The New England Journal of Medicine, ISSN 0028-4793, 04/2017, Volume 376, Issue 16, pp. 1540 - 1550
In a phase 2 clinical trial, eltrombopag plus standard immunosuppression resulted in a 6-month complete-response rate of 58% among patients receiving...
CELLS | MEDICINE, GENERAL & INTERNAL | THERAPY | MARROW | HEMATOPOIESIS | HORSE | ANTITHYMOCYTE GLOBULIN | THROMBOCYTOPENIA | MUTATIONS | MYELODYSPLASTIC SYNDROMES | CYCLOSPORINE | Antigens, CD34 | Benzoates - adverse effects | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Prospective Studies | Cell Count | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Young Adult | Antilymphocyte Serum - therapeutic use | Adult | Female | Drug Therapy, Combination | Pyrazoles - adverse effects | Hematologic Agents - adverse effects | Hydrazines - therapeutic use | Hematologic Agents - therapeutic use | Cyclosporine - therapeutic use | Receptors, Thrombopoietin - agonists | Immunosuppression | Adolescent | Anemia, Aplastic - drug therapy | Aged | Hydrazines - adverse effects | Treatment outcome | Eltrombopag | Analysis | Patient outcomes | Aplastic anemia | Dosage and administration | Drug therapy | Immunosuppressive agents | CD34 antigen | Anemia | Cell number | Research & development--R&D | Bone marrow | Age | Thrombopoietin | Hemopoiesis | Cancer
CELLS | MEDICINE, GENERAL & INTERNAL | THERAPY | MARROW | HEMATOPOIESIS | HORSE | ANTITHYMOCYTE GLOBULIN | THROMBOCYTOPENIA | MUTATIONS | MYELODYSPLASTIC SYNDROMES | CYCLOSPORINE | Antigens, CD34 | Benzoates - adverse effects | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Prospective Studies | Cell Count | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Young Adult | Antilymphocyte Serum - therapeutic use | Adult | Female | Drug Therapy, Combination | Pyrazoles - adverse effects | Hematologic Agents - adverse effects | Hydrazines - therapeutic use | Hematologic Agents - therapeutic use | Cyclosporine - therapeutic use | Receptors, Thrombopoietin - agonists | Immunosuppression | Adolescent | Anemia, Aplastic - drug therapy | Aged | Hydrazines - adverse effects | Treatment outcome | Eltrombopag | Analysis | Patient outcomes | Aplastic anemia | Dosage and administration | Drug therapy | Immunosuppressive agents | CD34 antigen | Anemia | Cell number | Research & development--R&D | Bone marrow | Age | Thrombopoietin | Hemopoiesis | Cancer
Journal Article
British Journal of Haematology, ISSN 0007-1048, 06/2014, Volume 165, Issue 6, pp. 865 - 869
Summary Thrombopoietin‐receptor agonists (Tpo‐RAs) are highly effective in immune thrombocytopenia (ITP). Recently, cases of durable remission after Tpo‐RA...
