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Methods (San Diego, Calif.), ISSN 1046-2023, 2017, Volume 115, pp. 80 - 90
[Display omitted] •TrackMate is a software tool for automated, and semi-automated particle tracking.•TrackMate’s major development focus is on usability and... 
Phototoxicity | Open-source software | Image analysis | Single-particle tracking | Microscopy | Clathin-mediated endocytosis | SYSTEM | CLATHRIN-MEDIATED ENDOCYTOSIS | TPLATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | TRANSPORT | DYNAMICS | ARABIDOPSIS | CELL | EMBRYOGENESIS | Image Processing, Computer-Assisted - statistics & numerical data | Plant Cells - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Cell Tracking - methods | Embryo, Nonmammalian - metabolism | Arabidopsis - ultrastructure | Clathrin - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Fibroblasts - ultrastructure | Cell Tracking - statistics & numerical data | Clathrin - metabolism | Arabidopsis - metabolism | Caenorhabditis elegans | Endocytosis | Algorithms | Animals | Light Signal Transduction | Single-Cell Analysis - statistics & numerical data | Single-Cell Analysis - methods | Embryo, Nonmammalian - ultrastructure | Plant Cells - ultrastructure | Gene Expression Regulation, Plant | Software | Fibroblasts - metabolism | Single-Cell Analysis/methods | Arabidopsis/metabolism | Embryo, Nonmammalian/ultrastructure | Cellular Biology | Life Sciences | Clathrin/genetics | Fibroblasts/metabolism | Cell Tracking/methods | Plant Cells/metabolism | Cell Tracking/statistics & numerical data | Arabidopsis/ultrastructure | Image Processing, Computer-Assisted/statistics & numerical data | Embryo, Nonmammalian/metabolism | Adaptor Proteins, Vesicular Transport/genetics | Clathrin/metabolism | Plant Cells/ultrastructure | Single-Cell Analysis/statistics & numerical data | Fibroblasts/ultrastructure | Adaptor Proteins, Vesicular Transport/metabolism
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 21, pp. 5474 - 5479
Mammalian sex determination is controlled by the antagonistic interactions of two genetic pathways: The SRY-SOX9-FGF9 network promotes testis determination... 
SOX9 Transcription Factor/genetics | Wnt Proteins/antagonists & inhibitors | Humans | Cells, Cultured | Testis/metabolism | Male | Zebrafish | Sex Differentiation | Mutation, Missense | Disorders of Sex Development/genetics | Young Adult | Animals | Gene Expression Regulation, Developmental | Adolescent | Gonads/metabolism | Embryo, Nonmammalian/cytology | Thrombospondins/genetics | Adult | Female | beta Catenin/antagonists & inhibitors | Mice | Ubiquitin-Protein Ligases/genetics | ZNRF3 | DSD | Sex determination | WNT signaling | Organogenesis | OVARIAN DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | organogenesis | BETA-CATENIN | REVERSAL | R-SPONDIN | TUMOR-SUPPRESSOR | MICE | TESTIS DEVELOPMENT | SOX9 | DIFFERENTIATION | sex determination | CRITICAL TIME WINDOW | Embryo, Nonmammalian - cytology | Testis - metabolism | Thrombospondins - genetics | Embryo, Nonmammalian - metabolism | Gonads - pathology | Ubiquitin-Protein Ligases - physiology | Wnt Proteins - metabolism | Wnt Proteins - genetics | Disorders of Sex Development - pathology | SOX9 Transcription Factor - metabolism | Disorders of Sex Development - genetics | beta Catenin - metabolism | beta Catenin - genetics | Gonads - metabolism | Testis - pathology | beta Catenin - antagonists & inhibitors | Ubiquitin-Protein Ligases - genetics | Wnt Proteins - antagonists & inhibitors | SOX9 Transcription Factor - genetics | Thrombospondins - metabolism | Biological research | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Wnt proteins | Sex determination, Genetic | Biology, Experimental | Wnt Proteins / genetics | SOX9 Transcription Factor / metabolism | SOX9 Transcription Factor / genetics | beta Catenin / metabolism | Testis / pathology | Life Sciences | Gonads / metabolism | Thrombospondins / metabolism | Genetics | Testis / metabolism | beta Catenin / genetics | Disorders of Sex Development / pathology | beta Catenin / antagonists & inhibitors | Wnt Proteins / antagonists & inhibitors | Embryo, Nonmammalian / cytology | Wnt Proteins / metabolism | Ubiquitin-Protein Ligases / genetics | Gonads / pathology | Thrombospondins / genetics | Ubiquitin-Protein Ligases / physiology | Disorders of Sex Development / genetics | Embryo, Nonmammalian / metabolism | Human genetics | Biological Sciences
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 463, Issue 7283, pp. 958 - 962
Heterozygous mutations in the gene encoding the CHD (chromo-domain helicase DNA-binding domain) member CHD7, an ATP-dependent chromatin remodeller homologous... 
