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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2012, Volume 32, Issue 3, pp. 745 - 755
OBJECTIVE—Age-related aortic stiffness is an independent risk factor for cardiovascular diseases. Although oxidative stress is implicated in aortic stiffness,... 
blood pressure | aging | signal transduction | vasodilation | reactive oxygen species | FORKHEAD TRANSCRIPTION FACTOR | PULSE-WAVE VELOCITY | CARDIOVASCULAR EVENTS | MATRIX METALLOPROTEINASE-2 | ANGIOTENSIN-II | DEFICIENT MICE | MANGANESE-SUPEROXIDE-DISMUTASE | ARTERIAL STIFFNESS | PERIPHERAL VASCULAR DISEASE | VASCULAR ENDOTHELIAL DYSFUNCTION | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | Superoxide Dismutase - genetics | Compliance | Oxidative Stress | Aorta - metabolism | Aortic Diseases - metabolism | Vasodilation | NADPH Oxidases - deficiency | Muscle, Smooth, Vascular - diagnostic imaging | Forkhead Transcription Factors - metabolism | NADPH Oxidases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Matrix Metalloproteinase 2 - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Genotype | Mitochondria - pathology | Hydrogen Peroxide - metabolism | Mice, Knockout | Aortic Diseases - genetics | Phenotype | Mice | Ultrasonography, Doppler, Pulsed | Ventricular Pressure | Insulin-Like Growth Factor I - metabolism | Aging - metabolism | Aortic Diseases - diagnostic imaging | Age Factors | Muscle, Smooth, Vascular - metabolism | Pulsatile Flow | Ventricular Function, Left | Actins - metabolism | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | Transfection | Superoxides - metabolism | Aorta - physiopathology | Myocytes, Smooth Muscle - metabolism | Elastin - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Cells, Cultured | Superoxide Dismutase - deficiency | Mitochondria - metabolism | Forkhead Transcription Factors - genetics | Aging - pathology | Stroke Volume | Aortic Diseases - physiopathology | Animals | Superoxide Dismutase-1 | Apoptosis | Index Medicus | arterial compliance | vascular wall remodeling | apoptosis | Akt | matrix metalloproteinases | superoxide dismutase 2
Journal Article
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 12/2013, Volume 1832, Issue 12, pp. 2077 - 2084
Journal Article
Cell Reports, ISSN 2211-1247, 01/2013, Volume 3, Issue 1, pp. 200 - 210
Journal Article
Experimental Gerontology, ISSN 0531-5565, 02/2013, Volume 48, Issue 2, pp. 269 - 276
We tested the hypothesis that curcumin supplementation would reverse arterial dysfunction and vascular oxidative stress with aging. Young (Y, 4–6 months) and... 
AGEs | Superoxide | Endothelial function | Arterial stiffness | Collagen | CARDIOVASCULAR EVENTS | PORCINE CORONARY-ARTERIES | AORTIC STIFFNESS | GERIATRICS & GERONTOLOGY | INDUCED HYPERTENSION | DEPENDENT DILATION | ADVANCED GLYCATION | NITRIC-OXIDE | CHEMOPREVENTIVE AGENT | VASCULAR ENDOTHELIAL DYSFUNCTION | AEROBIC EXERCISE | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Age Factors | Pulse Wave Analysis | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | Phosphoproteins - metabolism | Tyrosine - analogs & derivatives | Dose-Response Relationship, Drug | Superoxides - metabolism | Aorta - physiopathology | Nitric Oxide Synthase Type III - metabolism | Superoxide Dismutase - metabolism | Elastin - metabolism | Collagen Type I - metabolism | Vasodilator Agents - pharmacology | Aorta - drug effects | Mice, Inbred C57BL | Curcumin - pharmacology | Endothelium, Vascular - physiopathology | Antioxidants - pharmacology | Tyrosine - metabolism | Animals | Carotid Arteries - physiopathology | Endothelium, Vascular - metabolism | Glycation End Products, Advanced - metabolism | Vascular Stiffness - drug effects | Mice | Oxidative Stress - drug effects | Vasodilation - drug effects | Nitric Oxide - metabolism | Aging - metabolism | Index Medicus | arterial stiffness | endothelial function | collagen
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2015, Volume 309, Issue 1, pp. H103 - H113
Fibulin-4 is an extracellular matrix protein that is essential for proper assembly of arterial elastic fibers. Mutations in fibulin-4 cause cutis laxa with... 
