | Toxins
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1940 - 1940
Tumor necrosis factor (TNF)-alpha is a pleiotropic cytokine with intense pro-inflammatory and immunomodulatory properties, and anti-TNF-alpha biologics are... 
H-TL1 | Hydrophis cyanocinctus | Inflammatory bowel diseases | TNF-α | Anti-inflammatory | DEXTRAN SULFATE SODIUM | SNAKE-VENOM | inflammatory bowel diseases | TNF-alpha | CATHELICIDIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHAGE DISPLAY | FACTOR-KAPPA-B | PROLIFERATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | TUMOR-NECROSIS-FACTOR | anti-inflammatory | INFLAMMATORY RESPONSE | Colitis - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Peptide Library | Lipopolysaccharides | Reptilian Proteins - pharmacology | Receptors, Tumor Necrosis Factor, Type I - chemistry | Transcription, Genetic | Anti-Inflammatory Agents - isolation & purification | Colitis - drug therapy | Fibroblasts - metabolism | Cell Survival - drug effects | Acute Disease | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Reptilian Proteins - isolation & purification | Elapid Venoms - pharmacology | Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type I - genetics | Oligopeptides - isolation & purification | Tumor Necrosis Factor-alpha - chemistry | Fibroblasts - drug effects | Fibroblasts - cytology | Mice | Snake Venoms - isolation & purification | Elapid Venoms - chemical synthesis | Oligopeptides - pharmacology | p38 Mitogen-Activated Protein Kinases - chemistry | Reptilian Proteins - chemical synthesis | Dextran Sulfate | Phosphorylation | Colitis - pathology | Snake Venoms - chemistry | Colubridae - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Colitis - chemically induced | HEK293 Cells | Shock, Septic - drug therapy | Elapid Venoms - isolation & purification | Shock, Septic - genetics | Cell Line | Oligopeptides - chemical synthesis | Shock, Septic - pathology | Shock, Septic - chemically induced | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Animals | Extracellular Signal-Regulated MAP Kinases - chemistry | Anti-Inflammatory Agents - chemical synthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Inflammatory bowel disease | Tumor necrosis factor-TNF | Peptides | Cytokines | Index Medicus
Journal Article