NETWORK | COMPLEX | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | TRANSCRIPTION | POLYMERASE-II | MUTATIONS | EXPRESSION | CHARGE-SYNDROME | Embryonic Stem Cells - metabolism | Embryo, Nonmammalian - cytology | Embryonic Stem Cells - cytology | Xenopus Proteins - genetics | Humans | Multipotent Stem Cells - metabolism | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | DNA-Binding Proteins - deficiency | Neural Crest - metabolism | Xenopus Proteins - chemistry | DNA-Binding Proteins - metabolism | Gene Expression Regulation, Developmental | Transcription, Genetic | Cell Differentiation | Xenopus laevis - genetics | DNA Helicases - genetics | Snail Family Transcription Factors | SOX9 Transcription Factor - metabolism | Cell Line | DNA Helicases - chemistry | Neural Crest - cytology | Xenopus laevis - embryology | Chromosomal Proteins, Non-Histone - metabolism | DNA Helicases - deficiency | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Syndrome | Chromosomal Proteins, Non-Histone - genetics | Transcription Factors - metabolism | Cell Lineage | DNA Helicases - metabolism | Animals | Xenopus Proteins - deficiency | Multipotent Stem Cells - cytology | Neural Crest - embryology | Xenopus laevis - metabolism | Twist-Related Protein 1 - genetics | Protein Binding | Xenopus Proteins - metabolism | Enhancer Elements, Genetic - genetics | Twist-Related Protein 1 - metabolism | SOX9 Transcription Factor - genetics | Cell Movement | Chromatin | Drosophila | Polybrominated biphenyls | Physiological aspects | Genetic aspects | Research | Structure | Embryonic stem cells | Helicases | Proteins | Labeling | Evacuations & rescues | Cell adhesion & migration | Human | Peripheral nervous system | Genes | Charge | Bones | Activation | Numerical control | Gene expression
Journal Article
PLoS genetics, ISSN 1553-7404, 2007, Volume 3, Issue 5, pp. e78 - 801
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 467, Issue 7319, pp. 1128 - 1132
Piwi-associated RNAs (piRNAs), a specific class of 24- to 30-nucleotide-long RNAs produced by the Piwi-type of Argonaute proteins, have a specific germline... 
