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Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 14, pp. 10850 - 10861
A group of phosphoinositide 3-kinase (PI3K) inhibitors, such as 3-methyladenine (3-MA) and wortmannin, have been widely used as autophagy inhibitors based on... 
MAMMALIAN TARGET | RAPAMYCIN | COMPLEX | PROTEIN | DEPENDENT REGULATION | MONITORING AUTOPHAGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | MACROAUTOPHAGY | LC3 | MTOR | Embryo, Mammalian - drug effects | Fibroblasts - enzymology | Immunoprecipitation | Phosphatidylinositol Phosphates - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | Autophagy | Lysosomes - metabolism | Phosphatidylinositol 3-Kinases - classification | Embryo, Mammalian - enzymology | Phagosomes - drug effects | Lysosomes - drug effects | Adenine - analogs & derivatives | Phagosomes - metabolism | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Adenine - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Autophagy-Related Protein 7 | Animals | Androstadienes - pharmacology | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Fibroblasts - cytology | Mice | Enzymes | Inhibitors | Signal Transduction | Subcellular Organelles | Phosphatidylinositol 3-Kinase | Cell Death | Lysosomes | mTOR | Autophagy-related Gene | Cell Biology | 3-Methyladenine
Journal Article
Environmental Science & Technology, ISSN 0013-936X, 04/2006, Volume 40, Issue 7, pp. 2442 - 2447
The potential risk associated with the presence of low levels of pharmaceuticals in aquatic environments is currently under debate. In this study we... 
ENVIRONMENTAL SCIENCES | ACTIVATION | INHIBITION | REMOVAL | PHARMACEUTICALS | ENGINEERING, ENVIRONMENTAL | GROWTH | SENESCENCE | ERK | P53 | Embryo, Mammalian - drug effects | Gene Expression Regulation - drug effects | Cell Line | Cell Cycle | Embryo, Mammalian - cytology | Humans | Environmental Pollutants - toxicity | Embryo, Mammalian - metabolism
Journal Article
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 53 - 59
Reactive aldehydes are common carcinogens. They are also by-products of several metabolic pathways and, without enzymatic catabolism, may accumulate and cause... 
DNA-ADDUCTS | METABOLISM | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | FETAL ALCOHOL SYNDROME | ETHANOL | CHILDHOOD LEUKEMIA | KNOCKOUT MICE | ACETALDEHYDE | FANCONI-ANEMIA | CONSUMPTION | Embryo, Mammalian - drug effects | Acetaldehyde - metabolism | Clone Cells - drug effects | Teratogens - toxicity | Ethanol - toxicity | Fanconi Anemia Complementation Group D2 Protein - genetics | Weaning | Aldehyde Dehydrogenase, Mitochondrial | Male | DNA Repair - genetics | Aldehydes - metabolism | Aldehydes - antagonists & inhibitors | Fanconi Anemia Complementation Group D2 Protein - deficiency | Precursor Cell Lymphoblastic Leukemia-Lymphoma - chemically induced | Hematopoiesis - drug effects | Fetal Alcohol Spectrum Disorders - etiology | Gene Deletion | Aldehyde Dehydrogenase - deficiency | Embryo Loss - etiology | DNA Damage - genetics | Fanconi Anemia - pathology | Female | Fanconi Anemia - genetics | Aldehyde Dehydrogenase - metabolism | B-Lymphocytes - metabolism | Bone Marrow - drug effects | Cell Line | Cell Survival - drug effects | Aldehydes - toxicity | Bone Marrow - physiopathology | Ethanol - metabolism | Acetaldehyde - toxicity | Embryo Loss - chemically induced | Mice, Inbred C57BL | Aldehyde Dehydrogenase - genetics | Genes, Essential | Embryo, Mammalian - abnormalities | Pregnancy | B-Lymphocytes - drug effects | Animals | Embryo, Mammalian - embryology | Fanconi Anemia Complementation Group D2 Protein - metabolism | Bone Marrow - pathology | Chickens | Alleles | Mice | Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology | Teratogens - metabolism | Causes of | Research | Aldehydes | Health aspects | Fanconi's anemia | Mutation | DNA repair | Stem cells | Cancer
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2015, Volume 34, Issue 2, pp. 200 - 217
Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog... 
Gli inhibitors | Hedgehog | cancer | Gli1–DNA interaction | Gli1-DNA interaction | Cancer | CANCER-CELLS | STEM-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | HUMAN GLIOMA | CELL BIOLOGY | PATHWAY BLOCKADE | INHIBITION | GROWTH | SCORING FUNCTIONS | MEDULLOBLASTOMA | Embryo, Mammalian - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Receptors, G-Protein-Coupled - metabolism | Isoflavones - pharmacology | Cerebellum - drug effects | Embryo, Mammalian - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Female | Glioblastoma - metabolism | Receptors, Cell Surface - physiology | Patched Receptors | DNA - drug effects | Fibroblasts - metabolism | Mutagenesis, Site-Directed | Cerebellum - metabolism | DNA - metabolism | Mice, SCID | Mutation - genetics | Kruppel-Like Transcription Factors - chemistry | Molecular Dynamics Simulation | Mice, Knockout | Animals | Embryonic Stem Cells - drug effects | Signal Transduction - drug effects | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Glioblastoma - pathology | Cerebellum - cytology | Mice, Inbred NOD | Fibroblasts - cytology | Mice | Mice, Inbred BALB C | Zinc Finger Protein GLI1 | Glioblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Medical research | Amino acids | Molecular biology | Deoxyribonucleic acid--DNA | Stem cells | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23899
The Wnt/beta-catenin signalling pathway shares a key component, beta-catenin, with the cadherin-based adhesion system. The signalling function of beta-catenin... 