durable response | prolonged remission | thrombopoietin‐receptor agonists | immune thrombocytopenia | Immune thrombocytopenia | Durable response | Prolonged remission | Thrombopoietin-receptor agonists | LONG-TERM | EFFICACY | ITP | SAFETY | ROMIPLOSTIM | PURPURA | thrombopoietin-receptor agonists | CIRRHOSIS | BIOLOGY | ELTROMBOPAG | AGENTS | HEMATOLOGY | Purpura, Thrombocytopenic, Idiopathic - surgery | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Thrombopoietin - therapeutic use | Treatment Outcome | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Receptors, Fc - therapeutic use | Splenectomy | Young Adult | Receptors, Thrombopoietin - agonists | Aged, 80 and over | Adult | Female | Aged | Drug Therapy, Combination | France | Immunologic Factors - therapeutic use | Thrombocytopenia
durable response | prolonged remission | thrombopoietin‐receptor agonists | immune thrombocytopenia | Immune thrombocytopenia | Durable response | Prolonged remission | Thrombopoietin-receptor agonists | LONG-TERM | EFFICACY | ITP | SAFETY | ROMIPLOSTIM | PURPURA | thrombopoietin-receptor agonists | CIRRHOSIS | BIOLOGY | ELTROMBOPAG | AGENTS | HEMATOLOGY | Purpura, Thrombocytopenic, Idiopathic - surgery | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Thrombopoietin - therapeutic use | Treatment Outcome | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Receptors, Fc - therapeutic use | Splenectomy | Young Adult | Receptors, Thrombopoietin - agonists | Aged, 80 and over | Adult | Female | Aged | Drug Therapy, Combination | France | Immunologic Factors - therapeutic use | Thrombocytopenia
Journal Article
British Journal of Haematology, ISSN 0007-1048, 03/2017, Volume 176, Issue 6, pp. 991 - 994
treatment | romiplostim | eltrombopag | aplastic anaemia | HEMATOPOIESIS | HEMATOLOGY | Hydrazines - pharmacology | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - pharmacology | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Thrombopoietin - therapeutic use | Thrombopoietin - pharmacology | Receptors, Fc - therapeutic use | Young Adult | Anemia, Aplastic - drug therapy | Benzoates - pharmacology | Adult | Female | Aged | Pyrazoles - pharmacology | Care and treatment | Aplastic anemia | Anemia | Thrombopoietin
Journal Article
Annual Review of Medicine, ISSN 0066-4219, 2009, Volume 60, Issue 1, pp. 193 - 206
Although the thrombopoietin receptor was discovered in 1991 and thrombopoietin (TPO) was purified in 1994, the development of a clinically useful TPO was...
Romiplostim | Eltrombopag | Platelets | Immune thrombocytopenic purpura (ITP) | FACTOR PEG-RHUMGDF | ANTIBODIES | RECOMBINANT HUMAN THROMBOPOIETIN | PLATELET PRODUCTION | eltrombopag | platelets | MEDICINE, GENERAL & INTERNAL | CYTOKINE RECEPTOR | HUMAN MEGAKARYOCYTE GROWTH | DOUBLE-BLIND | romiplostim | C-MPL | immune thrombocytopenic purpura (ITP) | AGONIST | Benzoates - adverse effects | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - adverse effects | Humans | Recombinant Fusion Proteins - therapeutic use | Thrombopoietin - therapeutic use | Receptors, Fc - therapeutic use | Carrier Proteins - adverse effects | Thrombocytopenia - drug therapy | Thrombopoietin - adverse effects | Carrier Proteins - therapeutic use | Thrombopoietin - physiology | Hydrazines - adverse effects | Pyrazoles - adverse effects | Thrombocytopenia | Care and treatment | Research | Biomimetics
Romiplostim | Eltrombopag | Platelets | Immune thrombocytopenic purpura (ITP) | FACTOR PEG-RHUMGDF | ANTIBODIES | RECOMBINANT HUMAN THROMBOPOIETIN | PLATELET PRODUCTION | eltrombopag | platelets | MEDICINE, GENERAL & INTERNAL | CYTOKINE RECEPTOR | HUMAN MEGAKARYOCYTE GROWTH | DOUBLE-BLIND | romiplostim | C-MPL | immune thrombocytopenic purpura (ITP) | AGONIST | Benzoates - adverse effects | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - adverse effects | Humans | Recombinant Fusion Proteins - therapeutic use | Thrombopoietin - therapeutic use | Receptors, Fc - therapeutic use | Carrier Proteins - adverse effects | Thrombocytopenia - drug therapy | Thrombopoietin - adverse effects | Carrier Proteins - therapeutic use | Thrombopoietin - physiology | Hydrazines - adverse effects | Pyrazoles - adverse effects | Thrombocytopenia | Care and treatment | Research | Biomimetics
Journal Article
Drugs, ISSN 0012-6667, 11/2015, Volume 75, Issue 17, pp. 1981 - 1992
Thrombocytopenia (platelet count <150 x 10(9)/L) often complicates chronic liver disease, impeding optimal management of these patients. The prevalence of this...