Mechanics | Gene array | Fibulin-4 | Elastin | Aneurysm | aneurysm | MATRIX | NEUTROPHIL COLLAGENASE | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | EPIREGULIN | gene array | mechanics | ANGIOTENSIN-II | EXPRESSION PROFILES | elastin | fibulin-4 | MARFAN-SYNDROME | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | GROWTH-FACTOR | MUTATIONS | Heparin-binding EGF-like Growth Factor - genetics | Up-Regulation | Aorta - ultrastructure | Aortic Aneurysm, Thoracic - genetics | Muscle, Smooth, Vascular - metabolism | Elastic Modulus | Gene Expression Profiling | Acute-Phase Proteins - genetics | Aorta - metabolism | RNA, Messenger - metabolism | Cyclooxygenase 2 - genetics | Matrix Metalloproteinase 8 - metabolism | Muscle Proteins - metabolism | Aorta - physiopathology | Nuclear Proteins - genetics | Myocytes, Smooth Muscle - metabolism | Epiregulin - metabolism | Repressor Proteins - metabolism | Animals, Newborn | Matrix Metalloproteinase 8 - genetics | Serpins - genetics | Serpins - metabolism | Acute-Phase Proteins - metabolism | Extracellular Matrix Proteins - genetics | Aorta, Thoracic - metabolism | Receptors, Cell Surface - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aorta, Thoracic - physiopathology | Epiregulin - genetics | Microscopy, Electron | Muscle, Smooth, Vascular - cytology | Reverse Transcriptase Polymerase Chain Reaction | Aorta, Thoracic - ultrastructure | Mice, Knockout | Heparin-binding EGF-like Growth Factor - metabolism | Muscle Proteins - genetics | Animals | Cyclooxygenase 2 - metabolism | Collagen Type VIII - metabolism | Mice | Myocytes, Smooth Muscle - ultrastructure | Collagen Type VIII - genetics | Receptors, Cell Surface - genetics | Cellular proteins | Aortic aneurysms | Development and progression | Cellular signal transduction | Genetic aspects | Properties | Genetic regulation | Health aspects | Aneurysms | Gene expression | Analysis | Proteins | Genotype & phenotype | Pathogenesis | Physiology | Mutation | Index Medicus | Vascular Biology and Microcirculation
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 3/2008, Volume 25, Issue 3, pp. 692 - 699
In this study the chondrocytic differentiation and cartilage matrix accumulation of human mesenchymal stem cells (hMSCs) were investigated after encapsulation... 