TYROSINE PHOSPHORYLATION | WNT PATHWAY | DEPENDENT TRANSCRIPTION | FACTOR SCATTER FACTOR | BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | ADHERENS JUNCTIONS | BETA-CATENIN | CELL-CELL ADHESION | NUCLEAR TRANSLOCATION | N-CADHERIN | Embryo, Mammalian - drug effects | Transcription, Genetic - drug effects | Epithelial Cells - metabolism | Cadherins - metabolism | Epithelial Cells - drug effects | Humans | Transcriptional Activation - drug effects | Mesoderm - drug effects | Cytoplasm - metabolism | Epithelial-Mesenchymal Transition - drug effects | Protein Transport - drug effects | Mesoderm - cytology | Epithelial-Mesenchymal Transition - genetics | Hepatocyte Growth Factor - pharmacology | Embryo, Mammalian - metabolism | Protein Binding - drug effects | HEK293 Cells | Cell Membrane - metabolism | Epithelial Cells - cytology | Cell Membrane - drug effects | Endocytosis - drug effects | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Dogs | Mesoderm - metabolism | Mice | Cytoplasm - drug effects | Regulators | Phosphorylation | Wnt protein | Transcription | Mesenchyme | Colorectal cancer | Activation | Biology | Cell adhesion & migration | Signal transduction | β-catenin | Embryogenesis | Endocytosis | Cell growth | Tumorigenesis | Trends | Growth factors | Chromosomes | Medical research | Gastrulation | Hepatocyte growth factor | Gene expression | Cadherin | Adhesion | Embryonic growth stage | Signaling | Insects | Morphology | Stem cells | Ligands | Mutation | Endoplasmic reticulum | Cytoplasm
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2009, Volume 41, Issue 8, pp. 891 - 898
Although DNA damage is considered a driving force for aging, the nature of the damage that arises endogenously remains unclear. Replicative stress, a source of... 
CHROMOSOME INSTABILITY | GENE ATR | DNA-DAMAGE RESPONSE | HEMATOPOIETIC STEM-CELLS | GENETICS & HEREDITY | LEADS | CHECKPOINT | DEFICIENT MICE | ATAXIA-TELANGIECTASIA | AGE | P53 | Abnormalities, Multiple - pathology | Embryo, Mammalian - drug effects | Protein-Serine-Threonine Kinases - deficiency | Fibroblasts - enzymology | Apoptosis - drug effects | DNA Replication - drug effects | Humans | Aging - drug effects | Brain - enzymology | Embryo, Mammalian - metabolism | DNA-Binding Proteins - metabolism | Aging - genetics | Progeria - embryology | DNA-Activated Protein Kinase - metabolism | Progeria - pathology | Embryo, Mammalian - enzymology | Stress, Physiological - drug effects | Abnormalities, Multiple - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | DNA Repair - drug effects | Embryo, Mammalian - pathology | Progeria - enzymology | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | Fibroblasts - pathology | Tumor Suppressor Protein p53 - deficiency | Syndrome | Aging - pathology | Phenotype | Animals | Fibroblasts - drug effects | Alleles | Abnormalities, Multiple - enzymology | Brain - pathology | Mice | Protein Kinase Inhibitors - pharmacology | DNA Damage | Embryonic development | Usage | Control | Animal models in research | DNA damage | Causes of | Physiological aspects | Genetic aspects | Research | Proteins | Dwarfism | Studies | Genotype & phenotype | Cell cycle | Kinases | Molecular biology | Cancer
Journal Article
Developmental Biology, ISSN 0012-1606, 09/2012, Volume 369, Issue 1, pp. 101 - 114
Embryonic development is controlled by a small set of signal transduction pathways, with vastly different phenotypic outcomes depending on the time and place... 
Development | Calvarial mesenchyme | Mouse model | Ror2 | Hair follicles | Wnt5a | PLANAR CELL POLARITY | CONVERGENT EXTENSION | DEVELOPMENTAL BIOLOGY | BETA-CATENIN | XENOPUS EMBRYOS | GENE-EXPRESSION | HAIR FOLLICLE MORPHOGENESIS | BONE-MASS | TUMOR-SUPPRESSOR | AXIS FORMATION | RECEPTOR TYROSINE KINASE | Embryo, Mammalian - drug effects | Meninges - embryology | Skin - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Embryo, Mammalian - metabolism | Bone and Bones - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - genetics | Female | Models, Animal | Hair Follicle - embryology | Repressor Proteins - metabolism | Skin - embryology | Calcification, Physiologic - genetics | Calcification, Physiologic - drug effects | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Osteogenesis - drug effects | Tetracycline - pharmacology | Embryonic Development - genetics | Gene Expression Regulation, Developmental - drug effects | Mice, Transgenic | Meninges - drug effects | beta Catenin - metabolism | Hair Follicle - drug effects | Pregnancy | Hair Follicle - cytology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Mice | Bone and Bones - abnormalities | Bone and Bones - embryology | Embryonic Development - drug effects | Skin - drug effects | development | hair follicles | calvarial mesenchyme | mouse model
Journal Article
Journal Article