SUSTAINED VIROLOGICAL RESPONSE | HEPATOCELLULAR-CARCINOMA | ANTIVIRAL THERAPY | AKR-501 YM477 | CHRONIC HEPATITIS-C | PLATELET COUNT | PEGYLATED-INTERFERON | HUMAN THROMBOPOIETIN | ADVANCED FIBROSIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HCV INFECTION | Thiophenes - therapeutic use | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Recombinant Fusion Proteins - therapeutic use | Thrombopoietin - therapeutic use | Hepatitis C, Chronic - complications | Thiazoles - therapeutic use | Thrombocytopenia - complications | Receptors, Fc - therapeutic use | Receptors, Thrombopoietin - agonists | Thrombocytopenia - drug therapy | Liver Diseases - complications | Disease Management | Chronic Disease
SUSTAINED VIROLOGICAL RESPONSE | HEPATOCELLULAR-CARCINOMA | ANTIVIRAL THERAPY | AKR-501 YM477 | CHRONIC HEPATITIS-C | PLATELET COUNT | PEGYLATED-INTERFERON | HUMAN THROMBOPOIETIN | ADVANCED FIBROSIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HCV INFECTION | Thiophenes - therapeutic use | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Recombinant Fusion Proteins - therapeutic use | Thrombopoietin - therapeutic use | Hepatitis C, Chronic - complications | Thiazoles - therapeutic use | Thrombocytopenia - complications | Receptors, Fc - therapeutic use | Receptors, Thrombopoietin - agonists | Thrombocytopenia - drug therapy | Liver Diseases - complications | Disease Management | Chronic Disease
Journal Article
Journal of Pediatrics, The, ISSN 0022-3476, 2014, Volume 165, Issue 3, pp. 600 - 605.e4
Objectives To determine the safety, tolerability, or efficacy of 2 licensed thrombopoietic agents in children with persistent and chronic immune...
Pediatrics | EFFICACY | SAFETY | ROMIPLOSTIM | PURPURA | DOUBLE-BLIND | ELTROMBOPAG | PEDIATRICS | LONG-TERM TREATMENT | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Recombinant Fusion Proteins - therapeutic use | Child, Preschool | Male | Thrombopoietin - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Receptors, Fc - therapeutic use | Young Adult | Adolescent | Female | Retrospective Studies | Child | Chronic Disease | Thrombocytopenia | Drug therapy | Medical colleges
Pediatrics | EFFICACY | SAFETY | ROMIPLOSTIM | PURPURA | DOUBLE-BLIND | ELTROMBOPAG | PEDIATRICS | LONG-TERM TREATMENT | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Recombinant Fusion Proteins - therapeutic use | Child, Preschool | Male | Thrombopoietin - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Receptors, Fc - therapeutic use | Young Adult | Adolescent | Female | Retrospective Studies | Child | Chronic Disease | Thrombocytopenia | Drug therapy | Medical colleges
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 08/2016, Volume 63, Issue 8, pp. 1407 - 1413
Background Data on second‐line treatment options for pediatric patients with immune thrombocytopenia (ITP) are limited. Thrombopoietin receptor agonists...