LOCALIZATION | TRANSLATIONAL REGULATION | GERMLINE | ACTIVATION | NANOS | MULTIDISCIPLINARY SCIENCES | BINDING-PROTEIN | MUTATIONS | MELANOGASTER | PIWI | AXIS SPECIFICATION | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Drosophila melanogaster - embryology | Embryo, Nonmammalian - cytology | Ribonucleases - genetics | Embryo, Nonmammalian - metabolism | Zygote - metabolism | 3' Untranslated Regions - genetics | Cytoplasm - metabolism | Embryo, Nonmammalian - embryology | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila melanogaster - genetics | Mothers | Ribonucleases - metabolism | Gene Expression Regulation, Developmental | DNA Transposable Elements - genetics | Female | Cytoplasm - genetics | Repressor Proteins - metabolism | RNA, Messenger - genetics | Drosophila melanogaster - cytology | Repressor Proteins - genetics | RNA Stability | Peptide Initiation Factors - metabolism | Peptide Initiation Factors - genetics | Polyadenylation - genetics | Animals | Argonaute Proteins | Drosophila Proteins - genetics | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Embryonic development | Messenger RNA | Drosophila | Genetic aspects | Research | Gene expression | Properties | Proteins | Signal transduction | Cytoplasm | CCR4 deadenylase | RNA silencing | nanos | Translational control | piRNA | mRNA decay
Journal Article
Development (Cambridge), ISSN 1477-9129, 2013, Volume 140, Issue 3, pp. 573 - 582
The tailbud is the posterior leading edge of the growing vertebrate embryo and consists of motile progenitors of the axial skeleton, musculature and spinal... 
Zebrafish | Body elongation | Tailbud | Cell migration | CELL-MOVEMENT | INDUCED ANTAGONIST | BOX TRANSCRIPTION FACTORS | POSTERIOR BODY | DEVELOPMENTAL BIOLOGY | SMOOTHED PARTICLE HYDRODYNAMICS | ONE-EYED-PINHEAD | WNT SIGNALING PATHWAYS | SEGMENTATION CLOCK | MESODERM FORMATION | TAIL FORMATION | Cell Polarity | Embryo, Nonmammalian - cytology | Cadherins - metabolism | Cell Count | Embryo, Nonmammalian - metabolism | Fibroblast Growth Factors - genetics | Zebrafish - embryology | Fibroblast Growth Factors - metabolism | Time Factors | Gene Expression Regulation, Developmental | Computer Simulation | Body Patterning | Cadherins - genetics | Wnt Signaling Pathway | Tail - embryology | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Embryonic Development | Cell Adhesion | Zebrafish - genetics | Biomechanical Phenomena | Animals | Models, Biological | Zebrafish - metabolism | Tail - metabolism | Zebrafish Proteins - genetics | Cell Movement | Zebrafish/metabolism | Zebrafish Proteins/genetics | Life Sciences | Cadherins/metabolism | Tail/embryology | Embryo, Nonmammalian/cytology | Zebrafish/embryology | Tail/metabolism | Embryo, Nonmammalian/metabolism | Zebrafish/genetics | Cadherins/genetics | Fibroblast Growth Factors/genetics | Fibroblast Growth Factors/metabolism | Zebrafish Proteins/metabolism
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 5, pp. 1382 - 1395
Our aging society is confronted with a dramatic increase of patients suffering from tauopathies, which include Alzheimer disease and certain frontotemporal... 
DANIO-RERIO | MEDICINE, RESEARCH & EXPERIMENTAL | TRANSGENIC ZEBRAFISH | PHOSPHORYLATION | ALZHEIMERS-DISEASE | GLYCOGEN-SYNTHASE KINASE-3 | PAIRED HELICAL FILAMENTS | PROTEIN-TAU TAU | EXPRESSION | NEURODEGENERATIVE DISEASES | DEGENERATION | Neurons - pathology | Spinal Cord - metabolism | Humans | Embryo, Nonmammalian - metabolism | Tauopathies - pathology | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Embryo, Nonmammalian - drug effects | Motor Neurons - pathology | Escape Reaction | tau Proteins - genetics | Enzyme Inhibitors - pharmacokinetics | Larva - drug effects | Spinal Cord - pathology | Enzyme Inhibitors - chemistry | Cell Death | Drug Design | Molecular Structure | Neurons - metabolism | Larva - anatomy & histology | Phosphorylation - drug effects | Neurons - drug effects | Motor Neurons - drug effects | Disease Models, Animal | Drug Evaluation, Preclinical - methods | Glycogen Synthase Kinase 3 - chemistry | Animals, Genetically Modified | Embryo, Nonmammalian - pathology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Larva - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Zebrafish - genetics | Motor Neurons - metabolism | Synaptotagmins - metabolism | Embryo, Nonmammalian - abnormalities | Sequence Alignment | Tauopathies - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Luminescent Proteins - genetics | Protein Conformation | Tauopathies - drug therapy | Luminescent Proteins - metabolism | Enzyme inhibitors | Cell death | Physiological aspects | Nervous system | Dosage and administration | Degeneration | Research | Diagnosis | Drug therapy | Technical Advance
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 521, Issue 7551, pp. 217 - 221
Vertebrates have a unique 3D body shape in which correct tissue and organ shape and alignment are essential for function. For example, vision requires the lens... 