Biomedical Engineering | Biochemistry, general | silk-elastinelike polymers | tissue engineering | Biomedicine | Pharmacy | Medical Law | hydrogels | chondrogenesis | Pharmacology/Toxicology | genetically engineered polymers | Hydrogels | Chondrogenesis | Tissue engineering | Genetically engineered polymers | Silk-elastinelike polymers | MATRIX | DRUG-DELIVERY | BONE-MARROW | CONTROLLED-RELEASE | TISSUE-REPAIR | CHEMISTRY, MULTIDISCIPLINARY | PROTEIN POLYMER | ARTICULAR-CARTILAGE | PHARMACOLOGY & PHARMACY | GENE-THERAPY | DIFFERENTIATION | POLYPEPTIDE | Up-Regulation | Elastin - toxicity | Chondrogenesis - genetics | Humans | RNA, Messenger - metabolism | Transforming Growth Factor beta3 - metabolism | Collagen Type II - metabolism | Tissue Scaffolds | Collagen Type X - metabolism | Time Factors | Cell Shape | Cell Differentiation | Cell Culture Techniques | Insect Proteins - metabolism | Chondrocytes - metabolism | Recombinant Proteins - metabolism | Elastin - metabolism | High Mobility Group Proteins - metabolism | Cell Survival | Glycosaminoglycans - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Silk - metabolism | Aggrecans - metabolism | Cartilage - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Transcription Factors - metabolism | Silk - toxicity | Insect Proteins - chemistry | Elastin - chemistry | SOX9 Transcription Factor | Insect Proteins - toxicity | Silk - chemistry | Cell research | Stem cells | Cartilage | Cell culture | Pharmacology | Polymers | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 09/2015, Volume 309, Issue 5, pp. H906 - H917
Macrophages accumulate in blood vessels during hypertension. However, their contribution to vessel remodeling is unknown. In the present study, we examined the... 
Hypertension | Vessel remodeling | Blood pressure | Macrophage polarization | Angiotensin II | Chemokine (C-C motif) receptor 2 | blood pressure | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | vessel remodeling | CCR2 ANTAGONIST | MONOCYTES | ATHEROSCLEROSIS | macrophage polarization | MECHANISMS | INDUCED HYPERTENSION | HYPERTROPHY | INTERLEUKIN-17 | angiotensin II | ARTERIAL STIFFNESS | VASCULAR INFLAMMATION | PERIPHERAL VASCULAR DISEASE | hypertension | chemokine (C-C motif) receptor 2 | ALTERNATIVE ACTIVATION | Blood Pressure | Receptors, CCR2 - genetics | Antigens, Ly - genetics | Arginase - metabolism | Aorta - metabolism | Fibrosis - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Hypertension - etiology | Antigens, Ly - metabolism | Collagen - genetics | Angiotensin II - toxicity | Elastin - metabolism | Macrophages - classification | Aorta - drug effects | Mice, Inbred C57BL | Arginase - genetics | Hypertension - pathology | Hypertension - metabolism | Aorta - pathology | Collagen - metabolism | Macrophages - metabolism | Receptors, CCR2 - metabolism | Animals | Elastin - genetics | Nitric Oxide Synthase Type II - genetics | Macrophages - drug effects | Mice | Fibrosis - pathology | Nitric Oxide Synthase Type II - metabolism | Coronary vessels | Rodents | Gene expression | ACE inhibitors | Chemokines | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 04/2009, Volume 119, Issue 13, pp. 1785 - 1794
Background-Clinical studies have demonstrated that 50% of individuals with chronic renal disease (CRD) die of cardiovascular causes, including advanced... 
Calcification | Chronic | Kidney failure | Aortic valve | Elastin | Atherosclerosis | atherosclerosis | kidney failure, chronic | aortic valve | ELASTIN PEPTIDES | CARDIAC & CARDIOVASCULAR SYSTEMS | ATHEROSCLEROTIC PLAQUES | VASCULAR CALCIFICATION | elastin | POTENTIAL MECHANISM | FAILURE | IN-VIVO | CYSTATIN-C | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | calcification | CHRONIC KIDNEY-DISEASE | VULNERABLE PLAQUE | Tunica Media - pathology | Osteogenesis - physiology | Cystatin C - blood | Humans | Carotid Artery Diseases - physiopathology | Aorta - metabolism | Aortic Valve - pathology | Nephrectomy | Carotid Artery Diseases - pathology | Mice, Mutant Strains | Tunica Media - metabolism | Phosphates - blood | Calcinosis - metabolism | Carotid Artery Diseases - metabolism | Phosphates - pharmacology | Muscle, Smooth, Vascular - physiology | Kidney Failure, Chronic - physiopathology | Elastin - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Aortic Valve Stenosis - physiopathology | Cells, Cultured | Elastin - pharmacology | Muscle, Smooth, Vascular - cytology | Aortic Valve - metabolism | Kidney Failure, Chronic - metabolism | Aorta - pathology | Tunica Intima - metabolism | Animals | Aortic Valve Stenosis - pathology | Tunica Intima - pathology | Cathepsins - genetics | Cathepsins - metabolism | Apolipoproteins E - genetics | Creatinine - blood | Aortic Valve Stenosis - metabolism | Mice | Calcinosis - pathology | Cathepsins - deficiency | Calcinosis - physiopathology | Cathepsins | Physiological aspects | Research | Chronic kidney failure | Diseases | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 09/2015, Volume 309, Issue 5, pp. L463 - L474
Pulmonary alveolar fibroblasts produce extracellular matrix in a temporally and spatially regulated pattern to yield a durable yet pliable gas-exchange... 