treatment | ICON | thrombopoietin receptor agonists | immune thrombocytopenia | pediatrics | PURPURA ITP | CHRONIC IMMUNE THROMBOCYTOPENIA | EFFICACY | ROMIPLOSTIM | OPEN-LABEL | ONCOLOGY | DOUBLE-BLIND | ELTROMBOPAG | PLACEBO-CONTROLLED TRIAL | JAPANESE PATIENTS | HEMATOLOGY | LONG-TERM TREATMENT | Benzoates - adverse effects | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - adverse effects | Humans | Recombinant Fusion Proteins - therapeutic use | Male | Thrombopoietin - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - blood | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Receptors, Fc - therapeutic use | Receptors, Thrombopoietin - agonists | Platelet Count | Thrombopoietin - adverse effects | Adolescent | Female | Retrospective Studies | Child | Hydrazines - adverse effects | Pyrazoles - adverse effects | Pediatrics | Health aspects | Children | Consortia | Treatment | Thrombopoietin Receptor Agonists | Immune Thrombocytopenia
treatment | ICON | thrombopoietin receptor agonists | immune thrombocytopenia | pediatrics | PURPURA ITP | CHRONIC IMMUNE THROMBOCYTOPENIA | EFFICACY | ROMIPLOSTIM | OPEN-LABEL | ONCOLOGY | DOUBLE-BLIND | ELTROMBOPAG | PLACEBO-CONTROLLED TRIAL | JAPANESE PATIENTS | HEMATOLOGY | LONG-TERM TREATMENT | Benzoates - adverse effects | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - adverse effects | Humans | Recombinant Fusion Proteins - therapeutic use | Male | Thrombopoietin - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - blood | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Receptors, Fc - therapeutic use | Receptors, Thrombopoietin - agonists | Platelet Count | Thrombopoietin - adverse effects | Adolescent | Female | Retrospective Studies | Child | Hydrazines - adverse effects | Pyrazoles - adverse effects | Pediatrics | Health aspects | Children | Consortia | Treatment | Thrombopoietin Receptor Agonists | Immune Thrombocytopenia
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 1, pp. 11 - 19
A phase 2 study showed a 44% response rate with eltrombopag, an oral thrombopoietin mimetic, among 25 patients with refractory aplastic anemia. Severe aplastic...
STIMULATING FACTOR | SURVIVAL | MEDICINE, GENERAL & INTERNAL | IMMUNOSUPPRESSIVE THERAPY | STEM-CELLS | BONE-MARROW | C-MPL | RABBIT ANTITHYMOCYTE GLOBULIN | MARROW-TRANSPLANTATION | THROMBOPOIETIN | MICE LACKING | Benzoates - adverse effects | Recurrence | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Bone Marrow Cells - cytology | Humans | Middle Aged | Male | Benzoates - administration & dosage | Young Adult | Pyrazoles - administration & dosage | Adolescent | Anemia, Aplastic - drug therapy | Adult | Female | Aged | Chronic Disease | Hydrazines - administration & dosage | Drug Resistance | Anemia, Aplastic - pathology | Hydrazines - adverse effects | Pyrazoles - adverse effects | Eltrombopag | Hematopoiesis | Patient outcomes | Aplastic anemia | Causes of | Dosage and administration | Research | Drug therapy | Hypoplasia | Immune response | Transplants & implants | Anemia | Transplantation | Patients | Progenitor cells | Hematopoietic stem cells | Blood | Immunosuppressive agents | Thrombopoietin | Hemopoiesis | Immunosuppression | Pancytopenia | Fibrosis | Stem cells | Hemoglobin | Bone marrow | Platelets | Index Medicus | Abridged Index Medicus
STIMULATING FACTOR | SURVIVAL | MEDICINE, GENERAL & INTERNAL | IMMUNOSUPPRESSIVE THERAPY | STEM-CELLS | BONE-MARROW | C-MPL | RABBIT ANTITHYMOCYTE GLOBULIN | MARROW-TRANSPLANTATION | THROMBOPOIETIN | MICE LACKING | Benzoates - adverse effects | Recurrence | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Bone Marrow Cells - cytology | Humans | Middle Aged | Male | Benzoates - administration & dosage | Young Adult | Pyrazoles - administration & dosage | Adolescent | Anemia, Aplastic - drug therapy | Adult | Female | Aged | Chronic Disease | Hydrazines - administration & dosage | Drug Resistance | Anemia, Aplastic - pathology | Hydrazines - adverse effects | Pyrazoles - adverse effects | Eltrombopag | Hematopoiesis | Patient outcomes | Aplastic anemia | Causes of | Dosage and administration | Research | Drug therapy | Hypoplasia | Immune response | Transplants & implants | Anemia | Transplantation | Patients | Progenitor cells | Hematopoietic stem cells | Blood | Immunosuppressive agents | Thrombopoietin | Hemopoiesis | Immunosuppression | Pancytopenia | Fibrosis | Stem cells | Hemoglobin | Bone marrow | Platelets | Index Medicus | Abridged Index Medicus
Journal Article
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2011, Issue 7, p. CD008235
Background Chronic idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disorder that is characterized predominantly by a low platelet count....