ORGANIZATION | ZEBRAFISH | PROTEIN | PATHWAY | YAP/TAZ | MULTIDISCIPLINARY SCIENCES | DYNAMICS | EXTRACELLULAR-MATRIX | CELL-ADHESION | MEDAKA | FORCES | Embryo, Nonmammalian - anatomy & histology | Oryzias - anatomy & histology | Humans | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | GTPase-Activating Proteins - metabolism | Spheroids, Cellular - cytology | Fish Proteins - genetics | Organ Size - genetics | Oryzias - genetics | Protein-Serine-Threonine Kinases - metabolism | Genes, Essential - genetics | Gravitation | Morphogenesis - genetics | Signal Transduction | Spheroids, Cellular - metabolism | Protein-Serine-Threonine Kinases - genetics | Fish Proteins - metabolism | Mutation - genetics | Actomyosin - metabolism | Phenotype | Animals | Adaptor Proteins, Signal Transducing - genetics | Body Size - genetics | Adaptor Proteins, Signal Transducing - metabolism | Oryzias - embryology | Physiological aspects | Vertebrates | Cellular signal transduction | Observations | Guanosine triphosphatase | Morphogenesis | Genotype & phenotype | Cell growth | Developmental biology | Stem cells | Cell division | Polymerization | Gene expression | Cell adhesion & migration | Apoptosis | actomyosin network | morphogenesis | 3D body shape | cell stacking | tissue alignment | fibronectin assembly | tissue tension
Journal Article
Development (Cambridge), ISSN 1477-9129, 2007, Volume 135, Issue 2, pp. 367 - 375
Journal Article
Development, ISSN 0950-1991, 01/2010, Volume 137, Issue 2, pp. 203 - 212
The transcription factor neurogenin 3 (Neurog3 or Ngn3) controls islet cell fate specification in multipotent pancreatic progenitor cells in the mouse embryo.... 
Mouse | Rfx | Endocrine | Zebrafish | Cell differentiation | Pancreas | Transcription factor | Neurogenin 3 | PROGENITOR CELLS | NEUROGENIN3 | BETA-CELLS | DEVELOPMENTAL BIOLOGY | HORMONE-EXPRESSING CELLS | PROTEIN ISL-1 | ENDOCRINE PANCREAS | GENE | EMBRYONIC STEM-CELLS | DIFFERENTIATION | Immunohistochemistry | Paired Box Transcription Factors - genetics | Homeodomain Proteins - metabolism | Pancreas - cytology | Winged-Helix Transcription Factors - metabolism | Embryo, Nonmammalian - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Embryo, Mammalian - metabolism | Endocrine Cells - metabolism | In Situ Hybridization | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Somatostatin - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Zebrafish Proteins - metabolism | Winged-Helix Transcription Factors - genetics | Cells, Cultured | Pancreas - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | Pancreas - embryology | Homeodomain Proteins - genetics | Endoderm - metabolism | Ghrelin - metabolism | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Blotting, Northern | Animals | Endocrine Cells - cytology | Glucagon - metabolism | Mice | Zebrafish Proteins - genetics | In Vitro Techniques | Paired Box Transcription Factors - metabolism | Development and Stem Cells
Journal Article