Adipocyte | PDGF receptor-α | Cell differentiation | Endosome | Fibroblast | cell differentiation | PHYSIOLOGY | LUNG DEVELOPMENT | PROLIFERATION | FACTOR RECEPTOR-ALPHA | UBIQUITINATION | MORPHOGENESIS | endosome | fibroblast | PDGF receptor-alpha | RESPIRATORY SYSTEM | adipocyte | FGF18 | DIFFERENTIATION | STROMAL CELLS | FGFR3 | ADIPOSE-TISSUE | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Cell Proliferation | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Extracellular Matrix - metabolism | Fibroblast Growth Factors - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Myofibroblasts - metabolism | Fibroblast Growth Factors - metabolism | Pulmonary Alveoli - metabolism | Pulmonary Alveoli - cytology | Cell Differentiation | Membrane Proteins - metabolism | Cyclin-Dependent Kinases | Fibroblast Growth Factor 10 - genetics | Fibroblast Growth Factor 10 - metabolism | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | RNA, Messenger - genetics | Mice, Transgenic | Myofibroblasts - cytology | Platelet-Derived Growth Factor - metabolism | Animals | Elastin - biosynthesis | Chaperonin 10 - genetics | Multivesicular Bodies - metabolism | Mice | Receptor, Fibroblast Growth Factor, Type 1 - biosynthesis | Physiological aspects | Fibroblasts | Fibroblast growth factors | Signal transduction | RNA-protein interactions | Rodents | Heat shock proteins | Protein expression | Physiology | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 12/2017, Volume 136, Issue 23, pp. 2271 - 2283
BACKGROUND:Abnormal amino acid metabolism is associated with vascular disease. However, the causative link between dysregulated tryptophan metabolism and... 
indoleamine-pyrrole 2,3-dioxygenase | angiotensin II | matrix metallopeptidases | tryptophan | aortic aneurysm, abdominal | 3-hydroxyanthranilic acid | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | KYNURENINE PATHWAY | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | FAMILIAL HYPERTRYPTOPHANEMIA | DEGRADE INSOLUBLE ELASTIN | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CHRONIC KIDNEY-DISEASE | CARDIOVASCULAR RISK | HYPERCHOLESTEROLEMIC MICE | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Aortic Aneurysm, Abdominal - chemically induced | Hydrolases - genetics | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Humans | Myocytes, Smooth Muscle - pathology | NF-kappa B - metabolism | Interferon-gamma - metabolism | Tryptophan - metabolism | Aortic Aneurysm, Abdominal - metabolism | Elastic Tissue - metabolism | Time Factors | Bone Marrow Transplantation | Aorta, Abdominal - pathology | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Hydrolases - metabolism | Matrix Metalloproteinase 2 - metabolism | Cells, Cultured | Genotype | 3-Hydroxyanthranilic Acid - metabolism | Mice, Knockout, ApoE | Elastic Tissue - pathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Index Medicus | Abridged Index Medicus | matrix metallopeptidase | Abdominal aortic aneurysm
Journal Article