ADULT PATIENTS | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | EFFICACY | SAFETY | ROMIPLOSTIM | AMG-531 | GUIDELINES | DOUBLE-BLIND | ELTROMBOPAG | SPLENECTOMY | Benzoates - adverse effects | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - adverse effects | Humans | Recombinant Fusion Proteins - therapeutic use | Thrombopoietin - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Randomized Controlled Trials as Topic | Receptors, Fc - therapeutic use | Receptors, Thrombopoietin - agonists | Thrombopoietin - adverse effects | Chronic Disease | Hydrazines - adverse effects | Pyrazoles - adverse effects
ADULT PATIENTS | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | EFFICACY | SAFETY | ROMIPLOSTIM | AMG-531 | GUIDELINES | DOUBLE-BLIND | ELTROMBOPAG | SPLENECTOMY | Benzoates - adverse effects | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - adverse effects | Humans | Recombinant Fusion Proteins - therapeutic use | Thrombopoietin - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Randomized Controlled Trials as Topic | Receptors, Fc - therapeutic use | Receptors, Thrombopoietin - agonists | Thrombopoietin - adverse effects | Chronic Disease | Hydrazines - adverse effects | Pyrazoles - adverse effects
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 373, Issue 9664, pp. 641 - 648
Summary Background Eltrombopag is an oral, non-peptide, thrombopoietin-receptor agonist that stimulates thrombopoiesis, leading to increased platelet...
Internal Medicine | MEDICINE, GENERAL & INTERNAL | IN-VITRO | EFFICACY | ITP | SAFETY | AMG-531 | GROWTH | ADULTS | QUALITY-OF-LIFE | RECEPTOR AGONIST | TPOR AGONIST | Benzoates - adverse effects | Hydrazines - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - complications | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Middle Aged | Male | Hemorrhage - prevention & control | Purpura, Thrombocytopenic, Idiopathic - blood | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Young Adult | Platelet Count | Hemorrhage - etiology | Aged, 80 and over | Adult | Female | Aged | Chronic Disease | Hydrazines - adverse effects | Pyrazoles - adverse effects | Thrombocytopenic purpura | Dosage and administration | Eltrombopag | Drug therapy | Heart failure | Drugs | Heart attacks | Blood platelets | Clinical trials | Monoclonal antibodies | Data collection | Placebo effect | Quality of life | Index Medicus | Abridged Index Medicus
Internal Medicine | MEDICINE, GENERAL & INTERNAL | IN-VITRO | EFFICACY | ITP | SAFETY | AMG-531 | GROWTH | ADULTS | QUALITY-OF-LIFE | RECEPTOR AGONIST | TPOR AGONIST | Benzoates - adverse effects | Hydrazines - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - complications | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Middle Aged | Male | Hemorrhage - prevention & control | Purpura, Thrombocytopenic, Idiopathic - blood | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Young Adult | Platelet Count | Hemorrhage - etiology | Aged, 80 and over | Adult | Female | Aged | Chronic Disease | Hydrazines - adverse effects | Pyrazoles - adverse effects | Thrombocytopenic purpura | Dosage and administration | Eltrombopag | Drug therapy | Heart failure | Drugs | Heart attacks | Blood platelets | Clinical trials | Monoclonal antibodies | Data collection | Placebo effect | Quality of life | Index Medicus | Abridged Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2011, Volume 365, Issue 8, pp. 734 - 741
A young woman with immune thrombocytopenia (ITP) who has been treated with a thrombopoietin-receptor agonist presents for advice regarding long-term treatment....
AUTOANTIBODIES | ADULT PATIENTS | MEDICINE, GENERAL & INTERNAL | PLATELET COUNTS | EFFICACY | ITP | SAFETY | PURPURA | ROMIPLOSTIM | DOUBLE-BLIND | ELTROMBOPAG | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - pharmacology | Benzoates - chemistry | Humans | Recombinant Fusion Proteins - therapeutic use | Thrombopoietin - therapeutic use | Receptors, Fc - therapeutic use | Hydrazines - chemistry | Pyrazoles - chemistry | Thrombocytopenia - drug therapy | Adult | Female | Thrombopoietin - chemistry | Autoimmune Diseases - drug therapy | Pyrazoles - pharmacology | Receptors, Fc - chemistry | Hydrazines - pharmacology | Hydrazines - therapeutic use | Thrombocytopenia - immunology | Thrombopoietin - pharmacology | Recombinant Fusion Proteins - chemistry | Receptors, Thrombopoietin - agonists | Platelet Count | Benzoates - pharmacology | Practice Guidelines as Topic | Thrombocytopenia | Case studies | Causes of | Care and treatment | Diagnosis | Menstruation | Hematology | Bone marrow | Adults | Patients | Thrombopoietin
AUTOANTIBODIES | ADULT PATIENTS | MEDICINE, GENERAL & INTERNAL | PLATELET COUNTS | EFFICACY | ITP | SAFETY | PURPURA | ROMIPLOSTIM | DOUBLE-BLIND | ELTROMBOPAG | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Recombinant Fusion Proteins - pharmacology | Benzoates - chemistry | Humans | Recombinant Fusion Proteins - therapeutic use | Thrombopoietin - therapeutic use | Receptors, Fc - therapeutic use | Hydrazines - chemistry | Pyrazoles - chemistry | Thrombocytopenia - drug therapy | Adult | Female | Thrombopoietin - chemistry | Autoimmune Diseases - drug therapy | Pyrazoles - pharmacology | Receptors, Fc - chemistry | Hydrazines - pharmacology | Hydrazines - therapeutic use | Thrombocytopenia - immunology | Thrombopoietin - pharmacology | Recombinant Fusion Proteins - chemistry | Receptors, Thrombopoietin - agonists | Platelet Count | Benzoates - pharmacology | Practice Guidelines as Topic | Thrombocytopenia | Case studies | Causes of | Care and treatment | Diagnosis | Menstruation | Hematology | Bone marrow | Adults | Patients | Thrombopoietin
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2012, Volume 367, Issue 8, pp. 716 - 724
In this trial involving patients with cirrhosis and thrombocytopenia, treatment with eltrombopag before invasive procedures reduced the need for platelet...
MEDICINE, GENERAL & INTERNAL | COAGULATION | ARTICLE | PORTAL-VEIN THROMBOSIS | CHRONIC LIVER-DISEASE | Benzoates - adverse effects | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Middle Aged | Male | Hemorrhage - prevention & control | Thrombocytopenia - complications | Platelet Transfusion - statistics & numerical data | Young Adult | Aged, 80 and over | Adult | Female | Pyrazoles - adverse effects | Hydrazines - therapeutic use | Double-Blind Method | Hemorrhage - epidemiology | Liver Cirrhosis - complications | Receptors, Thrombopoietin - agonists | Receptors, Thrombopoietin - genetics | Platelet Count | Adolescent | Aged | Chronic Disease | Elective Surgical Procedures | Hydrazines - adverse effects | Thrombocytopenia | Treatment outcome | Usage | Care and treatment | Eltrombopag | Causes of | Venous thrombosis | Health aspects | Liver cirrhosis | Cirrhosis | Medical research | Liver diseases | Platelets | Thrombosis | Bleeding | Thrombopoietin
MEDICINE, GENERAL & INTERNAL | COAGULATION | ARTICLE | PORTAL-VEIN THROMBOSIS | CHRONIC LIVER-DISEASE | Benzoates - adverse effects | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Middle Aged | Male | Hemorrhage - prevention & control | Thrombocytopenia - complications | Platelet Transfusion - statistics & numerical data | Young Adult | Aged, 80 and over | Adult | Female | Pyrazoles - adverse effects | Hydrazines - therapeutic use | Double-Blind Method | Hemorrhage - epidemiology | Liver Cirrhosis - complications | Receptors, Thrombopoietin - agonists | Receptors, Thrombopoietin - genetics | Platelet Count | Adolescent | Aged | Chronic Disease | Elective Surgical Procedures | Hydrazines - adverse effects | Thrombocytopenia | Treatment outcome | Usage | Care and treatment | Eltrombopag | Causes of | Venous thrombosis | Health aspects | Liver cirrhosis | Cirrhosis | Medical research | Liver diseases | Platelets | Thrombosis | Bleeding | Thrombopoietin
Journal Article
British Journal of Haematology, ISSN 0007-1048, 05/2013, Volume 161, Issue 3, pp. 411 - 423
Summary Romiplostim was effective, safe, and well‐tolerated over 6–12 months of continuous treatment in Phase 3 trials in patients with immune thrombocytopenia...
autoimmunity | thrombopoietic agents | thrombopoiesis | platelets | TPO receptor agonists | Autoimmunity | Thrombopoiesis | Platelets | Thrombopoietic agents | PURPURA ITP | AUTOANTIBODIES | MANAGEMENT | AMG-531 | DOUBLE-BLIND | ELTROMBOPAG | HEMATOLOGY | STANDARD | Myocardial Infarction - chemically induced | Purpura, Thrombocytopenic, Idiopathic - complications | Thrombosis - chemically induced | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Thrombopoietin - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Receptors, Fc - therapeutic use | Dose-Response Relationship, Drug | Splenectomy | Self Administration | Hemorrhage - etiology | Injections, Subcutaneous | Adult | Female | Purpura, Thrombocytopenic, Idiopathic - surgery | Bone Marrow Diseases - chemically induced | Combined Modality Therapy | Thrombocytopenia - chemically induced | Platelet Count | Thrombopoietin - adverse effects | Aged | Thrombocytopenia | Complications and side effects | Care and treatment
autoimmunity | thrombopoietic agents | thrombopoiesis | platelets | TPO receptor agonists | Autoimmunity | Thrombopoiesis | Platelets | Thrombopoietic agents | PURPURA ITP | AUTOANTIBODIES | MANAGEMENT | AMG-531 | DOUBLE-BLIND | ELTROMBOPAG | HEMATOLOGY | STANDARD | Myocardial Infarction - chemically induced | Purpura, Thrombocytopenic, Idiopathic - complications | Thrombosis - chemically induced | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Thrombopoietin - therapeutic use | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Receptors, Fc - therapeutic use | Dose-Response Relationship, Drug | Splenectomy | Self Administration | Hemorrhage - etiology | Injections, Subcutaneous | Adult | Female | Purpura, Thrombocytopenic, Idiopathic - surgery | Bone Marrow Diseases - chemically induced | Combined Modality Therapy | Thrombocytopenia - chemically induced | Platelet Count | Thrombopoietin - adverse effects | Aged | Thrombocytopenia | Complications and side effects | Care and treatment
Journal Article